BuGuZhi （Psoraleae Fructus） is the dry mature peel of the leguminous plant. After ripening in autumn, the fruit is collected and dried to get its fruit, which has the effect of warming kidney and helping Yang, t...BuGuZhi （Psoraleae Fructus） is the dry mature peel of the leguminous plant. After ripening in autumn, the fruit is collected and dried to get its fruit, which has the effect of warming kidney and helping Yang, the effect of absorbing asthma, warming the kidney and relieving diarrhea, and treating vitiligo and alopecia. Because the clinical curative effect is exact, so it has been widely used in the treatment of clinical diseases. However, the recent reports and clinical cases reported that BuGuZhi has some toxic effects. According to domestic and foreign references, toxic effects are mainly divided into hepatotoxicity, nephrotoxicity, phototoxicity, reproductive toxicity, and rare cases of retinal vagueness reported by clinical reports. the toxicity of BuGuZhi is summarized. The article analyzed the way of synergism and reduction of BuGuZhi, which was based on data mainly coming from the compatibility of drugs, pattern identification, constitution identification and drug processing. All o-f analyses and summaries are in order to make the clinical medication safer and more scientific.展开更多
Background:Psoralea corylifolia L.(Buguzhi,BGZ),known for its efficacy in supporting pregnancy and preventing miscarriage,has been used in China for over 1000 years.Recently,BGZ has been identified as a potential caus...Background:Psoralea corylifolia L.(Buguzhi,BGZ),known for its efficacy in supporting pregnancy and preventing miscarriage,has been used in China for over 1000 years.Recently,BGZ has been identified as a potential cause of drug-induced liver injury.However,its safety during pregnancy remains unclear,which significantly hinders its routine clinical application.Objective:To investigate the effects of BGZ administration during pregnancy on the liver of mouse mothers and their weaned 21-day-old offspring.Methods:Mice were orally administered BGZ at doses of 2.5 and 10 g/kg during pregnancy,with BGZ withdrawal during the lactation period.Liver histopathology(hematoxylin-eosin staining),biochemical analysis,and evaluation of liver bile acid metabolism were per-formed after the lactation period.Results:BGZ administration at doses of 2.5 and 10 g/kg during pregnancy,followed by withdrawal during the lactation period,caused mild liver damage in both mothers and their 21-day-old offspring.Serum total bile acid(TBA)levels were elevated compared with those in the control group.Additionally,changes were observed in the levels and proportions of various bile acids(BAs)in the liver,suggesting mild effects on BA metabolism.Conclusion:BGZ administration during pregnancy caused mild liver damage and increased serum TBA levels in both mouse mothers and their 21-day-old offspring.This phenomenon may be associated with imbalanced BA metabolism in the liver.Based on the present study and the limited toxicological research on BGZ,pregnant women should avoid prolonged use of BGZ.If BGZ is administered dur-ing pregnancy,serum TBA levels should be monitored,and if elevated,BGZ should be discontinued.展开更多
文摘BuGuZhi （Psoraleae Fructus） is the dry mature peel of the leguminous plant. After ripening in autumn, the fruit is collected and dried to get its fruit, which has the effect of warming kidney and helping Yang, the effect of absorbing asthma, warming the kidney and relieving diarrhea, and treating vitiligo and alopecia. Because the clinical curative effect is exact, so it has been widely used in the treatment of clinical diseases. However, the recent reports and clinical cases reported that BuGuZhi has some toxic effects. According to domestic and foreign references, toxic effects are mainly divided into hepatotoxicity, nephrotoxicity, phototoxicity, reproductive toxicity, and rare cases of retinal vagueness reported by clinical reports. the toxicity of BuGuZhi is summarized. The article analyzed the way of synergism and reduction of BuGuZhi, which was based on data mainly coming from the compatibility of drugs, pattern identification, constitution identification and drug processing. All o-f analyses and summaries are in order to make the clinical medication safer and more scientific.
基金supported by the National Natural Science Foundation of China(82192913,82174073)the China Academy of Chinese Medical Sciences Innovation Fund(CI2021B016,CI2021A04801)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-040,ZXKT21028).
文摘Background:Psoralea corylifolia L.(Buguzhi,BGZ),known for its efficacy in supporting pregnancy and preventing miscarriage,has been used in China for over 1000 years.Recently,BGZ has been identified as a potential cause of drug-induced liver injury.However,its safety during pregnancy remains unclear,which significantly hinders its routine clinical application.Objective:To investigate the effects of BGZ administration during pregnancy on the liver of mouse mothers and their weaned 21-day-old offspring.Methods:Mice were orally administered BGZ at doses of 2.5 and 10 g/kg during pregnancy,with BGZ withdrawal during the lactation period.Liver histopathology(hematoxylin-eosin staining),biochemical analysis,and evaluation of liver bile acid metabolism were per-formed after the lactation period.Results:BGZ administration at doses of 2.5 and 10 g/kg during pregnancy,followed by withdrawal during the lactation period,caused mild liver damage in both mothers and their 21-day-old offspring.Serum total bile acid(TBA)levels were elevated compared with those in the control group.Additionally,changes were observed in the levels and proportions of various bile acids(BAs)in the liver,suggesting mild effects on BA metabolism.Conclusion:BGZ administration during pregnancy caused mild liver damage and increased serum TBA levels in both mouse mothers and their 21-day-old offspring.This phenomenon may be associated with imbalanced BA metabolism in the liver.Based on the present study and the limited toxicological research on BGZ,pregnant women should avoid prolonged use of BGZ.If BGZ is administered dur-ing pregnancy,serum TBA levels should be monitored,and if elevated,BGZ should be discontinued.
