Buerger disease,also known as thromboangiitis obliterans(TAO),is a challenging vascular condition that primarily affects young male smokers.The pathogenesis involves a combination of inflammatory and thrombotic proces...Buerger disease,also known as thromboangiitis obliterans(TAO),is a challenging vascular condition that primarily affects young male smokers.The pathogenesis involves a combination of inflammatory and thrombotic processes leading to segmental occlusion of small-and medium-sized arteries and veins,primarily in the extremities.Despite advances in medical management,many patients with Buerger disease continue to experience debilitating symptoms,including rest pain,ischemic ulcers,and the threat of limb loss.This underscores the need for alternative therapeutic strategies when conventional treatments fail.展开更多
A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoi...A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoids was isolated from Rubus buergeri Miq. The isolation of the above chemical constituents from this plant was reported for the first time.展开更多
文摘Buerger disease,also known as thromboangiitis obliterans(TAO),is a challenging vascular condition that primarily affects young male smokers.The pathogenesis involves a combination of inflammatory and thrombotic processes leading to segmental occlusion of small-and medium-sized arteries and veins,primarily in the extremities.Despite advances in medical management,many patients with Buerger disease continue to experience debilitating symptoms,including rest pain,ischemic ulcers,and the threat of limb loss.This underscores the need for alternative therapeutic strategies when conventional treatments fail.
文摘A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoids was isolated from Rubus buergeri Miq. The isolation of the above chemical constituents from this plant was reported for the first time.
