One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation...One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO_(3)precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO_(3)precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO_(3)precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO_(3)precipitation.In stage II,concentrated BS is utilized to produce looser CaCO_(3)flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO_(3)crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance.展开更多
Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreat...Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreatments,an inert environment,and long hours of physical ball milling for high homogeneity and synergistic effects.CaH_(2)also inhibits the hydrolysis reaction by forming its products on the Al/Si surface,which hinders the direct utilization of composites.This work represents the first investigation of NaH-CaH_(2)(Al/Si)fuel composites,which greatly overcome these limitations and can be directly used for on-site hydrogen generation and proton exchange membrane(PEM)fuel cells.The NaH-CaH_(2)(Al/Si)fuel composites were prepared by using a straightforward mixing method with variable composition ratios,showing high H_(2)yield and fuel cell(FC)performance.NaH addition provides the bridge effect,which opens up a new way to enable efficient hydrolysis and greatly enhances the hydrolysis activity of CaH_(2)/(Al/Si)composites.The novel fuel composites(NaH-CaH_(2)/Al)have extraordinary FC performance and a 0.42 W/cm2 peak power density greater than commercial hydrogen generators.It provides high H_(2)yield 84.4%for NaH-CaH_(2)/Al and 82%for NaH-CaH_(2)/Si compared to NaOH-CaH_(2)(Al/Si),NaCl-CaH_(2)(Al/Si),and KCl-CaH_(2)(Al/Si)composites.The NaH bridge effect hinders the direct water contact and stops the formation of Ca(OH)2 around Al/Si,which provides adequate pathways for the CaH_(2)(Al/Si)hydrolysis.The impressive capabilities of novel fuel composites are anticipated to offer practical uses in fuel cells,automobile applications,and portable/on-board H_(2)generation.展开更多
Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate(CaCO3)particles,whose diameter is consistent with the size of pores or apertures in th...Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate(CaCO3)particles,whose diameter is consistent with the size of pores or apertures in the reservoir,were selected as the bridging agent,and modified resolvable starch was selected as filtration loss reducing particles to form the non-clay low damage temporary bridging drilling/completion fluids system(NLTDFS).Under the simulated condition of the well bottom during real drilling,NLTDFS was used to conduct dynamic and static damage experiments of cores for 48 hours,respectively,and then the experimented cores were permeated with pure nitrogen from the undamaged end to the damaged one to measure their recovery of permeability.The results showed that the permeability recovery rate of the core reached 90%or so,and the damaged depth was less than 1 cm,which demonstrates that NLTDFS has higher temporary bridging effectiveness and lower damage to the gas-reservoir than other drilling fluids system.NLTDFS has been used to drill many horizontal wells,and four of them have obtained high yield of natural gas.The yield of natural gas of LP1 well reached 85×104 m3/day after completion with the rump pipe.The formation of the stable well wall and smooth drilling led to an API loss less than 4 mL and an HTHP loss less than 15 mL.展开更多
In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-ob...In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.展开更多
The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this...The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this paper,a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment,covering a vibration frequency from 5 Hz to 25 kHz.The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state,windblown disturbance,and walking vibration.Moreover,the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences,respectively.The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge,which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.展开更多
As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok...As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”展开更多
Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(L...Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.展开更多
Most studies have analyzed the aerodynamic characteristics and wind-train(vehicle)-bridge coupled vibration response of trains or vehicles on bridges of a certain structural system,while few comparative studies have b...Most studies have analyzed the aerodynamic characteristics and wind-train(vehicle)-bridge coupled vibration response of trains or vehicles on bridges of a certain structural system,while few comparative studies have been carried out on the wind-train-bridge coupled vibration response on bridges of three different structural systems.This paper takes the main span 1120 m dual-purpose highway-railway bridge as the engineering background,and studies the three bridge types of(122+1120+90+92)m suspension bridge,(130+432+1120+432+130)m cable-stayed bridge and(92+210+1120+210+92)m cable-stayed-suspension collaborative system bridge.The trend of the maximum value of the train dynamic response to the wind-train-bridge coupling of the three structural system bridges as well as the speed thresholds are compared and analyzed,and conclusions are drawn:1)Under the same speed,the maximum value of train safety indexes in three types of bridges increases with the increase of wind speed.2)Under the same wind speed,the safety and smoothness indicators of trains in three types of bridges without wind barriers rank in the order of cable-stayed suspension collaborative system bridge>cable-stayed bridge>suspension bridge.3)At low wind speeds(≤15 m/s),a 3.0 m wind barrier has negligible effect on speed thresholds.The safety ranking of structural systems remains unchanged:cable-stayed-suspension collaborative system bridge>cable-stayed bridge>suspension bridge.4)At high wind speeds(≥20 m/s),the 3.0 m wind barrier can increase the train speed threshold for bridges within the same structural system.The safety ranking of the three bridge types(3.0 m 30%wind barrier)remains unchanged:cable-stayed suspension collaborative system bridge>cable-stayed bridge>suspension bridge.This study represents the first systematic comparative analysis of wind speed critical values and performance ratings across three distinct bridge structural systems.展开更多
The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly elec...The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.展开更多
BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We presen...BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.展开更多
The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-orga...The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.展开更多
Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered ...Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.展开更多
Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration p...Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).展开更多
When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the l...When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.展开更多
There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and stru...There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and structural anomalies.To accurately alarm different risks of long-span railway bridges by structural health monitoring systems,this paper proposes a cross-cooperative alarm method using principal and secondary indicators during high-wind periods.It provides the prior criterion for monitoring systems under special conditions,defining the principal and secondary indicators,alarm levels,and thresholds based on the relationship between dynamic equilibrium equations and multiple linear regression analysis.Analysis of one-year monitoring data from a longspan railway cable-stayed bridge shows that the 10-min average cross-bridge wind speed(excitation indicator)can be selected as the principal indicator,while lateral displacement(response indicator)can serve as the secondary indicator.The threshold levels of the secondary indicator prioritize the safety of bridge operation(mainly aiming at the safety of trains traversing bridges),with values significantly lower than structural safety thresholds.This approach enhances alarm timeliness and effectively distinguishes between load anomalies,structural anomalies,and equipment failures.Consequently,it improves alarm accuracy and provides timely decision support for bridge maintenance,train traversing,and emergency treatment.展开更多
To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engi...To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.展开更多
Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.展开更多
The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and ...The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.展开更多
An output-only modal identification method by a combination use of the peak-picking method and the cross spectrum methods are presented. Meanwhile, a novel mode shape optimum method of the deck is proposed. The method...An output-only modal identification method by a combination use of the peak-picking method and the cross spectrum methods are presented. Meanwhile, a novel mode shape optimum method of the deck is proposed. The methods are applied to the operational modal identification system of the Runyang Suspension Bridge, which can be used to obtain the modal parameters of the bridge from out-only data sets collected by its structural health monitoring system （SHMS）. As an example, the vibration response data of the deck, cable and tower recorded during typhoon Matsa excitation are used to illustrate the program application. Some of the modal frequencies observed from deck vibration responses are also found in the vibration responses of the cable and the tower. The results show that some modal shapes of the deck are strongly coupled with the cable and the tower. By comparing the identification results from the operational modal system with those from field measurements, a good agreement between them is achieved, but some modal frequencies identified from the operational modal identification system （OMIS）, such as L1 and L2, obviously decrease compared with those from the field measurements.展开更多
Yangzhou Slender West Lake is narrow in shape. It is 4.3 km in total length with the width of about 100 m. It is a typical zonal water system. Through the research of its spatial structure, space sequence and view bor...Yangzhou Slender West Lake is narrow in shape. It is 4.3 km in total length with the width of about 100 m. It is a typical zonal water system. Through the research of its spatial structure, space sequence and view borrowing the garden bridges of Yangzhou Slender West Lake, the unique gardening method of zonal water system was expatiated.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2023YFC3007102)the National Natural Science Foundation of China(Grant Nos.42477188 and 41925012).
文摘One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO_(3)precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO_(3)precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO_(3)precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO_(3)precipitation.In stage II,concentrated BS is utilized to produce looser CaCO_(3)flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO_(3)crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance.
基金financial support granted by the National Natural Science Foundation of China (No. 22402225)the Gusu Innovation and Entrepreneurship Leading Talent Plan(No. ZXL2023193)+2 种基金the Sinano Talents Plan (No. 2022000175)the Guangdong Basic and Applied Basic Research Foundation (No.2023A1515111133)the ANSO Scholarship for Young Talents
文摘Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreatments,an inert environment,and long hours of physical ball milling for high homogeneity and synergistic effects.CaH_(2)also inhibits the hydrolysis reaction by forming its products on the Al/Si surface,which hinders the direct utilization of composites.This work represents the first investigation of NaH-CaH_(2)(Al/Si)fuel composites,which greatly overcome these limitations and can be directly used for on-site hydrogen generation and proton exchange membrane(PEM)fuel cells.The NaH-CaH_(2)(Al/Si)fuel composites were prepared by using a straightforward mixing method with variable composition ratios,showing high H_(2)yield and fuel cell(FC)performance.NaH addition provides the bridge effect,which opens up a new way to enable efficient hydrolysis and greatly enhances the hydrolysis activity of CaH_(2)/(Al/Si)composites.The novel fuel composites(NaH-CaH_(2)/Al)have extraordinary FC performance and a 0.42 W/cm2 peak power density greater than commercial hydrogen generators.It provides high H_(2)yield 84.4%for NaH-CaH_(2)/Al and 82%for NaH-CaH_(2)/Si compared to NaOH-CaH_(2)(Al/Si),NaCl-CaH_(2)(Al/Si),and KCl-CaH_(2)(Al/Si)composites.The NaH bridge effect hinders the direct water contact and stops the formation of Ca(OH)2 around Al/Si,which provides adequate pathways for the CaH_(2)(Al/Si)hydrolysis.The impressive capabilities of novel fuel composites are anticipated to offer practical uses in fuel cells,automobile applications,and portable/on-board H_(2)generation.
文摘Following the basic theory of protecting gas-reservoirs from damage with the temporary bridging technology,inert calcium carbonate(CaCO3)particles,whose diameter is consistent with the size of pores or apertures in the reservoir,were selected as the bridging agent,and modified resolvable starch was selected as filtration loss reducing particles to form the non-clay low damage temporary bridging drilling/completion fluids system(NLTDFS).Under the simulated condition of the well bottom during real drilling,NLTDFS was used to conduct dynamic and static damage experiments of cores for 48 hours,respectively,and then the experimented cores were permeated with pure nitrogen from the undamaged end to the damaged one to measure their recovery of permeability.The results showed that the permeability recovery rate of the core reached 90%or so,and the damaged depth was less than 1 cm,which demonstrates that NLTDFS has higher temporary bridging effectiveness and lower damage to the gas-reservoir than other drilling fluids system.NLTDFS has been used to drill many horizontal wells,and four of them have obtained high yield of natural gas.The yield of natural gas of LP1 well reached 85×104 m3/day after completion with the rump pipe.The formation of the stable well wall and smooth drilling led to an API loss less than 4 mL and an HTHP loss less than 15 mL.
文摘In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.
基金supported by the National Natural Science Foundation of China (No.6210031560)the Natural Science Foundation of Hebei Province (No.A2020202013)the Natural Science Foundation of Tianjin City (No.21JCQNJC00780)。
文摘The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities,including design,construction,and maintenance of bridges,tunnels,ports and other infrastructures.In this paper,a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment,covering a vibration frequency from 5 Hz to 25 kHz.The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state,windblown disturbance,and walking vibration.Moreover,the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences,respectively.The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge,which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.
文摘As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”
基金support of the National Natural Science Foundation of China(Grant No.52371279)the Program for International Exchange and Cooperation in Education by the Ministry of Education of the People's Republic of China(Grant No.57220500123).
文摘Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.
基金Project(52327810)supported by the National Natural Science Foundation of ChinaProject(51925808)supported by the National Natural Science Foundation for Distinguished Young Scholars of China+1 种基金Project(U1934209)supported by the Key Project of National Natural Science Foundation of ChinaProject(P2019G002)supported by the Science and Technology Research and Development Program of China National Railway Group Co.,Ltd。
文摘Most studies have analyzed the aerodynamic characteristics and wind-train(vehicle)-bridge coupled vibration response of trains or vehicles on bridges of a certain structural system,while few comparative studies have been carried out on the wind-train-bridge coupled vibration response on bridges of three different structural systems.This paper takes the main span 1120 m dual-purpose highway-railway bridge as the engineering background,and studies the three bridge types of(122+1120+90+92)m suspension bridge,(130+432+1120+432+130)m cable-stayed bridge and(92+210+1120+210+92)m cable-stayed-suspension collaborative system bridge.The trend of the maximum value of the train dynamic response to the wind-train-bridge coupling of the three structural system bridges as well as the speed thresholds are compared and analyzed,and conclusions are drawn:1)Under the same speed,the maximum value of train safety indexes in three types of bridges increases with the increase of wind speed.2)Under the same wind speed,the safety and smoothness indicators of trains in three types of bridges without wind barriers rank in the order of cable-stayed suspension collaborative system bridge>cable-stayed bridge>suspension bridge.3)At low wind speeds(≤15 m/s),a 3.0 m wind barrier has negligible effect on speed thresholds.The safety ranking of structural systems remains unchanged:cable-stayed-suspension collaborative system bridge>cable-stayed bridge>suspension bridge.4)At high wind speeds(≥20 m/s),the 3.0 m wind barrier can increase the train speed threshold for bridges within the same structural system.The safety ranking of the three bridge types(3.0 m 30%wind barrier)remains unchanged:cable-stayed suspension collaborative system bridge>cable-stayed bridge>suspension bridge.This study represents the first systematic comparative analysis of wind speed critical values and performance ratings across three distinct bridge structural systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.T2222027 and 12202416)。
文摘The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.
基金Supported by the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.
文摘The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.
文摘Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.
基金supported by the National Natural Science Foundation of China(No.82170206 and No.82470213)Project of Disciplines of Excellence(No.20234Z0002)。
文摘Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).
基金financially supported by the National Natural Science Foundation of China(Grants 52178124,52478151).
文摘When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.
基金supported by the National Natural Science Foundation of China(Grants U23A20660,52008099,and 52378288)the Major Science and Technology Project of Yunnan Province,China(Grant 202502AD080007)the China Railway Engineering Corporation Science and Technology Research and Development Project(Grant 2022-Key-44).
文摘There are multiple types of risks involved in the service of long-span railway bridges.Classical methods are difficult to provide targeted alarm information according to different situations of load anomalies and structural anomalies.To accurately alarm different risks of long-span railway bridges by structural health monitoring systems,this paper proposes a cross-cooperative alarm method using principal and secondary indicators during high-wind periods.It provides the prior criterion for monitoring systems under special conditions,defining the principal and secondary indicators,alarm levels,and thresholds based on the relationship between dynamic equilibrium equations and multiple linear regression analysis.Analysis of one-year monitoring data from a longspan railway cable-stayed bridge shows that the 10-min average cross-bridge wind speed(excitation indicator)can be selected as the principal indicator,while lateral displacement(response indicator)can serve as the secondary indicator.The threshold levels of the secondary indicator prioritize the safety of bridge operation(mainly aiming at the safety of trains traversing bridges),with values significantly lower than structural safety thresholds.This approach enhances alarm timeliness and effectively distinguishes between load anomalies,structural anomalies,and equipment failures.Consequently,it improves alarm accuracy and provides timely decision support for bridge maintenance,train traversing,and emergency treatment.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.
文摘Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.
文摘The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.
基金The National High Technology Research and Development Program of China(863Program)(No.2006AA04Z416)
文摘An output-only modal identification method by a combination use of the peak-picking method and the cross spectrum methods are presented. Meanwhile, a novel mode shape optimum method of the deck is proposed. The methods are applied to the operational modal identification system of the Runyang Suspension Bridge, which can be used to obtain the modal parameters of the bridge from out-only data sets collected by its structural health monitoring system （SHMS）. As an example, the vibration response data of the deck, cable and tower recorded during typhoon Matsa excitation are used to illustrate the program application. Some of the modal frequencies observed from deck vibration responses are also found in the vibration responses of the cable and the tower. The results show that some modal shapes of the deck are strongly coupled with the cable and the tower. By comparing the identification results from the operational modal system with those from field measurements, a good agreement between them is achieved, but some modal frequencies identified from the operational modal identification system （OMIS）, such as L1 and L2, obviously decrease compared with those from the field measurements.
文摘Yangzhou Slender West Lake is narrow in shape. It is 4.3 km in total length with the width of about 100 m. It is a typical zonal water system. Through the research of its spatial structure, space sequence and view borrowing the garden bridges of Yangzhou Slender West Lake, the unique gardening method of zonal water system was expatiated.
