As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes ...As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.展开更多
Soil acidification is a major threat to agricultural sustainability in tropical and subtropical regions.Biodegradable and environmentally friendly materials,such as calcium lignosulfonate(CaLS),calcium poly(aspartic a...Soil acidification is a major threat to agricultural sustainability in tropical and subtropical regions.Biodegradable and environmentally friendly materials,such as calcium lignosulfonate(CaLS),calcium poly(aspartic acid)(PASP-Ca),and calcium polyγ-glutamic acid(γ-PGA-Ca),are known to effectively ameliorate soil acidity.However,their effectiveness in inhibiting soil acidification has not been studied.This study aimed to evaluate the effect of CaLS,PASP-Ca,andγ-PGA-Ca on the resistance of soil toward acidification as directly and indirectly(i.e.,via nitrification)caused by the application of HNO_(3)and urea,respectively.For comparison,Ca(OH)_(2)and lignin were used as the inorganic and organic controls,respectively.Among the materials,γ-PGA-Ca drove the substantial improvements in the pH buffering capacity(pHBC)of the soil and exhibited the greatest potential in inhibiting HNO_(3)-induced soil acidification via protonation of carboxyl,complexing with Al~(3+),and cation exchange processes.Under acidification induced by urea,CaLS was the optimal one in inhibiting acidification and increasing exchangeable acidity during incubation.Furthermore,the sharp reduction in the population sizes of ammonia-oxidizing bacteria(AOB)and ammonia-oxidizing archaea(AOA)confirmed the inhibition of nitrification via CaLS application.Therefore,compared to improving soil pHBC,CaLS may play a more important role in suppressing indirect acidification.Overall,γ-PGA-Ca was superior to PASP-Ca and CaLS in enhancing the soil pHBC and the its resistance to acidification induced by HNO_(3) addition,whereas CaLS was the best at suppressing urea-driven soil acidification by inhibiting nitrification.In conclusion,these results provide a reference for inhibiting soil re-acidification in intensive agricultural systems.展开更多
Calcium-based desulfurization ash(CDA)is mainly produced in dry and semi-dry flue gas desulfurization processes.The property of CDA is extremely unstable because its main component,calcium sulfite,makes it difficult t...Calcium-based desulfurization ash(CDA)is mainly produced in dry and semi-dry flue gas desulfurization processes.The property of CDA is extremely unstable because its main component,calcium sulfite,makes it difficult to be directly applied to the field of building materials.The modification of desulfurization ash can be realized by high-temperature oxidation and wet oxidation.After modification,CDA can be widely used in building materials.Hydrothermal oxidation has broad development prospects because it can complete the oxidation of CDA and the removal of impurity elements at the same time.CDA can be used to prepare high value-added products of calcium sulfate whiskers and ecological rubber fillers.展开更多
During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expoun...During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expounded the combustion fluorine retention agent developing principle,and probed into the high-temperature fluorine retention agent technical approach.The results show that the calcium-based sorbent particle grain size and pore structure also have the bigger influence on the combustion fluorine retention ef- fect,and reducing the calcium-based sorbent particle grain size and improving the calcium sorbent structure characteristics at very high temperature to enhance the fluorine retention effect is the important approach to the fluorine retention agent development.展开更多
In order to provide experimental guide to commercial use of fluorine pollution control during coal combustion, with fluorine pollution control during coal combustion in mind, this paper proposed the theory of combusti...In order to provide experimental guide to commercial use of fluorine pollution control during coal combustion, with fluorine pollution control during coal combustion in mind, this paper proposed the theory of combustion fluorine retention technology. Feasibility of fluorine retention reaction with calcium-based fluorine retention agent was analyzed through thermo-dynamic calculation during coal combustion. By simulating the restraining and retention effects and influential factors of calcium-based sorbets on vaporized fluoride during experimental combustion using fixed bed tube furnace, the paper systematically explored the influential law of such factors as combustion temperature, retention time, and added quantities of calcium-based sorbets on effects of fluorine retention. The research result shows that adding calcium-based fluorine retention agent in coal combustion has double effects of fluorine retention and sulfur retention, it lays an experimental foundation for commercial test of combustion fluorine retention.展开更多
The H2S removal characteristics of Taxada lime tinder the high temperature of 600-900℃ have been investigated. The test results indicated that this kind of sorbent almost was inert to H2S When temperature lowered dow...The H2S removal characteristics of Taxada lime tinder the high temperature of 600-900℃ have been investigated. The test results indicated that this kind of sorbent almost was inert to H2S When temperature lowered down to 600℃,while its reactivity increased with increased temperature and the equilibrium conversion reached up to over 60% at temperatLlre of 900℃.However, side reactions of H2S in conjunction with high-temperature decomposition and mineral catalysis to elemental sulfur and sulfur dioxide were testified.展开更多
基金supported by the Major State Basic Research Development Program of China(No.2017YFA0205201)China Postdoctoral Science Foundation Funded Project(2021M702743)the National Natural Science Foundation of China(NSFC,Nos.81925019,32101113,and U1705281).
文摘As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.
基金supported by the Major project of Ministry of Agriculture and Rural Affairs of the People’s Republic of China(No.NK2022180401)the major project of Ministry of Agriculture and Rural Affairs of the People’s Republic of China(No.NK2022180404)。
文摘Soil acidification is a major threat to agricultural sustainability in tropical and subtropical regions.Biodegradable and environmentally friendly materials,such as calcium lignosulfonate(CaLS),calcium poly(aspartic acid)(PASP-Ca),and calcium polyγ-glutamic acid(γ-PGA-Ca),are known to effectively ameliorate soil acidity.However,their effectiveness in inhibiting soil acidification has not been studied.This study aimed to evaluate the effect of CaLS,PASP-Ca,andγ-PGA-Ca on the resistance of soil toward acidification as directly and indirectly(i.e.,via nitrification)caused by the application of HNO_(3)and urea,respectively.For comparison,Ca(OH)_(2)and lignin were used as the inorganic and organic controls,respectively.Among the materials,γ-PGA-Ca drove the substantial improvements in the pH buffering capacity(pHBC)of the soil and exhibited the greatest potential in inhibiting HNO_(3)-induced soil acidification via protonation of carboxyl,complexing with Al~(3+),and cation exchange processes.Under acidification induced by urea,CaLS was the optimal one in inhibiting acidification and increasing exchangeable acidity during incubation.Furthermore,the sharp reduction in the population sizes of ammonia-oxidizing bacteria(AOB)and ammonia-oxidizing archaea(AOA)confirmed the inhibition of nitrification via CaLS application.Therefore,compared to improving soil pHBC,CaLS may play a more important role in suppressing indirect acidification.Overall,γ-PGA-Ca was superior to PASP-Ca and CaLS in enhancing the soil pHBC and the its resistance to acidification induced by HNO_(3) addition,whereas CaLS was the best at suppressing urea-driven soil acidification by inhibiting nitrification.In conclusion,these results provide a reference for inhibiting soil re-acidification in intensive agricultural systems.
基金supported by the National Natural Science Foundation of China(Grant No.51704004).
文摘Calcium-based desulfurization ash(CDA)is mainly produced in dry and semi-dry flue gas desulfurization processes.The property of CDA is extremely unstable because its main component,calcium sulfite,makes it difficult to be directly applied to the field of building materials.The modification of desulfurization ash can be realized by high-temperature oxidation and wet oxidation.After modification,CDA can be widely used in building materials.Hydrothermal oxidation has broad development prospects because it can complete the oxidation of CDA and the removal of impurity elements at the same time.CDA can be used to prepare high value-added products of calcium sulfate whiskers and ecological rubber fillers.
基金the National Natural Science Foundation of China(50476032)China Postdoctoral Science Foundation(2004035555)New Century of Talents Scheme Projects of Universities in Liaoning Province(RC-04-04)
文摘During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expounded the combustion fluorine retention agent developing principle,and probed into the high-temperature fluorine retention agent technical approach.The results show that the calcium-based sorbent particle grain size and pore structure also have the bigger influence on the combustion fluorine retention ef- fect,and reducing the calcium-based sorbent particle grain size and improving the calcium sorbent structure characteristics at very high temperature to enhance the fluorine retention effect is the important approach to the fluorine retention agent development.
基金the National Natural Science Foundation of China(50476032)China Postdoctoral Science Foundation(2004035555)New Century of Talents Scheme Projects of Universities in Liaoning Province(RC-04-04)
文摘In order to provide experimental guide to commercial use of fluorine pollution control during coal combustion, with fluorine pollution control during coal combustion in mind, this paper proposed the theory of combustion fluorine retention technology. Feasibility of fluorine retention reaction with calcium-based fluorine retention agent was analyzed through thermo-dynamic calculation during coal combustion. By simulating the restraining and retention effects and influential factors of calcium-based sorbets on vaporized fluoride during experimental combustion using fixed bed tube furnace, the paper systematically explored the influential law of such factors as combustion temperature, retention time, and added quantities of calcium-based sorbets on effects of fluorine retention. The research result shows that adding calcium-based fluorine retention agent in coal combustion has double effects of fluorine retention and sulfur retention, it lays an experimental foundation for commercial test of combustion fluorine retention.
文摘The H2S removal characteristics of Taxada lime tinder the high temperature of 600-900℃ have been investigated. The test results indicated that this kind of sorbent almost was inert to H2S When temperature lowered down to 600℃,while its reactivity increased with increased temperature and the equilibrium conversion reached up to over 60% at temperatLlre of 900℃.However, side reactions of H2S in conjunction with high-temperature decomposition and mineral catalysis to elemental sulfur and sulfur dioxide were testified.
