To the Editor:The incidence and mortality of colorectal cancer(CRC)in China have increased significantly in recent years.Surpassing gastric cancer,CRC has become one of the main cancers threatening the life and health...To the Editor:The incidence and mortality of colorectal cancer(CRC)in China have increased significantly in recent years.Surpassing gastric cancer,CRC has become one of the main cancers threatening the life and health of Chinese people and causing a serious social burden.Early detection of CRC is critical for improving outcomes.Although colonoscopy remains the primary diagnostic and screening method,its invasiveness and low patient compliance hinder broad application.Non-invasive methods including fecal occult blood tests and carcinoembryonic antigen(CEA)lack sensitivity(20–40%)and specificity for early detection.Therefore,non-invasive biomarkers with high sensitivity and specificity for detecting CRC and precancerous adenomas are urgently needed.Altered gut microbiota is closely associated with colorectal carcinogenesis but exhibits high interindividual variability,limiting its clinical utility.Microbiota-derived metabolites such as bile acids and short-chain fatty acids are critical in CRC progression.Serum metabolite levels are strongly correlated with gut microbial abundance,providing a new direction for noninvasive diagnosis of CRC.展开更多
基金supported by a grant from the Beijing Hope Run Special Fund of Cancer Foundation of China(No.LC2021L02).
文摘To the Editor:The incidence and mortality of colorectal cancer(CRC)in China have increased significantly in recent years.Surpassing gastric cancer,CRC has become one of the main cancers threatening the life and health of Chinese people and causing a serious social burden.Early detection of CRC is critical for improving outcomes.Although colonoscopy remains the primary diagnostic and screening method,its invasiveness and low patient compliance hinder broad application.Non-invasive methods including fecal occult blood tests and carcinoembryonic antigen(CEA)lack sensitivity(20–40%)and specificity for early detection.Therefore,non-invasive biomarkers with high sensitivity and specificity for detecting CRC and precancerous adenomas are urgently needed.Altered gut microbiota is closely associated with colorectal carcinogenesis but exhibits high interindividual variability,limiting its clinical utility.Microbiota-derived metabolites such as bile acids and short-chain fatty acids are critical in CRC progression.Serum metabolite levels are strongly correlated with gut microbial abundance,providing a new direction for noninvasive diagnosis of CRC.
