A facile synthesis of benzofuro[2,3-c]pyridines has been achieved under mild conditions by using ammonium acetate as the nitrogen source through intramolecular cascade annulation.This reaction could efficiently constr...A facile synthesis of benzofuro[2,3-c]pyridines has been achieved under mild conditions by using ammonium acetate as the nitrogen source through intramolecular cascade annulation.This reaction could efficiently construct pyridine ring and furan ring in one step.Moreover,the key annulation step was demonstrated through dihydrobenzofuran intermediates.展开更多
Four types of unprecedented and chemodivergent reactions betweenα-diketones and alkynylα-diketones have been achieved under the catalysis of phosphine and Br?nsted base,respectively,leading to the rapid construction...Four types of unprecedented and chemodivergent reactions betweenα-diketones and alkynylα-diketones have been achieved under the catalysis of phosphine and Br?nsted base,respectively,leading to the rapid construction of four different classes of biologically important but synthetically challenging molecular scaffolds including 2-hydroxyfuran-3(2H)-ones,4-hydroxy-2-oxabicyclo[2.2.1]heptan-3-ones,1,3-diaryl cyclobutanes,and 4-(furan-2(3H)-ylidene)cyclopent-2-enones.The formation of the products includes two novel rearrangement processes,and further transformations on the products can be easily achieved to deliver value-added substances such as highly functionalized cyclopentanes.Moreover,the 2-hydroxyfuran-3(2H)-one products display promising photophysical properties such as green luminescence under UV light and aggregation-induced emission effect,showing the practical application value of this work.The great potential ofα-diketones in both synthetic chemistry and material science has been unambiguously demonstrated.展开更多
基金This work was financially supported by the Natural Science Foundation of Henan Province(No.132300410319)and Luoyang Normal University.
文摘A facile synthesis of benzofuro[2,3-c]pyridines has been achieved under mild conditions by using ammonium acetate as the nitrogen source through intramolecular cascade annulation.This reaction could efficiently construct pyridine ring and furan ring in one step.Moreover,the key annulation step was demonstrated through dihydrobenzofuran intermediates.
基金This work was supported by the National Natural Science Foundation of China(21871260,22071242)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000)+2 种基金Fujian Natural Science Foundation(2018J05035)the China Postdoctoral Science Foundation(2018M630734)the Science and Technology Research Program of the Education Department of Jiangxi Province(GJJ1991151).
文摘Four types of unprecedented and chemodivergent reactions betweenα-diketones and alkynylα-diketones have been achieved under the catalysis of phosphine and Br?nsted base,respectively,leading to the rapid construction of four different classes of biologically important but synthetically challenging molecular scaffolds including 2-hydroxyfuran-3(2H)-ones,4-hydroxy-2-oxabicyclo[2.2.1]heptan-3-ones,1,3-diaryl cyclobutanes,and 4-(furan-2(3H)-ylidene)cyclopent-2-enones.The formation of the products includes two novel rearrangement processes,and further transformations on the products can be easily achieved to deliver value-added substances such as highly functionalized cyclopentanes.Moreover,the 2-hydroxyfuran-3(2H)-one products display promising photophysical properties such as green luminescence under UV light and aggregation-induced emission effect,showing the practical application value of this work.The great potential ofα-diketones in both synthetic chemistry and material science has been unambiguously demonstrated.
