In order to obtain amphiphilic polysaccharide self-assembly micelles,the hydrophobic modification by grafting stearic acid(SA)onto the backbone of burdock root polysaccharide(BRP)was carried out and its main physicoch...In order to obtain amphiphilic polysaccharide self-assembly micelles,the hydrophobic modification by grafting stearic acid(SA)onto the backbone of burdock root polysaccharide(BRP)was carried out and its main physicochemical properties were characterized.The results showed that the optimal esterification conditions were as follows:reaction time of 2 h,reaction temperature of 55℃,system pH of 8.0 and the SA addition of 4 mmol,a maximum substitution degree(DS)of the esterification products was obtained as 0.1012.The FTIR analysis verified that the modified polysaccharide successfully introduced the ester carbonyl group.^(1)H NMR spectra further confirmed that the esterification reaction occurred.The SA-modified BRP micelles were roughly spherical with uniform dispersion and the particle size was in the range of 259-352 nm,which showed a negative correlation with the DS.The solubility of the esterification products also decreased.The smaller critical micelle concentration(CMC)led to easier formation of self-aggregating micelles and stronger solubilization effect.The above results indicated that SA-modified BRP as a novel carrier material possessed potential to deliver hydrophobic active substances.展开更多
Arctium lappa,widely recognized as burdock,is a perennial plant that is employed in the realm of traditional Chinese medicine for a wide range of medicinal applications.The herb is rich in bioactive metabolites with t...Arctium lappa,widely recognized as burdock,is a perennial plant that is employed in the realm of traditional Chinese medicine for a wide range of medicinal applications.The herb is rich in bioactive metabolites with therapeutic potential,encompassing polyphenolic antioxidants in its leaves,and flavonoids and fructo-oligosaccharides in its underground parts.Nutraceuticals originating from botanical sources such as Arctium lappa provide supplementary health advantages alongside their nutritional content and have demonstrated effectiveness in the prevention and management of specific ailments.The utilization of Arctium lappa root extract has exhibited encouraging outcomes in addressing hepatotoxicity induced by cadmium,lead,chromium,and acetaminophen,ameliorating liver damage and oxidative stress.Additionally,the root extract displays properties such as antidiabetic,hypolipidemic,aphrodisiac,anti-rheumatic,anti-Alzheimer,and various other pharmacological actions.展开更多
基金supported by the project of Natural Science Foundation of Jiangsu Province(Project No.BK20201241)Independent Innovation Fund Project of Agricultural Science and Technology in Jiangsu Province(Project No.CX(20)3047).
文摘In order to obtain amphiphilic polysaccharide self-assembly micelles,the hydrophobic modification by grafting stearic acid(SA)onto the backbone of burdock root polysaccharide(BRP)was carried out and its main physicochemical properties were characterized.The results showed that the optimal esterification conditions were as follows:reaction time of 2 h,reaction temperature of 55℃,system pH of 8.0 and the SA addition of 4 mmol,a maximum substitution degree(DS)of the esterification products was obtained as 0.1012.The FTIR analysis verified that the modified polysaccharide successfully introduced the ester carbonyl group.^(1)H NMR spectra further confirmed that the esterification reaction occurred.The SA-modified BRP micelles were roughly spherical with uniform dispersion and the particle size was in the range of 259-352 nm,which showed a negative correlation with the DS.The solubility of the esterification products also decreased.The smaller critical micelle concentration(CMC)led to easier formation of self-aggregating micelles and stronger solubilization effect.The above results indicated that SA-modified BRP as a novel carrier material possessed potential to deliver hydrophobic active substances.
文摘Arctium lappa,widely recognized as burdock,is a perennial plant that is employed in the realm of traditional Chinese medicine for a wide range of medicinal applications.The herb is rich in bioactive metabolites with therapeutic potential,encompassing polyphenolic antioxidants in its leaves,and flavonoids and fructo-oligosaccharides in its underground parts.Nutraceuticals originating from botanical sources such as Arctium lappa provide supplementary health advantages alongside their nutritional content and have demonstrated effectiveness in the prevention and management of specific ailments.The utilization of Arctium lappa root extract has exhibited encouraging outcomes in addressing hepatotoxicity induced by cadmium,lead,chromium,and acetaminophen,ameliorating liver damage and oxidative stress.Additionally,the root extract displays properties such as antidiabetic,hypolipidemic,aphrodisiac,anti-rheumatic,anti-Alzheimer,and various other pharmacological actions.
