Objective:Children below 14 years of age are highly vulnerable to dengue infection and are at a greater risk of developing severe dengue illness.This study aimed to investigate the trends in the burden of dengue fever...Objective:Children below 14 years of age are highly vulnerable to dengue infection and are at a greater risk of developing severe dengue illness.This study aimed to investigate the trends in the burden of dengue fever among children below 14 years of age in China from 1990 to 2021 and to project the disease burden from 2022 to 2035.Methods:Based on the datasets derived from the Global Burden of Disease Study 2021,the following data were collected from dengue-affected children aged ≤14 years in China from 1990 to 2021:number and rate of incident dengue cases,number of prevalent dengue cases,number of deaths due to dengue,and disability-adjusted life years(DALYs) lost due to dengue.The trends in disease burden were examined based on average annual percent change(AAPC) and annual percent change,and the burdens were proj ected from 2022 to 2035 by using a Bayesian age-period-cohort model.Results:The incidence and prevalence of dengue fever were increased in children aged ≤ 14 years in China from1990 to 2021(AAPC=5.42 % and 5.44 %,respectively,P <0.001),while the mortality and DALYs rates were reduced(AAPC=-8.21 % and-7.55 %,respectively,P <0.001).The burden was comparable between genders,with numerically lower incidence and prevalence in boys than in girls.The lowest incidence and prevalence and the highest mortality and DALYs rates were observed in children aged <5 years.The incidence and prevalence rates were projected to increase from 2022 to 2035;in contrast,the mortality and DALYs rates were projected to decrease during this period.Conclusions:Although the mortality and DALYs rates of dengue fever decreased significantly in children aged0-14 years in China from 1990 to 2021,the incidence and prevalence increased remarkably.Enhanced surveillance and ample health education programs and preventive interventions are recommended for targeting this high-risk population.展开更多
Background:Female fish farmers in coastal Bangladesh face significant reproductive health(RH)challenges due to occupational,nutritional,and sociocultural factors.However,their health burdens have been largely overlook...Background:Female fish farmers in coastal Bangladesh face significant reproductive health(RH)challenges due to occupational,nutritional,and sociocultural factors.However,their health burdens have been largely overlooked in labor and health policies.Objectives:This study aims to investigate the prevalence,severity,determinants,and emotional and relationship consequences of RH morbidities among female fish farmers in Shyamnagar,Satkhira,Bangladesh.Methods:A cross-sectional survey with structured questionnaires was conducted among 297 female fish farmers.Data were supplemented by rural appraisal activities.Descriptive statistics,chi-square tests,Poisson regression,and Structural Equation Modeling were used for analysis.Results:The study found that 59.60%(177/297)of participants suffered from moderate to severe uterine issues,remarkably menstrual irregularities(92.65%,164/177),backache(59.32%,105/177),pelvic and fatigue pain(42.37%,75/177),anemia(28.24%,50/177),with the"21-30"year age group bearing a higher physiological burden with greater relational and emotional disruptions than“31-40”year age group,and“41-50”year age group women.High exposure to occupational chemicals(81.82%,243/297)and lack of personal protective equipment(93.94%,279/297)were key contributors.Access to formal healthcare is limited due to financial hardships(85.86%,255/297),social stigma(51.52%,153/297),and inadequate health services(46.47%,138/297).Structural Equation Modeling results also revealed significant associations among RH morbidities,emotional distress,social isolation,and diminishing well-being.Conclusion:The study highlights the urgent need for integrated health policies addressing reproductive care,occupational safety,and mental health support for female fish farmers in coastal Bangladesh.Addressing these issues will improve their health,well-being,and resilience.展开更多
Background: Cancer diagnosis has been reported in some studies to have a significant psychosocial impact on both the patients and their caregivers. The estimated prevalence of psychosocial distress is between 35% and ...Background: Cancer diagnosis has been reported in some studies to have a significant psychosocial impact on both the patients and their caregivers. The estimated prevalence of psychosocial distress is between 35% and 55%. Commonly encountered psychological issues include and are not limited to fear, anxiety, and emotional distress. Many sources of emotional distress in patients with cancer during the COVID-19 pandemic have been reported to include poorly controlled symptoms arising from a lack of access to symptom control services and treatment. Social distress is associated with social isolation, separation from family and loss of employment. Cancer patients and society have been reported to experience anxiety, despair, and stress due to the COVID-19 restrictions on community movement and hospital appointment rescheduling. The objective of this study was to explore psychosocial distress and social burdens experienced by cancer patients during the COVID-19 pandemic. Methods: A descriptive phenomenological design was employed to describe “lived experiences of patients with Cancer” during the COVID-19 Pandemic. A total of 20 participants with Cancer and COVID-19 positive were purposefully selected and interviewed. Thematic analysis was utilized for data analysis by the use of themes generated from participants’ responses. Findings: Five major themes emerged: fear, self-isolation compliance, anxiety, low income and emotional distress. The findings of the study indicated that participants experienced fear, emotional distress and anxiety when diagnosed with COVID-19. Conclusion: The experiences of psychosocial distress and social burdens were a result of a lack of psychosocial support by both caregivers and health care workers. This study recommends appropriate health education concerning psychosocial support for cancer patients and the need to have appropriate clinical protocols and materials in allaying anxiety and fear in cancer patients during the COVID-19 pandemic.展开更多
In this issue of the Journal of Geriatric Cardiology,Huang et al. have reported the detection of coronary artery disease with electron-beam computed tomography (EBCT),utilizing non-contrast and contrast imaging te... In this issue of the Journal of Geriatric Cardiology,Huang et al. have reported the detection of coronary artery disease with electron-beam computed tomography (EBCT),utilizing non-contrast and contrast imaging techniques (EBCTA) in several subgroups including type 2 diabetes mellitus (DM), impaired glucose tolerance (IGT), coronary heart disease, and normal subjects. ……展开更多
Effect of distribution of iron concentrates between pelletized and matrix feed on the preparation of blast furnace burdens from two different kinds of fine iron concentrates (magnetite and hematite) by composite agglo...Effect of distribution of iron concentrates between pelletized and matrix feed on the preparation of blast furnace burdens from two different kinds of fine iron concentrates (magnetite and hematite) by composite agglomeration process (CAP) was explored. It was found that when the mass ratio of iron concentrate A (magnetite) to iron concentrate B (hematite) in the mixed feed was constant, the proportion of iron concentrate A in the pelletized and matrix feed significantly affected the quality of CAP products. Particularly, as the proportion of iron concentrate A in the pelletized feed increased from 0 to 100%, the yield decreased from 82.11% to 79.19% and the tumbler index decreased from 71.33% to 68.27%. The mineralization characterization results indicated that when 100% iron concentrate A was used as the pelletized feed, the crystallization styles of the outer layer and the inner layer of the pellet were different, and a lot of pores exist around hematite and magnetite phases in the pelletized part, with the weak connection of pelletized and matrix part, resulting in poor strength of agglomeration product.展开更多
The reducibility of iron-bearing burdens was emphasized for improving the operation efficiency of blast furnace. The blast furnace operation of charging the burdens with high reducibility has been numerically evaluate...The reducibility of iron-bearing burdens was emphasized for improving the operation efficiency of blast furnace. The blast furnace operation of charging the burdens with high reducibility has been numerically evaluated using a multi-fluid blast furnace model. The effects of reaction rate constants and diffusion coefficients were investigated separately or simultaneously for clarifying the variations of furnace state. According to the model simulation results, in the upper zone, the indirect reduction of the burdens proceeds at a faster rate and the shaft efficiency is enhanced with the improvement under the conditions of interface reaction and intra-particle diffusion. In the lower zone, direct reduction in molten slag is restrained. As a consequence, CO utilization of top gas is enhanced and the ratio of direct reduction is decreased. It is possible to achieve higher energy efficiency of the blast furnace, and this is represented by the improvement in productivity and the decrease in consumption of reducing agent. The use of high-reducibility burdens contributes to a better performance of blast furnace. More efforts are necessary to develop and apply highreducibility sinter and carbon composite agglomerates for practical application at a blast furnace.展开更多
Background Childhood infectious diseases and related symptoms,such as fever,cough,and diarrhea among children constitute the leading cause of death in low-and middle-income countries.We examined the environmental pred...Background Childhood infectious diseases and related symptoms,such as fever,cough,and diarrhea among children constitute the leading cause of death in low-and middle-income countries.We examined the environmental predictors of double and triple burden(D/TB)of infection symptoms among under-five children using multilevel machine learning(ML)methods.Methods We used Demographic and Health Surveys(DHS)data from 58 LMICs between 2000 and 2023.These data were merged with cluster-level particulate matter and nitrogen dioxide from the National Aeronautics and Space Administration and country-level data on political,social,and economic globalization from the World Bank report.We applied multilevel models to screen out the most important predictors of D/TB symptoms and applied machine learning algorithms to predict these symptoms among children across LMICs.We trained and validated ML algorithms on(80,70,and 60%)of the data and tested on the remaining(20,30,and 40%)with 2,5 and 10 cross-validations.Results Of 1,546,243 children,19.2%,20.5%and 12.6%had fever,cough,and diarrhea,respectively;while the overall D/TB prevalence was 11.9%and 3.7%,respectively.The result revealed D/TB were associated with the location of a child,survey years,wealth index,family size,air pollutants,and environmental covariates.The estimated prevalence of both D/TB symptoms substantially varies across districts[intraclass correlation(intraclass correlation,ICC=13.3%)]and countries(ICC=8.8%).We found that the Random Forest gave the maximum area Under the curve of 94%and 99%for D/TBs for the K10 protocol and 80:20 training and testing dataset splits.Conclusions The study found substantial variation in the prevalences of D/TB of illness among children under five and identified several environmental and sociodemographic predictors of these health outcomes.The Random Forest algorithm performed best in predicting these burdens.The study emphasized how integrating environmental and sociodemographic data with machine learning can enhance targeted interventions to reduce childhood infectious disease burdens in low-and middle-income countries.展开更多
Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adj...Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adjusted life years(DALYs),stratified by age,sex,and economic development level based on data retrieved from the Global Burden of Disease study 2021.Decomposition and frontier analyses were employed to identify key drivers of burden variation and visualize potential reductions based on development levels.Results:Between 1990 and 2021,the global burden of ARIs showed a significant decline in both achievable age-standardized DALYs rate and age-standardized mortality rates(EAPC=-3.87 and-3.81,respectively).Different age groups and sex witnessed different levels of ARI burden,males experienced heavier burden than females and the 0-4 years-old group experienced heavier burden than other study age groups.Most of the 204 countries and territories experienced a downward trend of ARI burden,with slight increases observed only in Lesotho and Dominica.A negative correlation was found between the Socio-demographic Index and ARI burden.Decomposition analysis indicated that the significant decreases in deaths and DALYs were primarily driven by epidemiological changes.Conclusions:The global burden of ARIs among children and adolescents has declined over the past three decades,but substantial regional disparities persist.Targeted public health strategies are needed to address the continued ARI burden in high-risk regions and vulnerable age groups.展开更多
Background Human behaviors and tumors go hand in hand.The wave of globalization has brought about a global homogenization of human behaviors,which further triggers a potential global human behavior-related cancer burd...Background Human behaviors and tumors go hand in hand.The wave of globalization has brought about a global homogenization of human behaviors,which further triggers a potential global human behavior-related cancer burden(HBRCB)convergence.Methods This study systematically evaluated the global,regional,and national metrics of HBRCBs over the last 30 years using data from the Global Burden of Diseases(GBD)2019 results and the WHO Global Health Observatory(GHO)data repository.Results The results showed the global remission and convergence of HBRCB in the last three decades and the foreseeable future(2020–2044).Overall,HBRCBs are decreasing with the global emphasis on positive dietary habits,safe sex,substance addiction withdrawal,and active physical exercise habits.Globally,from 1990 to 2019,with the development of social development index(SDI)level from 0.511 to 0.651,the HBRCBs had been decreasing from 1507.908 to 1145.344 in age-standardized disability-adjusted life years(ASDALY)and from 61.467 to 49.449 in(age-standardized death rates)ASDR per 100,000 population with changes of−24.04%and−19.55%,respectively.Meanwhile,the variance in HBRCBs among countries and territories generally showed a decreasing or flat trend.The variance of HBRCBs among 204 countries and territories in 2019–2044 decreased from 1495.210 to 449.202 in males and from 214.640 to 78.848 in females for ASDR due to all behavior risks,and from 911,211.676 to 317,233.590 in males and from 146,171.660 to 62,926.660 in females for ASDALY.The global HBRCBs was becoming more uniform due to the globalization of human behaviors.Conclusions This study revealed the significance of addressing HBRCBs as a uniform and continuous issue in future global health promotion.It also demonstrated the potential existence of a chain effect in global health,where globalization leads to human behavior homogenization,which in turn results in HBRCB convergence.Properly measuring the commonalities and individualities among different regions and finding a balance when designing and evaluating HBRCB-related global policies in the global convergence trend of HBRCBs will be major concerns in the future.展开更多
Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of n...Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of neurodegenerative diseases with glaucoma being highly prevalent.Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells and their axons which make up the optic nerve.It is the leading cause of irreversible vision loss and affects an estimated 80 million people.The mammalian central nervous system is non-regenerative and,once lost or injured,retinal ganglion cells cannot regenerate an axon into the optic nerve under basal conditions.Thus,strategies that provide neuroprotection to stressed,dysfunctional,or dying retinal ganglion cells are likely to be of high therapeutic and translational value.Advancing age,genetics,and elevated intraocular pressure are all major risk factors for glaucoma,however,all clinically available glaucoma treatments focus on intraocular pressure management and do not directly address the neurodegenerative component of glaucoma.展开更多
In this editorial,we comment on the study of the Yu et al on psychological distress in patients with hepatobiliary and pancreatic malignancies.Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma...In this editorial,we comment on the study of the Yu et al on psychological distress in patients with hepatobiliary and pancreatic malignancies.Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma,cholangiocarcinoma,gallbladder cancer and pancreatic cancer.These cancers are among the most aggressive and difficult to treat.Although improvements in surgery,drug treatments and palliative care have led to better survival rates and quality of life,the significant psychological impact on patients remains underrecognized.Anxiety and depression are prevalent at every stage of the disease,from the initial diagnosis to treatment,recurrence and end-of-life care.However,these issues often take a backseat to the urgent need to manage physical symptoms.Mental health challenges can greatly affect how well patients follow treatment plans,recover and their overall outlook.Yu et al explore the causes of psychological distress in hepatobiliary and pancreatic cancers,including disease severity,symptom burden,financial stress and fears about life and death.We highlight the importance of regular mental health screenings,psychological support and teamwork in oncology care.By focusing on emotional health alongside physical treatment,doctors can build resilience,improve outcomes and address a frequently ignored aspect of cancer care.展开更多
The growing recognition of the role of genetics in the development of amyotrophic lateral sclerosis is evident.However,there has yet to be a comprehensive analysis of the clinical characteristics and genetics of famil...The growing recognition of the role of genetics in the development of amyotrophic lateral sclerosis is evident.However,there has yet to be a comprehensive analysis of the clinical characteristics and genetics of familial amyotrophic lateral sclerosis in an Asian population.This study aimed to provide an in-depth analysis of the clinical features and genetic spectrum of familial amyotrophic lateral sclerosis over 15 years in a clinic-based cohort of patients from the Chinese mainland.Enrollment of 302 amyotrophic lateral sclerosis families from 28 provinces was undertaken from January 2008 to September 2023.A group-based trajectory model for disease progression based on amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R)scores was validated using bootstrap internal validation in patients with familial amyotrophic lateral sclerosis,as well as patients with sporadic amyotrophic lateral sclerosis(matched at a 1:4 ratio,with replacement).DNA samples from 244 index patients were screened for variants in the pathogenic genes SOD1,FUS,TDP43,and C9ORF72,of which 146 were also subjected to genome-wide next-generation sequencing.Gene-level burden analysis was used to evaluate the distribution of rare variants in the cohort.We found that rapid dynamic disease progression was associated with an older age at onset,shorter diagnostic delay,lower body mass index,bulbar onset,and≥1 affected first-degree relative.Certain attributes,such as age at onset and time from onset to diagnosis,had comparable impacts on the clinical progression trajectories of both familial amyotrophic lateral sclerosis and sporadic amyotrophic lateral sclerosis.Harboring pathogenic/likely pathogenic variants in amyotrophic lateral sclerosis-causative genes reduced the age of onset of familial amyotrophic lateral sclerosis.Among the patients with familial amyotrophic lateral sclerosis,17.8%possessed≥2 pathogenic/likely pathogenic variants.Sequencing kernel association test analysis showed that the SOD1 rare variant burden(P=1.3e-15)was associated with a significant risk of familial amyotrophic lateral sclerosis.Our findings conclusively confirmed the clinical features and genetic spectrum of familial amyotrophic lateral sclerosis over 15 years in a clinical cohort from China,contributing to a deeper understanding of genotype-phenotype relationships in familial amyotrophic lateral sclerosis.This comprehensive evaluation of specific clinical characteristics,clinical prognosis,and genetic variants of amyotrophic lateral sclerosis based on detailed clinical and genetic information may lead to the development of genotype-specific treatment approaches.展开更多
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most prominent cause of dementia.In 2019,over 57.4million people were living with AD and other dementia subtypes,a number which is ex...Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most prominent cause of dementia.In 2019,over 57.4million people were living with AD and other dementia subtypes,a number which is expected to increase to over 152.8 million in the next 25years.This ever-increasing burden has resulted in AD and other neurodegenerative diseases rising to one of the top 10 causes of death globally (O'Connell et al.,2024).展开更多
Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving re...Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of mul...Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.展开更多
The Chinese Government’s recent economic stimulus measures are attracting much attention because of its plan to increase people’s incomes and alleviate enterprises and residents’ economic burden.
YAN Cailing lives on the Loess Plateau in northwestern China. In spite of her lightheartedness and cheer, she actually leads an uneasy life. At 37,she has three children. When she was small, her family lived a hard li...YAN Cailing lives on the Loess Plateau in northwestern China. In spite of her lightheartedness and cheer, she actually leads an uneasy life. At 37,she has three children. When she was small, her family lived a hard life. Her parents couldn’t afford tuition fees for all their six daughters. She went to school without textbooks, always having to listen attentively to insure she would remember the teacher’s lessons. In winter, she wore thin clothes and ragged shoes. Even when both her feet were frostbitten, she still continued to go to school. In 1974, Yan Cailing was admitted to a senior high school but then failed to pass展开更多
Background:Data on the incidence,mortality,and other burden of oral cancer as well as their secular trends are necessary to provide policy-makers with the information needed to allocate resources appropriately.The pur...Background:Data on the incidence,mortality,and other burden of oral cancer as well as their secular trends are necessary to provide policy-makers with the information needed to allocate resources appropriately.The purpose of this study was to use the Global Burden of Disease(GBD)2017 results to estimate the incidence,mortality,and disability-adjusted life years(DALYs)for oral cancer from 1990 to 2017.Methods:We collected detailed data on oral cancer from 1990 to 2017 from the GBD 2017.The global incidence,mortality,and DALYs attributable to oral cancer as well as the corresponding age-standardized rates(ASRs)were calculated.The estimated annual percentage changes in the ASRs of incidence(ASRI)and mortality(ASRM)and age-standardized DALYs of oral cancer were also calculated according to regions and countries to quantify the secular trends in these rates.Results:We tracked the incidence,mortality,and DALYs of oral cancer in 195 countries/territories over 28 years.Globally,the incidence,mortality,and DALYs of oral cancer increased by about 1.0-fold from 1990 to 2017.The ASRI of oral cancer showed a similar trend,increasing from 4.41 to 4.84 per 100,000 person-years during the study period.The ASRM remained approximately stable at about 2.4 per 100,000 from 1990 to 2017,as did the age-standardized DALYs,at about 64.0 per 100,000 person-years.ASRI was highest in Pakistan(27.03/100,000,95%CI=22.13-32.75/100,000),followed by Taiwan China,and lowest in Iraq(0.96/100,000,95%CI=0.86-1.06/100,000).ASRM was highest in Pakistan(16.85/100,000,95%CI=13.92-20.17/100,000)and lowest in Kuwait(0.51/100,000,95%CI=0.45-0.58/100,000).Conclusions:The ASRI of oral cancer has increased slightly worldwide,while the ASRM and age-standardized DALY have remained stable.However,these characteristics vary between countries,suggesting that current prevention strategies should be reoriented,and much more targeted and specific strategies should be established in some countries to forestall the increase in oral cancer.展开更多
The environmental burdens of Chinese copper production have been identified and quantified in the context of typical technologies, materials supplies and environmental emissions by a life cycle approach. Primary and s...The environmental burdens of Chinese copper production have been identified and quantified in the context of typical technologies, materials supplies and environmental emissions by a life cycle approach. Primary and secondary copper production using copper ores and scraps, respectively, were analyzed in detail. The flash and bath smelting approaches and the recycling of copper scraps were selected as representative copper production processes. A quantitative analysis was also conducted to assess the influence of material transport distance in copper production. Life cycle assessment （LCA） results showed that resources depletion and human health contribute significantly to environmental burdens in Chinese copper production. In addition, the secondary copper production has dramatically lower environmental burdens than the primary production. There is no obvious distinction in overall environmental burdens in primary copper production by flash or bath smelting approach. However, resources depletion is lower and the damage to human health is higher for flash smelting approach. Ecosystem quality damage is slight for both approaches. Environ- mental burdens from the mining stage contribute most in all life cycle stages in primary copper production. In secondary copper production, the electrolytic refining stage dominates. Based on the life cycle assessment results, some suggestions for improving environmental performance were proposed to meet the sustainable development of Chinese copper industry.展开更多
基金the Military Program for Clinical Cultivation Specialty and Chinese Preventive Medicine Association.
文摘Objective:Children below 14 years of age are highly vulnerable to dengue infection and are at a greater risk of developing severe dengue illness.This study aimed to investigate the trends in the burden of dengue fever among children below 14 years of age in China from 1990 to 2021 and to project the disease burden from 2022 to 2035.Methods:Based on the datasets derived from the Global Burden of Disease Study 2021,the following data were collected from dengue-affected children aged ≤14 years in China from 1990 to 2021:number and rate of incident dengue cases,number of prevalent dengue cases,number of deaths due to dengue,and disability-adjusted life years(DALYs) lost due to dengue.The trends in disease burden were examined based on average annual percent change(AAPC) and annual percent change,and the burdens were proj ected from 2022 to 2035 by using a Bayesian age-period-cohort model.Results:The incidence and prevalence of dengue fever were increased in children aged ≤ 14 years in China from1990 to 2021(AAPC=5.42 % and 5.44 %,respectively,P <0.001),while the mortality and DALYs rates were reduced(AAPC=-8.21 % and-7.55 %,respectively,P <0.001).The burden was comparable between genders,with numerically lower incidence and prevalence in boys than in girls.The lowest incidence and prevalence and the highest mortality and DALYs rates were observed in children aged <5 years.The incidence and prevalence rates were projected to increase from 2022 to 2035;in contrast,the mortality and DALYs rates were projected to decrease during this period.Conclusions:Although the mortality and DALYs rates of dengue fever decreased significantly in children aged0-14 years in China from 1990 to 2021,the incidence and prevalence increased remarkably.Enhanced surveillance and ample health education programs and preventive interventions are recommended for targeting this high-risk population.
文摘Background:Female fish farmers in coastal Bangladesh face significant reproductive health(RH)challenges due to occupational,nutritional,and sociocultural factors.However,their health burdens have been largely overlooked in labor and health policies.Objectives:This study aims to investigate the prevalence,severity,determinants,and emotional and relationship consequences of RH morbidities among female fish farmers in Shyamnagar,Satkhira,Bangladesh.Methods:A cross-sectional survey with structured questionnaires was conducted among 297 female fish farmers.Data were supplemented by rural appraisal activities.Descriptive statistics,chi-square tests,Poisson regression,and Structural Equation Modeling were used for analysis.Results:The study found that 59.60%(177/297)of participants suffered from moderate to severe uterine issues,remarkably menstrual irregularities(92.65%,164/177),backache(59.32%,105/177),pelvic and fatigue pain(42.37%,75/177),anemia(28.24%,50/177),with the"21-30"year age group bearing a higher physiological burden with greater relational and emotional disruptions than“31-40”year age group,and“41-50”year age group women.High exposure to occupational chemicals(81.82%,243/297)and lack of personal protective equipment(93.94%,279/297)were key contributors.Access to formal healthcare is limited due to financial hardships(85.86%,255/297),social stigma(51.52%,153/297),and inadequate health services(46.47%,138/297).Structural Equation Modeling results also revealed significant associations among RH morbidities,emotional distress,social isolation,and diminishing well-being.Conclusion:The study highlights the urgent need for integrated health policies addressing reproductive care,occupational safety,and mental health support for female fish farmers in coastal Bangladesh.Addressing these issues will improve their health,well-being,and resilience.
文摘Background: Cancer diagnosis has been reported in some studies to have a significant psychosocial impact on both the patients and their caregivers. The estimated prevalence of psychosocial distress is between 35% and 55%. Commonly encountered psychological issues include and are not limited to fear, anxiety, and emotional distress. Many sources of emotional distress in patients with cancer during the COVID-19 pandemic have been reported to include poorly controlled symptoms arising from a lack of access to symptom control services and treatment. Social distress is associated with social isolation, separation from family and loss of employment. Cancer patients and society have been reported to experience anxiety, despair, and stress due to the COVID-19 restrictions on community movement and hospital appointment rescheduling. The objective of this study was to explore psychosocial distress and social burdens experienced by cancer patients during the COVID-19 pandemic. Methods: A descriptive phenomenological design was employed to describe “lived experiences of patients with Cancer” during the COVID-19 Pandemic. A total of 20 participants with Cancer and COVID-19 positive were purposefully selected and interviewed. Thematic analysis was utilized for data analysis by the use of themes generated from participants’ responses. Findings: Five major themes emerged: fear, self-isolation compliance, anxiety, low income and emotional distress. The findings of the study indicated that participants experienced fear, emotional distress and anxiety when diagnosed with COVID-19. Conclusion: The experiences of psychosocial distress and social burdens were a result of a lack of psychosocial support by both caregivers and health care workers. This study recommends appropriate health education concerning psychosocial support for cancer patients and the need to have appropriate clinical protocols and materials in allaying anxiety and fear in cancer patients during the COVID-19 pandemic.
文摘 In this issue of the Journal of Geriatric Cardiology,Huang et al. have reported the detection of coronary artery disease with electron-beam computed tomography (EBCT),utilizing non-contrast and contrast imaging techniques (EBCTA) in several subgroups including type 2 diabetes mellitus (DM), impaired glucose tolerance (IGT), coronary heart disease, and normal subjects. ……
基金supported by the National Natural Science Foundation of China under Grant U1960114,51774337,and U1660206the Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University under Grant CSUZC201905the Fundamental Research Funds for the Central Universities of Central South University under Grant 2018zzts220.
文摘Effect of distribution of iron concentrates between pelletized and matrix feed on the preparation of blast furnace burdens from two different kinds of fine iron concentrates (magnetite and hematite) by composite agglomeration process (CAP) was explored. It was found that when the mass ratio of iron concentrate A (magnetite) to iron concentrate B (hematite) in the mixed feed was constant, the proportion of iron concentrate A in the pelletized and matrix feed significantly affected the quality of CAP products. Particularly, as the proportion of iron concentrate A in the pelletized feed increased from 0 to 100%, the yield decreased from 82.11% to 79.19% and the tumbler index decreased from 71.33% to 68.27%. The mineralization characterization results indicated that when 100% iron concentrate A was used as the pelletized feed, the crystallization styles of the outer layer and the inner layer of the pellet were different, and a lot of pores exist around hematite and magnetite phases in the pelletized part, with the weak connection of pelletized and matrix part, resulting in poor strength of agglomeration product.
文摘The reducibility of iron-bearing burdens was emphasized for improving the operation efficiency of blast furnace. The blast furnace operation of charging the burdens with high reducibility has been numerically evaluated using a multi-fluid blast furnace model. The effects of reaction rate constants and diffusion coefficients were investigated separately or simultaneously for clarifying the variations of furnace state. According to the model simulation results, in the upper zone, the indirect reduction of the burdens proceeds at a faster rate and the shaft efficiency is enhanced with the improvement under the conditions of interface reaction and intra-particle diffusion. In the lower zone, direct reduction in molten slag is restrained. As a consequence, CO utilization of top gas is enhanced and the ratio of direct reduction is decreased. It is possible to achieve higher energy efficiency of the blast furnace, and this is represented by the improvement in productivity and the decrease in consumption of reducing agent. The use of high-reducibility burdens contributes to a better performance of blast furnace. More efforts are necessary to develop and apply highreducibility sinter and carbon composite agglomerates for practical application at a blast furnace.
基金the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Actions grant agreement No.101126602(Data4Healthcare),and the University of Oulu.
文摘Background Childhood infectious diseases and related symptoms,such as fever,cough,and diarrhea among children constitute the leading cause of death in low-and middle-income countries.We examined the environmental predictors of double and triple burden(D/TB)of infection symptoms among under-five children using multilevel machine learning(ML)methods.Methods We used Demographic and Health Surveys(DHS)data from 58 LMICs between 2000 and 2023.These data were merged with cluster-level particulate matter and nitrogen dioxide from the National Aeronautics and Space Administration and country-level data on political,social,and economic globalization from the World Bank report.We applied multilevel models to screen out the most important predictors of D/TB symptoms and applied machine learning algorithms to predict these symptoms among children across LMICs.We trained and validated ML algorithms on(80,70,and 60%)of the data and tested on the remaining(20,30,and 40%)with 2,5 and 10 cross-validations.Results Of 1,546,243 children,19.2%,20.5%and 12.6%had fever,cough,and diarrhea,respectively;while the overall D/TB prevalence was 11.9%and 3.7%,respectively.The result revealed D/TB were associated with the location of a child,survey years,wealth index,family size,air pollutants,and environmental covariates.The estimated prevalence of both D/TB symptoms substantially varies across districts[intraclass correlation(intraclass correlation,ICC=13.3%)]and countries(ICC=8.8%).We found that the Random Forest gave the maximum area Under the curve of 94%and 99%for D/TBs for the K10 protocol and 80:20 training and testing dataset splits.Conclusions The study found substantial variation in the prevalences of D/TB of illness among children under five and identified several environmental and sociodemographic predictors of these health outcomes.The Random Forest algorithm performed best in predicting these burdens.The study emphasized how integrating environmental and sociodemographic data with machine learning can enhance targeted interventions to reduce childhood infectious disease burdens in low-and middle-income countries.
文摘Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adjusted life years(DALYs),stratified by age,sex,and economic development level based on data retrieved from the Global Burden of Disease study 2021.Decomposition and frontier analyses were employed to identify key drivers of burden variation and visualize potential reductions based on development levels.Results:Between 1990 and 2021,the global burden of ARIs showed a significant decline in both achievable age-standardized DALYs rate and age-standardized mortality rates(EAPC=-3.87 and-3.81,respectively).Different age groups and sex witnessed different levels of ARI burden,males experienced heavier burden than females and the 0-4 years-old group experienced heavier burden than other study age groups.Most of the 204 countries and territories experienced a downward trend of ARI burden,with slight increases observed only in Lesotho and Dominica.A negative correlation was found between the Socio-demographic Index and ARI burden.Decomposition analysis indicated that the significant decreases in deaths and DALYs were primarily driven by epidemiological changes.Conclusions:The global burden of ARIs among children and adolescents has declined over the past three decades,but substantial regional disparities persist.Targeted public health strategies are needed to address the continued ARI burden in high-risk regions and vulnerable age groups.
基金supported by the Development Center for Medical Science and Technology National Health Commission of the People's Republic of China(WA2021RW27).
文摘Background Human behaviors and tumors go hand in hand.The wave of globalization has brought about a global homogenization of human behaviors,which further triggers a potential global human behavior-related cancer burden(HBRCB)convergence.Methods This study systematically evaluated the global,regional,and national metrics of HBRCBs over the last 30 years using data from the Global Burden of Diseases(GBD)2019 results and the WHO Global Health Observatory(GHO)data repository.Results The results showed the global remission and convergence of HBRCB in the last three decades and the foreseeable future(2020–2044).Overall,HBRCBs are decreasing with the global emphasis on positive dietary habits,safe sex,substance addiction withdrawal,and active physical exercise habits.Globally,from 1990 to 2019,with the development of social development index(SDI)level from 0.511 to 0.651,the HBRCBs had been decreasing from 1507.908 to 1145.344 in age-standardized disability-adjusted life years(ASDALY)and from 61.467 to 49.449 in(age-standardized death rates)ASDR per 100,000 population with changes of−24.04%and−19.55%,respectively.Meanwhile,the variance in HBRCBs among countries and territories generally showed a decreasing or flat trend.The variance of HBRCBs among 204 countries and territories in 2019–2044 decreased from 1495.210 to 449.202 in males and from 214.640 to 78.848 in females for ASDR due to all behavior risks,and from 911,211.676 to 317,233.590 in males and from 146,171.660 to 62,926.660 in females for ASDALY.The global HBRCBs was becoming more uniform due to the globalization of human behaviors.Conclusions This study revealed the significance of addressing HBRCBs as a uniform and continuous issue in future global health promotion.It also demonstrated the potential existence of a chain effect in global health,where globalization leads to human behavior homogenization,which in turn results in HBRCB convergence.Properly measuring the commonalities and individualities among different regions and finding a balance when designing and evaluating HBRCB-related global policies in the global convergence trend of HBRCBs will be major concerns in the future.
基金supported by St.Erik Eye Hospital philanthropic donations,Vetenskapsrådet 2022-00799(to PAW).
文摘Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of neurodegenerative diseases with glaucoma being highly prevalent.Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells and their axons which make up the optic nerve.It is the leading cause of irreversible vision loss and affects an estimated 80 million people.The mammalian central nervous system is non-regenerative and,once lost or injured,retinal ganglion cells cannot regenerate an axon into the optic nerve under basal conditions.Thus,strategies that provide neuroprotection to stressed,dysfunctional,or dying retinal ganglion cells are likely to be of high therapeutic and translational value.Advancing age,genetics,and elevated intraocular pressure are all major risk factors for glaucoma,however,all clinically available glaucoma treatments focus on intraocular pressure management and do not directly address the neurodegenerative component of glaucoma.
文摘In this editorial,we comment on the study of the Yu et al on psychological distress in patients with hepatobiliary and pancreatic malignancies.Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma,cholangiocarcinoma,gallbladder cancer and pancreatic cancer.These cancers are among the most aggressive and difficult to treat.Although improvements in surgery,drug treatments and palliative care have led to better survival rates and quality of life,the significant psychological impact on patients remains underrecognized.Anxiety and depression are prevalent at every stage of the disease,from the initial diagnosis to treatment,recurrence and end-of-life care.However,these issues often take a backseat to the urgent need to manage physical symptoms.Mental health challenges can greatly affect how well patients follow treatment plans,recover and their overall outlook.Yu et al explore the causes of psychological distress in hepatobiliary and pancreatic cancers,including disease severity,symptom burden,financial stress and fears about life and death.We highlight the importance of regular mental health screenings,psychological support and teamwork in oncology care.By focusing on emotional health alongside physical treatment,doctors can build resilience,improve outcomes and address a frequently ignored aspect of cancer care.
基金supported by the Natural Science Foundation of Beijing,Nos.7244428(to WZ)and 7222215(to JH)the Peking University Medicine Sailing Program forYoung Scholars’Scientific and Technological Innovation,No.BMU2023YFJHPY034(to WZ)+4 种基金the National Natural Science Foundation of China,Nos.81873784,82071426(to DF),and81974197(to JH)the Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(to DF)Beijing Physician-Scientist TrainingProgram,No.BJPSTP-2024-03(to JH)the China Postdoctoral Science Foundation,Nos.2022TQ0014(to LX),2022M720284(to LX)the E-Town Cooperation&Development Foundation,No.YCXJ-JZ-2023-017(to LX).
文摘The growing recognition of the role of genetics in the development of amyotrophic lateral sclerosis is evident.However,there has yet to be a comprehensive analysis of the clinical characteristics and genetics of familial amyotrophic lateral sclerosis in an Asian population.This study aimed to provide an in-depth analysis of the clinical features and genetic spectrum of familial amyotrophic lateral sclerosis over 15 years in a clinic-based cohort of patients from the Chinese mainland.Enrollment of 302 amyotrophic lateral sclerosis families from 28 provinces was undertaken from January 2008 to September 2023.A group-based trajectory model for disease progression based on amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R)scores was validated using bootstrap internal validation in patients with familial amyotrophic lateral sclerosis,as well as patients with sporadic amyotrophic lateral sclerosis(matched at a 1:4 ratio,with replacement).DNA samples from 244 index patients were screened for variants in the pathogenic genes SOD1,FUS,TDP43,and C9ORF72,of which 146 were also subjected to genome-wide next-generation sequencing.Gene-level burden analysis was used to evaluate the distribution of rare variants in the cohort.We found that rapid dynamic disease progression was associated with an older age at onset,shorter diagnostic delay,lower body mass index,bulbar onset,and≥1 affected first-degree relative.Certain attributes,such as age at onset and time from onset to diagnosis,had comparable impacts on the clinical progression trajectories of both familial amyotrophic lateral sclerosis and sporadic amyotrophic lateral sclerosis.Harboring pathogenic/likely pathogenic variants in amyotrophic lateral sclerosis-causative genes reduced the age of onset of familial amyotrophic lateral sclerosis.Among the patients with familial amyotrophic lateral sclerosis,17.8%possessed≥2 pathogenic/likely pathogenic variants.Sequencing kernel association test analysis showed that the SOD1 rare variant burden(P=1.3e-15)was associated with a significant risk of familial amyotrophic lateral sclerosis.Our findings conclusively confirmed the clinical features and genetic spectrum of familial amyotrophic lateral sclerosis over 15 years in a clinical cohort from China,contributing to a deeper understanding of genotype-phenotype relationships in familial amyotrophic lateral sclerosis.This comprehensive evaluation of specific clinical characteristics,clinical prognosis,and genetic variants of amyotrophic lateral sclerosis based on detailed clinical and genetic information may lead to the development of genotype-specific treatment approaches.
文摘Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most prominent cause of dementia.In 2019,over 57.4million people were living with AD and other dementia subtypes,a number which is expected to increase to over 152.8 million in the next 25years.This ever-increasing burden has resulted in AD and other neurodegenerative diseases rising to one of the top 10 causes of death globally (O'Connell et al.,2024).
基金Da Nang University of Medical Technology and PharmacyDa Nang C Hospital for the invaluable support they provided in facilitating this research。
文摘Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金funded by the Research,Development,and Innovation Authority(RDIA)—Kingdom of Saudi Arabia(Grant No.13292-psu-2023-PSNU-R-3-1-EF-).
文摘Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.
文摘The Chinese Government’s recent economic stimulus measures are attracting much attention because of its plan to increase people’s incomes and alleviate enterprises and residents’ economic burden.
文摘YAN Cailing lives on the Loess Plateau in northwestern China. In spite of her lightheartedness and cheer, she actually leads an uneasy life. At 37,she has three children. When she was small, her family lived a hard life. Her parents couldn’t afford tuition fees for all their six daughters. She went to school without textbooks, always having to listen attentively to insure she would remember the teacher’s lessons. In winter, she wore thin clothes and ragged shoes. Even when both her feet were frostbitten, she still continued to go to school. In 1974, Yan Cailing was admitted to a senior high school but then failed to pass
基金This study was supported by The Interdisciplinary Program of Shanghai Jiao Tong University(ZH2018QNA08)(Zhang Zhiyuan)Academician Workstation Scientific Research Fund(2019)+2 种基金The SHIPM-mu fund No.JC201902 from the Shanghai Institute of Precision Medicine,Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineThe Shanghai Anticancer Association Eyas Project(SACA-CY1B06)the National Social Science Foundation of China(No.16BGL183).
文摘Background:Data on the incidence,mortality,and other burden of oral cancer as well as their secular trends are necessary to provide policy-makers with the information needed to allocate resources appropriately.The purpose of this study was to use the Global Burden of Disease(GBD)2017 results to estimate the incidence,mortality,and disability-adjusted life years(DALYs)for oral cancer from 1990 to 2017.Methods:We collected detailed data on oral cancer from 1990 to 2017 from the GBD 2017.The global incidence,mortality,and DALYs attributable to oral cancer as well as the corresponding age-standardized rates(ASRs)were calculated.The estimated annual percentage changes in the ASRs of incidence(ASRI)and mortality(ASRM)and age-standardized DALYs of oral cancer were also calculated according to regions and countries to quantify the secular trends in these rates.Results:We tracked the incidence,mortality,and DALYs of oral cancer in 195 countries/territories over 28 years.Globally,the incidence,mortality,and DALYs of oral cancer increased by about 1.0-fold from 1990 to 2017.The ASRI of oral cancer showed a similar trend,increasing from 4.41 to 4.84 per 100,000 person-years during the study period.The ASRM remained approximately stable at about 2.4 per 100,000 from 1990 to 2017,as did the age-standardized DALYs,at about 64.0 per 100,000 person-years.ASRI was highest in Pakistan(27.03/100,000,95%CI=22.13-32.75/100,000),followed by Taiwan China,and lowest in Iraq(0.96/100,000,95%CI=0.86-1.06/100,000).ASRM was highest in Pakistan(16.85/100,000,95%CI=13.92-20.17/100,000)and lowest in Kuwait(0.51/100,000,95%CI=0.45-0.58/100,000).Conclusions:The ASRI of oral cancer has increased slightly worldwide,while the ASRM and age-standardized DALY have remained stable.However,these characteristics vary between countries,suggesting that current prevention strategies should be reoriented,and much more targeted and specific strategies should be established in some countries to forestall the increase in oral cancer.
基金This research was supported financially by the Key Project （No.71033005） from National Natural Science Foundation of China.
文摘The environmental burdens of Chinese copper production have been identified and quantified in the context of typical technologies, materials supplies and environmental emissions by a life cycle approach. Primary and secondary copper production using copper ores and scraps, respectively, were analyzed in detail. The flash and bath smelting approaches and the recycling of copper scraps were selected as representative copper production processes. A quantitative analysis was also conducted to assess the influence of material transport distance in copper production. Life cycle assessment （LCA） results showed that resources depletion and human health contribute significantly to environmental burdens in Chinese copper production. In addition, the secondary copper production has dramatically lower environmental burdens than the primary production. There is no obvious distinction in overall environmental burdens in primary copper production by flash or bath smelting approach. However, resources depletion is lower and the damage to human health is higher for flash smelting approach. Ecosystem quality damage is slight for both approaches. Environ- mental burdens from the mining stage contribute most in all life cycle stages in primary copper production. In secondary copper production, the electrolytic refining stage dominates. Based on the life cycle assessment results, some suggestions for improving environmental performance were proposed to meet the sustainable development of Chinese copper industry.
