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Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer 被引量:2
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作者 Feng Liu Zhao-Shen Li +5 位作者 Guo-Ming Xu Zhen-Xing Sun Guo-Xiong Zhou Xue-Xin Ren Zhen-Xing Tu Yan-Fang Gong the Department of Gastroenterology, Changhai Hospital, Second Military Medical Univercity, Shanghai 200433, China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2003年第2期629-633,共5页
OBJECTIVE: To assess the diagnostic value of endoscopic pancreatic duct brushing in detecting mutation of the K-ras gene at codon 12 in cytologic specimens from patients with pancreatic cancer. METHODS: Thirty-five pa... OBJECTIVE: To assess the diagnostic value of endoscopic pancreatic duct brushing in detecting mutation of the K-ras gene at codon 12 in cytologic specimens from patients with pancreatic cancer. METHODS: Thirty-five patients treated at Changhai Hospital, Shanghai between 1999 and 2001 were enrolled. Their cells obtained by pancreatic duct brushing during endoscopic retrograde tholangiopancreatography (ERCP) were suspended with phosphate buffer solution (PBS). DNA of the cells was extracted and mutation of the K-ras gene at codon 12 detected by means of PCR-SSCP. RESULTS: The K-ras gene mutation rate of pancreatic cancer was 70%, which was higher than that of chronic pancreatitis (14%, P<0.05). K-ras gene mutation was not found in patients with pancreatic cystorcarcinoma and duodenum carcinoma. As to the location of pancreatic cancer, no significant difference was observed between the head, the body and tail. The sensitivity, specificity, accuracy of pancreatic duct brushing in detecting pancreatic cancer was 70%, 94%, and 83%, respectively. CONCLUSION: K-ras analysis of pancreatic brushing samples is helpful in the diagnosis of patients with early pancreatic cancer. 展开更多
关键词 pancreatic cancer chronic pancreatitis K-RAS ENDOSCOPY pancreatic duct brushing CYTOLOGY
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The value of cytologic brushing with the aid of fiberoptic colonoscopy in the diagnosis of carcinoma of colon
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作者 季晨阳 张义熏 +1 位作者 白敦衍 何碧强 《Journal of Medical Colleges of PLA(China)》 CAS 1991年第2期156-160,169,共6页
Preoperative cytologic brushing and biopsy under direct Vision withfiberoptic colonoscopy(FC)and postoperative histopathologic examination wereperformed in 147 patients who were suspected of suffering from carcinoma o... Preoperative cytologic brushing and biopsy under direct Vision withfiberoptic colonoscopy(FC)and postoperative histopathologic examination wereperformed in 147 patients who were suspected of suffering from carcinoma of co-lon.In FC cytologic brushing,128 cases were positive for malignancy(87.1percent),18 false-negative(12.2 percent)and only one false-positive(0.7 percent).In the 146 FC biopsy specimens,124 were positive for malignancy(84 4 percent)and 22 false-negative and no false-positive.Combination of FC cytologic brushingwith FC biopsy could raise the diagnostic rate of colonic carcinoma to 95.2% anddecrease false-negative and false-positive because the two methods may replenisheach other in sampling and observation.Cytologic brushing is most valuable tothe early diagnosis of colonic carcinoma.When colonic stricture and obstructionprevent the colonoscope from reaching the lesion and FC biopsy cannot bedone,FC cytologic brushing is an effective method for diagnosis.The positiverate and false-negative rate of the cytologic brushing did not correlate to grosstyping,histopathologic typing and Dukes staging(P】0.05).The factorsinfluencing the correct diagnosis of colonic carcinoma by FC cytologic brushingare discussed in this paper. 展开更多
关键词 CYTOLOGIC brushing fiberoptic COLONOSCOPY COLORECTAL CARCINOMA cytodiagnostic method
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Effects of Chairside Polishing and Brushing on SurfaceRoughness of Acrylic Denture Base Resins
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作者 Seung-Kyun Kim Ju-Mi Park +3 位作者 Min-Ho Lee Jae-Youn Jung Shipu Li Xinyu Wang 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2009年第1期100-105,共6页
The effects of 3 chairside polishing kits and mechanical brushing on the surface roughness of 3 different acrylic denture base resins were compared. Acrylic denture base resins (auto-polymerizing, heat-polymerizing, ... The effects of 3 chairside polishing kits and mechanical brushing on the surface roughness of 3 different acrylic denture base resins were compared. Acrylic denture base resins (auto-polymerizing, heat-polymerizing, injected heat-polymerizing resins) were examined after a tungsten carbide bur, and after chairside polishing using 3 polishing kits and pumice. The specimens were subjected to mechanical brushing using a wear tester to simulate 30 000 strokes of brushing. The surface roughness of the acrylic denture base resin specimens was measured using a contact pro-filometer. After the test, the random polished acrylic resins were evaluated by scanning electron mi-croscopy (SEM) and atomic force microscopy (AFM). Acrylic denture base resins polished using the 3 types of polishing kits had a smoother surface than those finished with the tungsten carbide bur (p〈0.05). The surface of the resin polished by a TC cutter exceeded the Ra of 0.2 μm (p〈0.05). The auto-polymerizing resin showed a significantly higher surface roughness than the heat-polymerizing resin and injected heat-polymerizing resin (p〉0.05). In the case of polishing step wise, there was almost no change in surface roughness after brushing (p〉0.05). 展开更多
关键词 acrylic denture base resin POLISHING brushing surface roughness
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Statistical Evaluation of Anthropometric Measures and Oral Health Status in Terms of Diet, Smoking and Brushing Habits
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作者 Rukiye Dagalp Sema P. Aka +1 位作者 Itir Aydintug Doruk Iper 《Health》 2019年第4期391-405,共15页
Introduction and Objective: The aim of this research was to find out the interaction of anthropometric measurements particularly body mass and oral health status of Turkish young adult nationals regionally, depending ... Introduction and Objective: The aim of this research was to find out the interaction of anthropometric measurements particularly body mass and oral health status of Turkish young adult nationals regionally, depending on the effects of diet (food and fluid consumption), smoking and tooth brushing habits, which were determined by using the body mass index (BMI) and dental health index (DMFT). Material and Methods: The BMI and DMFT of 202 cases, with an age average 22.5 years, were recorded through physical and clinical examinations. Statistical evaluation of the data was checked by Cronbach’s Alpha Reliability Scale and performed by analysis of variance, Somer’s d and Pearson Chi-Square statistics, Poisson Regression and Odds Ratio analysis. Results: The results showed that the mean of BMI was at the optimum level (21.52) for all cases. The DMFT was higher for underweight females and for overweight males. The mean of DMFT according to sexes seemingly had no significant difference;however, females had 8.6% more DMFT than males. When the risk factors of dental caries were evaluated, the DMFT was found as 19.3% more for cases consuming high carbohydrate foods, 4.5% more for high beverage consumption and 18% more for smokers. Conclusions: In conclusion, tooth brushing 3 or more times a day is necessary to decrease the DMFT and tooth brushing 3 times a day as opposed to 1 or 2 times shows significant difference regarding oral health. 展开更多
关键词 ANTHROPOMETRIC Measures (BMI) Dental Index (DMFT) Oral Health DIET SMOKING Tooth brushing
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Brushing up My Chinese in Beijing
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作者 Selene kaye 《China & The World Cultural Exchange》 2000年第5期40-41,共2页
关键词 brushing up My Chinese in Beijing
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Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research 被引量:2
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作者 Pei-Fen Zhang Xiao-Hui Zheng +4 位作者 Xi-Zhao Li Tian Tian Shao-Dan Zhang Ye-Zhu Hu Wei-Hua Jia 《Cancer Communications》 SCIE 2018年第1期95-104,共10页
Background:Tissue specimens for nasopharyngeal carcinoma(NPC)research are scarce because of sampling dif-ficulties.Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method f... Background:Tissue specimens for nasopharyngeal carcinoma(NPC)research are scarce because of sampling dif-ficulties.Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC diagnosis.The present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for research.Methods:Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC patients.Tissues from 48 NPC and 18 nasopharyngitis patients were collected by endoscopic biopsy.The expression levels of tumor suppressor genes(TSGs)and Epstein-Barr virus(EBV)-encoded microRNAs as well as EBV DNA copy number were measured by quantitative polymerase chain reaction in both types of samples.Results:Among six TSGs examined,the expression levels of two genes were significantly decreased in nasopharyn-geal brushing and tissue samples from NPC patients as compared with those from healthy/nasopharyngitis indi-viduals.Four EBV-encoded microRNAs,mir-bart1-5p,mir-bart5,mir-bart6-5p,and mir-bart17-5p,were significantly up-regulated in both NPC brushing and tissue samples compared with those from healthy/nasopharyngitis controls(P<0.001).EBV DNA was significantly increased in both nasopharyngeal brushing samples(P<0.001)and tissue sam-ples(P<0.001)from NPC patients in comparison with those from healthy controls.Conclusions:Nasopharyngeal brushing can obtain sufficient tumoral materials for the analysis of viral nucleic acid,including EBV-encoded microRNAs and EBV DNA.For the detection of TSG expression,nasopharyngeal brushings was feasible but inferior to tissue samples.This study confirms nasopharyngeal brushing as an applicable sampling method that can aid in nucleic acid-based NPC research. 展开更多
关键词 Nasopharyngeal brushing Tissue samples Nasopharyngeal carcinoma Nucleic acid Cancer research
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Brushing, Flossing Stave Off Diabetes
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作者 Deena Beasley 欧阳倩芳 《当代外语研究》 2002年第4期1-2,共2页
人类对人体奥秘的探索与了解尚处初级阶段。本文提出的一个问题就让我们感到新奇与愕然。洁齿与口腔卫生有助于抑制糖尿病: Gum(齿龈)disease may even be more important than obesity or age as a factorin the onset of diabetes in ... 人类对人体奥秘的探索与了解尚处初级阶段。本文提出的一个问题就让我们感到新奇与愕然。洁齿与口腔卫生有助于抑制糖尿病: Gum(齿龈)disease may even be more important than obesity or age as a factorin the onset of diabetes in adults。 上句可译:就诱发成年人糖尿病的因素而言,齿龈疾病也许比肥胖和年龄这两个因素更为重要。 因此,我们有必要认识:the importance of prevention and early treatment ofgum disease in people who are at risk of developing diabetes。 本文对inflammation([医]炎症,发炎)提出了一个颇有原创性的观点:…heart disease has a substantial inflammatory component。】 展开更多
关键词 Flossing Stave Off Diabetes brushing 糖尿病
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ASK THE DOC Quick tips on avoiding over-brushing
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作者 TOM LEE 《城市漫步(GBA版)》 2014年第7期45-45,共1页
What damage can be done to teeth by over-brushing?The enamel of the teeth ran he worn out;the gum can he hurt by over-brushing.And your teeth will feel sensitive if the enamel gets thinner and/or the gum recedes.How o... What damage can be done to teeth by over-brushing?The enamel of the teeth ran he worn out;the gum can he hurt by over-brushing.And your teeth will feel sensitive if the enamel gets thinner and/or the gum recedes.How often should we be brushing our teeth?Two to three rimes a day.What is the recommended amount of time people should spend brushing their teeth? 展开更多
关键词 DAMAGE BRUSH teeth
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Uniaxial alignment of perovskite nanowires via brush painting technique for efficient flexible polarized photodetectors 被引量:1
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作者 Mi Kyong Kim Su Min Park +8 位作者 Haedam Jin Jeongbeom Cha Dohun Baek Tae Oh Yoon Gibaek Lee Se Gyo Han Sae Byeok Jo Seok Joo Yang Min Kim 《Journal of Materials Science & Technology》 2025年第4期24-33,共10页
A polarization-sensitive and flexible photodetector was fabricated through the precise alignment of perovskite nanowires(NWs)using a brush coating technique.The alignment of the NWs was meticulously examined,consideri... A polarization-sensitive and flexible photodetector was fabricated through the precise alignment of perovskite nanowires(NWs)using a brush coating technique.The alignment of the NWs was meticulously examined,considering various chemical properties of the solvent,such as boiling point,viscosity,and surface tension.Notably,when the NWs were brush-coated with toluene dispersion,the NWs were aligned in higher order than those processed from octane dispersion.The degree of alignment was correlated with the photodetector property.Especially,the well-aligned NW photodetector exhibited a two-fold disparity in current response contingent on the polarization direction.Furthermore,even after enduring 500 bending cycles,the device retained 80%of its photodetector performance.This approach underscores the potential of solution-processed flexible photodetectors for advanced optical applications under dynamic operating conditions. 展开更多
关键词 Perovskite photodetectors Perovskite nanowires Brush coating technique Aligned nanowires
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My Summer Holiday
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作者 曾琬茗 汤建邦(指导) 《疯狂英语(双语世界)》 2025年第2期72-73,共2页
Hello,everyone!I am Cici.I had a summer holiday that was both busy and happy.From July 11th to July 20th,I went to school every day to learn traditional Chinese painting.The soft brushes glided across the paper,creati... Hello,everyone!I am Cici.I had a summer holiday that was both busy and happy.From July 11th to July 20th,I went to school every day to learn traditional Chinese painting.The soft brushes glided across the paper,creating beautiful and vivid images. 展开更多
关键词 soft brushes summer holiday traditional chinese painting IMAGES traditional chinese paintingthe BRUSHES
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英语练习专题(三)
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《初中生辅导》 2025年第9期29-32,共4页
一、阅读理解[核心素养·文化意识](2024·贵州铜仁一模) The brush pen, one of the “Four Treasures of the Study”, was invented thou-sands of years ago. However, the oldest pen was just a stick or a piece of bamb... 一、阅读理解[核心素养·文化意识](2024·贵州铜仁一模) The brush pen, one of the “Four Treasures of the Study”, was invented thou-sands of years ago. However, the oldest pen was just a stick or a piece of bamboo. It was difficult for people to write well on thin silk. 展开更多
关键词 thin silk STICK piece bamboo four treasures study brush pen SILK
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论二则托忒蒙古文《字母》
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作者 特尔巴图 《西部蒙古论坛》 2025年第3期120-124,M0006,共6页
Both the Todo Alphabet written with bambuu pen that is kept by Burintögs Khagai in County Zhaosu and the one written with soft brush that is kept by Namrjil Vjar have distinct characteristics in symbols for vowel... Both the Todo Alphabet written with bambuu pen that is kept by Burintögs Khagai in County Zhaosu and the one written with soft brush that is kept by Namrjil Vjar have distinct characteristics in symbols for vowels,consonants,terminal letters and transcription letters.The two of them fundamentally adhered to the orthography established by Zaya Pandida and most likely were compiled in the transitional phase of the todo script. 展开更多
关键词 todo script Todo Mongolian todo alphabet zaya pandida bambuu pen ALPHABET soft brush
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Insight into the Solution Self-Assembly of Amphiphilic Asymmetric Brush Copolymers via Computer Simulations
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作者 Wei-Ting Zeng Wei-Sheng Feng +3 位作者 Xing Zhang Yuan Yao Bin-Bin Xu Shao-Liang Lin 《Chinese Journal of Polymer Science》 2025年第1期132-140,I0010,共10页
Amphiphilic asymmetric brush copolymers(AABCs)possess unique self-assembly behaviors owing to their asymmetric brush architecture and multiple functionalities of multicomponent side chains.However,the synthesis of AAB... Amphiphilic asymmetric brush copolymers(AABCs)possess unique self-assembly behaviors owing to their asymmetric brush architecture and multiple functionalities of multicomponent side chains.However,the synthesis of AABCs presents challenges,which greatly limits the exploration of their self-assembly behaviors.In this work,we employed dissipative particle dynamics(DPD)simulations to investigate the self-assembly behaviors of AABCs in selective solution.By varying the copolymer concentration and structure,we conducted the self-assembly phase diagrams of AABCs,revealing complex morphologies such as channelized micelles with one or more solvophilic channels.Moreover,the number,surface area,and one-dimensional density distribution of the channelized micelles were calculated to demonstrate the internal structure and morphological transformation during the self-assembly process.Our findings indicate that the morphology of the internal solvophilic channels is greatly influenced by the copolymer structure,concentration,and interaction parameters between the different side chains.The simulation results are consistent with available experimental observations,which can offer theoretical insights into the self-assembly of AABCs. 展开更多
关键词 Dissipative particle dynamics Brush copolymer SELF-ASSEMBLY Channelized micelle
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萧散淡泊 逸气古意——元代文人画“写意精神”美学内涵 被引量:1
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作者 余昭 《吉林艺术学院学报》 2016年第4期33-35,共3页
中国画的发展需要传承和创新,又不能死守传统,但对于传统的绘画精神需要领会,切身实践。每一个时代需要对其以新的阐释,学习和解读传统元代文人画精神对于拓展当代中国画的时代精神具有实质性的价值,进一步贴近文脉,把握当代中国画发展... 中国画的发展需要传承和创新,又不能死守传统,但对于传统的绘画精神需要领会,切身实践。每一个时代需要对其以新的阐释,学习和解读传统元代文人画精神对于拓展当代中国画的时代精神具有实质性的价值,进一步贴近文脉,把握当代中国画发展方向。 展开更多
关键词 spirit brushing ancient conception grace revolution
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多模式拉制微纳光纤
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作者 曲广媛 逯与凯 +5 位作者 高星宇 华健男 闫东 赵伟 朱玲 张增明 《物理实验》 2019年第3期8-11,19,共5页
搭建了基于火焰加热法的微纳光纤拉制装置,通过软件控制,实现了3种模式下的微纳光纤拉制.基于传统的单边拉制和双边拉制,引入了Flame brush拉制方式,增加了火焰加热区域.根据测量结果优化了拉制模式中的参量,成功拉制出传输损耗、束腰... 搭建了基于火焰加热法的微纳光纤拉制装置,通过软件控制,实现了3种模式下的微纳光纤拉制.基于传统的单边拉制和双边拉制,引入了Flame brush拉制方式,增加了火焰加热区域.根据测量结果优化了拉制模式中的参量,成功拉制出传输损耗、束腰直径及束腰长度均良好的微纳光纤. 展开更多
关键词 微纳光纤 拉制平台 FLAME brush模式
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Numerical Analysis of Tilted Cutting and F128 Brushes
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作者 Libardo V.Vanegas-Useche Magd M.Abdel-Wahab Graham A.Parker 《Computer Modeling in Engineering & Sciences》 SCIE EI 2019年第10期23-47,共25页
Road sweeping is an essential service that has to be conducted for public health,as well as aesthetic purposes.In many countries,sweeping vehicles are used for this activity.They usually comprise a gutter brush that s... Road sweeping is an essential service that has to be conducted for public health,as well as aesthetic purposes.In many countries,sweeping vehicles are used for this activity.They usually comprise a gutter brush that sweeps the debris that is located in the road gutter.This work studies the performance of two kinds of gutter brushes:a cutting brush and a flicking(F128)brush.This is carried out by means of a 3-D dynamic,nonlinear Finite Element(FE)brush model developed by the authors.In this model,inertia forces are applied to the bristle,and its clamped end is fixed.Consequently,the surface(road)is rotated,translated,and raised.Bristle-road interaction is modelled as flexible-to-rigid contact.In particular,the aim of this article is to compare the performance of a conventional brush and a brush rotating at variable speed.As brushes normally work tilted,FE analyses are carried out for tilted cutting and F128 brushes,rotating at speeds that fluctuate at different frequencies.It is concluded that brush oscillations have a significant effect on bristle tip velocities and bristle-road forces.Also,at certain frequencies,oscillations seem to improve sweeping performance of the F128 brush.However,they do not appear to improve significantly the performance of the cutting brush. 展开更多
关键词 GUTTER BRUSHES CUTTING BRUSH flicking BRUSH FEM variable speed brushing
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PHOTOTHERAPY OF GINGIVITIS:PILOT CLINICAL STUDY
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作者 ELINA A.GENINA VLADIMIR A.TITORENKO +6 位作者 VALERY V.TUCHIN GEORGY V.SIMONENKO ALEXEY N.BASHKATOV GENNADY M.SHUB ALEXANDER V.LEPILIN ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2011年第4期437-446,共10页
The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solu... The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were conducted.The microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the R-LETB.For the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two groups.Subjects in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized toothpaste.The second(control)group used only the toothpaste and a regular toothbrush.Subjects in both groups followed their respective procedures 2 times a day(morning and evening)for 30 days.Indices of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day timepoints.In the both groups,all indices improved in comparison with baseline.However,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum tissue.Thus,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction. 展开更多
关键词 Tooth brushing methylene blue photodynamic therapy pathogenic bacteria
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Sliding electrical contact behavior of AuAgCu brush on Au plating 被引量:26
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作者 谢鑫林 张雷 +3 位作者 肖金坤 钱志源 张涛 周科朝 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第9期3029-3036,共8页
The sliding electrical contact behavior of AuAgCu brush on Au plating was investigated at various normal loads and sliding speeds.The contact voltage drop and electrical noise between the two brushes were measured and... The sliding electrical contact behavior of AuAgCu brush on Au plating was investigated at various normal loads and sliding speeds.The contact voltage drop and electrical noise between the two brushes were measured and the resistance waveforms were recorded.The morphologies of the worn surfaces and wear debris of the brush and plating were observed.The results show that the contact voltage drop and electrical noise decrease with the addition of load whereas increase drastically with increasing sliding speed.With the electrical current in vacuum,the wear process of AuAgCu brush on Au plating involves adhesion,transfer of gold from the plating to the brush,rolling of wear debris between contact surfaces and arc-induced melt at the contact edge,and this gold-on-gold sliding electrical contact system is reliable within experiment period. 展开更多
关键词 sliding electrical contact AuAgCu brush GOLD WEAR ADHESION
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Effectiveness of Oral Health Education Program on Prevention of Periodontal Disease in Japanese Pregnant Women
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作者 Mayumi Noguchi Akira Tagaya +3 位作者 Ayako Sakoda Hitoshi Komatsuzawa Natsumi Fujiwara Motoyuki Sugai 《Open Journal of Nursing》 2016年第4期282-293,共12页
The prevalence of periodontal disease among pregnant women increases with gestational age. Therefore, oral health education in the early stage of pregnancy should prevent periodontal disease and decrease the risk of a... The prevalence of periodontal disease among pregnant women increases with gestational age. Therefore, oral health education in the early stage of pregnancy should prevent periodontal disease and decrease the risk of an adverse pregnancy outcome such as preterm delivery and low birth weight. However, there has been no study on oral health care intervention for prevention of periodontal disease during pregnancy. The purpose of this study was to examine the efficiency of an oral health education program on periodontal disease among Japanese low-risk pregnant women. A total of 207 pregnant women before 20 weeks of gestation were recruited. The first 131 of them were assigned to the control group and the remaining 76 to the experimental group. The experiment participants received an oral health education program including the toothpick brushing method in their early stage of pregnancy. Improvement of the self-assessment score of periodontal symptoms was used as a binary outcome variable. A logistic regression analysis indicated that the intervention (OR = 3.83) and proficiency of the toothpick brushing method (OR = 24.93) were statistically significant predictors of the outcome in the late stage of pregnancy. The positive outcome appeared after practice of the toothpick method brushing for 20 or more weeks, and was associated with the decrease in the log-transformed proportion of the count of Candida species in salivary microbiota (p = 0.026). 展开更多
关键词 Periodontal Disease PREGNANCY Oral Health Educational Intervention Toothpick brushing Method
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Diagnostic approaches for cholangiocarcinoma 被引量:26
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作者 Andreas Weber Roland M Schmid Christian Prinz 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第26期4131-4136,共6页
Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to be challenging. C... Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to be challenging. Cholangiocarcinomas often grow longitudinally along the bile duct rather than in a radial direction. Thus, large tumor masses are frequently absent and imaging techniques, including ultrasound, CT, and MRI have only limited sensitivity. Tissue collection during endoscopic (ERCP) and/or percutaneous transhepatic (PTC) procedures are usually used to confirm a definitive diagnosis of cholangiocarcinoma. However, forceps biopsy and brush cytology provide positive results for malignancy in about only 50% of patients. Percutaneous and peroral cholangioscopy using fiber-optic techniques were therefore developed for direct visualization of the biliary tree, yielding additional information about endoscopic appearance and tumor extension, as well as a guided biopsy acquistion. Finally, endoscopic ultrasonography (EUS) complements endoscopic and percutaneous approaches and may provide a tissue diagnosis of tumors in the biliary region through fine-needle aspiration. In the future, new techniques allowing for early detection, including molecular markers, should be developed to improve the diagnostic sensitivity in this increasing tumor entity. 展开更多
关键词 DIAGNOSIS Brush cytology Forceps biopsy CHOLANGIOCARCINOMA
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