The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this...The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this paper,a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment,covering a vibration frequency from 5 Hz to 25 kHz.The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state,windblown disturbance,and walking vibration.Moreover,the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences,respectively.The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge,which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.展开更多
As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok...As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”展开更多
Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(L...Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.展开更多
The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly elec...The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.展开更多
BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We presen...BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.展开更多
The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-orga...The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.展开更多
Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered ...Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.展开更多
Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration p...Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).展开更多
When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the l...When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.展开更多
There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and stru...There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and structural anomalies.To accurately alarm different risks of long-span railway bridges by structural health monitoring systems,this paper proposes a cross-cooperative alarm method using principal and secondary indicators during high-wind periods.It provides the prior criterion for monitoring systems under special conditions,defining the principal and secondary indicators,alarm levels,and thresholds based on the relationship between dynamic equilibrium equations and multiple linear regression analysis.Analysis of one-year monitoring data from a longspan railway cable-stayed bridge shows that the 10-min average cross-bridge wind speed(excitation indicator)can be selected as the principal indicator,while lateral displacement(response indicator)can serve as the secondary indicator.The threshold levels of the secondary indicator prioritize the safety of bridge operation(mainly aiming at the safety of trains traversing bridges),with values significantly lower than structural safety thresholds.This approach enhances alarm timeliness and effectively distinguishes between load anomalies,structural anomalies,and equipment failures.Consequently,it improves alarm accuracy and provides timely decision support for bridge maintenance,train traversing,and emergency treatment.展开更多
To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engi...To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.展开更多
Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.展开更多
The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and ...The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.展开更多
We report a novel double-shelled nanoboxes photocatalyst architecture with tailored interfaces that accelerate quantum efficiency for photocatalytic CO_(2) reduction reaction(CO_(2)RR)via Mo–S bridging bonds sites in...We report a novel double-shelled nanoboxes photocatalyst architecture with tailored interfaces that accelerate quantum efficiency for photocatalytic CO_(2) reduction reaction(CO_(2)RR)via Mo–S bridging bonds sites in S_(v)–In_(2)S_(3)@2H–MoTe_(2).The X-ray absorption near-edge structure shows that the formation of S_(v)–In_(2)S_(3)@2H–MoTe_(2) adjusts the coordination environment via interface engineering and forms Mo–S polarized sites at the interface.The interfacial dynamics and catalytic behavior are clearly revealed by ultrafast femtosecond transient absorption,time-resolved,and in situ diffuse reflectance–Infrared Fourier transform spectroscopy.A tunable electronic structure through steric interaction of Mo–S bridging bonds induces a 1.7-fold enhancement in S_(v)–In_(2)S_(3)@2H–MoTe_(2)(5)photogenerated carrier concentration relative to pristine S_(v)–In_(2)S_(3).Benefiting from lower carrier transport activation energy,an internal quantum efficiency of 94.01%at 380 nm was used for photocatalytic CO_(2)RR.This study proposes a new strategy to design photocatalyst through bridging sites to adjust the selectivity of photocatalytic CO_(2)RR.展开更多
Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate (CaCO3) particles,whose diameter is consistent with the size of pores or apertures in ...Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate (CaCO3) particles,whose diameter is consistent with the size of pores or apertures in the reservoir,were selected as the bridging agent,and modified resolvable starch was selected as filtration loss reducing particles to form the non-clay low damage temporary bridging drilling/completion fluids system (NLTDFS). Under the simulated condition of the well bottom during real drilling,NLTDFS was used to conduct dynamic and static damage experiments of cores for 48 hours,respectively,and then the experimented cores were permeated with pure nitrogen from the undamaged end to the damaged one to measure their recovery of permeability. The results showed that the permeability recovery rate of the core reached 90% or so,and the damaged depth was less than 1 cm,which demonstrates that NLTDFS has higher temporary bridging effectiveness and lower damage to the gas-reservoir than other drilling fluids system. NLTDFS has been used to drill many horizontal wells,and four of them have obtained high yield of natural gas. The yield of natural gas of LP1 well reached 85×104 m3/day after completion with the rump pipe. The formation of the stable well wall and smooth drilling led to an API loss less than 4 mL and an HTHP loss less than 15 mL.展开更多
In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-ob...In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.展开更多
The seismic damage to ancillary facilities on high-speed railway(HSR)bridges can affect the normal movement of trains.To propose the bridge deck acceleration response spectra of the typical HSR simply-supported girder...The seismic damage to ancillary facilities on high-speed railway(HSR)bridges can affect the normal movement of trains.To propose the bridge deck acceleration response spectra of the typical HSR simply-supported girder bridge for simplifying the seismic responses analysis of the facilities on bridges,the finite element models of the HSR multi-span simply-supported girder bridges with CRTSII track were established,and the numerical model was validated by tests.Besides,the effects of the span number,peak ground acceleration(PGA),pier height on the seismic acceleration and response spectra of the bridge deck were investigated.Afterward,the bridge acceleration amplification factor curves and bridge deck response spectra with different PGAs and pier heights were obtained.The formula for bridge deck acceleration amplification factor,with a 95%guarantee rate,was fitted.Moreover,the finite element models of the overhead contact lines(OCL)mounted on rigid base and bridges were established to validate the fitted formula.The results indicated that the maximum seismic acceleration response is in the midspan of the beam.The proposed formula for the bridge deck acceleration response spectra can be used to analyze the earthquake response of the OCL and other ancillary facilities on HSR simply-supported girder bridges.The bridge deck acceleration response spectra are conservative in terms of structural safety and can significantly improving the analysis efficiency.展开更多
In particle-filled polymer composites with selective distributions of fillers in one phase,much attention has been focused on the“volume exclusion effect”in reducing the percolation threshold of filler,while the rol...In particle-filled polymer composites with selective distributions of fillers in one phase,much attention has been focused on the“volume exclusion effect”in reducing the percolation threshold of filler,while the role of dispersed polymer phase acting as bridges of fillers in the particle network has largely been ignored.Herein,we studied industrially important ternary composites,polypropylene(PP)/ethylene-octene copolymer(a polyolefin elastomer,POE)/talc systems,and adopted rheology to reveal the bridging behavior of POE droplets in the network of talc particles.It is found that talc fillers concentrate in the PP phase using the“blend first”protocol,while more talc particles are located at the interface of PP and POE phases using the“filler first”protocol.Changing the POE viscosity and talc size can affect the migration of talc from the POE phase to the PP phase in the“filler first”protocol.The linear rheology behavior indicates that besides the“volume exclusion effect”,the talc-POE hybrid network can further contribute to the reinforcement effect.Meanwhile,the POE droplet bridging structure can facilitate the rebuilding of the hybrid network after large amplitude oscillatory shear,in contrast to the un-recoverable structures in the PP/talc binary composites.The correlation between rheology and selective distribution of fillers in ternary composites may provide practical guidance for processing and designing advanced polymer composites with controlled selective location of fillers.展开更多
The high-performance Basalt Fiber Reinforced Polymer(BFRP)composites have been prepared by guiding Micro/Nano Short Aramid Fiber(MNSAF)into the interlayer to improve the resin-rich region and the interfacial transitio...The high-performance Basalt Fiber Reinforced Polymer(BFRP)composites have been prepared by guiding Micro/Nano Short Aramid Fiber(MNSAF)into the interlayer to improve the resin-rich region and the interfacial transition region,and the flexible fiber bridging claws of MNSAF were constructed to grasp the adjacent layers for stronger interlaminar bond.The lowvelocity impact results show that the MNSAF could improve the impact resistance of BFRP composites.The compression test results demonstrate that the compressive strength and the residual compressive strength after impact of MNSAF-reinforced BFRP composites were greater than those of unreinforced one,exhibiting the greatest 56.2% and 73.3% increments respectively for BFRP composites improved by 4wt%MNSAF.X-ray micro-computed tomography scanning results indicate that the“fiber bridging claws”contributed to better mechanical interlocking to inhibit the crack generation and propagation under impact and compression load,and the original delamination-dominated failure of unreinforced BFRP composites was altered into sheardominated failure of MNSAF-reinforced BFRP composites.Overall,the MNSAF interleaving might be an effective method in manufacturing high-performance laminated fiber in industrial production.展开更多
Computational Intelligent(CI)systems represent a pivotal intersection of cutting-edge technologies and complex engineering challenges aimed at solving real-world problems.This comprehensive body of work delves into th...Computational Intelligent(CI)systems represent a pivotal intersection of cutting-edge technologies and complex engineering challenges aimed at solving real-world problems.This comprehensive body of work delves into the realm of CI,which is designed to tackle intricate and multifaceted engineering problems through advanced computational techniques.The history of CI systems is a fascinating journey that spans several decades and has its roots in the development of artificial intelligence and machine learning techniques.Through a wide array of practical examples and case studies,this special issue bridges the gap between theoretical concepts and practical implementation,shedding light on how CI systems can optimize processes,design solutions,and inform decisions in complex engineering landscapes.This compilation stands as an essential resource for both novice learners and seasoned practitioners,offering a holistic perspective on the potential of CI in reshaping the future of engineering problem-solving.展开更多
基金supported by the National Natural Science Foundation of China (No.6210031560)the Natural Science Foundation of Hebei Province (No.A2020202013)the Natural Science Foundation of Tianjin City (No.21JCQNJC00780)。
文摘The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this paper,a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment,covering a vibration frequency from 5 Hz to 25 kHz.The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state,windblown disturbance,and walking vibration.Moreover,the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences,respectively.The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge,which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.
文摘As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”
基金support of the National Natural Science Foundation of China(Grant No.52371279)the Program for International Exchange and Cooperation in Education by the Ministry of Education of the People's Republic of China(Grant No.57220500123).
文摘Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.
基金supported by the National Natural Science Foundation of China(Grant Nos.T2222027 and 12202416)。
文摘The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.
基金Supported by the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.
文摘The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.
文摘Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.
基金supported by the National Natural Science Foundation of China(No.82170206 and No.82470213)Project of Disciplines of Excellence(No.20234Z0002)。
文摘Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).
基金financially supported by the National Natural Science Foundation of China(Grants 52178124,52478151).
文摘When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.
基金supported by the National Natural Science Foundation of China(Grants U23A20660,52008099,and 52378288)the Major Science and Technology Project of Yunnan Province,China(Grant 202502AD080007)the China Railway Engineering Corporation Science and Technology Research and Development Project(Grant 2022-Key-44).
文摘There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and structural anomalies.To accurately alarm different risks of long-span railway bridges by structural health monitoring systems,this paper proposes a cross-cooperative alarm method using principal and secondary indicators during high-wind periods.It provides the prior criterion for monitoring systems under special conditions,defining the principal and secondary indicators,alarm levels,and thresholds based on the relationship between dynamic equilibrium equations and multiple linear regression analysis.Analysis of one-year monitoring data from a longspan railway cable-stayed bridge shows that the 10-min average cross-bridge wind speed(excitation indicator)can be selected as the principal indicator,while lateral displacement(response indicator)can serve as the secondary indicator.The threshold levels of the secondary indicator prioritize the safety of bridge operation(mainly aiming at the safety of trains traversing bridges),with values significantly lower than structural safety thresholds.This approach enhances alarm timeliness and effectively distinguishes between load anomalies,structural anomalies,and equipment failures.Consequently,it improves alarm accuracy and provides timely decision support for bridge maintenance,train traversing,and emergency treatment.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.
文摘Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.
文摘The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.
基金the Natural Science Foundation of China(11922415,12274471)Guangdong Basic and Applied Basic Research Foundation(2022A1515011168,2019A1515011718,2019A1515011337)the Key Research and Development Program of Guangdong Province,China(2019B110209003).
文摘We report a novel double-shelled nanoboxes photocatalyst architecture with tailored interfaces that accelerate quantum efficiency for photocatalytic CO_(2) reduction reaction(CO_(2)RR)via Mo–S bridging bonds sites in S_(v)–In_(2)S_(3)@2H–MoTe_(2).The X-ray absorption near-edge structure shows that the formation of S_(v)–In_(2)S_(3)@2H–MoTe_(2) adjusts the coordination environment via interface engineering and forms Mo–S polarized sites at the interface.The interfacial dynamics and catalytic behavior are clearly revealed by ultrafast femtosecond transient absorption,time-resolved,and in situ diffuse reflectance–Infrared Fourier transform spectroscopy.A tunable electronic structure through steric interaction of Mo–S bridging bonds induces a 1.7-fold enhancement in S_(v)–In_(2)S_(3)@2H–MoTe_(2)(5)photogenerated carrier concentration relative to pristine S_(v)–In_(2)S_(3).Benefiting from lower carrier transport activation energy,an internal quantum efficiency of 94.01%at 380 nm was used for photocatalytic CO_(2)RR.This study proposes a new strategy to design photocatalyst through bridging sites to adjust the selectivity of photocatalytic CO_(2)RR.
文摘Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate (CaCO3) particles,whose diameter is consistent with the size of pores or apertures in the reservoir,were selected as the bridging agent,and modified resolvable starch was selected as filtration loss reducing particles to form the non-clay low damage temporary bridging drilling/completion fluids system (NLTDFS). Under the simulated condition of the well bottom during real drilling,NLTDFS was used to conduct dynamic and static damage experiments of cores for 48 hours,respectively,and then the experimented cores were permeated with pure nitrogen from the undamaged end to the damaged one to measure their recovery of permeability. The results showed that the permeability recovery rate of the core reached 90% or so,and the damaged depth was less than 1 cm,which demonstrates that NLTDFS has higher temporary bridging effectiveness and lower damage to the gas-reservoir than other drilling fluids system. NLTDFS has been used to drill many horizontal wells,and four of them have obtained high yield of natural gas. The yield of natural gas of LP1 well reached 85×104 m3/day after completion with the rump pipe. The formation of the stable well wall and smooth drilling led to an API loss less than 4 mL and an HTHP loss less than 15 mL.
文摘In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.
基金Project(HNTY2022K03)supported by the Hunan Tieyuan Civil Engineering Testing Co.,Ltd.,ChinaProject(52478573)supported by the National Natural Science Foundation of China。
文摘The seismic damage to ancillary facilities on high-speed railway(HSR)bridges can affect the normal movement of trains.To propose the bridge deck acceleration response spectra of the typical HSR simply-supported girder bridge for simplifying the seismic responses analysis of the facilities on bridges,the finite element models of the HSR multi-span simply-supported girder bridges with CRTSII track were established,and the numerical model was validated by tests.Besides,the effects of the span number,peak ground acceleration(PGA),pier height on the seismic acceleration and response spectra of the bridge deck were investigated.Afterward,the bridge acceleration amplification factor curves and bridge deck response spectra with different PGAs and pier heights were obtained.The formula for bridge deck acceleration amplification factor,with a 95%guarantee rate,was fitted.Moreover,the finite element models of the overhead contact lines(OCL)mounted on rigid base and bridges were established to validate the fitted formula.The results indicated that the maximum seismic acceleration response is in the midspan of the beam.The proposed formula for the bridge deck acceleration response spectra can be used to analyze the earthquake response of the OCL and other ancillary facilities on HSR simply-supported girder bridges.The bridge deck acceleration response spectra are conservative in terms of structural safety and can significantly improving the analysis efficiency.
基金This work was financially supported by the National Natural Science Foundation of China(No.22341303)forms part of the research program of DPI,project#841.
文摘In particle-filled polymer composites with selective distributions of fillers in one phase,much attention has been focused on the“volume exclusion effect”in reducing the percolation threshold of filler,while the role of dispersed polymer phase acting as bridges of fillers in the particle network has largely been ignored.Herein,we studied industrially important ternary composites,polypropylene(PP)/ethylene-octene copolymer(a polyolefin elastomer,POE)/talc systems,and adopted rheology to reveal the bridging behavior of POE droplets in the network of talc particles.It is found that talc fillers concentrate in the PP phase using the“blend first”protocol,while more talc particles are located at the interface of PP and POE phases using the“filler first”protocol.Changing the POE viscosity and talc size can affect the migration of talc from the POE phase to the PP phase in the“filler first”protocol.The linear rheology behavior indicates that besides the“volume exclusion effect”,the talc-POE hybrid network can further contribute to the reinforcement effect.Meanwhile,the POE droplet bridging structure can facilitate the rebuilding of the hybrid network after large amplitude oscillatory shear,in contrast to the un-recoverable structures in the PP/talc binary composites.The correlation between rheology and selective distribution of fillers in ternary composites may provide practical guidance for processing and designing advanced polymer composites with controlled selective location of fillers.
基金supported financially by the National Natural Science Foundation of China(No.52102115)the High-end Foreign Expert Recruitment Plan of China(No.G2023036002L)+1 种基金the Basalt Fiber and Composite Key Laboratory of Sichuan Province,China(No.XXKFJJ202308)Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province,China(No.23kfgk06).
文摘The high-performance Basalt Fiber Reinforced Polymer(BFRP)composites have been prepared by guiding Micro/Nano Short Aramid Fiber(MNSAF)into the interlayer to improve the resin-rich region and the interfacial transition region,and the flexible fiber bridging claws of MNSAF were constructed to grasp the adjacent layers for stronger interlaminar bond.The lowvelocity impact results show that the MNSAF could improve the impact resistance of BFRP composites.The compression test results demonstrate that the compressive strength and the residual compressive strength after impact of MNSAF-reinforced BFRP composites were greater than those of unreinforced one,exhibiting the greatest 56.2% and 73.3% increments respectively for BFRP composites improved by 4wt%MNSAF.X-ray micro-computed tomography scanning results indicate that the“fiber bridging claws”contributed to better mechanical interlocking to inhibit the crack generation and propagation under impact and compression load,and the original delamination-dominated failure of unreinforced BFRP composites was altered into sheardominated failure of MNSAF-reinforced BFRP composites.Overall,the MNSAF interleaving might be an effective method in manufacturing high-performance laminated fiber in industrial production.
文摘Computational Intelligent(CI)systems represent a pivotal intersection of cutting-edge technologies and complex engineering challenges aimed at solving real-world problems.This comprehensive body of work delves into the realm of CI,which is designed to tackle intricate and multifaceted engineering problems through advanced computational techniques.The history of CI systems is a fascinating journey that spans several decades and has its roots in the development of artificial intelligence and machine learning techniques.Through a wide array of practical examples and case studies,this special issue bridges the gap between theoretical concepts and practical implementation,shedding light on how CI systems can optimize processes,design solutions,and inform decisions in complex engineering landscapes.This compilation stands as an essential resource for both novice learners and seasoned practitioners,offering a holistic perspective on the potential of CI in reshaping the future of engineering problem-solving.
