Orthotopic liver transplantation(OLT)is the mainstay treatment for malignant liver cancer and end-stage liver diseases.Nevertheless,liver ischemia-reperfusion injury(IRI),which is regarded as a major risk factor for p...Orthotopic liver transplantation(OLT)is the mainstay treatment for malignant liver cancer and end-stage liver diseases.Nevertheless,liver ischemia-reperfusion injury(IRI),which is regarded as a major risk factor for primary graft dysfunction,acute or chronic tissue rejection and organ damage[1],greatly limits the indication of liver resection and the application of marginal donor liver,seriously hindering the application of liver transplantation.展开更多
文摘Orthotopic liver transplantation(OLT)is the mainstay treatment for malignant liver cancer and end-stage liver diseases.Nevertheless,liver ischemia-reperfusion injury(IRI),which is regarded as a major risk factor for primary graft dysfunction,acute or chronic tissue rejection and organ damage[1],greatly limits the indication of liver resection and the application of marginal donor liver,seriously hindering the application of liver transplantation.
