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C.S.刘易斯的莎士比亚评论及其批评史意义
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作者 辛雅敏 《山东师范大学学报(社会科学版)》 北大核心 2025年第6期34-43,共10页
作为文学批评家的C.S.刘易斯曾在20世纪30年代末40年代初公开发表过两篇莎士比亚评论文章,其中一篇反驳了当时依然流行的人物性格分析批评,另一篇则总结了莎士比亚乃至整个伊丽莎白时代戏剧语言艺术的特点,即文体上的“变奏”方法。如... 作为文学批评家的C.S.刘易斯曾在20世纪30年代末40年代初公开发表过两篇莎士比亚评论文章,其中一篇反驳了当时依然流行的人物性格分析批评,另一篇则总结了莎士比亚乃至整个伊丽莎白时代戏剧语言艺术的特点,即文体上的“变奏”方法。如果将其置于更宏大的批评史视野,刘易斯的两篇莎士比亚评论论文不仅反映了20世纪上半叶莎评风向的改变,而且对正在发生的批评观念变革起到了一定程度的推动作用。一方面,刘易斯的观点暗合了正在兴起的剑桥派批评和新批评等形式主义批评,因此也汇入了时代文学观念变革的洪流;而另一方面,他对阅读体验的重视又让其游离于主流的形式主义批评之外。但无论如何,刘易斯的莎士比亚评论都应该被视为英国文学批评史的有机组成部分。 展开更多
关键词 c.S.刘易斯 莎士比亚 文学批评
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线性乘积和规划问题的基于D.C.松弛的分支定界算法
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作者 张博 王红雨 高岳林 《运筹学学报(中英文)》 北大核心 2025年第4期159-174,共16页
线性乘积和规划已出现在工程实践和管理科学等领域,是一类NP-难问题。针对该问题目标函数的特殊结构,将其重构为一个D.C.(difference of convex functions)规划问题。再利用凹函数的凸包络,构造出了一种D.C.松弛问题,并将其分解为两个... 线性乘积和规划已出现在工程实践和管理科学等领域,是一类NP-难问题。针对该问题目标函数的特殊结构,将其重构为一个D.C.(difference of convex functions)规划问题。再利用凹函数的凸包络,构造出了一种D.C.松弛问题,并将其分解为两个凸子问题。然后将该D.C.松弛与超矩形的标准二分法相结合,设计了新的分支定界算法,并分析了其理论收敛性和计算复杂度。最后,借助大量数值实验验证了该算法的有效性。 展开更多
关键词 全局优化 线性乘积和规划 分支定界 D.c.规划松弛技术
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C.I.颜料黄74的分散及改性方法
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作者 马素芳 李学敏 +1 位作者 邢颖 修迪 《染料与染色》 2025年第3期1-8,共8页
本文概述了C.I.颜料黄74的性质、性能、合成路线,介绍了C.I.颜料黄74的分散和改性方法,重点对表面改性法加以叙述。
关键词 c.I.颜料黄74 分散 改性 色浆
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General and Specific Combining Abilities of Pacific Oyster(Crassostrea gigas)and Fujian Oyster(C.angulata)for Growth,Survival and Thermal Tolerance of Their Reciprocal Hybrids 被引量:1
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作者 JIANG Gaowei XU Chengxun LI Qi 《Journal of Ocean University of China》 2025年第1期238-248,共11页
A crossbreeding program was established in 2019 to address the declining Crassostrea gigas harvests caused by Pacific Oyster Mortality Syndrome(POMS).As a part of the program,this study was performed to estimate the g... A crossbreeding program was established in 2019 to address the declining Crassostrea gigas harvests caused by Pacific Oyster Mortality Syndrome(POMS).As a part of the program,this study was performed to estimate the genetic structure underlying phenotypic variation.Fifteen complete diallel crossings of C.gigas and C.angulata,comprising 60 full-sib families,were used to evaluate the general combining ability(GCA)and specific combining ability(SCA),as well as genotype and environment interactions for shell height(SH),summer survival(SS),and thermal tolerance(TT)of reciprocal hybrids GA(C.gigas♀×C.angulata♂)and AG(C.angulata♀×C.gigas♂)grown in Rongcheng and Rushan,Shandong Province,China.The results suggested that heterosis of the reciprocal hybrids was evident for SH,SS,and TT.The hybrid GA had larger heterosis than AG in both testing environments,and can be a potential donor in the breeding program.The male C.gigas had better GCA for SH in Rongcheng,whereas male C.angulata was a good general combiner for SS and TT in both Rongcheng and Rushan.The estimate of SCA was much higher than GCA for SH and lower than GCA for TT.To harness both additive and non-additive genetic effects,combination breed-ing could be taken to develop hybrid varieties possessing both thermal tolerance and fast-growing traits.The positive correlations between SH and TT suggested that these traits could be improved simultaneously.The significant G×E interactions demonstrated the importance to undertake site-specific breeding programs in different environments.Overall,this study can provide essential information for developing crossbreeding strategies for the oyster farming industry. 展开更多
关键词 cROSSBREEDING combining ability genotype×environment interaction crassostrea gigas c.angulata
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Interspecific Transition Among Caragana microphylla, C. davazamcii and C. korshinskii Along Geographic Gradient. Ⅰ. Ecological and RAPD Evidence 被引量:12
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作者 马成仓 高玉葆 +2 位作者 刘惠芬 王金龙 郭宏宇 《Acta Botanica Sinica》 CSCD 2003年第10期1218-1227,共10页
The former plant population survey has shown that three genetically-related species, Caraganamicrophylla Lam., C. davazamcii Sancz. and C. korshinskii Kom., form a geographical replacement series inNei Mongol Plateau.... The former plant population survey has shown that three genetically-related species, Caraganamicrophylla Lam., C. davazamcii Sancz. and C. korshinskii Kom., form a geographical replacement series inNei Mongol Plateau. The present study on population distribution, taxonomy, morphology, development andgenetic structure demonstrated that the geographical distribution of these three species was successiveand in gradual change, thus forming a geographical cline which extended from the east to the west of NeiMongol Plateau. With an analysis of climate change over time, it was considered that the formation of thisgeographical cline was a result of plant adaptation to its natural environment. 展开更多
关键词 caragana microphylla c. davazamcii c. korshinskii interspecific transition alonggeographical gradient Morphology TAXONOMY RAPD
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Interspecific Transition Among Caragana microphylla, C. davazamcii and C. korshinskii Along Geographic Gradient. Ⅱ. Characteristics of Photosynthesis and Water Metabolism 被引量:14
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作者 马成仓 高玉葆 +1 位作者 郭宏宇 王金龙 《Acta Botanica Sinica》 CSCD 2003年第10期1228-1237,共10页
The characteristics of photosynthesis and water metabolism of Caragana microphylla Lam.,C. davazamcii Sancz. and C. korshinskii Kom. populations in different sites (117.6o-105.7o E, 44.6o-38.8o N)were studied. (1) Fro... The characteristics of photosynthesis and water metabolism of Caragana microphylla Lam.,C. davazamcii Sancz. and C. korshinskii Kom. populations in different sites (117.6o-105.7o E, 44.6o-38.8o N)were studied. (1) From the east to the west, the responses of the three species to photosyntheticallyavailable radiation (PAR) in net photosynthesis rate increased, the relative humidity of the air whichcorresponded to the occurrence of maximum photosynthesis rate decreased, and the corresponding airtemperature increased. Along the same gradient, the before-noon superiority of the photosynthesis be-came evident, and the photosynthesis rate and the light use efficiency (LUE ) increased, while the transp-iration rate decreased, thus the water use efficiency (WUE ) increased notably, and the leaf water contentdecreased gradually. From the east to the west, the plants took a water-saving strategy step by step withhigher photosynthesis rate and lower transpiration rate. These physiological changes in the plants wereadaptable to the conditions of light, temperature and humidity in the habitat of the plants, and might be thebiological foundation for the geographical transition among C. microphylla , C. davazamcii and C. korshinskii.(2) The adaptation of photosynthetic system of C. microphylla , C. davazamcii and C. korshinskii to PAR, airhumidity and temperature exhibited the interspecific continuity, which was consistent with theenvironmental gradient. In different species and different sites, the diurnal changes of net photosynthesisrate, the daily cumulative value of net photosynthesis, the diurnal changes of transpiration rate, the dailycumulative value of transpiration, the water use efficiency and the diurnal changes of leaf water contentvaried with longitudinal descent (from the east to the west). The characteristics of photosynthesis andwater metabolism indicated that the geographical transition among C. microphylla , C. davazamcii and C.korshinskii was in gradual change, and these three species formed a geographical cline. 展开更多
关键词 caragana microphylla c. davazamcii c. korshinskii geographical transition PHOTOSYNTHESIS water metabolism
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13例罕见型β地贫HBB:c.-81 A>C的研究报告
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作者 赖柏如 葛毅媛 +9 位作者 马晓敏 曾广款 余晓华 廖裕威 刘莉莉 曹延斌 曾燕清 黄玉婵 梁简恋 杨立业 《分子诊断与治疗杂志》 2025年第12期2389-2391,共3页
目的分析罕见型β地贫HBB:c.-81 A>C基因型与表型的关系。方法对血液学表型与常规地贫基因检测结果不相符的标本进行GAP-PCR检测及Sanger测序。结果检出13例患者HBB基因发生罕见突变,HGVS命名为HBB:c.-81 A>C(-31 A>C),其中1... 目的分析罕见型β地贫HBB:c.-81 A>C基因型与表型的关系。方法对血液学表型与常规地贫基因检测结果不相符的标本进行GAP-PCR检测及Sanger测序。结果检出13例患者HBB基因发生罕见突变,HGVS命名为HBB:c.-81 A>C(-31 A>C),其中1例病例为HBB:c.-81 A>C(-31 A>C)合并IVS-Ⅱ-654(C>T,654M)突变双重杂合子,呈中度贫血;12例HBB:c.-81 A>C(-31 A>C)突变杂合子中,2例无血红蛋白数据,3例轻度贫血,1例重度贫血,6例无贫血症状;HbA_(2)(4.0%~5.4%)均升高,MCV(57.1~80.8fl)均下降,11例MCH(16.2-26.6pg)下降,1例MCH正常;12例杂合子中,9例有HbF数据,其中7例HbF(0.4%~7.4%)升高。结论罕见型HBB:c.-81 A>C杂合子可表现为β+地贫的表型;当HBB:c.-81 A>C位点杂合突变复合其他HBB基因突变时,会表现为中间型或重型β地贫特征;当血液学表型与常规地贫基因突变检测结果不符时,应进一步做罕见基因型检测。 展开更多
关键词 Β-地中海贫血 罕见突变 DNA测序 HBB:c.-81 A>c
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Comparative Analysis of Growth and Survival Among Triploid Oysters from Crassostrea gigas and C.angulata Under Varying Temperature and Salinity Levels
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作者 FENG Jianxuan JIANG Gaowei +2 位作者 SUN Lingling XU Chengxun LI Qi 《Journal of Ocean University of China》 2025年第6期1747-1760,共14页
Recently,allotriploids from Pacific oysters(Crassostrea gigas)and Fujian oysters(C.angulata)have been grown for aquaculture.However,the viability of these allotriploids remains uncertain.In this study,two autotriploid... Recently,allotriploids from Pacific oysters(Crassostrea gigas)and Fujian oysters(C.angulata)have been grown for aquaculture.However,the viability of these allotriploids remains uncertain.In this study,two autotriploids,TGG(diploid C.gigas♀×tetraploid C.gigas♂)and TAA(diploid C.angulata♀×tetraploid C.angulata♂),and two allotriploids,TGA(diploid C.gigas♀×tetraploid C.angulata♂)and TAG(diploid C.angulata♀×tetraploid C.gigas♂),were studied to assess the heterosis in growth and survival at different temperatures and salinities.The results showed that during the larval stage,TAG exhibited increased heterosis in growth and survival when temperature rose.During the adult stage,the growth of TGA significantly outperformed other triploids at higher temperatures(23 and 28℃)and salinities(25 and 30).In contrast,TAG demonstrated the highest survival probability across all conditions except at salinity 25,where it equaled TAA after day 19.The highest oxygen consumption rates(OCR)of TGA and TAG were observed at 23 and 28℃,while the ammonia excretion rate(AER)of TAG was significantly higher than that of TGA at 23℃.These physiological parameters reflect the advantage of TAG in terms of survival.Notably,the temperature coefficient of allotriploids was higher than that of autotriploids in the range of 18–23℃.At 28℃,TAG showed the highest superoxide dismutase(SOD)and catalase(CAT)activities and the lowest malondialdehyde(MDA)content,showing its advantage when encountering high-temperature. 展开更多
关键词 ALLOTRIPLOID crassostrea gigas c.angulata temperature SALINITY
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Nutritional quality of interspecific backcross between hybrids of Crassostrea gigas×C.angulata and their two parental species
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作者 Chenchen WEI Luping WANG +4 位作者 Xinfeng SUN Wei WANG Guofan ZHANG Li LI Rihao CONG 《Journal of Oceanology and Limnology》 2025年第3期1022-1035,共14页
Oysters are of the most economically important bivalves worldwide.It has high nutritional value and is regarded as a good source of proteins,lipids,glycogen,and amino acids.C.gigas and C.angulata are allopatric congen... Oysters are of the most economically important bivalves worldwide.It has high nutritional value and is regarded as a good source of proteins,lipids,glycogen,and amino acids.C.gigas and C.angulata are allopatric congeneric dominant oysters that are widely cultivated in the northern and southern coast of China,and have shown remarkable differentiation in the nutritional content.Interspecific hybridization and backcross of the two species are effective ways to improve the nutritional quality of the oyster.Sixteen progenies were constructed based on a 4×4 diallel crosses among broodstock of C.gigas(G),C.angulata(A)and their hybrids GA(H)and AG(R).The glycogen,fatty acids,and amino acids performance of these progenies were evaluated in 22 months after fertilization.The glycogen content of AA was significantly lower than that of the other 15 progenies(P<0.05),while only the GH progeny was significantly higher than the GG(P<0.05),with a heterosis value of 21.06%.The backcross progenies GR exhibited significantly higher saturated fatty acids,eicosapentaenoic acid(EPA),and polyunsaturated fatty acids(PUFAs)content than those of GG(P<0.05),and did not show significant differences from AA.The AA showed significantly higher content of total amino acids(TAAs)than GG(P<0.05).The AH progeny displayed significantly higher taurine(Tau)content than GG(P<0.05),and the heterosis value was 27.88%.Therefore,the backcross breeding was shown an effective way to improve the glycogen,fatty acids,and TAAs of GG,and the glycogen of AA.This study provided useful information to characterize the benefits of backcrossing in nutritional quality,which will facilitate the production of differentiated products and increase the efficiency of the oyster industry. 展开更多
关键词 crassostrea gigas c.angulata interspecific backcross GLYcOGEN fatty acid amino acid
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诸神的复活:C.S.刘易斯“空间三部曲”的行星神话书写
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作者 王逸橦 《长江大学学报(社会科学版)》 2025年第4期7-13,共7页
C.S.刘易斯在“空间三部曲”中实现了传统神话元素与现代科学幻想的巧妙结合。在刘易斯生活的年代,关于火星运河的激情想象和金星女神的浪漫遐想业已被逐渐精进的观测仪器祛魅,但“空间三部曲”在20世纪的科幻版图中独树一帜,恢复了远... C.S.刘易斯在“空间三部曲”中实现了传统神话元素与现代科学幻想的巧妙结合。在刘易斯生活的年代,关于火星运河的激情想象和金星女神的浪漫遐想业已被逐渐精进的观测仪器祛魅,但“空间三部曲”在20世纪的科幻版图中独树一帜,恢复了远古泛灵论的宇宙观。在火星神话与金星神话的重述中,刘易斯将关于天界诸神的古老神话元素转化为星际叙事,以波澜壮阔的星际冒险再现人类认识宇宙的原始冲动,从而以“科幻新瓶装神话旧酒”的方式,将“空间三部曲”升格为对抗现代虚无主义的科幻文本。 展开更多
关键词 c.S.刘易斯 空间三部曲 科幻小说 行星神话
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C.I.直接红227替代品的合成
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作者 陈锋 陈庆林 +3 位作者 方岩波 余自琳 李茂 侯洪明 《染料与染色》 2025年第2期8-11,共4页
本文对合成C.I.直接红227的替代品进行了工艺优化。以反应时间、产物固色率与色光为指标,采用单因素实验分析了一缩反应pH、苯胺重氮化反应方式、苯胺重氮化反应时间以及偶合反应pH对产物影响,得到了制备C.I.227红替代品最佳工艺条件,... 本文对合成C.I.直接红227的替代品进行了工艺优化。以反应时间、产物固色率与色光为指标,采用单因素实验分析了一缩反应pH、苯胺重氮化反应方式、苯胺重氮化反应时间以及偶合反应pH对产物影响,得到了制备C.I.227红替代品最佳工艺条件,即一缩反应pH为2.0~2.5、苯胺在一缩产物中进行重氮反应、苯胺重氮反应时间为30 min、偶合反应pH为7.5~8.5,在此工艺条件下,一缩反应时间所需为1~1.5 h,偶合反应所需时间为2.5 h,产物固色率为100%,色光为近似~近似。 展开更多
关键词 c.I.直接红227 替代品 一缩反应 重氮反应 偶合反应
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基于C.R.A.P.原则乔家大院百寿图照壁寿字分析设计
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作者 张雯蓉 《设计》 2025年第15期136-140,共5页
乔家大院百寿图照壁是中国百寿图中的代表之作,百寿皆有不同的寓意,是中国传统哲学思想祝寿的体现。通过对寿字的分析研究,重新设计出适合当下审美的寿文化图样及其应用。首先,研究乔家大院百寿图照壁的特点,探究寿字的起源及发展;然后... 乔家大院百寿图照壁是中国百寿图中的代表之作,百寿皆有不同的寓意,是中国传统哲学思想祝寿的体现。通过对寿字的分析研究,重新设计出适合当下审美的寿文化图样及其应用。首先,研究乔家大院百寿图照壁的特点,探究寿字的起源及发展;然后选取百寿图中有代表性的寿字,进行分析,研究字体特征、形态和笔画提取;接着按照C.A.R.P.原则,对提炼的元素进行对比、重复、对齐和亲近重新设计,再进行填色,生成“寿”字衍生图;最后将衍生图应用于包装设计和室内设计之中,以实际案例的方法验证效果。将乔家大院百寿图“寿”字进行分析和重新设计,赋予中国传统色,生成新的衍生图样,应用于当下包装设计和室内设计之中,让传统文化焕发出新的生命力。 展开更多
关键词 乔家大院 百寿图 照壁 c.A.R.P.原则 设计应用
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C.I.分散棕27分析检测实例
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作者 樊春梅 《染料与染色》 2025年第4期55-58,共4页
本文验证了C.I.分散棕27行业标准中的检测方法,分析了这些检测指标的用途,提出高效液相色谱(HPLC)检测与UV检测不能互相替代的原因。
关键词 c.I.分散棕27 色谱分析 分散研磨 染色分析
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Climate Suitability Zoning of Morinda officinalis F. C. How and Sarcandra glabra (Thunb.) Nakai Planting in Xinfeng County Based on GIS
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作者 Jundao PAN Xizi PEI +2 位作者 Wenjian PAN Xiaoyun CHEN Jie GAO 《Meteorological and Environmental Research》 2025年第1期24-27,36,共5页
Based on the meteorological data of 24 automatic stations in Xinfeng County,combined with the climatic conditions for the growth of Morinda officinalis F.C.How and Sarcandra glabra(Thunb.)Nakai,the climate suitability... Based on the meteorological data of 24 automatic stations in Xinfeng County,combined with the climatic conditions for the growth of Morinda officinalis F.C.How and Sarcandra glabra(Thunb.)Nakai,the climate suitability zoning indicators of M.officinalis and S.glabra in Xinfeng County were constructed by relevant statistical methods,and the climate suitability zoning indicators were divided into four grades:most suitable,suitable,sub-suitable and unsuitable.According to the results of expert scores,the relevant growth impact factors were assigned weight values.Based on geographic information system(GIS),the climate suitability zoning of M.officinalis and S.glabra planting in Xinfeng County was carried out.The results show that most areas of Xinfeng County were suitable for planting M.officinalis and S.glabra.Among them,the most suitable planting areas of M.officinalis were mainly distributed in most of Huilong Town,from Jiangnan Community of Fengcheng Street to Yuntianhai area of Meikeng Town,Matouwantian Village and areas to the south,and areas to the south of Zhutong Village,Fengcheng Street.The most suitable areas for S.glabra planting were mainly distributed in Puchang Village of Huilong Town,the northeast of Huangzhai Town,the south of Fengcheng Street,and the central-southern part of Matou Town.The zoning results provide a scientific basis for the rational layout of M.officinalis and S.glabra planting in Xinfeng County. 展开更多
关键词 Morinda officinalis F.c.How Sarcandra glabra(Thunb.)Nakai climate suitability Geographic information system Xinfeng county
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中文可读性与C.Test阅读题目难度关系探究
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作者 郑尚毅 《太原城市职业技术学院学报》 2025年第6期114-117,共4页
研究实用汉语水平认定考试(C.Test)阅读文本的可读性与题目难度的关系,可为测试选取文本、提高测试效度提供参考。使用两个适于高级汉语水平阅读测试文本的可读性公式,对C.Test(A-D)J06AD01试卷的阅读文本进行可读性评估,对比阅读文本... 研究实用汉语水平认定考试(C.Test)阅读文本的可读性与题目难度的关系,可为测试选取文本、提高测试效度提供参考。使用两个适于高级汉语水平阅读测试文本的可读性公式,对C.Test(A-D)J06AD01试卷的阅读文本进行可读性评估,对比阅读文本可读性与阅读题目难度关系,研究发现:一是两公式所得阅读文本可读性指数趋于一致;二是可读性指数高(难度高)的阅读文本对应了难度较低的题目,而低难度阅读文本对应了难度较高的题目。这一结果可能会威胁阅读测试效度,建议汉语水平测试使用中文可读性公式控制文本难度,同时合理控制阅读题目难度。 展开更多
关键词 实用汉语水平认定考试(c.Test) 阅读测试 可读性 题目难度
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混合偶合对C.I.颜料黄150性能的影响
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作者 李静 孙宇航 +3 位作者 孔欣怡 邵建宇 吕东军 陈都民 《染料与染色》 2025年第3期9-12,30,共5页
在合成偶氮巴比妥酸钠盐的过程中添加第二偶合组分硫代巴比妥酸,采用混合偶合工艺对C.I.颜料黄150实施表面改性处理。考察了硫代巴比妥酸添加量对C.I.颜料黄150色光、着色强度及热稳定性的影响。结果表明:改性后的C.I.颜料黄150具有更... 在合成偶氮巴比妥酸钠盐的过程中添加第二偶合组分硫代巴比妥酸,采用混合偶合工艺对C.I.颜料黄150实施表面改性处理。考察了硫代巴比妥酸添加量对C.I.颜料黄150色光、着色强度及热稳定性的影响。结果表明:改性后的C.I.颜料黄150具有更高的饱和度和着色力,色泽更加鲜艳,同时展现出更好的热稳定性。 展开更多
关键词 c.I.颜料黄150 混合偶合工艺 表面改性
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“More Like a Real Person Walking on a Thin Line”─On the Characterizational Shift of C.Auguste Dupin in Edgar Allan Poe’s Detective Stories
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作者 Billy Bin Feng Huang 《Journal of Literature and Art Studies》 2025年第10期737-749,共13页
This paper aims to examine the characterizational shift of C.Auguste Dupin in Edgar Allan Poe’s detective stories.First,Poe’s detective stories were written when the Enlightenment,which emphasizes Reason,was being e... This paper aims to examine the characterizational shift of C.Auguste Dupin in Edgar Allan Poe’s detective stories.First,Poe’s detective stories were written when the Enlightenment,which emphasizes Reason,was being embedded in the fabric of American culture.Meanwhile,beneath the Enlightenment was also an undercurrent of irrationality.In Poe’s“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Dupin typifies a flat character standing for Reason/Good.However,in Poe’s“The Purloined Letter,”Dupin has been depicted as a round character;not only is he characterized a lot more vividly but also he bears striking resemblance to his opponent,Minister D.Namely,the dichotomous relationship between them has been erased,and Dupin has been portrayed more like a real person walking on the thin line between Good and Evil.Speaking of dissecting this characterizational shift of Dupin,I believe the key lies in the fact that Poe actually has taken an attitude of openness about Reason and Unreason,and that he has a way with opposing elements.In“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Poe intends for Reason,represented by Dupin,to keep under control Unreason,represented by the criminals.In such a case,Dupin only needs to be a flat character representing Good/Reason.But in“The Purloined Letter,”Poe intends for Reason/Good and Unreason/Evil to be merged.Under such circumstances,Dupin will conveniently evolve into a round character. 展开更多
关键词 (c.Auguste)Dupin (Edgar Allan)Poe the characterization(al shift) detective stories
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WDR45基因c.637del杂合突变导致β螺旋蛋白相关性神经变性病1例
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作者 周新平 卢志杰 +1 位作者 范进 张明杰 《四川医学》 2025年第9期1068-1071,共4页
1临床资料患者,女,27岁。因“行走缓慢,起坐困难1年余”于2024年5月16日入院。患者母亲诉1年余前(2023年3月)患者无明显诱因出现行走缓慢,行走1公里需休息后才能继续,且坐下后起立困难,需多次尝试,或借助于外力支撑。9个月前(2023年8月... 1临床资料患者,女,27岁。因“行走缓慢,起坐困难1年余”于2024年5月16日入院。患者母亲诉1年余前(2023年3月)患者无明显诱因出现行走缓慢,行走1公里需休息后才能继续,且坐下后起立困难,需多次尝试,或借助于外力支撑。9个月前(2023年8月)上述症状加重,表现为上下楼梯困难,平地行走300~400米需停下休息1~2 min后才能继续行走或需要母亲帮助。 展开更多
关键词 WDR45基因 c.637del杂合突变 β螺旋蛋白相关性神经变性病
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钴胺素相关C型代谢基因c.80A>G突变cblC型甲基丙二酸血症患儿临床特征
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作者 程沛迪 郑萍 +9 位作者 陈倩 申梦瑶 程大伟 姬辛娜 冯硕 谢丽娜 李淑品 吴欢欢 刘婉婷 刘硕 《中国医学前沿杂志(电子版)》 北大核心 2025年第7期41-47,共7页
目的探讨钴胺素相关C型代谢(metabolism of cobalamin associated C,MMACHC)基因c.80A>G突变位点的cblC型甲基丙二酸血症(methylmalonic acidemia,MMA)患儿的临床特征及预后。方法回顾性分析2024年1月至12月于首都医科大学附属首都... 目的探讨钴胺素相关C型代谢(metabolism of cobalamin associated C,MMACHC)基因c.80A>G突变位点的cblC型甲基丙二酸血症(methylmalonic acidemia,MMA)患儿的临床特征及预后。方法回顾性分析2024年1月至12月于首都医科大学附属首都儿童医学中心神经内科就诊的19例携带MMACHC c.80A>G突变位点的MMA患儿的临床特征及治疗转归,按起始治疗时间将病程≤1年开始治疗者分为早治疗组,将病程>1年开始治疗者分为晚治疗组。应用中文版儿童生活质量普通适用核心4.0版(pediatric quality of life inventory 4.0,PedsQL 4.0)量表对患儿进行生活质量调查,并对预后相关影响因素进行分析。结果在19例携带MMACHC c.80A>G突变的患儿中,c.80A>G纯合突变4例,占21.1%;复合杂合突变15例,占78.9%。18例在出现临床症状后诊断,余1例通过新生儿代谢筛查,于症状出现前确诊。在18例发病患儿中,贫血者14例,占77.8%;发育迟缓者13例,占72.2%;肾损害者11例,占61.1%。早发型(起病年龄≤1岁,11例)患儿肌张力增高或低下者明显多余晚发型(起病年龄>1岁,7例)患儿(54.5%比0,P<0.05)。早治疗组患儿的生活质量总分和社会功能分项得分明显高于晚治疗组[(81.83±8.29)分比(65.61±15.93)分和(87.00±28.30)分比(58.33±36.15)分,P均<0.05]。生活质量量表总分及社会功能分项得分均与起始治疗时间呈负相关(r=-0.592,P=0.016;r=-0.555,P=0.026)。结论MMACHC c.80A>G纯合突变患儿多为晚发型,携带MMACHC c.80A>G突变的早发型患儿更易合并肌张力异常。尽早诊断并开始治疗,对提高患儿生活质量、改善其社会功能具有重要的意义。 展开更多
关键词 甲基丙二酸血症 钴胺素相关c型代谢 临床特征 生活质量
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辣椒C.baccatum×C.frutescens种间杂种的获得与鉴定 被引量:3
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作者 张凯 刁卫平 +4 位作者 郭广君 潘宝贵 戈伟 刘金兵 王述彬 《江西农业学报》 CAS 2019年第8期1-5,13,共6页
种间杂交已被广泛用于扩大作物的遗传背景和优良性状改良。运用有性杂交的方法,以Capsicum baccatum PI441570为母本,Capsicum frutescens PI634826为父本进行杂交试验,成功获得杂交种子。对杂种F 1植株20个农艺性状进行观察比较,发现... 种间杂交已被广泛用于扩大作物的遗传背景和优良性状改良。运用有性杂交的方法,以Capsicum baccatum PI441570为母本,Capsicum frutescens PI634826为父本进行杂交试验,成功获得杂交种子。对杂种F 1植株20个农艺性状进行观察比较,发现其生长势具有明显的杂种优势,果型则小于双亲,其他表型大部分介于双亲之间,但是花粉可染率仅为4.9%,远低于母本的42.0%和父本的87.0%。同时应用EST-SSR分子标记证实了杂种的真实性。C.baccatum×C.frutescens杂种的获得,不仅扩大了辣椒遗传背景,而且为下一步通过三元杂交改良一年生辣椒C.annuum奠定了基础。 展开更多
关键词 c.bac.atum c.frutesc.ns 种间杂交 表型性状 SSR
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