Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
Objective:To analyze the application value of prescription management of traditional Chinese medicine formula granules in reducing unreasonable prescriptions.Methods:From January to June 2024,before improving prescrip...Objective:To analyze the application value of prescription management of traditional Chinese medicine formula granules in reducing unreasonable prescriptions.Methods:From January to June 2024,before improving prescription management strategies,118 patients treated with traditional Chinese medicine formula granules were included in the control group.From July to December 2024,after improving prescription management strategies,118 patients treated with traditional Chinese medicine formula granules were included in the observation group.The unqualified prescription rate,incidence of adverse reactions,complaint rate,and satisfaction were compared.Results:The unqualified prescription rate of traditional Chinese medicine formula granules in the observation group was lower than that in the control group(P<0.05);the incidence of adverse reactions and patient complaint rate of traditional Chinese medicine formula granules in the observation group were lower than those in the control group(P<0.05);the satisfaction of traditional Chinese medicine formula granules in the observation group was higher than that in the control group(P<0.05).Conclusion:Improving the prescription management strategy of traditional Chinese medicine formula granules can reduce the unqualified prescription rate and the incidence of adverse drug reactions,reduce patient complaints,and is conducive to improving patient satisfaction.展开更多
Objective To configure the complex traditional Chinese medicine(TCM)prescription using digit topology circle and to derive digit topology circle.Methods The basic digit topology circles were constructed.Different digi...Objective To configure the complex traditional Chinese medicine(TCM)prescription using digit topology circle and to derive digit topology circle.Methods The basic digit topology circles were constructed.Different digit topology circles were derived using basic digit topology circle,the character strings,and the digit groups.Different digit topology circles with ternary Chinese medicine were derived by adding ternary Chinese medicine into digit topology circles.The valuable TCM prescriptions were configured using the derived digit topology circles.Results Nine simple basic digit topology circles were constructed from the character strings.Multiple digit topology circles and some digit topology circles with ternary Chinese medicine were derived using basic digit topology circles,the character strings,and the digit groups.Four complex TCM prescriptions were configured using four derived digit topology circles digit topology circles,respectively.Conclusion The digit topology circles can be used to configure some existing TCM prescriptions and many novel TCM prescriptions.It has been verified that some existing TCM prescriptions have been used successfully to treat patients with diseases.Some novel valuable TCM prescriptions configured by digit topology circles may be used to treat patients with diseases.展开更多
Dunhuang medicine is an important part of Dunhuang studies,boasting rich and comprehensive connotations.It records more than 1,000 Dunhuang medical prescriptions,involving internal,external,gynecological,pediatric,Bud...Dunhuang medicine is an important part of Dunhuang studies,boasting rich and comprehensive connotations.It records more than 1,000 Dunhuang medical prescriptions,involving internal,external,gynecological,pediatric,Buddhist,and Daoist medicine,and has demonstrated good clinical effects.However,the mechanism of action of relevant Dunhuang medical prescriptions is still unclear,existing research lacks systematic review and summarization,which has limited their further development.At the same time,the inheritance,innovation,and transformation of Dunhuang medicine are critical issues for the development of Dunhuang medicine,which has important guiding significance for the future development of Dunhuang medicine.Therefore,this study systematically summarizes the experimental research progress of Dunhuang medical prescriptions[except for those contained in Fu Xing Jue Zang Fu Yong Yao Fa Yao(《辅行诀脏腑用药法要》The Guideline to Use Medicines for Zang-fu)],and seven such prescriptions were selected based on three criteria:well-preserved texts,no prior transmission to the outside world,and having extensive research and clinical application over the past decade.The findings indicate that this type of prescription is applicable to a broad spectrum of diseases and has a promising application prospect in health preservation and disease prevention,as it exerts therapeutic effects through multiple targets and pathways.Based on this,specific strategies for the transformation of Dunhuang characteristic prescriptions were proposed from three aspects:inheritance,innovative development,and transformation strategies,aiming to provide insights for the future development of Dunhuang medical prescriptions.展开更多
This article provides a comprehensive review of the advancements in the application of artificial intelligence(AI)technology in the modernization of traditional Chinese medicine(TCM)compound prescriptions,and emphasiz...This article provides a comprehensive review of the advancements in the application of artificial intelligence(AI)technology in the modernization of traditional Chinese medicine(TCM)compound prescriptions,and emphasizes recent research developments,including intelligent design,prediction of mechanisms of action,and precise application of TCM compound prescriptions.The integration of multi-omics data,deep learning algorithms,and knowledge graph technologies has established novel technical avenues for the modernization research of TCM.This study systematically analyzes the advantages and challenges associated with AI technologies in the research of TCM compound prescriptions,highlighting issues such as data heterogeneity,limited interpretability of AI models,and the absence of standardized procedures.Furthermore,this article examines the prospective developmental trajectories within this field,highlighting the importance of synergistic collaboration between AI and traditional pharmacology to improve the clinical applicability and effectiveness of TCM.The objective is to offer valuable insights into the modernization of TCM driven by AI and to stimulate further research in this area.展开更多
Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasu...Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.展开更多
Purpose: Based on the National Natural Science Foundation of China, we collect and sort out the literature published in approximately the last 30 years, which use prescriptions in Synopsis of the Golden Chamber to tre...Purpose: Based on the National Natural Science Foundation of China, we collect and sort out the literature published in approximately the last 30 years, which use prescriptions in Synopsis of the Golden Chamber to treat pelvic inflammatory disease (PID). This study provides theoretical basis for the treatment of PID;we recommend this achievement to colleagues. Method: Firstly, we searched and collected the literatures from last three decades in CNKI, Wanfang and VIP databases, which are about classical prescriptions treating endometriosis. Then, by screening all the literatures, we obtained the clinical research literatures and individual case reports. Finally, we went through the internal quality of the two categories of literatures to get the dominant prescriptions. Using a retrospective study of evidence-based medicine research, we comprehensively collect literature, standardize the disease spectrum, classify the evidence, and then evaluate the internal quality. Results: We refine 4 prescriptions which commonly are used in the treatment of PID;in other words, they are also the clinical symptoms of PID: Gui Zhi Fu Ling Wan symptom, which manifests blood stasis and cold-damp stagnancy;Dang Gui Shao Yao San symptom, which manifests disharmony of liver and spleen, qi-blood stasis and damp obstruction;Da Huang Mu Dan Tang symptom, which manifests the gathering toxic heat and qi-blood stasis;Yi Yi Fu Zi Bai Jiang San symptom, which manifests the internal toxic heat and qi-blood injury. Conclusion: This study is gospel for the patients with recurrent episodes of PID who can’t often use antibiotics. At the same time, it is also a green therapeutics which Chinese ancients dedicated to human medicine.展开更多
OBJECTIVE:To investigate the effect of correspondence of prescriptions and the traditional Chinese medicine(TCM) syndrome of ischemic stroke.METHODS:Based on standard syndrome diagnosis and a series of effective formu...OBJECTIVE:To investigate the effect of correspondence of prescriptions and the traditional Chinese medicine(TCM) syndrome of ischemic stroke.METHODS:Based on standard syndrome diagnosis and a series of effective formulas,a randomized,double-blind,parallel-controlled clinical trial on correspondence of prescriptions and the TCM syndrome of ischemic stroke was conducted.The formulas were dynamically changed according to the patient's TCM syndrome.RESULTS:The treatment was composed of a series of formulas changed daily according to the TCM syndrome.Treatments which were composed of a series of formulas had similar short-term(1 month after onset) effects in improving mild and moderate neurological deficits compared with treatments composed of only one formula.However,patients treated with a series of formulas showed improved subjective symptoms in the short-term and a decreased risk of stroke recurrence within three months after onset.CONCLUSION:Complete(series of formulas) and incomplete(only one formula) correspondence of prescriptions and TCM syndrome have similar effects on the central clinical manifestation of ischemic stroke,such as neurological deficit and activities in daily living.However,they have significant differences regarding individual dysfunctions,such as subjective symptoms.展开更多
We discuss here the complexity of the doses of traditional Chinese medicine(TCM) prescriptions and herbs from different viewpoints,including the heterogeneity of drug quality,the flexibility of prescriptions,and the d...We discuss here the complexity of the doses of traditional Chinese medicine(TCM) prescriptions and herbs from different viewpoints,including the heterogeneity of drug quality,the flexibility of prescriptions,and the diversity of drug effects.Then,the corresponding research ideas and strategies are proposed.We can reveal the actual situation of clinical doses based on in-depth "real-world study" of the safety and effectiveness of TCM prescriptions,create an analytical method for dose-effect relationships in accordance with the features of TCM,and reveal the correlated regular nature of the effectiveness and dosage of TCM prescriptions and herbs.展开更多
During the epidemics in the Qing dynasty,many medical professionals,nonprofessionals,and social organizations collected and sorted medical prescriptions related to infectious diseases.These people also compiled,publis...During the epidemics in the Qing dynasty,many medical professionals,nonprofessionals,and social organizations collected and sorted medical prescriptions related to infectious diseases.These people also compiled,published,disseminated,and consulted related medical formularies.The above historical event can be viewed as the construction and dissemination of medical knowledge.They edited and published medical formularies on infectious diseases with lower cost and in flexible ways by taking the initiative and giving full scope to creativity.Diverse anti-epidemic medical prescriptions from these medical formularies can be used for infectious diseases in the event of the outbreaks.However,the therapeutic effects of classical prescriptions and folk recipes cannot be regarded as the same.The wide circulation of anti-epidemic medical prescriptions and medical formularies was essentially a process of epidemic prevention resource allocation.Not only did it enable many nonprofessionals to participate in epidemic prevention and control,but it also enhanced awareness,knowledge,and capacity for epidemic prevention at the individual level.At the same time,due to the uneven quality and individual differences in the physical fitness and condition of the prescriptions and formularies,they had the capacity of causing inconveniences to the readers or patients.展开更多
The three chapters in Woman Section of Synopsis of Prescriptions of the Golden Chamber are the earliest medical articles in the diagnosis and treatment of gynecological diseases. They have already had the embryonic fo...The three chapters in Woman Section of Synopsis of Prescriptions of the Golden Chamber are the earliest medical articles in the diagnosis and treatment of gynecological diseases. They have already had the embryonic form of traditional Chinese gynecology,and laid a certain foundation for the future development of gynecology. There are 35 prescriptions in the Woman Section of Synopsis of Prescriptions of the Golden Chamber,using 66 kinds of traditional Chinese medicines and discussing more than 20 kinds of gynecological diseases. There are complete theory,methods,formulas and medicinals,and internal and external therapies. In curing gynecological diseases,the prescriptions are highly characteristic and are worth discussion and learning.展开更多
The increasing prevalence of hypothyroidism,which can cause endocrine dysfunction,abnormal neurological function,and cardiovascular and cerebrovascular injuries,poses serious health problems.Thyroid hormone supplement...The increasing prevalence of hypothyroidism,which can cause endocrine dysfunction,abnormal neurological function,and cardiovascular and cerebrovascular injuries,poses serious health problems.Thyroid hormone supplementation constitutes the current main therapeutic method for hypothyroidism,yet it has many limitations and risks and is not suitable for everyone.Therefore,it is necessary to seek alternative and complementary treatment methods.It has been proven in practice that traditional Chinese medicine(TCM)possesses multi-channel comprehensive characteristics for the treatment of hypothyroidism and has more advantages than single thyroid hormone supplementation.Through a comprehensive examination of existing literature about TCM efficacy in addressing hypothyroidism,we have meticulously consolidated the most recent research findings on prescriptions and herbal substances employed in the treatment of this condition.Furthermore,we have explicated their respective functions in the management of hypothyroidism,thereby offering valuable perspectives and recommendations for the prospective utilization of natural remedies in its treatment.展开更多
This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinati...This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.展开更多
Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely cl...Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely clear.This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evidence for clinical applications.Methods We searched Chinese databases the China National Knowledge Infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP),as well as English databases Pub Med and Cochrane Library,from time of establishment to April 14,2021.Literature quality was evaluated according to the bias risk assessment criteria of Cochrane Collaboration network.Rev Man 5.3 and Stata 12.0 software were used to perform this research.Results A total of 23 articles,3282 patients,and 25 TCM prescriptions were included in this study.NAs plus TCM remarkably improved the clinical total effective rate[Odds ratio(OR)=3.92,P<0.00001],TCM syndrome score(Mean difference=-3.73,P<0.00001),hepatitis B virus(HBV)DNA negative conversion rate(OR=1.49,P=0.0001),hepatitis Be antigen(HBe Ag)negative conversion rate(OR=2.03,P<0.00001),alanine aminotransferase levels[Std mean difference(SMD)=-0.95,P<0.00001],and aspartate aminotransferase levels(SMD=-0.70,P=0.0004).Adverse reaction rates did not increase in the combined treatment group(OR=0.97,P=0.84).A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs,demonstrated better clinical efficacy against CHB than NAs alone.In addition,the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy.However,more randomized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.展开更多
Objective To improve the compound--Gankang granules(GKGs) on the odor,taste and efficacy by decreasing 30% components and to prepare the new compound GKGs based on the Traditional Chinese Medicine Theory.Methods The d...Objective To improve the compound--Gankang granules(GKGs) on the odor,taste and efficacy by decreasing 30% components and to prepare the new compound GKGs based on the Traditional Chinese Medicine Theory.Methods The drug was extracted by the optimized technology ascertained in the previous studies.The cytotoxicity of the prescriptions was tested by MTT [3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyl tetrazolium] assay,and the anti-hepatitis B virus(anti-HBV) activity was determined by ELISA(enzyme-linked-immunosorbent assay) in vitro.Results In the human HBV-transfected liver cell line HepG2.2.15,the new GKGs did not show any cytotoxicity with the 50% cytotoxic concentration(TC50) of 7.131,1.756 and 1.809 mg/mL after treatment for 3,6 and 9 days respectively,which was obviously higher than that in the human liver cell line HepG2.Moreover,they effectively suppressed the secretion of the HBV antigens with the TI of 8.519,5.730 and 7.066 for HBsAg,and 1.723,12.839 and 47.65 for HBeAg at day 3,6 and 9 respectively.This effect was as good as that of the old GKGs.On the 6th and 9th day,the rate of HBeAg inhibition exceeded 90% even with the concentration as low as 0.16 mg/mL,which was similar to that of the old GKGs.Conclusions These results reflect that the new GKGs precede the old GKGs by much lower cytotoxicity with similar anti-HBV activity,which provides reliable evidences for further pharmacological and toxicological exploration on this new compound.展开更多
More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NO...More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.展开更多
The prescription must include the name of the drugs or products prescribed, dosage form, dosage, directions for use and duration of treatment. However, sometimes errors can occur that can have consequences for the hea...The prescription must include the name of the drugs or products prescribed, dosage form, dosage, directions for use and duration of treatment. However, sometimes errors can occur that can have consequences for the health of patients. Our study concerns the use of medical prescriptions received in pharmacies in the Dakar department. The survey was conducted in 90 pharmacies in these communes, which represent one third of the 270 pharmacies in the department of Dakar. This allowed us to study 2700 prescriptions. The study took place from 1 December 2016 to 30 June 2017, <i><span>i.e</span></i><span>. over a period of 7 months. Our results show that neurologists and urologists have a longer average treatment time than other specialists, with an average of 120 days and 90 days of treatment respectively. Then, the specialist</span><span>s</span><span> who take a long time the drug represent more than 27%, </span><span>and </span><span>require renewal of the drug. In 63.90% of the cases, no notification on the duration of treatment was given by the prescriber. Only 5.39% were only given the mention </span><span>“</span><span>to be renewed</span><span>”</span><span>. At the end of our analysis</span><span>,</span><span> we can say that the prescription must be perfectly legible to avoid confusion by the patient or the pharmacist. The pharmacist then participates in the therapeutic education of the patient and thus helps him/her to live better with his/her disease. Therefore, socio-professional health associations and organisations must provide more continuous training on prescribing to ensure good compliance and above all avoid people buying medicines in the parallel circuit in order to better control health expenditure.</span>展开更多
Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical ...Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the market.Identifying constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.展开更多
Context: Diabetes mellitus is experiencing an alarming progression throughout the world, but more and more drugs are available with the use not always adapted. The aim of this work is to analyze the anti-diabetic pres...Context: Diabetes mellitus is experiencing an alarming progression throughout the world, but more and more drugs are available with the use not always adapted. The aim of this work is to analyze the anti-diabetic prescriptions at the university hospital center of Libreville (Gabon) and confront them with the concept of therapeutic inertia. Patients and Methods: In diabetics coming for their periodic control, we transcripted for 2 months, beyond their characteristics, their glycated hemoglobin rate and the treatment followed. Results: 200 patients have consulted and among them, 160 (80%) had done their A1c analysis. 46% had an A1c ≤ 7% and 54% above with sometimes an unsuitable treatment evoking therapeutic inertia, the factors of which we discuss. Conclusion: Therapeutic inertia is a multifactorial problem, one of the components of which may be the resistance to change of the adult learners who are the practitioners.展开更多
Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes...Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard·Traditional Chinese Medicine Set Prescription Preparation(called Traditional Chinese Medicine Set Prescription Preparation for short).After standardization,the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform(V2.5),and the relevant rules of the software were adopted.Data mining methods were used to analyze the frequency of drugs,main symptoms and diseases in prescriptions,and to analyze the regularity of prescriptions.The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed.Results:There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases.The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and stomach,and the high frequency syndromes were anorexia and irregular menstruation.Conclusion:The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases;it mostly takes tonifying deficiency efficat.It can treat different diseases being compatible with different medicinal materials.The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala.展开更多
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
文摘Objective:To analyze the application value of prescription management of traditional Chinese medicine formula granules in reducing unreasonable prescriptions.Methods:From January to June 2024,before improving prescription management strategies,118 patients treated with traditional Chinese medicine formula granules were included in the control group.From July to December 2024,after improving prescription management strategies,118 patients treated with traditional Chinese medicine formula granules were included in the observation group.The unqualified prescription rate,incidence of adverse reactions,complaint rate,and satisfaction were compared.Results:The unqualified prescription rate of traditional Chinese medicine formula granules in the observation group was lower than that in the control group(P<0.05);the incidence of adverse reactions and patient complaint rate of traditional Chinese medicine formula granules in the observation group were lower than those in the control group(P<0.05);the satisfaction of traditional Chinese medicine formula granules in the observation group was higher than that in the control group(P<0.05).Conclusion:Improving the prescription management strategy of traditional Chinese medicine formula granules can reduce the unqualified prescription rate and the incidence of adverse drug reactions,reduce patient complaints,and is conducive to improving patient satisfaction.
基金National Natural Science Foundation of China(91748125)National Administration of Traditional Chinese Medicine’s National Inheritance Studio Construction Project for Famous Veteran Traditional Chinese Medicine Experts([2022]75)。
文摘Objective To configure the complex traditional Chinese medicine(TCM)prescription using digit topology circle and to derive digit topology circle.Methods The basic digit topology circles were constructed.Different digit topology circles were derived using basic digit topology circle,the character strings,and the digit groups.Different digit topology circles with ternary Chinese medicine were derived by adding ternary Chinese medicine into digit topology circles.The valuable TCM prescriptions were configured using the derived digit topology circles.Results Nine simple basic digit topology circles were constructed from the character strings.Multiple digit topology circles and some digit topology circles with ternary Chinese medicine were derived using basic digit topology circles,the character strings,and the digit groups.Four complex TCM prescriptions were configured using four derived digit topology circles digit topology circles,respectively.Conclusion The digit topology circles can be used to configure some existing TCM prescriptions and many novel TCM prescriptions.It has been verified that some existing TCM prescriptions have been used successfully to treat patients with diseases.Some novel valuable TCM prescriptions configured by digit topology circles may be used to treat patients with diseases.
基金financed by the grants from Dunhuang Medical Literature Compilation and Application Research Center Project of Gansu Provincial Key Research Base for Humanities and Social Sciences(No.DHYXJD2025)National Social Science Fund General Project(No.22BYY038).
文摘Dunhuang medicine is an important part of Dunhuang studies,boasting rich and comprehensive connotations.It records more than 1,000 Dunhuang medical prescriptions,involving internal,external,gynecological,pediatric,Buddhist,and Daoist medicine,and has demonstrated good clinical effects.However,the mechanism of action of relevant Dunhuang medical prescriptions is still unclear,existing research lacks systematic review and summarization,which has limited their further development.At the same time,the inheritance,innovation,and transformation of Dunhuang medicine are critical issues for the development of Dunhuang medicine,which has important guiding significance for the future development of Dunhuang medicine.Therefore,this study systematically summarizes the experimental research progress of Dunhuang medical prescriptions[except for those contained in Fu Xing Jue Zang Fu Yong Yao Fa Yao(《辅行诀脏腑用药法要》The Guideline to Use Medicines for Zang-fu)],and seven such prescriptions were selected based on three criteria:well-preserved texts,no prior transmission to the outside world,and having extensive research and clinical application over the past decade.The findings indicate that this type of prescription is applicable to a broad spectrum of diseases and has a promising application prospect in health preservation and disease prevention,as it exerts therapeutic effects through multiple targets and pathways.Based on this,specific strategies for the transformation of Dunhuang characteristic prescriptions were proposed from three aspects:inheritance,innovative development,and transformation strategies,aiming to provide insights for the future development of Dunhuang medical prescriptions.
文摘This article provides a comprehensive review of the advancements in the application of artificial intelligence(AI)technology in the modernization of traditional Chinese medicine(TCM)compound prescriptions,and emphasizes recent research developments,including intelligent design,prediction of mechanisms of action,and precise application of TCM compound prescriptions.The integration of multi-omics data,deep learning algorithms,and knowledge graph technologies has established novel technical avenues for the modernization research of TCM.This study systematically analyzes the advantages and challenges associated with AI technologies in the research of TCM compound prescriptions,highlighting issues such as data heterogeneity,limited interpretability of AI models,and the absence of standardized procedures.Furthermore,this article examines the prospective developmental trajectories within this field,highlighting the importance of synergistic collaboration between AI and traditional pharmacology to improve the clinical applicability and effectiveness of TCM.The objective is to offer valuable insights into the modernization of TCM driven by AI and to stimulate further research in this area.
基金Scientific Research Fund Project of Yunnan Provincial Department of Education(Project No.:2024J2130)。
文摘Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.
文摘Purpose: Based on the National Natural Science Foundation of China, we collect and sort out the literature published in approximately the last 30 years, which use prescriptions in Synopsis of the Golden Chamber to treat pelvic inflammatory disease (PID). This study provides theoretical basis for the treatment of PID;we recommend this achievement to colleagues. Method: Firstly, we searched and collected the literatures from last three decades in CNKI, Wanfang and VIP databases, which are about classical prescriptions treating endometriosis. Then, by screening all the literatures, we obtained the clinical research literatures and individual case reports. Finally, we went through the internal quality of the two categories of literatures to get the dominant prescriptions. Using a retrospective study of evidence-based medicine research, we comprehensively collect literature, standardize the disease spectrum, classify the evidence, and then evaluate the internal quality. Results: We refine 4 prescriptions which commonly are used in the treatment of PID;in other words, they are also the clinical symptoms of PID: Gui Zhi Fu Ling Wan symptom, which manifests blood stasis and cold-damp stagnancy;Dang Gui Shao Yao San symptom, which manifests disharmony of liver and spleen, qi-blood stasis and damp obstruction;Da Huang Mu Dan Tang symptom, which manifests the gathering toxic heat and qi-blood stasis;Yi Yi Fu Zi Bai Jiang San symptom, which manifests the internal toxic heat and qi-blood injury. Conclusion: This study is gospel for the patients with recurrent episodes of PID who can’t often use antibiotics. At the same time, it is also a green therapeutics which Chinese ancients dedicated to human medicine.
基金Supported by the National Key Basic Research Development Program(973 Program) No.2003CB517102the National Key Project of Science and Technology "Important New Drug Creation" NO.2009ZXO9502-028
文摘OBJECTIVE:To investigate the effect of correspondence of prescriptions and the traditional Chinese medicine(TCM) syndrome of ischemic stroke.METHODS:Based on standard syndrome diagnosis and a series of effective formulas,a randomized,double-blind,parallel-controlled clinical trial on correspondence of prescriptions and the TCM syndrome of ischemic stroke was conducted.The formulas were dynamically changed according to the patient's TCM syndrome.RESULTS:The treatment was composed of a series of formulas changed daily according to the TCM syndrome.Treatments which were composed of a series of formulas had similar short-term(1 month after onset) effects in improving mild and moderate neurological deficits compared with treatments composed of only one formula.However,patients treated with a series of formulas showed improved subjective symptoms in the short-term and a decreased risk of stroke recurrence within three months after onset.CONCLUSION:Complete(series of formulas) and incomplete(only one formula) correspondence of prescriptions and TCM syndrome have similar effects on the central clinical manifestation of ischemic stroke,such as neurological deficit and activities in daily living.However,they have significant differences regarding individual dysfunctions,such as subjective symptoms.
基金Supported by Scientific Research Special Project of TCM Profession (200907001E)Science and Technology Special Major Project for "Significant New Drugs Formulation"(2009ZX09301-005)
文摘We discuss here the complexity of the doses of traditional Chinese medicine(TCM) prescriptions and herbs from different viewpoints,including the heterogeneity of drug quality,the flexibility of prescriptions,and the diversity of drug effects.Then,the corresponding research ideas and strategies are proposed.We can reveal the actual situation of clinical doses based on in-depth "real-world study" of the safety and effectiveness of TCM prescriptions,create an analytical method for dose-effect relationships in accordance with the features of TCM,and reveal the correlated regular nature of the effectiveness and dosage of TCM prescriptions and herbs.
基金financially supported by the National Social Science Foundation of China(No.ZDA175)the Humanities and Social Science Foundation of the Ministry of Education(No.20YJC770021)。
文摘During the epidemics in the Qing dynasty,many medical professionals,nonprofessionals,and social organizations collected and sorted medical prescriptions related to infectious diseases.These people also compiled,published,disseminated,and consulted related medical formularies.The above historical event can be viewed as the construction and dissemination of medical knowledge.They edited and published medical formularies on infectious diseases with lower cost and in flexible ways by taking the initiative and giving full scope to creativity.Diverse anti-epidemic medical prescriptions from these medical formularies can be used for infectious diseases in the event of the outbreaks.However,the therapeutic effects of classical prescriptions and folk recipes cannot be regarded as the same.The wide circulation of anti-epidemic medical prescriptions and medical formularies was essentially a process of epidemic prevention resource allocation.Not only did it enable many nonprofessionals to participate in epidemic prevention and control,but it also enhanced awareness,knowledge,and capacity for epidemic prevention at the individual level.At the same time,due to the uneven quality and individual differences in the physical fitness and condition of the prescriptions and formularies,they had the capacity of causing inconveniences to the readers or patients.
文摘The three chapters in Woman Section of Synopsis of Prescriptions of the Golden Chamber are the earliest medical articles in the diagnosis and treatment of gynecological diseases. They have already had the embryonic form of traditional Chinese gynecology,and laid a certain foundation for the future development of gynecology. There are 35 prescriptions in the Woman Section of Synopsis of Prescriptions of the Golden Chamber,using 66 kinds of traditional Chinese medicines and discussing more than 20 kinds of gynecological diseases. There are complete theory,methods,formulas and medicinals,and internal and external therapies. In curing gynecological diseases,the prescriptions are highly characteristic and are worth discussion and learning.
文摘The increasing prevalence of hypothyroidism,which can cause endocrine dysfunction,abnormal neurological function,and cardiovascular and cerebrovascular injuries,poses serious health problems.Thyroid hormone supplementation constitutes the current main therapeutic method for hypothyroidism,yet it has many limitations and risks and is not suitable for everyone.Therefore,it is necessary to seek alternative and complementary treatment methods.It has been proven in practice that traditional Chinese medicine(TCM)possesses multi-channel comprehensive characteristics for the treatment of hypothyroidism and has more advantages than single thyroid hormone supplementation.Through a comprehensive examination of existing literature about TCM efficacy in addressing hypothyroidism,we have meticulously consolidated the most recent research findings on prescriptions and herbal substances employed in the treatment of this condition.Furthermore,we have explicated their respective functions in the management of hypothyroidism,thereby offering valuable perspectives and recommendations for the prospective utilization of natural remedies in its treatment.
文摘This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.
基金We thank for the funding support from the Hundred Talents Program of Hunan Province(No.9999004007)the Startup grant of Hunan University of Chinese Medicine(No.999900201107).
文摘Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely clear.This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evidence for clinical applications.Methods We searched Chinese databases the China National Knowledge Infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP),as well as English databases Pub Med and Cochrane Library,from time of establishment to April 14,2021.Literature quality was evaluated according to the bias risk assessment criteria of Cochrane Collaboration network.Rev Man 5.3 and Stata 12.0 software were used to perform this research.Results A total of 23 articles,3282 patients,and 25 TCM prescriptions were included in this study.NAs plus TCM remarkably improved the clinical total effective rate[Odds ratio(OR)=3.92,P<0.00001],TCM syndrome score(Mean difference=-3.73,P<0.00001),hepatitis B virus(HBV)DNA negative conversion rate(OR=1.49,P=0.0001),hepatitis Be antigen(HBe Ag)negative conversion rate(OR=2.03,P<0.00001),alanine aminotransferase levels[Std mean difference(SMD)=-0.95,P<0.00001],and aspartate aminotransferase levels(SMD=-0.70,P=0.0004).Adverse reaction rates did not increase in the combined treatment group(OR=0.97,P=0.84).A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs,demonstrated better clinical efficacy against CHB than NAs alone.In addition,the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy.However,more randomized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.
基金grants from Scientific and Technological Plan ofChangsha City (No. K0902033-31)Scientific and Technologi-cal Plan of Hunan Province (No. 2009FJ3209)
文摘Objective To improve the compound--Gankang granules(GKGs) on the odor,taste and efficacy by decreasing 30% components and to prepare the new compound GKGs based on the Traditional Chinese Medicine Theory.Methods The drug was extracted by the optimized technology ascertained in the previous studies.The cytotoxicity of the prescriptions was tested by MTT [3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyl tetrazolium] assay,and the anti-hepatitis B virus(anti-HBV) activity was determined by ELISA(enzyme-linked-immunosorbent assay) in vitro.Results In the human HBV-transfected liver cell line HepG2.2.15,the new GKGs did not show any cytotoxicity with the 50% cytotoxic concentration(TC50) of 7.131,1.756 and 1.809 mg/mL after treatment for 3,6 and 9 days respectively,which was obviously higher than that in the human liver cell line HepG2.Moreover,they effectively suppressed the secretion of the HBV antigens with the TI of 8.519,5.730 and 7.066 for HBsAg,and 1.723,12.839 and 47.65 for HBeAg at day 3,6 and 9 respectively.This effect was as good as that of the old GKGs.On the 6th and 9th day,the rate of HBeAg inhibition exceeded 90% even with the concentration as low as 0.16 mg/mL,which was similar to that of the old GKGs.Conclusions These results reflect that the new GKGs precede the old GKGs by much lower cytotoxicity with similar anti-HBV activity,which provides reliable evidences for further pharmacological and toxicological exploration on this new compound.
基金Supported by"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:The Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.
文摘The prescription must include the name of the drugs or products prescribed, dosage form, dosage, directions for use and duration of treatment. However, sometimes errors can occur that can have consequences for the health of patients. Our study concerns the use of medical prescriptions received in pharmacies in the Dakar department. The survey was conducted in 90 pharmacies in these communes, which represent one third of the 270 pharmacies in the department of Dakar. This allowed us to study 2700 prescriptions. The study took place from 1 December 2016 to 30 June 2017, <i><span>i.e</span></i><span>. over a period of 7 months. Our results show that neurologists and urologists have a longer average treatment time than other specialists, with an average of 120 days and 90 days of treatment respectively. Then, the specialist</span><span>s</span><span> who take a long time the drug represent more than 27%, </span><span>and </span><span>require renewal of the drug. In 63.90% of the cases, no notification on the duration of treatment was given by the prescriber. Only 5.39% were only given the mention </span><span>“</span><span>to be renewed</span><span>”</span><span>. At the end of our analysis</span><span>,</span><span> we can say that the prescription must be perfectly legible to avoid confusion by the patient or the pharmacist. The pharmacist then participates in the therapeutic education of the patient and thus helps him/her to live better with his/her disease. Therefore, socio-professional health associations and organisations must provide more continuous training on prescribing to ensure good compliance and above all avoid people buying medicines in the parallel circuit in order to better control health expenditure.</span>
基金the Guangxi Science and Technology Major Program(Grant No.:GUIKEAA23023035)Key Program of National Natural Science Foundation of China(Grant No.:82130111)+1 种基金Guangxi Science and Technology Major Project(Grant No.:GUIKEAA22096029)Science and Technology Major Project of Inner Mongolia(Grant No.:2021ZD0017).
文摘Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the market.Identifying constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.
文摘Context: Diabetes mellitus is experiencing an alarming progression throughout the world, but more and more drugs are available with the use not always adapted. The aim of this work is to analyze the anti-diabetic prescriptions at the university hospital center of Libreville (Gabon) and confront them with the concept of therapeutic inertia. Patients and Methods: In diabetics coming for their periodic control, we transcripted for 2 months, beyond their characteristics, their glycated hemoglobin rate and the treatment followed. Results: 200 patients have consulted and among them, 160 (80%) had done their A1c analysis. 46% had an A1c ≤ 7% and 54% above with sometimes an unsuitable treatment evoking therapeutic inertia, the factors of which we discuss. Conclusion: Therapeutic inertia is a multifactorial problem, one of the components of which may be the resistance to change of the adult learners who are the practitioners.
文摘Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard·Traditional Chinese Medicine Set Prescription Preparation(called Traditional Chinese Medicine Set Prescription Preparation for short).After standardization,the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform(V2.5),and the relevant rules of the software were adopted.Data mining methods were used to analyze the frequency of drugs,main symptoms and diseases in prescriptions,and to analyze the regularity of prescriptions.The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed.Results:There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases.The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and stomach,and the high frequency syndromes were anorexia and irregular menstruation.Conclusion:The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases;it mostly takes tonifying deficiency efficat.It can treat different diseases being compatible with different medicinal materials.The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala.
