Branch size is a crucial characteristic,closely linked to both tree growth and wood quality.A review of existing branch size models reveals various approaches,but the ability to estimate branch diameter and length wit...Branch size is a crucial characteristic,closely linked to both tree growth and wood quality.A review of existing branch size models reveals various approaches,but the ability to estimate branch diameter and length within the same whorl remains underexplored.In this study,a total of 77 trees were sampled from Northeast China to model the vertical distribution of branch diameter and length within each whorl along the crown.Several commonly used functions were taken as the alternative model forms,and the quantile regression method was employed and compared with the classical two-step modeling approach.The analysis incorporated stand,tree,and competition factors,with a particular focus on how these factors influence branches of varying sizes.The modified Weibull function was chosen as the optimal model,due to its excellent performance across all quantiles.Eight quantile regression curves(ranging from 0.20 to 0.85)were combined to predict branch diameter,while seven curves(ranging from 0.20 to 0.80)were used for branch length.The results showed that the quantile regression method outperformed the classical approach at model fitting and validation,likely due to its ability to estimate different rates of change across the entire branch size distribution.Lager branches in each whorl were more sensitive to changes in DBH,crown length(CL),crown ratio(CR)and dominant tree height(H_(dom)),while slenderness(HDR)more effectively influenced small and medium-sized branches.The effect of stand basal area(BAS)was relatively consistent across different branch sizes.The findings indicate that quantile regression is a good way not only a more accurate method for predicting branch size but also a valuable tool for understanding how branch growth responds to stand and tree factors.The models developed in this study are prepared to be further integrated into tree growth and yield simulation system,contributing to the assessment and promotion of wood quality.展开更多
The female inflorescence,or ear,of maize develops no branch meristem(BM),which differs from the male inforescence,or tassel.While the mutations of some well documented genes,such as fea2/3/4 and ramosa1/2/3,can cause ...The female inflorescence,or ear,of maize develops no branch meristem(BM),which differs from the male inforescence,or tassel.While the mutations of some well documented genes,such as fea2/3/4 and ramosa1/2/3,can cause the branched architecture of ears in maize,such mutations also change the normal phenotypic performance of the tassels.In the present study,a natural maize mutant with branched ears,named branched ear1(be1),was characterized.be1 shows several branched ears at the base of the central ear with unchanged architecture of the tassels.Besides,both the branched and central ears of be1 possess regularly arranged kerels.The phenotypic characteristics of be1 differ completely from those reported mutants of fasciated ears or RAMOSA-like ears in maize.An SEM survey at the very early development stage showed that meristems with three protrusions,similar to the BM in tassels,were present during the development of the branched ears in be1.Gene mapping and sequence alignment suggested that TEOSINTE BRANCHED1(TB1)was the candidate gene of BE1.Further verification showed that a be1-specific 31 bp deletion at the downstream of BE1 led to statistically reduced expression of this gene in the immature ear,which serves as the potential causal reason for the branched ears of be1.CRISPR/Cas9-based gene editing downstream of TB1 complemented the phenotypic architecture of branched ears,suggesting that TB1 was the target of BE1,and it was named as Zm TB1be1.The results of the present study implied a novel function of TB1 in female inforescence development,rather than shaping the plant architecture in maize.Meanwhile,further functional dissection of ZmTB1be1might shed new light on TB1,the most famous domestication related gene in maize.展开更多
Branching is a critical aspect of plant architecture that significantly impacts the yield and adaptability of staple cereal crops like rice and wheat.Cereal crops develop tillers during the vegetative stage and panicl...Branching is a critical aspect of plant architecture that significantly impacts the yield and adaptability of staple cereal crops like rice and wheat.Cereal crops develop tillers during the vegetative stage and panicle or spike branches during the reproductive stage,respectively,both of which are significantly impacted by hormones and genetic factors.Tillering and panicle branching are closely interconnected and exhibit high environmental plasticity.Here,we summarize the recent progress in genetic,hormonal,and environmental factors regulation in the branching of rice and wheat.This review not only provides a comprehensive overview of the current knowledge on branching mechanisms in rice and wheat,but also explores the prospects for future research aimed at optimizing crop architecture for enhanced productivity.展开更多
Plant height(PH),primary lateral branch length(PBL),and branch number(BN)are architectural components impacting peanut pod yield,biomass production,and adaptivity to mechanical harvesting.In this study,a recombinant i...Plant height(PH),primary lateral branch length(PBL),and branch number(BN)are architectural components impacting peanut pod yield,biomass production,and adaptivity to mechanical harvesting.In this study,a recombinant inbred population consisting of 181 individual lines was used to determine genetic controls of PH,PBL,and BN across three environments.Phenotypic data collected from the population demonstrated continuous distributions and transgressive segregation patterns.Broad-sense heritability of PH,PBL,and BN was found to be 0.87,0.88,and 0.92,respectively.Unconditional individual environmental analysis revealed 35 additive QTLs with phenotypic variation explained(PVE)ranging from 4.57 to 21.68%.A two-round meta-analysis resulted in 24consensus and 19 unique QTLs.Five unique QTLs exhibited pleiotropic effects and their genetic bases(pleiotropy or tight linkage)were evaluated.A joint analysis was performed to estimate the QTL by environment interaction(QEI)effects on PH,PBL,and BN,collectively explaining phenotypic variations of 10.80,11.02,and 7.89%,respectively.We identified 3 major and stable QTL regions(uq9-3,uq10-2,and uq16-1)on chromosomes 9,10,and 16,spanning1.43-1.53 Mb genomic regions.Candidate genes involved in phytohormones biosynthesis,signaling,and cell wall development were proposed to regulate these morphological traits.These results provide valuable information for further genetic studies and the development of molecular markers applicable to peanut architecture improvement.展开更多
Branch length and branch diameter are important characteristics that determine wood quality and yield.Development of static branch length and diameter models by incorporating individual tree variables,site quality and...Branch length and branch diameter are important characteristics that determine wood quality and yield.Development of static branch length and diameter models by incorporating individual tree variables,site quality and competition have been widely studied,while the climate effect has rarely been reported.In this study,mixed-effects climate-sensitive branch length and diameter models were developed based on 228 sample trees of Larix kaempferi from three latitude regions in China(approximate 42°N in Liaoning Province,33°N in Gansu Province,and 30°N in Hubei Province).Results revealed that diameter at breast height,and crown ratio,sum of the basal areas of trees larger than the subject trees,dominant tree height,mean warmest month temperature,and summer precipitation substantially improved branch length model.Diameter at breast height,and crown ratio,ratio of the sum of DBH in sample plot to the subject tree,dominant tree height,mean warmest month temperature,and spring precipitation significantly improved branch diameter model.Compared with base model,mean square error reduction of mixed-effects branch length and diameter models were 32.9%and 44.1%,respectively.The relative contributions of covariates to branch length model were tree size(59.1%),site quality(25.7%),competition(13.5%),and climate(1.7%),and branch diameter model were tree size(57.0%),competition(21.9%),site quality(18.3%),and climate(2.8%).Relative contributions of covariates on branch length and diameter models from different latitude regions were different.Effects of competition on branch length model in Liaoning and Hubei were larger than climate,whereas climate in Gansu was larger than competition.As for branch diameter model,competition in Liaoning was larger than site quality,whereas site quality in Hubei and Gansu was larger than competition.The present study strengthened the importance of considering climate variables in developing branch length and diameter model.It is desirable to disentangle the different sources of variations in affecting branch length and diameter from different latitude regions to reduce the uncertainty in predicting branch characteristics under the condition of climate changing.展开更多
Mechanochromic polyolefins represent a novel class of functionalized polyolefins,which still remains significant challenges.Pd(II)-catalyzed coordination-insertion copolymerization is a feasible method for achieving t...Mechanochromic polyolefins represent a novel class of functionalized polyolefins,which still remains significant challenges.Pd(II)-catalyzed coordination-insertion copolymerization is a feasible method for achieving this kind of polymers,yet with linear microstructures.Ringopening metathesis polymerization(ROMP)offers another promising avenue for affording functionalized polyolefins.This method exhibits high polar group tolerance and the ability to precisely regulate polymer branches.In this study,we report the method for producing mechanochromic branched polyethylenes via ROMP.By employing the terpolymerization of a well-designed monomer containing the mechanochromic group,NB-ABF,with cyclooctene(COE)and long-chain 5-hexylcyclooctene(COE-C6),following by hydrogenation process,we synthesized a range of functionalized branched polyethylenes characterized by varied branching density and polar monomer incorporation.These polymers bear a structural resemblance to functionalized ethylene-octene copolymers.After crosslinking,mechanochromophores are generated,and mechanochromism is achieved in uniaxial tensile testing.A comprehensive assessment reveals that both the incorporation of polar monomers and variations in branching density significantly influence their mechanical properties.Notably,upon stretching,these materials display pronounced visible color change,confirming the successful development of mechanochromic branched polyethylenes.展开更多
University student Party branches serve as the Party’s grassroots organizations within universities and act as a bridge and link between the Party and students.Therefore,it is essential to strengthen the development ...University student Party branches serve as the Party’s grassroots organizations within universities and act as a bridge and link between the Party and students.Therefore,it is essential to strengthen the development of student Party branches and enhance the effectiveness of student Party member education and training.This paper summarizes and analyzes the issues in the construction of student Party branches in universities and explores strategies for improving their quality,aiming to provide a reference for relevant personnel.展开更多
In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addi...In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.展开更多
In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversar...In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversary,this expression captures the spirit of an institution that has stood the test of time.Since its establishment in Singapore in 1936,the BOCSG has maintained a strong and enduring presence not only in Singapore but across Southeast Asia,serving as a bridge between China and Singapore,and more broadly,between China and the ASEAN region.Its continued growth has been underpinned by the mutual prosperity of both economies and the strength of their longstanding and harmonious ties.展开更多
The present study presents an assessment of the interrelations between long-chain branching,specific nucleation,and end-use properties of polypropylene blends:blends of linear polypropylene(L-PP)and long-chain branche...The present study presents an assessment of the interrelations between long-chain branching,specific nucleation,and end-use properties of polypropylene blends:blends of linear polypropylene(L-PP)and long-chain branched polypropylene(LCB-PP)modified by a specificβ-nucleating agent(NA).Specimens with various LCB-PP compositions with and without NA were prepared under complex flow fields by injection molding.Wide-angle X-ray scattering was employed to capture the X-ray patterns of both the skin and core of the specimens,determining the overall crystallinity and amounts of individual polymorphs.The increasing content of LCB-PP andγ-phase,at the same time,in the blends is reflected in both increasing crystallinity and improved mechanical properties,namely,yield stress and Young’s modulus.On the other hand,the composition of the blends had no significant effect on the impact strength,except for nucleated L-PP.It has been demonstrated that adding a relatively small amount of LCB-PP is sufficient to modify the mechanical properties of linear polypropylene.Even a very small amount of LCB-PP in the L-PP suppressed the effectiveness of NA.展开更多
Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements u...Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.展开更多
AIM:To investigate the possible relationship between inflammatory biomarkers in the peripheral blood of patients with branch retinal vein occlusion(BRVO).METHODS:A total of 63 BRVO patients were enrolled in this cross...AIM:To investigate the possible relationship between inflammatory biomarkers in the peripheral blood of patients with branch retinal vein occlusion(BRVO).METHODS:A total of 63 BRVO patients were enrolled in this cross-sectional observational study.Meanwhile,63 age-and gender-matched cataract patients were included as controls.Complete blood count and biochemical tests were performed,and inflammatory biomarkers including platelet to lymphocyte ratio(PLR),red blood cell distribution width to albumin ratio(RAR),neutrophil to lymphocyte ratio(NLR),systemic immune inflammation index(SII),and monocyte to high density lipoprotein cholesterol ratio(MHR)were compared between the two groups.RESULTS:There were no significant differences between the two groups in terms of age,sex,and prevalence of diabetes mellitus.Compared with the controls,patients with BRVO had a higher prevalence of hypertension and higher body mass index(BMI).Red blood cell distribution width(RDW),triglycerides,MHR,NLR,and RAR were elevated,whereas lymphocyte count and high-density lipoprotein were decreased in the BRVO group.Multivariate logistic regression analysis revealed that NLR(adjusted OR=1.686,95%CI 1.075-2.646),RAR(adjusted OR=8.930,95%CI 1.911-41.730),and body mass index(BMI;adjusted OR=1.174,95%CI 1.010-1.365)were significantly associated with the risk of BRVO.In the receiver operating characteristic analysis,the area under the curve for NLR,RAR,and BMI were 0.602,0.630,and 0.603,respectively.The sensitivity and specificity were 61.9%and 60.3%,38.1%and 82.5%,and 61.9%and 57.1%,respectively.CONCLUSION:Peripheral blood inflammatory biomarkers are elevated in BRVO patients,suggesting systemic inflammation involvement.NLR,RAR,and BMI are positively correlated with BRVO.Monitoring NLR and RAR and strict weight control may be beneficial for the prevention and treatment of BRVO.展开更多
Cutting-edge research has primarily focused on flow synthesis of linear block copolymers,lacking the ability for manipulating chain architectures for more extensive applications.Herein,we develop a flow chemistry plat...Cutting-edge research has primarily focused on flow synthesis of linear block copolymers,lacking the ability for manipulating chain architectures for more extensive applications.Herein,we develop a flow chemistry platform for the continuous microflow synthesis of bottlebrush block copolymers(BBCPs)using a grafting-through method.This involves performing ring-opening metathesis polymerization(ROMP)of two different macromonomers within two microfluidic reactors connected in series.The microflow environment allows for complete monomer conversion within a few tens of seconds,benefiting from the superior mixing efficiency achieved in Z-shaped channels as indicated by both theoretical simulations and experimental results.Consequently,a library of well-defined BBCPs of up to 528 distinct samples can be produced within one day through automation of the continuous procedure,while keeping precise control on degree of polymerization(DP<4)and polydispersity indices(PDI<1.2).The synthetic method is generally applicable to different macromonomers with different compositions and contour lengths,yielding libraries of branched block copolymers with great diversity in physiochemical properties and chain architectures.This work presents a powerful platform for high-throughput production of branched copolymers,significantly lowering the costs of the materials for real applications.展开更多
Smart grid substation operations often take place in hazardous environments and pose significant threats to the safety of power personnel.Relying solely on manual supervision can lead to inadequate oversight.In respon...Smart grid substation operations often take place in hazardous environments and pose significant threats to the safety of power personnel.Relying solely on manual supervision can lead to inadequate oversight.In response to the demand for technology to identify improper operations in substation work scenarios,this paper proposes a substation safety action recognition technology to avoid the misoperation and enhance the safety management.In general,this paper utilizes a dual-branch transformer network to extract spatial and temporal information from the video dataset of operational behaviors in complex substation environments.Firstly,in order to capture the spatial-temporal correlation of people's behaviors in smart grid substation,we devise a sparse attention module and a segmented linear attention module that are embedded into spatial branch transformer and temporal branch transformer respectively.To avoid the redundancy of spatial and temporal information,we fuse the temporal and spatial features using a tensor decomposition fusion module by a decoupled manner.Experimental results indicate that our proposed method accurately detects improper operational behaviors in substation work scenarios,outperforming other existing methods in terms of detection and recognition accuracy.展开更多
Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is...Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.展开更多
We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the un...We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the unit speed. The models, without or with immigration, are constructed as measure-valued processes by pathwise unique solutions of stochastic equations driven by time-space Poisson random measures. In the subcritical branching case, we give a sufficient condition for the ergodicity of the process with immigration. Two large number laws and a central limit theorem of the occupation times are proved.展开更多
Athletes often use branched-chain amino acid (BCAAs) supplements with a ratio of 2:1:1 (leucine:isoleucine:valine) for their impact on muscle building. Research suggests that by altering the ratio, an improvement in g...Athletes often use branched-chain amino acid (BCAAs) supplements with a ratio of 2:1:1 (leucine:isoleucine:valine) for their impact on muscle building. Research suggests that by altering the ratio, an improvement in glucose metabolism might be possible. The purpose of this study was to examine how isoleucine would influence glucose tolerance. We recruited healthy male (n = 13) and female (n = 5) participants who were asked to fast for 12 hours before coming to the laboratory. A fasting blood sample was collected, followed by the subjects consuming a breakfast containing 113 g carbohydrates, 8 g protein, 1.5 g fat, and BCAA powder in the 2:1:1 ratio (Control) or BCAA powder enriched with Isoleucine (2:6:1), both added to orange juice. The opposite meal was consumed on a second visit one week apart. Blood was collected at 30, 60, 90, and 120 minutes post-meal. No differences were observed between the Control and Isoleucine for changes in serum glucose or insulin response when examining all subjects together. However, when comparing between genders, males tended to have a significantly lower serum glucose response compared to females when consuming the Isoleucine, with no difference between the genders when consuming the Control. Also, males had significantly lower serum glucose responses when consuming the Isoleucine compared to when they consumed the Control, while females had significantly higher serum glucose responses when consuming the Isoleucine compared to when they consumed the Control. In general, males tended to have a lower serum insulin response than females when consuming both the Control and the Isoleucine. Our study indicates a significant difference in the way genders respond to BCAA supplementation, where isoleucine may improve glucose tolerance and insulin response in males but not females.展开更多
To improve the amylose content(AC)and resistant starch content(RSC)of maize kernel starch,we employed the CRISPR/Cas9 system to create mutants of starch branching enzyme I(SBEI)and starch branching enzyme IIb(SBEIIb)....To improve the amylose content(AC)and resistant starch content(RSC)of maize kernel starch,we employed the CRISPR/Cas9 system to create mutants of starch branching enzyme I(SBEI)and starch branching enzyme IIb(SBEIIb).A frameshift mutation in SBEI(E1,a nucleotide insertion in exon 6)led to plants with higher RSC(1.07%),lower hundred-kernel weight(HKW,24.71±0.14 g),and lower plant height(PH,218.50±9.42 cm)compared to the wild type(WT).Like the WT,E1 kernel starch had irregular,polygonal shapes with sharp edges.A frameshift mutation in SBEIIb(E2,a four-nucleotide deletion in exon 8)led to higher AC(53.48%)and higher RSC(26.93%)than that for the WT.E2 kernel starch was significantly different from the WT regarding granule morphology,chain length distribution pattern,X-ray diffraction pattern,and thermal characteristics;the starch granules were more irregular in shape and comprised typical B-type crystals.Mutating SBEI and SBEIIb(E12)had a synergistic effect on RSC,HKW,PH,starch properties,and starch biosynthesis-associated gene expression.SBEIIa,SS1,SSIIa,SSIIIa,and SSIIIb were upregulated in E12 endosperm compared to WT endosperm.This study lays the foundation for rapidly improving the starch properties of elite maize lines.展开更多
The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP...The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that still our opinions on this technique are largely based on observational data and there is a dire need for larger RCTs to ascertain the position of LBBPCRT in management of heart failure patients with left bundle branch block.展开更多
基金supported by the Young Scientists Fund of the National Key R&D Program of China(No.2022YFD2201800)the Youth Science Fund Program of National Natural Science Foundation of China(No.32301581)+2 种基金the Joint Funds for Regional Innovation and Development of the National Natural Science Foundation of China(No.U21A20244)the China Postdoctoral Science Foundation(No.2024M750383)the Heilongjiang Touyan Innovation Team Program(Technology Development Team for High-Efficiency Silviculture of Forest Resources).
文摘Branch size is a crucial characteristic,closely linked to both tree growth and wood quality.A review of existing branch size models reveals various approaches,but the ability to estimate branch diameter and length within the same whorl remains underexplored.In this study,a total of 77 trees were sampled from Northeast China to model the vertical distribution of branch diameter and length within each whorl along the crown.Several commonly used functions were taken as the alternative model forms,and the quantile regression method was employed and compared with the classical two-step modeling approach.The analysis incorporated stand,tree,and competition factors,with a particular focus on how these factors influence branches of varying sizes.The modified Weibull function was chosen as the optimal model,due to its excellent performance across all quantiles.Eight quantile regression curves(ranging from 0.20 to 0.85)were combined to predict branch diameter,while seven curves(ranging from 0.20 to 0.80)were used for branch length.The results showed that the quantile regression method outperformed the classical approach at model fitting and validation,likely due to its ability to estimate different rates of change across the entire branch size distribution.Lager branches in each whorl were more sensitive to changes in DBH,crown length(CL),crown ratio(CR)and dominant tree height(H_(dom)),while slenderness(HDR)more effectively influenced small and medium-sized branches.The effect of stand basal area(BAS)was relatively consistent across different branch sizes.The findings indicate that quantile regression is a good way not only a more accurate method for predicting branch size but also a valuable tool for understanding how branch growth responds to stand and tree factors.The models developed in this study are prepared to be further integrated into tree growth and yield simulation system,contributing to the assessment and promotion of wood quality.
基金supported by the Special Key Project for Technological Innovation and Application Development in Chongqing,China(CSTB2022TIAD-KPX0011)the Special Fund for Youth Team of the Southwest Universities,China(SWU-XJPY202306)+1 种基金the Natural Science Foundation of Chongqing,China(cstc2021jcyj-msxmX0583)the Fundamental Research Funds for the Central Universities of Southwest University,China(S202210635326)。
文摘The female inflorescence,or ear,of maize develops no branch meristem(BM),which differs from the male inforescence,or tassel.While the mutations of some well documented genes,such as fea2/3/4 and ramosa1/2/3,can cause the branched architecture of ears in maize,such mutations also change the normal phenotypic performance of the tassels.In the present study,a natural maize mutant with branched ears,named branched ear1(be1),was characterized.be1 shows several branched ears at the base of the central ear with unchanged architecture of the tassels.Besides,both the branched and central ears of be1 possess regularly arranged kerels.The phenotypic characteristics of be1 differ completely from those reported mutants of fasciated ears or RAMOSA-like ears in maize.An SEM survey at the very early development stage showed that meristems with three protrusions,similar to the BM in tassels,were present during the development of the branched ears in be1.Gene mapping and sequence alignment suggested that TEOSINTE BRANCHED1(TB1)was the candidate gene of BE1.Further verification showed that a be1-specific 31 bp deletion at the downstream of BE1 led to statistically reduced expression of this gene in the immature ear,which serves as the potential causal reason for the branched ears of be1.CRISPR/Cas9-based gene editing downstream of TB1 complemented the phenotypic architecture of branched ears,suggesting that TB1 was the target of BE1,and it was named as Zm TB1be1.The results of the present study implied a novel function of TB1 in female inforescence development,rather than shaping the plant architecture in maize.Meanwhile,further functional dissection of ZmTB1be1might shed new light on TB1,the most famous domestication related gene in maize.
基金funded by grants from the National Natural Science Foundation of China (31930006 to Y.W.)the National Key Research and Development Program of China (2022YFF1002903 to Y.W.)+1 种基金the Top Talents Program “One Case One Discussion”(Yishiyiyi to Y.W.)from Shandong provinceShandong Agricultural University Talent Introduction Start-up Fund (to N.Z.)
文摘Branching is a critical aspect of plant architecture that significantly impacts the yield and adaptability of staple cereal crops like rice and wheat.Cereal crops develop tillers during the vegetative stage and panicle or spike branches during the reproductive stage,respectively,both of which are significantly impacted by hormones and genetic factors.Tillering and panicle branching are closely interconnected and exhibit high environmental plasticity.Here,we summarize the recent progress in genetic,hormonal,and environmental factors regulation in the branching of rice and wheat.This review not only provides a comprehensive overview of the current knowledge on branching mechanisms in rice and wheat,but also explores the prospects for future research aimed at optimizing crop architecture for enhanced productivity.
基金supported by the Natural Science Foundation of Shandong Province,China(ZR2022MC045)the National Natural Science Foundation of China(32001584,32201876)+2 种基金the Major Science and Technology Program of Xinjiang Uygur Autonomous Region,China(2022A02008-3)the Breeding Project from Department of Science&Technology of Shandong Province,China(2022LZGC007)the Agricultural Scientific and the Technological Innovation Project of Shandong Academy of Agricultural Sciences,China(CXGC2023A06,CXGC2023A39 and CXGC2023A46),and the Major Scientific and Technological Achievements Cultivation Program of Shandong Academy of Agricultural Sciences,China(CXGC2025E02)。
文摘Plant height(PH),primary lateral branch length(PBL),and branch number(BN)are architectural components impacting peanut pod yield,biomass production,and adaptivity to mechanical harvesting.In this study,a recombinant inbred population consisting of 181 individual lines was used to determine genetic controls of PH,PBL,and BN across three environments.Phenotypic data collected from the population demonstrated continuous distributions and transgressive segregation patterns.Broad-sense heritability of PH,PBL,and BN was found to be 0.87,0.88,and 0.92,respectively.Unconditional individual environmental analysis revealed 35 additive QTLs with phenotypic variation explained(PVE)ranging from 4.57 to 21.68%.A two-round meta-analysis resulted in 24consensus and 19 unique QTLs.Five unique QTLs exhibited pleiotropic effects and their genetic bases(pleiotropy or tight linkage)were evaluated.A joint analysis was performed to estimate the QTL by environment interaction(QEI)effects on PH,PBL,and BN,collectively explaining phenotypic variations of 10.80,11.02,and 7.89%,respectively.We identified 3 major and stable QTL regions(uq9-3,uq10-2,and uq16-1)on chromosomes 9,10,and 16,spanning1.43-1.53 Mb genomic regions.Candidate genes involved in phytohormones biosynthesis,signaling,and cell wall development were proposed to regulate these morphological traits.These results provide valuable information for further genetic studies and the development of molecular markers applicable to peanut architecture improvement.
基金funded by the National Key Research and Development Program of China(2023YFD2200801)National Natural Science Foundation of China(No.32471864)+1 种基金the Science&Technology Project for Excellent Young Scholars of Liaoning Province(2024JH3/10200036)Liao Ning Revitalization Talents Program(No.XLYC2403180).
文摘Branch length and branch diameter are important characteristics that determine wood quality and yield.Development of static branch length and diameter models by incorporating individual tree variables,site quality and competition have been widely studied,while the climate effect has rarely been reported.In this study,mixed-effects climate-sensitive branch length and diameter models were developed based on 228 sample trees of Larix kaempferi from three latitude regions in China(approximate 42°N in Liaoning Province,33°N in Gansu Province,and 30°N in Hubei Province).Results revealed that diameter at breast height,and crown ratio,sum of the basal areas of trees larger than the subject trees,dominant tree height,mean warmest month temperature,and summer precipitation substantially improved branch length model.Diameter at breast height,and crown ratio,ratio of the sum of DBH in sample plot to the subject tree,dominant tree height,mean warmest month temperature,and spring precipitation significantly improved branch diameter model.Compared with base model,mean square error reduction of mixed-effects branch length and diameter models were 32.9%and 44.1%,respectively.The relative contributions of covariates to branch length model were tree size(59.1%),site quality(25.7%),competition(13.5%),and climate(1.7%),and branch diameter model were tree size(57.0%),competition(21.9%),site quality(18.3%),and climate(2.8%).Relative contributions of covariates on branch length and diameter models from different latitude regions were different.Effects of competition on branch length model in Liaoning and Hubei were larger than climate,whereas climate in Gansu was larger than competition.As for branch diameter model,competition in Liaoning was larger than site quality,whereas site quality in Hubei and Gansu was larger than competition.The present study strengthened the importance of considering climate variables in developing branch length and diameter model.It is desirable to disentangle the different sources of variations in affecting branch length and diameter from different latitude regions to reduce the uncertainty in predicting branch characteristics under the condition of climate changing.
基金supported by the National Natural Science Foundation of China(No.U23B6011)the Jilin Provincial Science and Technology Department Program(No.20230101347JC)。
文摘Mechanochromic polyolefins represent a novel class of functionalized polyolefins,which still remains significant challenges.Pd(II)-catalyzed coordination-insertion copolymerization is a feasible method for achieving this kind of polymers,yet with linear microstructures.Ringopening metathesis polymerization(ROMP)offers another promising avenue for affording functionalized polyolefins.This method exhibits high polar group tolerance and the ability to precisely regulate polymer branches.In this study,we report the method for producing mechanochromic branched polyethylenes via ROMP.By employing the terpolymerization of a well-designed monomer containing the mechanochromic group,NB-ABF,with cyclooctene(COE)and long-chain 5-hexylcyclooctene(COE-C6),following by hydrogenation process,we synthesized a range of functionalized branched polyethylenes characterized by varied branching density and polar monomer incorporation.These polymers bear a structural resemblance to functionalized ethylene-octene copolymers.After crosslinking,mechanochromophores are generated,and mechanochromism is achieved in uniaxial tensile testing.A comprehensive assessment reveals that both the incorporation of polar monomers and variations in branching density significantly influence their mechanical properties.Notably,upon stretching,these materials display pronounced visible color change,confirming the successful development of mechanochromic branched polyethylenes.
文摘University student Party branches serve as the Party’s grassroots organizations within universities and act as a bridge and link between the Party and students.Therefore,it is essential to strengthen the development of student Party branches and enhance the effectiveness of student Party member education and training.This paper summarizes and analyzes the issues in the construction of student Party branches in universities and explores strategies for improving their quality,aiming to provide a reference for relevant personnel.
基金National Natural Science Foundation of China(61703363)Shanxi Provincial Basic Research Program(202403021221206)+2 种基金Key Project of Shanxi Provincial Strategic Research on Science and Technology(202304031401011)Funding Project for Scientific Research Innovation Team on Data Mining and Industrial Intelligence Applications(YCXYTD-202402)Yuncheng University Research Project(YQ-2020021)。
文摘In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.
文摘In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversary,this expression captures the spirit of an institution that has stood the test of time.Since its establishment in Singapore in 1936,the BOCSG has maintained a strong and enduring presence not only in Singapore but across Southeast Asia,serving as a bridge between China and Singapore,and more broadly,between China and the ASEAN region.Its continued growth has been underpinned by the mutual prosperity of both economies and the strength of their longstanding and harmonious ties.
文摘The present study presents an assessment of the interrelations between long-chain branching,specific nucleation,and end-use properties of polypropylene blends:blends of linear polypropylene(L-PP)and long-chain branched polypropylene(LCB-PP)modified by a specificβ-nucleating agent(NA).Specimens with various LCB-PP compositions with and without NA were prepared under complex flow fields by injection molding.Wide-angle X-ray scattering was employed to capture the X-ray patterns of both the skin and core of the specimens,determining the overall crystallinity and amounts of individual polymorphs.The increasing content of LCB-PP andγ-phase,at the same time,in the blends is reflected in both increasing crystallinity and improved mechanical properties,namely,yield stress and Young’s modulus.On the other hand,the composition of the blends had no significant effect on the impact strength,except for nucleated L-PP.It has been demonstrated that adding a relatively small amount of LCB-PP is sufficient to modify the mechanical properties of linear polypropylene.Even a very small amount of LCB-PP in the L-PP suppressed the effectiveness of NA.
基金supported by the Chinese Scholarship Council under Grant 202106910006.
文摘Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.
基金Supported by the Sichuan Provincial Science and Technology Support Project(No.2024YFFK0303).
文摘AIM:To investigate the possible relationship between inflammatory biomarkers in the peripheral blood of patients with branch retinal vein occlusion(BRVO).METHODS:A total of 63 BRVO patients were enrolled in this cross-sectional observational study.Meanwhile,63 age-and gender-matched cataract patients were included as controls.Complete blood count and biochemical tests were performed,and inflammatory biomarkers including platelet to lymphocyte ratio(PLR),red blood cell distribution width to albumin ratio(RAR),neutrophil to lymphocyte ratio(NLR),systemic immune inflammation index(SII),and monocyte to high density lipoprotein cholesterol ratio(MHR)were compared between the two groups.RESULTS:There were no significant differences between the two groups in terms of age,sex,and prevalence of diabetes mellitus.Compared with the controls,patients with BRVO had a higher prevalence of hypertension and higher body mass index(BMI).Red blood cell distribution width(RDW),triglycerides,MHR,NLR,and RAR were elevated,whereas lymphocyte count and high-density lipoprotein were decreased in the BRVO group.Multivariate logistic regression analysis revealed that NLR(adjusted OR=1.686,95%CI 1.075-2.646),RAR(adjusted OR=8.930,95%CI 1.911-41.730),and body mass index(BMI;adjusted OR=1.174,95%CI 1.010-1.365)were significantly associated with the risk of BRVO.In the receiver operating characteristic analysis,the area under the curve for NLR,RAR,and BMI were 0.602,0.630,and 0.603,respectively.The sensitivity and specificity were 61.9%and 60.3%,38.1%and 82.5%,and 61.9%and 57.1%,respectively.CONCLUSION:Peripheral blood inflammatory biomarkers are elevated in BRVO patients,suggesting systemic inflammation involvement.NLR,RAR,and BMI are positively correlated with BRVO.Monitoring NLR and RAR and strict weight control may be beneficial for the prevention and treatment of BRVO.
基金financially supported by the National Natural Science Foundation of China(No.22071176)。
文摘Cutting-edge research has primarily focused on flow synthesis of linear block copolymers,lacking the ability for manipulating chain architectures for more extensive applications.Herein,we develop a flow chemistry platform for the continuous microflow synthesis of bottlebrush block copolymers(BBCPs)using a grafting-through method.This involves performing ring-opening metathesis polymerization(ROMP)of two different macromonomers within two microfluidic reactors connected in series.The microflow environment allows for complete monomer conversion within a few tens of seconds,benefiting from the superior mixing efficiency achieved in Z-shaped channels as indicated by both theoretical simulations and experimental results.Consequently,a library of well-defined BBCPs of up to 528 distinct samples can be produced within one day through automation of the continuous procedure,while keeping precise control on degree of polymerization(DP<4)and polydispersity indices(PDI<1.2).The synthetic method is generally applicable to different macromonomers with different compositions and contour lengths,yielding libraries of branched block copolymers with great diversity in physiochemical properties and chain architectures.This work presents a powerful platform for high-throughput production of branched copolymers,significantly lowering the costs of the materials for real applications.
文摘Smart grid substation operations often take place in hazardous environments and pose significant threats to the safety of power personnel.Relying solely on manual supervision can lead to inadequate oversight.In response to the demand for technology to identify improper operations in substation work scenarios,this paper proposes a substation safety action recognition technology to avoid the misoperation and enhance the safety management.In general,this paper utilizes a dual-branch transformer network to extract spatial and temporal information from the video dataset of operational behaviors in complex substation environments.Firstly,in order to capture the spatial-temporal correlation of people's behaviors in smart grid substation,we devise a sparse attention module and a segmented linear attention module that are embedded into spatial branch transformer and temporal branch transformer respectively.To avoid the redundancy of spatial and temporal information,we fuse the temporal and spatial features using a tensor decomposition fusion module by a decoupled manner.Experimental results indicate that our proposed method accurately detects improper operational behaviors in substation work scenarios,outperforming other existing methods in terms of detection and recognition accuracy.
文摘Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.
基金supported by the National Key R&D Program of China(2020YFA0712901).
文摘We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the unit speed. The models, without or with immigration, are constructed as measure-valued processes by pathwise unique solutions of stochastic equations driven by time-space Poisson random measures. In the subcritical branching case, we give a sufficient condition for the ergodicity of the process with immigration. Two large number laws and a central limit theorem of the occupation times are proved.
文摘Athletes often use branched-chain amino acid (BCAAs) supplements with a ratio of 2:1:1 (leucine:isoleucine:valine) for their impact on muscle building. Research suggests that by altering the ratio, an improvement in glucose metabolism might be possible. The purpose of this study was to examine how isoleucine would influence glucose tolerance. We recruited healthy male (n = 13) and female (n = 5) participants who were asked to fast for 12 hours before coming to the laboratory. A fasting blood sample was collected, followed by the subjects consuming a breakfast containing 113 g carbohydrates, 8 g protein, 1.5 g fat, and BCAA powder in the 2:1:1 ratio (Control) or BCAA powder enriched with Isoleucine (2:6:1), both added to orange juice. The opposite meal was consumed on a second visit one week apart. Blood was collected at 30, 60, 90, and 120 minutes post-meal. No differences were observed between the Control and Isoleucine for changes in serum glucose or insulin response when examining all subjects together. However, when comparing between genders, males tended to have a significantly lower serum glucose response compared to females when consuming the Isoleucine, with no difference between the genders when consuming the Control. Also, males had significantly lower serum glucose responses when consuming the Isoleucine compared to when they consumed the Control, while females had significantly higher serum glucose responses when consuming the Isoleucine compared to when they consumed the Control. In general, males tended to have a lower serum insulin response than females when consuming both the Control and the Isoleucine. Our study indicates a significant difference in the way genders respond to BCAA supplementation, where isoleucine may improve glucose tolerance and insulin response in males but not females.
基金supported by the National Key Research and Development Program of China(2023YFD1202901)the China Agriculture Research System of MOF and MARA(CARS-02-06)the Key Area Research and Development Program of Guangdong Province(2018B020202008).
文摘To improve the amylose content(AC)and resistant starch content(RSC)of maize kernel starch,we employed the CRISPR/Cas9 system to create mutants of starch branching enzyme I(SBEI)and starch branching enzyme IIb(SBEIIb).A frameshift mutation in SBEI(E1,a nucleotide insertion in exon 6)led to plants with higher RSC(1.07%),lower hundred-kernel weight(HKW,24.71±0.14 g),and lower plant height(PH,218.50±9.42 cm)compared to the wild type(WT).Like the WT,E1 kernel starch had irregular,polygonal shapes with sharp edges.A frameshift mutation in SBEIIb(E2,a four-nucleotide deletion in exon 8)led to higher AC(53.48%)and higher RSC(26.93%)than that for the WT.E2 kernel starch was significantly different from the WT regarding granule morphology,chain length distribution pattern,X-ray diffraction pattern,and thermal characteristics;the starch granules were more irregular in shape and comprised typical B-type crystals.Mutating SBEI and SBEIIb(E12)had a synergistic effect on RSC,HKW,PH,starch properties,and starch biosynthesis-associated gene expression.SBEIIa,SS1,SSIIa,SSIIIa,and SSIIIb were upregulated in E12 endosperm compared to WT endosperm.This study lays the foundation for rapidly improving the starch properties of elite maize lines.
文摘The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that still our opinions on this technique are largely based on observational data and there is a dire need for larger RCTs to ascertain the position of LBBPCRT in management of heart failure patients with left bundle branch block.
