118 kinds of Pt-Zr phases were established and investigated by considering various structures. Then the related physical properties, such as structural stability, lattice constants, formation enthalpies, elastic const...118 kinds of Pt-Zr phases were established and investigated by considering various structures. Then the related physical properties, such as structural stability, lattice constants, formation enthalpies, elastic constants and bulk moduli, are obtained by ab initio calculations. Based on the calculated results of formation enthalpies, the ground-state convex hull is derived for the Pt-Zr system. The calculated physical data would provide a basis for further thermodynamic calculations and atomistic simulations. For these Pt-Zr compounds, it is found there are a positive linear correlation between the formation enthalpies and atomic volumes, and a negative linear correlation between the bulk modules and atomic volumes.展开更多
A dendritic β-phase reinforced bulk metallic glass(BMG) composite named as D2 was prepared by rapid quenching of a homogenous Zr60Ti14.67Nb5.33Cu5.56Ni4.44Be10 melt, and characterized by means of X-ray diffraction(XR...A dendritic β-phase reinforced bulk metallic glass(BMG) composite named as D2 was prepared by rapid quenching of a homogenous Zr60Ti14.67Nb5.33Cu5.56Ni4.44Be10 melt, and characterized by means of X-ray diffraction(XRD), scanning electron microscopy(SEM) observation and room-temperature compression test. The microstructure and mechanical properties were compared with those of the spherical β-phase reinforced composite named as composite S2. It was found that the composite D2 contains β-phase dendrites up to 56% in volume-fraction, and exhibits a ductile compressive behavior with plastic strain of 12.7%. As the high-volumefractioned β-phase dendrites transferred to coarse spherical particles of about 20 μm in diameter in the composite S2, a much improved plastic strain up to 20.4% can be achieved. Micrographs of the fractured samples reveal different interaction modes of the propagating shear bands with the dendritic and spherical β phase inclusions, resulting in different shear strains in the composite samples. The matrix of composite S2 undergoes a significantly larger shear strain than that of the composite D2 before ultimate failure, which is thought to be mainly responsible for the greatly increased global plastic strain of the S2 relative to D2.展开更多
The organic compound composition ofwastewater,serves as a crucial indicator for the operational performance of activated sludge processes and has a major influence on the development of filamentous bulking in activate...The organic compound composition ofwastewater,serves as a crucial indicator for the operational performance of activated sludge processes and has a major influence on the development of filamentous bulking in activated sludge.This study focused on the impact of typical soluble and slowly-biodegradable organic compounds,investigating the pathways through which these substrates affect the occurrence of filamentous bulking in systems operated under both high-and low-oxygen conditions.Results showed that slowly-biodegradable organic compounds lead to a concentrated distribution of microorganisms within flocs,with inward growth of filamentous bacteria.Both Tween-80 and granular starch treated systems exhibited a significant increase in protein content.The glucose system,utilizing soluble substrates,exhibited a markedly higher total polysaccharide content.Microbial communities in the Tween-80 and granular starch treated systems were characterized by a higher abundance of bacteria known to enhance sludge flocculation and settling,such as Competibacter,Xanthomonadaceae and Zoogloea.These findings are of high significance for controlling the operational performance and stability of activated sludge systems,deepening our understanding and providing a novel perspective for the improvement of wastewater treatment processes.展开更多
A bulk superconductor hosting intrinsic surface superconductivity provides a unique platform for exploring Majorana bound states.Trigonal γ-PtBi_(2),a superconductor,is a promising candidate,as both surface supercond...A bulk superconductor hosting intrinsic surface superconductivity provides a unique platform for exploring Majorana bound states.Trigonal γ-PtBi_(2),a superconductor,is a promising candidate,as both surface superconducting gaps and topological surface states have been observed.However,the simultaneous presence of bulk and surface superconductivity has remained unresolved.In this study,we directly visualize coexisting bulk and surface superconducting gaps in trigonal PtBi_(2) using ultra-low-temperature scanning tunneling microscopy/spectroscopy.The bulk gap,Δ,is∼0.053 meV,with a critical temperature(T_(c))of∼0.5K and a critical field below 0.01 T,accompanied by a vortex lattice and vortex bound states and yielding a coherence length of∼200 nm.Remarkably,certain surface regions exhibit a much larger gap(Δ)of∼0.42 meV,persisting up to a T_(c)value of∼3K and surviving magnetic fields of up to 2 T,yet lacking a static vortex lattice.This coexistence of robust surface and bulk superconductivity establishes γ-PtBi_(2)as a unique platform for exploring the interplay between bulk and surface Cooper pairings in topological superconductors.展开更多
In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sampl...In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sample is used to determine the bulk volume of the sample grains.During this test procedure,the surface of water infiltrated sample grains must be dried with a wet towel.Experience shows,that this drying step is the main root cause for variation in reproducibility of results and even repeatability of tests.A new spin dryer(centrifuge)was developed and introduced to automate this surface drying step,and is now included as a new method in ISO 8840:2021.The paper discusses the improvement of measurement with the new approach and industrial experiences from two big industrial players in the raw material business.展开更多
Background Spinal cord injury causes severe disability,with ferroptosis,an iron-dependent cell death,contributing to its pathogenesis.Electroacupuncture is widely used in spinal cord injury treatment,but its effects o...Background Spinal cord injury causes severe disability,with ferroptosis,an iron-dependent cell death,contributing to its pathogenesis.Electroacupuncture is widely used in spinal cord injury treatment,but its effects on ferroptosis remain unclear.Objective This study explores electroacupuncture’s mechanisms on ferroptosis and its potential targets.Methods Spinal cord injury was induced in rats at the T10 segment using a modified Allen’s test.Electroacupuncture treatment was applied at Jiaji(EX-B2)acupoints with a 2/100 Hz frequency.Bulk and single-cell RNA sequencing were used to analyze gene expression.Differential expression analysis was performed using DESeq2,and validations included qRT-PCR,western blot,immunohistochemistry,and lipid peroxidation assays.Results Ferroptosis-related gene expression peaked on day 3 post-spinal cord injury.Electroacupuncture-treated rats showed improved motor function,reduced ferroptosis via Alox15 inhibition and GPX4 promotion,and decreased neutrophil infiltration,evidenced by reduced myeloperoxidase expression.Single-cell RNA sequencing identified Fkbp5 as a key electroacupuncture target,predominantly expressed in oligodendrocytes.Cells with high Fkbp5 expression demonstrated lower ferroptosis scores and enhanced antioxidant capacity.Conclusion Electroacupuncture reduces ferroptosis by mitigating reactive oxygen species production and neutrophil infiltration.Fkbp5 may serve as a critical target for electroacupuncture,promoting antioxidant mechanisms in oligodendrocytes and providing new insights into spinal cord injury therapy.展开更多
The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components....The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components.The transmembrane protein-39(TMEM-39)mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin cuticles.TMEM-39 primarily co-localizes with the coat protein II complex(COPII)in large vesicles rather than small COPII vesicles.These TMEM-39-associated large vesicles(TMEM-39-LVs)form robustly during the molting period and co-localize with various extracellular matrix components,including BLI-1 collagen,BLI-3 dual oxidase,and carboxypeptidases.Through immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells,we identify TMEM39A-associated proteins,including TMEM131.Knockdown of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both C.elegans and human sarcoma cells,indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPII vesicles.Given the conservation of TMEM39A and its associated proteins between C.elegans and humans,TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.展开更多
To advance materials with superior performance,the construction of gradient structures has emerged as a promising strategy.In this study,a gradient nanocrystalline-amorphous structure was induced in Zr46Cu46Al8 bulk m...To advance materials with superior performance,the construction of gradient structures has emerged as a promising strategy.In this study,a gradient nanocrystalline-amorphous structure was induced in Zr46Cu46Al8 bulk metallic glass(BMG)through ultrasonic vibration(UV)treatment.Applying a 20 kHz ultrasonic cyclic loading in the elastic regime,controllable gradient structures with varying crystallized volume fractions can be achieved in less than 2 s by adjusting the input UV energy.In contrast to tradi-tional methods of inducing structural gradients in BMGs,this novel approach offers distinct advantages:it is exceptionally rapid,requires minimal stress,and allows for easy tuning of the extent of structural gradients through precise adjustment of processing parameters.Nanoindentation tests reveal higher hard-ness near the struck surface,attributed to a greater degree of nanocrystal formation,which gradually di-minishes with depth.As a result of the gradient dispersion of nanocrystals,an increased plasticity was found after UV treatment,characterized by the formation of multiple shear bands.Microstructural in-vestigations suggest that UV-induced nanocrystallization originates from local atomic rearrangements in phase-separated Cu-rich regions with high diffusional mobility.Our study underscores the tunability of structural gradients and corresponding performance improvements in BMGs through ultrasonic energy modulation,offering valuable insights for designing advanced metallic materials with tailored mechanical properties.展开更多
By analyzing core data from an offshore Gulf of Mexico reservoir and developing analytical solutions,it can be demonstrated that laboratory measurements on pore-volume compressibility include artifacts,leading to a mi...By analyzing core data from an offshore Gulf of Mexico reservoir and developing analytical solutions,it can be demonstrated that laboratory measurements on pore-volume compressibility include artifacts,leading to a misinterpretation of porosity and permeability trends.A systematic evaluation of poro-elastic changes in pore volumes(and quantifying any consequent fluid expulsion during reservoir compaction)suggests that poro-elastic relaxation may enhance fluid production rates from deep reservoirs by up to 25%.This value may be inadvertently inflated if the core samples used for pore-volume compressibility measurements suffered from handling damage.Nonetheless,poro-elastic fluid expulsion from the pores in producing reservoirs can provide additional lift and thus may enhance the recovery factor.Therefore,the possible contribution to well performance from poro-elastic production drive mechanisms ought to be carefully evaluated in reserves estimation.Reversely,injection wells may encounter poro-elastic suppression of injectivity due to elastic resistance,which would adversely affect the storage coefficient.By integrating geomechanical reservoir response with traditional fluid production models,reservoir model predictions of production under pressure depletion and injection conditions will be more accurate.The new insights reported here are essential for optimizing well performance,improving reservoir management,and extending the economic life of geological reservoirs.However,caution is warranted regarding pore-volume compressibility measurements.To what degree laboratory measurements of pore-volume compressibility measure true values or mainly record handling damage could not be conclusively settled in the present study.展开更多
Bulk modulus is a constant that measures the incompressibility of materials, which can be obtained in high pressure experiment by fitting the equations of state(EOS), like third-order Birch–Murnaghan EOS(BM EOS) and ...Bulk modulus is a constant that measures the incompressibility of materials, which can be obtained in high pressure experiment by fitting the equations of state(EOS), like third-order Birch–Murnaghan EOS(BM EOS) and Vinet EOS. Bulk modulus reflects the intermolecular interaction inside molecular crystals, making it useful for researchers to design novel high pressure materials. This review systematically examines bulk moduli of various molecular crystals, including rare-gas solids, di-atom and triplet-atom molecules, saturated organic molecules, and aromatic organic crystals. Comparisons with ionic crystals are presented, along with an analysis of connections between bulk modulus and crystal structures.展开更多
To understand the differences in the composition and sources of PM_(2.5) and PM_(10) caused by coarse particles,integrated PM_(2.5) and PM_(10) samples were synchronously collected in Nanjing,East China,in summer 2020...To understand the differences in the composition and sources of PM_(2.5) and PM_(10) caused by coarse particles,integrated PM_(2.5) and PM_(10) samples were synchronously collected in Nanjing,East China,in summer 2020 and winter 2020/2021.Bulk and molecular speciation and light absorption measurements of aerosol extractswere performed,followed by positivematrix factorization(PMF)based on the PM_(2.5) and PM_(10) data sets,respectively.The difference in average concentrations of total bulk species between PM_(2.5) and PM_(10) was mainly caused by the distribution of considerable NO_(3)^(–),SO42–,Ca^(2+),and organic carbon(OC)in coarse particles.Coarse PMinfluenced by abrasion products from tirewear and leaves contributed about half of the low-volatility n-alkanes in summer.The contribution of coarse PM to biomass burning tracers and water-soluble OC increased in winter when biomass combustion was excessively active.More than 70%of sugar polyols were attributable to coarse PM in summer,and biomass burning could be an important source in winter.The light-absorbing organic chromophores were almost entirely associated with PM_(2.5),but water-soluble organic carbon(WSOC)exhibited stronger light absorption in PM_(10) extracts than in PM_(2.5) extracts possibly due to the influence of coarse PMon pH.PMF analysis indicated that biomass burning,aqueous-phase reactions,and processed dust were the main contributors of organic matter and its light absorption in winter.Biogenic primary and secondary sources made discernable contributions only in summer.The differences between PM_(2.5) and PM_(10) were likely attributed to mixing of crustal dust,combustion particles,and surface reactions.展开更多
Water depth significantly affects ship resistance,which,in turn,influences fuel consumption.Furthermore,the urgent need to reduce carbon emissions for environmental sustainability highlights the importance of applying...Water depth significantly affects ship resistance,which,in turn,influences fuel consumption.Furthermore,the urgent need to reduce carbon emissions for environmental sustainability highlights the importance of applying drag reduction methods to shallow-water vehicles.To effectively employ these methods,the initial step entails an in-depth investigation of how shallow water impacts the resistance and flow dynamics of a mini-bulk carrier.This study extensively analyzes the hydrodynamic characteristics of mini-bulk carriers,focusing on the impact of shallow water on resistance and flow dynamics utilizing a combination of experimental tests and numerical analyses.This study emphasizes the interaction between the hull and the shallow seabed.This study also highlights increased frictional drag and significant residual resistance by analyzing the total resistance at various speeds in shallow waters.The results of five key factors influencing resistance in shallow waters,namely,boundary layer thickness,shear stress,velocity and pressure,turbulence,and waves,are discussed.A decrease in water depth accelerates the flow under the hull,increasing shear stress and resistance.The accelerated flow reduces the gap between the hull and the shallow seabed,elevating water pressure and increasing sinkage and resistance.Heightened turbulence in shallow water intensifies Reynolds stress,augmenting friction and viscous resistance.展开更多
Large-grain REBa_(2)Cu_(3)O_(7-δ)(REBCO,RE=rare earth)bulk superconductors offer promising magnetic field trapping capabilities due to their high critical current density,making them ideal for many important applicat...Large-grain REBa_(2)Cu_(3)O_(7-δ)(REBCO,RE=rare earth)bulk superconductors offer promising magnetic field trapping capabilities due to their high critical current density,making them ideal for many important applications such as trapped field magnets.However,for such large-grain superconductor bulks,there are lots of voids and cracks forming during the process of melting preparation,and some of them can be up to hundreds of microns or even millimeters in size.Consequently,these larger size voids/cracks pose a great threat to the strength of the bulks due to the inherent brittleness of superconductor REBCO materials.In order to ensure the operational safety of related superconducting devices with bulk superconductors,it is firstly important to accurately detect these voids/cracks in them.In this paper,we proposed a method for quantitatively evaluating multiple voids/cracks in bulk superconductors through the magnetic field and displacement response signals at superconductor bulk surface.The proposed method utilizes a damage index constructed from the magnetic field signals and displacement responses to identify the number and preliminary location of multiple defects.By dividing the detection area into subdomains and combining the magnetic field signals with displacement responses within each subdomain,a particle swarm algorithm was employed to evaluate the location and size parameters of the defects.In contrast to other evaluation methods using only magnetic field or displacement response signals,the combined evaluation method using both signals can identify the number of cracks effectively.Numerical studies demonstrate that the morphology of voids and cracks reconstructed using the proposed algorithm ideally matches real defects and is applicable to cases where voids and cracks coexist.This study provides a theoretical basis for the quantitative detection of voids/cracks in bulk superconductors.展开更多
The improvement of soybean seed carotenoid contents is very important due to the beneficial role of carotenoids in human health and nutrition. However, the genetic architecture underlying soybean carotenoid biosynthes...The improvement of soybean seed carotenoid contents is very important due to the beneficial role of carotenoids in human health and nutrition. However, the genetic architecture underlying soybean carotenoid biosynthesis remains largely unknown. In the present study, we employed next generation sequencing-based bulked-segregant analysis to identify new genomic regions governing seed carotenoids in 1,551 natural soybean accessions. The genomic DNA samples of individual plants with extreme phenotypes were pooled to form two bulks with high(50 accessions) and low(50 accessions) carotenoid contents for Illumina sequencing. A total of 125.09 Gb of clean bases and 89.82% of Q30 were obtained, and the average alignment efficiency was 99.45% with an average coverage depth of 62.20× and 99.75% genome coverage. Based on the G prime statistic algorithm(G') method analysis, 16 candidate genomic loci with a total length 20.41 Mb were found to be related to the trait. Of these loci, the most significant regions displaying the highest elevated G' values were found in chromosome 06 at a position of 18.53–22.67 Mb, and chromosome 19 at genomic region intervals of 8.36–10.94, 12.06–13.79 and 18.45–20.26 Mb. These regions were then used to identify the key candidate genes. In these regions, 250 predicted genes were found and analyzed to obtain 90 significantly enriched(P<0.05) Gene Ontology(GO) terms. Based on ANNOVAR analysis, 50 genes with non-synonymous and stopgained mutations were preferentially selected as potential candidate genes. Of those 50 genes, following their gene annotation functions and high significant haplotype variations in various environments,five genes were identified as the most promising candidate genes regulating soybean seed carotenoid accumulation, and they should be investigated in further functional validation studies. Collectively, understanding the genetic basis of carotenoid pigments and identifying genes underpinning carotenoid accumulation via a bulked-segregant analysis-based sequencing(BSA-seq) approach provide new insights for exploring future molecular breeding efforts to produce soybean cultivars with high carotenoid content.展开更多
Avoiding crystallization while maintaining the original microstructure and mechanical properties of the material are long-term goals of laser welding of Zr-based bulk metallic glass(BMG).In this paper,the effect of pu...Avoiding crystallization while maintaining the original microstructure and mechanical properties of the material are long-term goals of laser welding of Zr-based bulk metallic glass(BMG).In this paper,the effect of pulsed laser welding parameters on the microstructure,crystallization degree,and mechanical properties of Zr57Nb5Cu15.4Ni12.6Al10 BMG is investigated.Non-crystallized welding forming of a zirconium-based amorphous alloy is achieved by optimizing the process parameters of pulsed laser welding.The crystallization degree of Zr-based BMG is mainly determined by the welding speed and power.The welding depth and crystallization area fraction increase with an increase in the effective peak power density.The optimized welding process can effectively reduce the heat accumulation of the weld,thus avoiding crystallization.The flexural strength of the weld can be maintained at 96.5%of the matrix.展开更多
Ti-based bulk metallic glasses(BMGs)have attracted increasing attention due to their high specific strength.However,a fundamental conflict exists between the specific strength and glass-forming ability(GFA)of Ti-based...Ti-based bulk metallic glasses(BMGs)have attracted increasing attention due to their high specific strength.However,a fundamental conflict exists between the specific strength and glass-forming ability(GFA)of Ti-based BMGs,restricting their commercial applications significantly.In this study,this challenge was addressed by introducing a two-step alloying strategy to mitigate the remarkable density increment effect associated with heavy alloying elements required for enhancing the GFA.Consequently,through two-step alloying with Al and Fe in sequence,simultaneous enhancements in specific strength and GFA were achieved based on a Ti-Zr-Be ternary metallic glass,resulting in the development of a series of centimeter-sized metallic glasses exhibiting ultrahigh-specific strength.Notably,the newly developed(Ti_(45)Zr_(20)Be_(31)A_(l4))_(94)Fe_(6)alloy established a new record for the specific strength of Ti-based BMGs.Along with a critical diameter(D_(c))of 10 mm,it offers the optimal scheme for balancing the specific strength and GFA of Ti-based BMGs.The present results further brighten the application prospects of Ti-based BMGs as lightweight materials.展开更多
This article investigates the second overtone thickness-extensional(TE2)vibrations and associated mode-coupling behaviors in ZnO piezoelectric film bulk acoustic resonator(FBAR),utilizing its wave dispersion relation ...This article investigates the second overtone thickness-extensional(TE2)vibrations and associated mode-coupling behaviors in ZnO piezoelectric film bulk acoustic resonator(FBAR),utilizing its wave dispersion relation and the higher-order stress balance principle.By superimposing the general wave solutions of multiple eigenmodes within the frequency range of the TE2 mode,mode-coupling solutions for ZnO FBAR are constructed.The substitution of these mode-coupling solutions into the higher-order stress balance principle,as laterally weak boundary conditions,leads to the frequency spectrogram equation,determining the relationship between resonance frequency and plate length-to-thickness ratio.A modified algorithm that combines the bisection method and the complex modulus ratio method is developed to solve the dispersion equation and frequency spectrogram equation(namely a kind of 2D complex transcendental equations)accurately and efficiently.The obtained results indicate that the operational TE2 mode may couple to unwanted 3^(rd)thickness-shear,fundamental thickness-shear,and flexural modes.Moreover,the mode-coupling behaviors depend strongly on resonance frequencies and plate length-to-thickness ratio.The displacement distributions of total displacement components,alongside the main displacement com-ponents of all considered eigenmodes,clearly demonstrate the variety of coupling behaviors.According to the obtained frequency spectrograms,the desirable values of plate length-to-thickness ratio for a clean operating mode with very weak coupling intensity are determined.These findings are of vital importance for the understanding of the mode-coupling me-chanism in overtone thickness-extensional FBARs,which will facilitate the structural design and optimization of FBAR devices.展开更多
Accurate detection of dimethyl methylphosphonate(DMMP),a simulant for chemical warfare agents,is vital for both public safety and military defense.However,conventional detection methods suffer from low selectivity,owi...Accurate detection of dimethyl methylphosphonate(DMMP),a simulant for chemical warfare agents,is vital for both public safety and military defense.However,conventional detection methods suffer from low selectivity,owing to interference from structurally similar compounds.In this study,we present a highly sensitive and selective gas sensor utilizing a solid-mounted film bulk acoustic resonator based on carbon nanotubes functionalized with hexafluoroisopropanol(HFiP)to enhance DMMP detection.This approach leverages the strong hydrogen bonding between HFiP and DMMP molecules to significantly improve the sensor’s adsorption capacity and selectivity.To further refine selectivity and at the same time solve the cross-sensitivity problem of sensitive membranes,we introduce a virtual sensor array design,generated by modulating the input power to the resonator,which enables the sensor to operate in multiple response modes across varying vibrational amplitudes.These multimodal responses are subjected to linear discriminant analysis,allowing precise differentiation of DMMP from other volatile organic compounds such as tributyl phosphate and dimethyl phthalate.Our results demonstrate superior performance in terms of both sensitivity and selectivity,offering a robust solution for detecting low-concentration DMMP in complex environments.展开更多
基金Projects (50971072,51131003) support by the National Natural Science Foundation of ChinaProjects (2011CB606301,2012CB825700) supported by the Ministry of Science and Technology of ChinaProject supported by the Administration of Tsinghua University
文摘118 kinds of Pt-Zr phases were established and investigated by considering various structures. Then the related physical properties, such as structural stability, lattice constants, formation enthalpies, elastic constants and bulk moduli, are obtained by ab initio calculations. Based on the calculated results of formation enthalpies, the ground-state convex hull is derived for the Pt-Zr system. The calculated physical data would provide a basis for further thermodynamic calculations and atomistic simulations. For these Pt-Zr compounds, it is found there are a positive linear correlation between the formation enthalpies and atomic volumes, and a negative linear correlation between the bulk modules and atomic volumes.
基金supported by the State Key Lab.of Advanced Metals and Materials,China(Grant No.2012-Z07)
文摘A dendritic β-phase reinforced bulk metallic glass(BMG) composite named as D2 was prepared by rapid quenching of a homogenous Zr60Ti14.67Nb5.33Cu5.56Ni4.44Be10 melt, and characterized by means of X-ray diffraction(XRD), scanning electron microscopy(SEM) observation and room-temperature compression test. The microstructure and mechanical properties were compared with those of the spherical β-phase reinforced composite named as composite S2. It was found that the composite D2 contains β-phase dendrites up to 56% in volume-fraction, and exhibits a ductile compressive behavior with plastic strain of 12.7%. As the high-volumefractioned β-phase dendrites transferred to coarse spherical particles of about 20 μm in diameter in the composite S2, a much improved plastic strain up to 20.4% can be achieved. Micrographs of the fractured samples reveal different interaction modes of the propagating shear bands with the dendritic and spherical β phase inclusions, resulting in different shear strains in the composite samples. The matrix of composite S2 undergoes a significantly larger shear strain than that of the composite D2 before ultimate failure, which is thought to be mainly responsible for the greatly increased global plastic strain of the S2 relative to D2.
基金supported by the Opening Project of National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology,and the National Natural Science Foundation of China(No.52270017).
文摘The organic compound composition ofwastewater,serves as a crucial indicator for the operational performance of activated sludge processes and has a major influence on the development of filamentous bulking in activated sludge.This study focused on the impact of typical soluble and slowly-biodegradable organic compounds,investigating the pathways through which these substrates affect the occurrence of filamentous bulking in systems operated under both high-and low-oxygen conditions.Results showed that slowly-biodegradable organic compounds lead to a concentrated distribution of microorganisms within flocs,with inward growth of filamentous bacteria.Both Tween-80 and granular starch treated systems exhibited a significant increase in protein content.The glucose system,utilizing soluble substrates,exhibited a markedly higher total polysaccharide content.Microbial communities in the Tween-80 and granular starch treated systems were characterized by a higher abundance of bacteria known to enhance sludge flocculation and settling,such as Competibacter,Xanthomonadaceae and Zoogloea.These findings are of high significance for controlling the operational performance and stability of activated sludge systems,deepening our understanding and providing a novel perspective for the improvement of wastewater treatment processes.
基金supported by the National Natural Science Foundation of China(Grant No.62488201)the National Key Research and Development Projects of China(Grant Nos.2022YFA1204100 and 2023YFA1607400)+1 种基金the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-003)the Innovation Program of Quantum Science and Technology(Grant No.2021ZD0302700)。
文摘A bulk superconductor hosting intrinsic surface superconductivity provides a unique platform for exploring Majorana bound states.Trigonal γ-PtBi_(2),a superconductor,is a promising candidate,as both surface superconducting gaps and topological surface states have been observed.However,the simultaneous presence of bulk and surface superconductivity has remained unresolved.In this study,we directly visualize coexisting bulk and surface superconducting gaps in trigonal PtBi_(2) using ultra-low-temperature scanning tunneling microscopy/spectroscopy.The bulk gap,Δ,is∼0.053 meV,with a critical temperature(T_(c))of∼0.5K and a critical field below 0.01 T,accompanied by a vortex lattice and vortex bound states and yielding a coherence length of∼200 nm.Remarkably,certain surface regions exhibit a much larger gap(Δ)of∼0.42 meV,persisting up to a T_(c)value of∼3K and surviving magnetic fields of up to 2 T,yet lacking a static vortex lattice.This coexistence of robust surface and bulk superconductivity establishes γ-PtBi_(2)as a unique platform for exploring the interplay between bulk and surface Cooper pairings in topological superconductors.
文摘In order to determine the bulk density of refractory raw materials,the so-called water method following the Archimedes principle is normally used.This is where the effect of water displacement on the mass of the sample is used to determine the bulk volume of the sample grains.During this test procedure,the surface of water infiltrated sample grains must be dried with a wet towel.Experience shows,that this drying step is the main root cause for variation in reproducibility of results and even repeatability of tests.A new spin dryer(centrifuge)was developed and introduced to automate this surface drying step,and is now included as a new method in ISO 8840:2021.The paper discusses the improvement of measurement with the new approach and industrial experiences from two big industrial players in the raw material business.
基金supported by the National Natural Science Foundation of China(grant 82205258 to K.L.H.,grant 82174487 to R.J.M.,grant82205282 to L.W.)Zhejiang Chinese Medical University Research Fund(grant 2022FSYYZZ08 to R.J.M.and D.X.H.,grant 2022FSYYZY09 to K.L.H.and R.J.M.)。
文摘Background Spinal cord injury causes severe disability,with ferroptosis,an iron-dependent cell death,contributing to its pathogenesis.Electroacupuncture is widely used in spinal cord injury treatment,but its effects on ferroptosis remain unclear.Objective This study explores electroacupuncture’s mechanisms on ferroptosis and its potential targets.Methods Spinal cord injury was induced in rats at the T10 segment using a modified Allen’s test.Electroacupuncture treatment was applied at Jiaji(EX-B2)acupoints with a 2/100 Hz frequency.Bulk and single-cell RNA sequencing were used to analyze gene expression.Differential expression analysis was performed using DESeq2,and validations included qRT-PCR,western blot,immunohistochemistry,and lipid peroxidation assays.Results Ferroptosis-related gene expression peaked on day 3 post-spinal cord injury.Electroacupuncture-treated rats showed improved motor function,reduced ferroptosis via Alox15 inhibition and GPX4 promotion,and decreased neutrophil infiltration,evidenced by reduced myeloperoxidase expression.Single-cell RNA sequencing identified Fkbp5 as a key electroacupuncture target,predominantly expressed in oligodendrocytes.Cells with high Fkbp5 expression demonstrated lower ferroptosis scores and enhanced antioxidant capacity.Conclusion Electroacupuncture reduces ferroptosis by mitigating reactive oxygen species production and neutrophil infiltration.Fkbp5 may serve as a critical target for electroacupuncture,promoting antioxidant mechanisms in oligodendrocytes and providing new insights into spinal cord injury therapy.
基金supported by the National Institutes of Health-Office of Research Infrastructure Programs(P40 OD010440)supported in part by grants from the National Cancer Center of Korea(NCC-2110160,NCC-2110263,and NCC-2310750)supported by the Basic Science Research Program of the National Research Foundation of Korea,funded by the Ministry of Science,ICT,and Future Planning(NRF-2015R1C1A1A01053611).
文摘The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components.The transmembrane protein-39(TMEM-39)mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin cuticles.TMEM-39 primarily co-localizes with the coat protein II complex(COPII)in large vesicles rather than small COPII vesicles.These TMEM-39-associated large vesicles(TMEM-39-LVs)form robustly during the molting period and co-localize with various extracellular matrix components,including BLI-1 collagen,BLI-3 dual oxidase,and carboxypeptidases.Through immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells,we identify TMEM39A-associated proteins,including TMEM131.Knockdown of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both C.elegans and human sarcoma cells,indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPII vesicles.Given the conservation of TMEM39A and its associated proteins between C.elegans and humans,TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.
基金supported by the Key Basic and Applied Research Program of Guangdong Province,China(Grant No.2019B030302010)the NSF of China(Grant Nos.52122105,52271150,52201185,52201186,52371160)+1 种基金the Science and Technology Innovation Commission Shenzhen(Grants Nos.RCJC20221008092730037,20220804091920001)the Research Team Cultivation Program of Shenzhen University,Grant No.2023QNT001.
文摘To advance materials with superior performance,the construction of gradient structures has emerged as a promising strategy.In this study,a gradient nanocrystalline-amorphous structure was induced in Zr46Cu46Al8 bulk metallic glass(BMG)through ultrasonic vibration(UV)treatment.Applying a 20 kHz ultrasonic cyclic loading in the elastic regime,controllable gradient structures with varying crystallized volume fractions can be achieved in less than 2 s by adjusting the input UV energy.In contrast to tradi-tional methods of inducing structural gradients in BMGs,this novel approach offers distinct advantages:it is exceptionally rapid,requires minimal stress,and allows for easy tuning of the extent of structural gradients through precise adjustment of processing parameters.Nanoindentation tests reveal higher hard-ness near the struck surface,attributed to a greater degree of nanocrystal formation,which gradually di-minishes with depth.As a result of the gradient dispersion of nanocrystals,an increased plasticity was found after UV treatment,characterized by the formation of multiple shear bands.Microstructural in-vestigations suggest that UV-induced nanocrystallization originates from local atomic rearrangements in phase-separated Cu-rich regions with high diffusional mobility.Our study underscores the tunability of structural gradients and corresponding performance improvements in BMGs through ultrasonic energy modulation,offering valuable insights for designing advanced metallic materials with tailored mechanical properties.
基金support provided by the College of Petroleum Engineering&Geosciences(CPG)at King Fahd University of Petroleum&Minerals(KFUPM).
文摘By analyzing core data from an offshore Gulf of Mexico reservoir and developing analytical solutions,it can be demonstrated that laboratory measurements on pore-volume compressibility include artifacts,leading to a misinterpretation of porosity and permeability trends.A systematic evaluation of poro-elastic changes in pore volumes(and quantifying any consequent fluid expulsion during reservoir compaction)suggests that poro-elastic relaxation may enhance fluid production rates from deep reservoirs by up to 25%.This value may be inadvertently inflated if the core samples used for pore-volume compressibility measurements suffered from handling damage.Nonetheless,poro-elastic fluid expulsion from the pores in producing reservoirs can provide additional lift and thus may enhance the recovery factor.Therefore,the possible contribution to well performance from poro-elastic production drive mechanisms ought to be carefully evaluated in reserves estimation.Reversely,injection wells may encounter poro-elastic suppression of injectivity due to elastic resistance,which would adversely affect the storage coefficient.By integrating geomechanical reservoir response with traditional fluid production models,reservoir model predictions of production under pressure depletion and injection conditions will be more accurate.The new insights reported here are essential for optimizing well performance,improving reservoir management,and extending the economic life of geological reservoirs.However,caution is warranted regarding pore-volume compressibility measurements.To what degree laboratory measurements of pore-volume compressibility measure true values or mainly record handling damage could not be conclusively settled in the present study.
基金Project supported by the National Key Research and Development Program of China (Grant Nos. 2019YFA0708502 and 2023YFA1406200)the National Natural Science Foundation of China (Grant No. 22022101)。
文摘Bulk modulus is a constant that measures the incompressibility of materials, which can be obtained in high pressure experiment by fitting the equations of state(EOS), like third-order Birch–Murnaghan EOS(BM EOS) and Vinet EOS. Bulk modulus reflects the intermolecular interaction inside molecular crystals, making it useful for researchers to design novel high pressure materials. This review systematically examines bulk moduli of various molecular crystals, including rare-gas solids, di-atom and triplet-atom molecules, saturated organic molecules, and aromatic organic crystals. Comparisons with ionic crystals are presented, along with an analysis of connections between bulk modulus and crystal structures.
基金supported by the National Natural Science Foundation of China(Nos.42007325 and 42177211).
文摘To understand the differences in the composition and sources of PM_(2.5) and PM_(10) caused by coarse particles,integrated PM_(2.5) and PM_(10) samples were synchronously collected in Nanjing,East China,in summer 2020 and winter 2020/2021.Bulk and molecular speciation and light absorption measurements of aerosol extractswere performed,followed by positivematrix factorization(PMF)based on the PM_(2.5) and PM_(10) data sets,respectively.The difference in average concentrations of total bulk species between PM_(2.5) and PM_(10) was mainly caused by the distribution of considerable NO_(3)^(–),SO42–,Ca^(2+),and organic carbon(OC)in coarse particles.Coarse PMinfluenced by abrasion products from tirewear and leaves contributed about half of the low-volatility n-alkanes in summer.The contribution of coarse PM to biomass burning tracers and water-soluble OC increased in winter when biomass combustion was excessively active.More than 70%of sugar polyols were attributable to coarse PM in summer,and biomass burning could be an important source in winter.The light-absorbing organic chromophores were almost entirely associated with PM_(2.5),but water-soluble organic carbon(WSOC)exhibited stronger light absorption in PM_(10) extracts than in PM_(2.5) extracts possibly due to the influence of coarse PMon pH.PMF analysis indicated that biomass burning,aqueous-phase reactions,and processed dust were the main contributors of organic matter and its light absorption in winter.Biogenic primary and secondary sources made discernable contributions only in summer.The differences between PM_(2.5) and PM_(10) were likely attributed to mixing of crustal dust,combustion particles,and surface reactions.
基金Supported by the Ministry of Shipping,India(Grant No.OEC/18-19/157/MOSH/RVIJ).
文摘Water depth significantly affects ship resistance,which,in turn,influences fuel consumption.Furthermore,the urgent need to reduce carbon emissions for environmental sustainability highlights the importance of applying drag reduction methods to shallow-water vehicles.To effectively employ these methods,the initial step entails an in-depth investigation of how shallow water impacts the resistance and flow dynamics of a mini-bulk carrier.This study extensively analyzes the hydrodynamic characteristics of mini-bulk carriers,focusing on the impact of shallow water on resistance and flow dynamics utilizing a combination of experimental tests and numerical analyses.This study emphasizes the interaction between the hull and the shallow seabed.This study also highlights increased frictional drag and significant residual resistance by analyzing the total resistance at various speeds in shallow waters.The results of five key factors influencing resistance in shallow waters,namely,boundary layer thickness,shear stress,velocity and pressure,turbulence,and waves,are discussed.A decrease in water depth accelerates the flow under the hull,increasing shear stress and resistance.The accelerated flow reduces the gap between the hull and the shallow seabed,elevating water pressure and increasing sinkage and resistance.Heightened turbulence in shallow water intensifies Reynolds stress,augmenting friction and viscous resistance.
基金supported by the National Natural Science Foundation of China(Grant Nos.12232005 and 12072101).
文摘Large-grain REBa_(2)Cu_(3)O_(7-δ)(REBCO,RE=rare earth)bulk superconductors offer promising magnetic field trapping capabilities due to their high critical current density,making them ideal for many important applications such as trapped field magnets.However,for such large-grain superconductor bulks,there are lots of voids and cracks forming during the process of melting preparation,and some of them can be up to hundreds of microns or even millimeters in size.Consequently,these larger size voids/cracks pose a great threat to the strength of the bulks due to the inherent brittleness of superconductor REBCO materials.In order to ensure the operational safety of related superconducting devices with bulk superconductors,it is firstly important to accurately detect these voids/cracks in them.In this paper,we proposed a method for quantitatively evaluating multiple voids/cracks in bulk superconductors through the magnetic field and displacement response signals at superconductor bulk surface.The proposed method utilizes a damage index constructed from the magnetic field signals and displacement responses to identify the number and preliminary location of multiple defects.By dividing the detection area into subdomains and combining the magnetic field signals with displacement responses within each subdomain,a particle swarm algorithm was employed to evaluate the location and size parameters of the defects.In contrast to other evaluation methods using only magnetic field or displacement response signals,the combined evaluation method using both signals can identify the number of cracks effectively.Numerical studies demonstrate that the morphology of voids and cracks reconstructed using the proposed algorithm ideally matches real defects and is applicable to cases where voids and cracks coexist.This study provides a theoretical basis for the quantitative detection of voids/cracks in bulk superconductors.
基金financially supported by the National Natural Science Foundation of China (32161143033, 32272178, and 32001574)National Key Research and Development Program of China (2021YFD1201605)the Agricultural Science and Technology Innovation Project of CAAS。
文摘The improvement of soybean seed carotenoid contents is very important due to the beneficial role of carotenoids in human health and nutrition. However, the genetic architecture underlying soybean carotenoid biosynthesis remains largely unknown. In the present study, we employed next generation sequencing-based bulked-segregant analysis to identify new genomic regions governing seed carotenoids in 1,551 natural soybean accessions. The genomic DNA samples of individual plants with extreme phenotypes were pooled to form two bulks with high(50 accessions) and low(50 accessions) carotenoid contents for Illumina sequencing. A total of 125.09 Gb of clean bases and 89.82% of Q30 were obtained, and the average alignment efficiency was 99.45% with an average coverage depth of 62.20× and 99.75% genome coverage. Based on the G prime statistic algorithm(G') method analysis, 16 candidate genomic loci with a total length 20.41 Mb were found to be related to the trait. Of these loci, the most significant regions displaying the highest elevated G' values were found in chromosome 06 at a position of 18.53–22.67 Mb, and chromosome 19 at genomic region intervals of 8.36–10.94, 12.06–13.79 and 18.45–20.26 Mb. These regions were then used to identify the key candidate genes. In these regions, 250 predicted genes were found and analyzed to obtain 90 significantly enriched(P<0.05) Gene Ontology(GO) terms. Based on ANNOVAR analysis, 50 genes with non-synonymous and stopgained mutations were preferentially selected as potential candidate genes. Of those 50 genes, following their gene annotation functions and high significant haplotype variations in various environments,five genes were identified as the most promising candidate genes regulating soybean seed carotenoid accumulation, and they should be investigated in further functional validation studies. Collectively, understanding the genetic basis of carotenoid pigments and identifying genes underpinning carotenoid accumulation via a bulked-segregant analysis-based sequencing(BSA-seq) approach provide new insights for exploring future molecular breeding efforts to produce soybean cultivars with high carotenoid content.
基金Supported by Guangdong Major Project of Basic and Applied Research,China(Grant No.2019B030302010)National Natural Science Foundation of China (Grant Nos.51735003,52205456)
文摘Avoiding crystallization while maintaining the original microstructure and mechanical properties of the material are long-term goals of laser welding of Zr-based bulk metallic glass(BMG).In this paper,the effect of pulsed laser welding parameters on the microstructure,crystallization degree,and mechanical properties of Zr57Nb5Cu15.4Ni12.6Al10 BMG is investigated.Non-crystallized welding forming of a zirconium-based amorphous alloy is achieved by optimizing the process parameters of pulsed laser welding.The crystallization degree of Zr-based BMG is mainly determined by the welding speed and power.The welding depth and crystallization area fraction increase with an increase in the effective peak power density.The optimized welding process can effectively reduce the heat accumulation of the weld,thus avoiding crystallization.The flexural strength of the weld can be maintained at 96.5%of the matrix.
基金supported by the National Natural Science Foundation of China(Nos.52271148 and 51871129).
文摘Ti-based bulk metallic glasses(BMGs)have attracted increasing attention due to their high specific strength.However,a fundamental conflict exists between the specific strength and glass-forming ability(GFA)of Ti-based BMGs,restricting their commercial applications significantly.In this study,this challenge was addressed by introducing a two-step alloying strategy to mitigate the remarkable density increment effect associated with heavy alloying elements required for enhancing the GFA.Consequently,through two-step alloying with Al and Fe in sequence,simultaneous enhancements in specific strength and GFA were achieved based on a Ti-Zr-Be ternary metallic glass,resulting in the development of a series of centimeter-sized metallic glasses exhibiting ultrahigh-specific strength.Notably,the newly developed(Ti_(45)Zr_(20)Be_(31)A_(l4))_(94)Fe_(6)alloy established a new record for the specific strength of Ti-based BMGs.Along with a critical diameter(D_(c))of 10 mm,it offers the optimal scheme for balancing the specific strength and GFA of Ti-based BMGs.The present results further brighten the application prospects of Ti-based BMGs as lightweight materials.
基金supported by the National Natural Science Foundation of China(Grant Nos.12192210,12192211,12102183,12302200,and 12402192)the Natural Science Foundation of Zhejiang Province(Grant No.LD21A020001)+2 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20230873)the National Postdoctoral Program for Innovation Talents(Grant No.BX2021261)supported by the specialized research projects of Huanjiang Laboratory,Zhuji,Zhejiang Province.
文摘This article investigates the second overtone thickness-extensional(TE2)vibrations and associated mode-coupling behaviors in ZnO piezoelectric film bulk acoustic resonator(FBAR),utilizing its wave dispersion relation and the higher-order stress balance principle.By superimposing the general wave solutions of multiple eigenmodes within the frequency range of the TE2 mode,mode-coupling solutions for ZnO FBAR are constructed.The substitution of these mode-coupling solutions into the higher-order stress balance principle,as laterally weak boundary conditions,leads to the frequency spectrogram equation,determining the relationship between resonance frequency and plate length-to-thickness ratio.A modified algorithm that combines the bisection method and the complex modulus ratio method is developed to solve the dispersion equation and frequency spectrogram equation(namely a kind of 2D complex transcendental equations)accurately and efficiently.The obtained results indicate that the operational TE2 mode may couple to unwanted 3^(rd)thickness-shear,fundamental thickness-shear,and flexural modes.Moreover,the mode-coupling behaviors depend strongly on resonance frequencies and plate length-to-thickness ratio.The displacement distributions of total displacement components,alongside the main displacement com-ponents of all considered eigenmodes,clearly demonstrate the variety of coupling behaviors.According to the obtained frequency spectrograms,the desirable values of plate length-to-thickness ratio for a clean operating mode with very weak coupling intensity are determined.These findings are of vital importance for the understanding of the mode-coupling me-chanism in overtone thickness-extensional FBARs,which will facilitate the structural design and optimization of FBAR devices.
基金supported by the State Key Laboratory of Pathogens and Biosecurity(Grant No.SKLPBS2240).
文摘Accurate detection of dimethyl methylphosphonate(DMMP),a simulant for chemical warfare agents,is vital for both public safety and military defense.However,conventional detection methods suffer from low selectivity,owing to interference from structurally similar compounds.In this study,we present a highly sensitive and selective gas sensor utilizing a solid-mounted film bulk acoustic resonator based on carbon nanotubes functionalized with hexafluoroisopropanol(HFiP)to enhance DMMP detection.This approach leverages the strong hydrogen bonding between HFiP and DMMP molecules to significantly improve the sensor’s adsorption capacity and selectivity.To further refine selectivity and at the same time solve the cross-sensitivity problem of sensitive membranes,we introduce a virtual sensor array design,generated by modulating the input power to the resonator,which enables the sensor to operate in multiple response modes across varying vibrational amplitudes.These multimodal responses are subjected to linear discriminant analysis,allowing precise differentiation of DMMP from other volatile organic compounds such as tributyl phosphate and dimethyl phthalate.Our results demonstrate superior performance in terms of both sensitivity and selectivity,offering a robust solution for detecting low-concentration DMMP in complex environments.
