Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been proven successful ...Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been proven successful for other viral vaccines are not enough to tackle HIV-1 and new approaches to design effective preventive AIDS vaccines are of utmost importance. Due to enormous diversity among global circulating HIV strains, an effective HIV vaccine must elicit broadly protective antibodies based responses;therefore discovering new broadly neutralizing antibodies (bNAbs) against HIV has become major focus in HIV vaccine research. However further understanding of the viral targets of such antibodies and mechanisms of action of bNAbs is required for advancement of HIV vaccine research. This technical note discusses our current knowledge on the bNAbs and immunoprophylaxis using viral vectors with their relevance in designing of new candidates to HIV-1 vaccines.展开更多
The global spread of Severe Acute Respiratory Syndrome Coronavirus 2.(SARS-CoV-2)and its variant strains,including Alpha,Beta,Gamma,Delta,and now Omicron,pose a significant challenge.With the constant evolution of the...The global spread of Severe Acute Respiratory Syndrome Coronavirus 2.(SARS-CoV-2)and its variant strains,including Alpha,Beta,Gamma,Delta,and now Omicron,pose a significant challenge.With the constant evolution of the virus,Omicron and its subtypes BA.1,BA.2,BA.3,BA.4,and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or infection.This evasion highlights the urgency in discovering new monoclonal antibodies(mAbs)with neutralizing activity,especially broadly neutralizing antibodies(bnAbs),to combat the virus.In the current study,we introduced a fully human neutralizing mAb,CR9,that targets Omicron variants.We demonstrated the mAb’s effectiveness in inhibiting Omicron replication both in vitro and in vivo.Structural analysis using cryo-electron microscopy(cryo-EM)revealed that CR9 binds to an epitope formed by RBD residues,providing a molecular understanding of its neutralization mechanism.Given its potency and specificity,CR9 holds promise as a potential adjunct therapy for treating Omicron infections.Our findings highlight the importance of continuous mAb discovery and characterization in addressing the evolving threat of COVID-19.展开更多
A study published in Nature'by Gonelli and colleagues reveals that potent,broadly neutralizing antibodies(bNAbs)delay viremic simian immunodeficiency virus(SIV)infection in rhesus macaques but do not fully prevent...A study published in Nature'by Gonelli and colleagues reveals that potent,broadly neutralizing antibodies(bNAbs)delay viremic simian immunodeficiency virus(SIV)infection in rhesus macaques but do not fully prevent subclinical infections.Despite bNAb concentrations being significantly higher than supposed protective thresholds,transient viral"blips"occurred,which suggests that bNAb prophylaxis can mask subclinical infections and has implications for the interpretation of HIV-1 prevention trials.展开更多
Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I(HIV-1)through antiretroviral therapy.However,vaccine development has remained challengin...Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I(HIV-1)through antiretroviral therapy.However,vaccine development has remained challenging.Recent discoveries in broadly neutralizing monoclonal antibodies(bNAbs)has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response.Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein(Env)during infection.Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.展开更多
We report on broadly wavelength-tunable passive mode-locking with high power operating at the 2 μm water absorption band in a Tm:CYA crystal laser. With a simple quartz plate, stable mode-locking wavelengths can be t...We report on broadly wavelength-tunable passive mode-locking with high power operating at the 2 μm water absorption band in a Tm:CYA crystal laser. With a simple quartz plate, stable mode-locking wavelengths can be tuned from 1874 to 1973 nm, with a tunable wavelength range up to ~100 nm and maximum output power up to 1.35 W. The bandwidth is narrow as ~6 GHz, corresponding to a high coherence. To our knowledge, this is the first demonstration of wavelength-tunable mode-locking with watt-level in the 2 μm water absorption band.The high temporal coherent laser can be further applied in spectroscopy, the efficient excitation of molecules, sensing, and quantum optics.展开更多
Investors greet China's first QDII products with caution Ms. Wang, a financial planner at one of China's largest state-owned banks, takes five phone inquiries a day from clients I about its new QDII products, ...Investors greet China's first QDII products with caution Ms. Wang, a financial planner at one of China's largest state-owned banks, takes five phone inquiries a day from clients I about its new QDII products, with most clients saying they will consider it. "I have an enquiry about your bank's QDII products. What are the returns?展开更多
This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground commu...This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground communication.The array consists of ten broadside-radiating,ultrawide-beamwidth elements that are cascaded by a central-symmetry series-fed network with tapered currents following Dolph-Chebyshev distribution to provide low SLL.First,an innovative design of end-fire Huygens source antenna that is compatible with metal ground is presented.A low-profile,half-mode Microstrip Patch Antenna(MPA)is utilized to serve as the magnetic dipole and a monopole is utilized to serves as the electric dipole,constructing the compact,end-fire,grounded Huygens source antenna.Then,two opposite-oriented end-fire Huygens source antennas are seamlessly integrated into a single antenna element in the form of monopole-loaded MPA to accomplish the ultrawide,broadside-radiating beam.Particular consideration has been applied into the design of series-fed network as well as antenna element to compensate the adverse coupling effects between elements on the radiation performance.Experiment indicates an ultrawide Half-Power Beamwidth(HPBW)of 161°and a low SLL of-25 dB with a high gain of 12 d Bi under a single-layer configuration.The concurrent ultrawide beamwidth and low SLL make it particularly attractive for applications of UAV air-to-ground communication.展开更多
6G is desired to support more intelligence networks and this trend attaches importance to the self-healing capability if degradation emerges in the cellular networks.As a primary component of selfhealing networks,faul...6G is desired to support more intelligence networks and this trend attaches importance to the self-healing capability if degradation emerges in the cellular networks.As a primary component of selfhealing networks,fault detection is investigated in this paper.Considering the fast response and low timeand-computational consumption,it is the first time that the Online Broad Learning System(OBLS)is applied to identify outages in cellular networks.In addition,the Automatic-constructed Online Broad Learning System(AOBLS)is put forward to rationalize its structure and consequently avoid over-fitting and under-fitting.Furthermore,a multi-layer classification structure is proposed to further improve the classification performance.To face the challenges caused by imbalanced data in fault detection problems,a novel weighting strategy is derived to achieve the Multilayer Automatic-constructed Weighted Online Broad Learning System(MAWOBLS)and ensemble learning with retrained Support Vector Machine(SVM),denoted as EMAWOBLS,for superior treatment with this imbalance issue.Simulation results show that the proposed algorithm has excellent performance in detecting faults with satisfactory time usage.展开更多
BACKGROUND Leiomyomas or fibroids commonly originate from the uterus;extrauterine leiomyomas are rare and most often arise from the broad ligament.Diagnosing broad ligament leiomyomas becomes particularly challenging ...BACKGROUND Leiomyomas or fibroids commonly originate from the uterus;extrauterine leiomyomas are rare and most often arise from the broad ligament.Diagnosing broad ligament leiomyomas becomes particularly challenging when they undergo degenerative changes because their clinical and radiological features often mimic those of ovarian tumors.We report a rare case of a giant broad ligament fibroid with cystic degeneration,which was initially mistaken for an ovarian mass.CASE SUMMARY A 49-year-old woman presented with mild abdominal distension and pain as the only symptoms.Upon abdominal examination,a large mass measuring approximately 30 cm and extending from the pelvic cavity to just below the xiphoid process was identified.Both transvaginal ultrasound and contrast-enhanced computed tomography suggested an ovarian origin of the mass.However,laparotomy confirmed that the mass originated from the right broad ligament.The mass was separated from the uterus and bilateral ovaries,with no involvement of the uterus or ovaries.The mass was completely resected with respecting the patient’s desire to retain her uterus and adnexa.Postoperative histopathological examination confirmed leiomyoma with cystic degeneration.CONCLUSION Broad ligament myomas mimic ovarian tumors;accurate diagnosis and careful operation are critical to avoid complications and ensure safety.展开更多
Wheat leaf rust,caused by Puccinia triticina(Pt),is one of the most devastating diseases in common wheat(Triticum aestivum L.)and can lead to heavy yield loss(Chai et al.2020).Leaf rust can result in 50%yield loss dur...Wheat leaf rust,caused by Puccinia triticina(Pt),is one of the most devastating diseases in common wheat(Triticum aestivum L.)and can lead to heavy yield loss(Chai et al.2020).Leaf rust can result in 50%yield loss during epidemic years(Huerta-Espino et al.2011;Gebrewahid et al.2020;Kolomiets et al.2021).Breeding varieties resistant to leaf rust have been recognized as the most effective and economical method to mitigate wheat losses caused by Pt.The narrow genetic basis of wheat constrains the number of cultivars resistant to leaf rust(Jin et al.2021).展开更多
On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japa...On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japan relations,people-to-people exchanges and cooperation between the two organisations.展开更多
In this paper, the containment control problem in nonlinear multi-agent systems(NMASs) under denial-of-service(DoS) attacks is addressed. Firstly, a prediction model is obtained using the broad learning technique to t...In this paper, the containment control problem in nonlinear multi-agent systems(NMASs) under denial-of-service(DoS) attacks is addressed. Firstly, a prediction model is obtained using the broad learning technique to train historical data generated by the system offline without DoS attacks. Secondly, the dynamic linearization method is used to obtain the equivalent linearization model of NMASs. Then, a novel model-free adaptive predictive control(MFAPC) framework based on historical and online data generated by the system is proposed, which combines the trained prediction model with the model-free adaptive control method. The development of the MFAPC method motivates a much simpler robust predictive control solution that is convenient to use in the case of DoS attacks. Meanwhile, the MFAPC algorithm provides a unified predictive framework for solving consensus tracking and containment control problems. The boundedness of the containment error can be proven by using the contraction mapping principle and the mathematical induction method. Finally, the proposed MFAPC is assessed through comparative experiments.展开更多
Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost n...Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost not been reported.In this work,Bi_(2)YbO_(4)Cl was synthesized using the solid-state method and the solvothermal method.Yb3+ions show a strong characteristic absorption peak at 980 nm,which was measured by ultraviolet-visible-near-infrared absorption spectra.The transient photoconductivity of Bi_(2)YbO_(4)Cl was obtained by time-resolved terahertz spectroscopy system under 400 and 800 nm laser excitations,respectively.The frequency-dependent transient photoconductivity analysis reveals the Drude-Smith behavior in Bi_(2)YbO_(4)Cl.Under photoexcitation,the hot charge carriers with a long relaxation lifetime and a carrier mobility of 48 cm^(2)/(V·s) are obtained.The synthesis of Bi_(2)YbO_(4)Cl is of great significance for the development of novel photocatalytic and photo harvesting materials with broad spectral response.展开更多
Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resist...Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resistance.But strategies for expanding NLR recognition spectra[[1],[2],[3],[4],[5]]are often limited by the rapid evolution of pathogens and pests.In our recent study,we developed an innovative strategy to engineer broad-spectrum,durable and complete disease resistance in plants by remodeling autoactive NLRs into protease-activated switches[6].展开更多
Coronaviruses are single-stranded,positive-sense RNA enveloped viruses that have posed a significant threat to human health over the past few decades,particularly severe acute respiratory syndrome coronavirus(SARS-CoV...Coronaviruses are single-stranded,positive-sense RNA enveloped viruses that have posed a significant threat to human health over the past few decades,particularly severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and SARS-CoV-2.These viruses have caused widespread infections and fatalities,with profound impacts on global economies,social life,and public health systems.Due to their broad host range in natural settings and the consequent high potential for zoonotic spillover events,a thorough investigation of the common viral mechanisms and the identification of druggable targets for pan-coronavirus antiviral development are of utmost importance.展开更多
This paper introduced the definition and importance of combination of sta-ple food. With broad bean nutrition flour as a sample, the preparation of the combi-nation of staple food was also described. In addition, the ...This paper introduced the definition and importance of combination of sta-ple food. With broad bean nutrition flour as a sample, the preparation of the combi-nation of staple food was also described. In addition, the main nutritional value of broad bean nutrition flour was introduced. Compared with those of other single flours, the nutritional value of broad bean nutrition flour was improved. Moreover, the nutrients in the broad bean nutrition flour would not be destroyed during the processing and preparation of staple food, and the processed steamed bread and raw noodle are more characteristic. The application value and prospects of broad bean nutrition flour, as a combination of staple food, were further discussed.展开更多
[Objective] The aim was to indentify diseased leaves of broad bean by vibra- tional spectroscopy. [Method] In this paper, broad bean rust, fusarium rhizome rot, broad bean zonate spot, yellow leaf curl virus and norma...[Objective] The aim was to indentify diseased leaves of broad bean by vibra- tional spectroscopy. [Method] In this paper, broad bean rust, fusarium rhizome rot, broad bean zonate spot, yellow leaf curl virus and normal leaves were studied using Fourier transform infrared spectroscopy combined with chemometrics. [Result] The spectra of the samples were similar, only with minor differences in absorption inten- sity of several peaks. Second derivative analyses show that the significant difference of all samples was in the range of 1 200-700 cm2. The data in the range of 1 200- 700 cm＇ were selected to evaluate correlation coefficients, hierarchical cluster analy- sis （HCA） and principal component analysis （PCA）. Results showed that the correla- tion coefficients are larger than 0.928 not only between the healthy leaves, but also between the same diseased leaves. The values between healthy and diseased leaves, and among diseased leaves, are all declined. HCA and PCA yielded about 73.3% and 82.2% accuracy, respectively. [Conclusion] This study demonstrated that FTIR techniques might be used to detect crop diseases.展开更多
Using Tongxian No.2 as material, the effects of different film-covering time, different sowing time and different planting density on the occurrence of freeze injury and yield of fresh broad beans were investigated. T...Using Tongxian No.2 as material, the effects of different film-covering time, different sowing time and different planting density on the occurrence of freeze injury and yield of fresh broad beans were investigated. The randomized block design was adopted. The results showed that with the delayed film covering, the incidence of mild freeze injury and number of headless seedlings were increased correspondingly, but the yield was increased; with the delayed sowing, the branch number per plant, effective branch number per plant, incidence of mild freeze injury and number of headless seedlings were all reduced, and the broad beans, sowed on September 30 th, obtained the highest yield; planting density showed on effect on the occurrence of freeze injury, and the yield was increased with the increase of planting density. Under the same film-covering time, the incidence of freeze injury was reduced with the delayed sowing time and it showed no changes when planting density was changed, but the yield was increased with the increase of planting density and it was highest when broad bean seeds were sowed on September 30th;under the same sowing time, the incidence of freeze injury was increased with the delayed film-covering time and it showed no changes when planting density was changed, and the yield was increased with the delayed film-covering time and increased planting density; under the same planting density, the incidence of freeze injury was increased with the delayed film-covering time but was reduced with the delayed sowing time, and the yield was increased with the delayed film-covering time and it was highest when the broad bean seeds were sowed on September30 th. Under same film-covering time and sowing time, the total branch number per plant and effective branch number per plant were reduced, but the yield was increased with the increase of planting density; under same film-covering time and planting density, the incidence of freeze injury was reduced with the delayed sowing time, and the yield was highest when broad bean seeds were sowed on September30th; under same sowing time and planting density, the incidence of freeze injury and the yield were all increased with the delayed film-covering time.展开更多
The nucleotide sequence of small coat protein(CPS) gene of Broad bean stain virus(BBSV) was determined and compared with other comoviruses.The CPS gene of BBSV consisted of 687 nucleotides and encodes a putative prote...The nucleotide sequence of small coat protein(CPS) gene of Broad bean stain virus(BBSV) was determined and compared with other comoviruses.The CPS gene of BBSV consisted of 687 nucleotides and encodes a putative protein of 228 amino acid residues.The CPS sequence of BBSV and those of other comoviruses shared identities of 36.5%-58.9% and 35.2%-70.3% at the nucleotide and amino acid levels,respectively.The RT-PCR method specific for BBSV detection was developed based on the determined CPS sequence.The RT-PCR assay presented here allows,for the first time,rapid and specific detection of BBSV.展开更多
Fourier transform infrared （FTIR） spectroscopy was used to study diseased leaves in broad bean. Results showed that the infrared spectra of different broad bean diseased leaves were similar, which were mainly made u...Fourier transform infrared （FTIR） spectroscopy was used to study diseased leaves in broad bean. Results showed that the infrared spectra of different broad bean diseased leaves were similar, which were mainly made up of the vibrational absorption bands of protein,lipid and polysaccharide.There were minor differences in-cluding the spectral peak position, peak shape and the absorption intensity in the range of 1 800-1 300 cm-1. There were obvious differences among their second derivative spectra in the range of 1 800-1 300 cm-1. After the procedure of the Fourier self-deconvolution and curve fitting of health bean leaves and broad bean diseased leaves in the range of 1 700-1 500 cm-1, three sub-peaks were obtained at 1 550 cm-1 （protein amide Ⅱ band）, 1 605 cm-1 （lignin） and 1 650 cm-1 （protein amide I band）.The ratios of relative areas of the bands of amide Ⅱ, lignin, and amide I were 38.86%, 28.68% and 32.47% in the spectra of healthy leaves, respec-tively. It was distinguished from the diseased leaves （chocolate spot leaf： 15.42%, 42.98% and 41.61%, ring spot leaf：32.39%, 35.63% and 31.98%, rust leaf： 13.97%, 46.40% and 39.65%, yel owing leaf curl disease leaf： 24.01%,36.55% and 39.44%）. For sub-peak area ratios （A1 563/A1 605, A1 650/A1 605 and A1 563/A1 654）, those of four kinds of diseased leaves were smal er than that of healthy leaves, and there were also differences among four kinds of diseased leaves. The results proved that FTIR combining with curve fitting might be a potential y useful tool for detecting different kinds of broad bean diseases.展开更多
文摘Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been proven successful for other viral vaccines are not enough to tackle HIV-1 and new approaches to design effective preventive AIDS vaccines are of utmost importance. Due to enormous diversity among global circulating HIV strains, an effective HIV vaccine must elicit broadly protective antibodies based responses;therefore discovering new broadly neutralizing antibodies (bNAbs) against HIV has become major focus in HIV vaccine research. However further understanding of the viral targets of such antibodies and mechanisms of action of bNAbs is required for advancement of HIV vaccine research. This technical note discusses our current knowledge on the bNAbs and immunoprophylaxis using viral vectors with their relevance in designing of new candidates to HIV-1 vaccines.
基金supported by the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-037,2021-I2M-1-038)the National Research and Development Project of China(grant no.2023YFF0724800)+2 种基金the CAMS Initiative for Innovative Medicine of China(grant no.2021-I2M-1-035)the National Science and Technology Infrastructure of China(Project No.National Pathogen Resource Center-NPRC-32)We thank Changwen Ke from Guangdong Provincial Center for Disease Control and Prevention for providing SARS-CoV-2 BA.2,BA.2.12.1,BA.4,and BA.5 as a gift.We thank the Scripps Institute for providing the pComb3H and PIGG vectors.
文摘The global spread of Severe Acute Respiratory Syndrome Coronavirus 2.(SARS-CoV-2)and its variant strains,including Alpha,Beta,Gamma,Delta,and now Omicron,pose a significant challenge.With the constant evolution of the virus,Omicron and its subtypes BA.1,BA.2,BA.3,BA.4,and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or infection.This evasion highlights the urgency in discovering new monoclonal antibodies(mAbs)with neutralizing activity,especially broadly neutralizing antibodies(bnAbs),to combat the virus.In the current study,we introduced a fully human neutralizing mAb,CR9,that targets Omicron variants.We demonstrated the mAb’s effectiveness in inhibiting Omicron replication both in vitro and in vivo.Structural analysis using cryo-electron microscopy(cryo-EM)revealed that CR9 binds to an epitope formed by RBD residues,providing a molecular understanding of its neutralization mechanism.Given its potency and specificity,CR9 holds promise as a potential adjunct therapy for treating Omicron infections.Our findings highlight the importance of continuous mAb discovery and characterization in addressing the evolving threat of COVID-19.
文摘A study published in Nature'by Gonelli and colleagues reveals that potent,broadly neutralizing antibodies(bNAbs)delay viremic simian immunodeficiency virus(SIV)infection in rhesus macaques but do not fully prevent subclinical infections.Despite bNAb concentrations being significantly higher than supposed protective thresholds,transient viral"blips"occurred,which suggests that bNAb prophylaxis can mask subclinical infections and has implications for the interpretation of HIV-1 prevention trials.
文摘Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I(HIV-1)through antiretroviral therapy.However,vaccine development has remained challenging.Recent discoveries in broadly neutralizing monoclonal antibodies(bNAbs)has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response.Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein(Env)during infection.Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.
基金Natural Science Foundation of Jiangsu Province(BK20160221)Natural Science Foundation of Xuzhou,China(KC16SG247)+1 种基金Doctoral Research Funding of Jiangsu Normal University(15XLR024)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘We report on broadly wavelength-tunable passive mode-locking with high power operating at the 2 μm water absorption band in a Tm:CYA crystal laser. With a simple quartz plate, stable mode-locking wavelengths can be tuned from 1874 to 1973 nm, with a tunable wavelength range up to ~100 nm and maximum output power up to 1.35 W. The bandwidth is narrow as ~6 GHz, corresponding to a high coherence. To our knowledge, this is the first demonstration of wavelength-tunable mode-locking with watt-level in the 2 μm water absorption band.The high temporal coherent laser can be further applied in spectroscopy, the efficient excitation of molecules, sensing, and quantum optics.
文摘Investors greet China's first QDII products with caution Ms. Wang, a financial planner at one of China's largest state-owned banks, takes five phone inquiries a day from clients I about its new QDII products, with most clients saying they will consider it. "I have an enquiry about your bank's QDII products. What are the returns?
基金supported by the National Natural Science Foundation of China(No.62371080 and 62031006)the National Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX0597)the Venture&Innovation Support Program for Chongqing Overseas Returnees,China(No.cx2022063)。
文摘This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground communication.The array consists of ten broadside-radiating,ultrawide-beamwidth elements that are cascaded by a central-symmetry series-fed network with tapered currents following Dolph-Chebyshev distribution to provide low SLL.First,an innovative design of end-fire Huygens source antenna that is compatible with metal ground is presented.A low-profile,half-mode Microstrip Patch Antenna(MPA)is utilized to serve as the magnetic dipole and a monopole is utilized to serves as the electric dipole,constructing the compact,end-fire,grounded Huygens source antenna.Then,two opposite-oriented end-fire Huygens source antennas are seamlessly integrated into a single antenna element in the form of monopole-loaded MPA to accomplish the ultrawide,broadside-radiating beam.Particular consideration has been applied into the design of series-fed network as well as antenna element to compensate the adverse coupling effects between elements on the radiation performance.Experiment indicates an ultrawide Half-Power Beamwidth(HPBW)of 161°and a low SLL of-25 dB with a high gain of 12 d Bi under a single-layer configuration.The concurrent ultrawide beamwidth and low SLL make it particularly attractive for applications of UAV air-to-ground communication.
基金supported in part by the National Key Research and Development Project under Grant 2020YFB1806805partially funded through a grant from Qualcomm。
文摘6G is desired to support more intelligence networks and this trend attaches importance to the self-healing capability if degradation emerges in the cellular networks.As a primary component of selfhealing networks,fault detection is investigated in this paper.Considering the fast response and low timeand-computational consumption,it is the first time that the Online Broad Learning System(OBLS)is applied to identify outages in cellular networks.In addition,the Automatic-constructed Online Broad Learning System(AOBLS)is put forward to rationalize its structure and consequently avoid over-fitting and under-fitting.Furthermore,a multi-layer classification structure is proposed to further improve the classification performance.To face the challenges caused by imbalanced data in fault detection problems,a novel weighting strategy is derived to achieve the Multilayer Automatic-constructed Weighted Online Broad Learning System(MAWOBLS)and ensemble learning with retrained Support Vector Machine(SVM),denoted as EMAWOBLS,for superior treatment with this imbalance issue.Simulation results show that the proposed algorithm has excellent performance in detecting faults with satisfactory time usage.
文摘BACKGROUND Leiomyomas or fibroids commonly originate from the uterus;extrauterine leiomyomas are rare and most often arise from the broad ligament.Diagnosing broad ligament leiomyomas becomes particularly challenging when they undergo degenerative changes because their clinical and radiological features often mimic those of ovarian tumors.We report a rare case of a giant broad ligament fibroid with cystic degeneration,which was initially mistaken for an ovarian mass.CASE SUMMARY A 49-year-old woman presented with mild abdominal distension and pain as the only symptoms.Upon abdominal examination,a large mass measuring approximately 30 cm and extending from the pelvic cavity to just below the xiphoid process was identified.Both transvaginal ultrasound and contrast-enhanced computed tomography suggested an ovarian origin of the mass.However,laparotomy confirmed that the mass originated from the right broad ligament.The mass was separated from the uterus and bilateral ovaries,with no involvement of the uterus or ovaries.The mass was completely resected with respecting the patient’s desire to retain her uterus and adnexa.Postoperative histopathological examination confirmed leiomyoma with cystic degeneration.CONCLUSION Broad ligament myomas mimic ovarian tumors;accurate diagnosis and careful operation are critical to avoid complications and ensure safety.
基金funded by the National Natural Science Foundation of China(32272083)。
文摘Wheat leaf rust,caused by Puccinia triticina(Pt),is one of the most devastating diseases in common wheat(Triticum aestivum L.)and can lead to heavy yield loss(Chai et al.2020).Leaf rust can result in 50%yield loss during epidemic years(Huerta-Espino et al.2011;Gebrewahid et al.2020;Kolomiets et al.2021).Breeding varieties resistant to leaf rust have been recognized as the most effective and economical method to mitigate wheat losses caused by Pt.The narrow genetic basis of wheat constrains the number of cultivars resistant to leaf rust(Jin et al.2021).
文摘On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japan relations,people-to-people exchanges and cooperation between the two organisations.
基金supported in part by the National Natural Science Foundation of China(62403396,62433018,62373113)the Guangdong Basic and Applied Basic Research Foundation(2023A1515011527,2023B1515120010)the Postdoctoral Fellowship Program of CPSF(GZB20240621)
文摘In this paper, the containment control problem in nonlinear multi-agent systems(NMASs) under denial-of-service(DoS) attacks is addressed. Firstly, a prediction model is obtained using the broad learning technique to train historical data generated by the system offline without DoS attacks. Secondly, the dynamic linearization method is used to obtain the equivalent linearization model of NMASs. Then, a novel model-free adaptive predictive control(MFAPC) framework based on historical and online data generated by the system is proposed, which combines the trained prediction model with the model-free adaptive control method. The development of the MFAPC method motivates a much simpler robust predictive control solution that is convenient to use in the case of DoS attacks. Meanwhile, the MFAPC algorithm provides a unified predictive framework for solving consensus tracking and containment control problems. The boundedness of the containment error can be proven by using the contraction mapping principle and the mathematical induction method. Finally, the proposed MFAPC is assessed through comparative experiments.
基金Project supported by the National Natural Science Foundation of China (61988102)the Key-Area Research and Development Program of Guangdong Province(2019B090917007)the Science and Technology Planning Project of Guangdong Province (2019B090909011)。
文摘Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost not been reported.In this work,Bi_(2)YbO_(4)Cl was synthesized using the solid-state method and the solvothermal method.Yb3+ions show a strong characteristic absorption peak at 980 nm,which was measured by ultraviolet-visible-near-infrared absorption spectra.The transient photoconductivity of Bi_(2)YbO_(4)Cl was obtained by time-resolved terahertz spectroscopy system under 400 and 800 nm laser excitations,respectively.The frequency-dependent transient photoconductivity analysis reveals the Drude-Smith behavior in Bi_(2)YbO_(4)Cl.Under photoexcitation,the hot charge carriers with a long relaxation lifetime and a carrier mobility of 48 cm^(2)/(V·s) are obtained.The synthesis of Bi_(2)YbO_(4)Cl is of great significance for the development of novel photocatalytic and photo harvesting materials with broad spectral response.
基金supported by the Biological Breeding-National Science and Technology Major Project(2024ZD04077).
文摘Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resistance.But strategies for expanding NLR recognition spectra[[1],[2],[3],[4],[5]]are often limited by the rapid evolution of pathogens and pests.In our recent study,we developed an innovative strategy to engineer broad-spectrum,durable and complete disease resistance in plants by remodeling autoactive NLRs into protease-activated switches[6].
基金supported by the Key Research and Development Program,Ministry of Science and Technology of the People’s Republic of China(Nos.2023YFC2606500,2023YFE0206500).
文摘Coronaviruses are single-stranded,positive-sense RNA enveloped viruses that have posed a significant threat to human health over the past few decades,particularly severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and SARS-CoV-2.These viruses have caused widespread infections and fatalities,with profound impacts on global economies,social life,and public health systems.Due to their broad host range in natural settings and the consequent high potential for zoonotic spillover events,a thorough investigation of the common viral mechanisms and the identification of druggable targets for pan-coronavirus antiviral development are of utmost importance.
基金Supported by Jiangsu Agricultural Science and Technology Innovation Fund[CX(13)3084]Jiangsu Province Science and Technology Support Program,China(BE2013352)~~
文摘This paper introduced the definition and importance of combination of sta-ple food. With broad bean nutrition flour as a sample, the preparation of the combi-nation of staple food was also described. In addition, the main nutritional value of broad bean nutrition flour was introduced. Compared with those of other single flours, the nutritional value of broad bean nutrition flour was improved. Moreover, the nutrients in the broad bean nutrition flour would not be destroyed during the processing and preparation of staple food, and the processed steamed bread and raw noodle are more characteristic. The application value and prospects of broad bean nutrition flour, as a combination of staple food, were further discussed.
基金Supported by National Natural Science Foundation of China(30960179)Natural Science Foundation of Yunnan Province(2007A048M)~~
文摘[Objective] The aim was to indentify diseased leaves of broad bean by vibra- tional spectroscopy. [Method] In this paper, broad bean rust, fusarium rhizome rot, broad bean zonate spot, yellow leaf curl virus and normal leaves were studied using Fourier transform infrared spectroscopy combined with chemometrics. [Result] The spectra of the samples were similar, only with minor differences in absorption inten- sity of several peaks. Second derivative analyses show that the significant difference of all samples was in the range of 1 200-700 cm2. The data in the range of 1 200- 700 cm＇ were selected to evaluate correlation coefficients, hierarchical cluster analy- sis （HCA） and principal component analysis （PCA）. Results showed that the correla- tion coefficients are larger than 0.928 not only between the healthy leaves, but also between the same diseased leaves. The values between healthy and diseased leaves, and among diseased leaves, are all declined. HCA and PCA yielded about 73.3% and 82.2% accuracy, respectively. [Conclusion] This study demonstrated that FTIR techniques might be used to detect crop diseases.
基金Supported by Jiangsu Agricultural Science and Technology Innovation Fund[CX(12)3006]Jiangsu Province Science and Technology Support Program,China(BE2013352)Study on Saving the Cost Facility Cultivation Techniques of High-quality,Safe and Efficient in Fresh Faba Bean(HL2014029)~~
文摘Using Tongxian No.2 as material, the effects of different film-covering time, different sowing time and different planting density on the occurrence of freeze injury and yield of fresh broad beans were investigated. The randomized block design was adopted. The results showed that with the delayed film covering, the incidence of mild freeze injury and number of headless seedlings were increased correspondingly, but the yield was increased; with the delayed sowing, the branch number per plant, effective branch number per plant, incidence of mild freeze injury and number of headless seedlings were all reduced, and the broad beans, sowed on September 30 th, obtained the highest yield; planting density showed on effect on the occurrence of freeze injury, and the yield was increased with the increase of planting density. Under the same film-covering time, the incidence of freeze injury was reduced with the delayed sowing time and it showed no changes when planting density was changed, but the yield was increased with the increase of planting density and it was highest when broad bean seeds were sowed on September 30th;under the same sowing time, the incidence of freeze injury was increased with the delayed film-covering time and it showed no changes when planting density was changed, and the yield was increased with the delayed film-covering time and increased planting density; under the same planting density, the incidence of freeze injury was increased with the delayed film-covering time but was reduced with the delayed sowing time, and the yield was increased with the delayed film-covering time and it was highest when the broad bean seeds were sowed on September30 th. Under same film-covering time and sowing time, the total branch number per plant and effective branch number per plant were reduced, but the yield was increased with the increase of planting density; under same film-covering time and planting density, the incidence of freeze injury was reduced with the delayed sowing time, and the yield was highest when broad bean seeds were sowed on September30th; under same sowing time and planting density, the incidence of freeze injury and the yield were all increased with the delayed film-covering time.
文摘The nucleotide sequence of small coat protein(CPS) gene of Broad bean stain virus(BBSV) was determined and compared with other comoviruses.The CPS gene of BBSV consisted of 687 nucleotides and encodes a putative protein of 228 amino acid residues.The CPS sequence of BBSV and those of other comoviruses shared identities of 36.5%-58.9% and 35.2%-70.3% at the nucleotide and amino acid levels,respectively.The RT-PCR method specific for BBSV detection was developed based on the determined CPS sequence.The RT-PCR assay presented here allows,for the first time,rapid and specific detection of BBSV.
基金Supported by National Natural Science Foundation of China(30960179)Program for Innovative Research Team in Science and Technology in University of Yunnan Province~~
文摘Fourier transform infrared （FTIR） spectroscopy was used to study diseased leaves in broad bean. Results showed that the infrared spectra of different broad bean diseased leaves were similar, which were mainly made up of the vibrational absorption bands of protein,lipid and polysaccharide.There were minor differences in-cluding the spectral peak position, peak shape and the absorption intensity in the range of 1 800-1 300 cm-1. There were obvious differences among their second derivative spectra in the range of 1 800-1 300 cm-1. After the procedure of the Fourier self-deconvolution and curve fitting of health bean leaves and broad bean diseased leaves in the range of 1 700-1 500 cm-1, three sub-peaks were obtained at 1 550 cm-1 （protein amide Ⅱ band）, 1 605 cm-1 （lignin） and 1 650 cm-1 （protein amide I band）.The ratios of relative areas of the bands of amide Ⅱ, lignin, and amide I were 38.86%, 28.68% and 32.47% in the spectra of healthy leaves, respec-tively. It was distinguished from the diseased leaves （chocolate spot leaf： 15.42%, 42.98% and 41.61%, ring spot leaf：32.39%, 35.63% and 31.98%, rust leaf： 13.97%, 46.40% and 39.65%, yel owing leaf curl disease leaf： 24.01%,36.55% and 39.44%）. For sub-peak area ratios （A1 563/A1 605, A1 650/A1 605 and A1 563/A1 654）, those of four kinds of diseased leaves were smal er than that of healthy leaves, and there were also differences among four kinds of diseased leaves. The results proved that FTIR combining with curve fitting might be a potential y useful tool for detecting different kinds of broad bean diseases.
