To the Editor:With the aging of the population,the prevalence of Alzheimer’s disease(AD)has increased significantly.Mild cognitive impairment(MCI)is the transition period between normal aging and dementia.[1]Quantita...To the Editor:With the aging of the population,the prevalence of Alzheimer’s disease(AD)has increased significantly.Mild cognitive impairment(MCI)is the transition period between normal aging and dementia.[1]Quantitative susceptibility mapping(QSM)allows for the direct measurement of iron metabolism disorders and iron deposition in AD brain tissue,represented as susceptibility(SUS).Voxel-based morphometry(VBM)is widely applied to evaluate gray and white matter lesions in the brain,reflecting differences in the corresponding anatomical structures by quantitatively calculating and analyzing the density or volume of brain gray/white matter for each voxel in the T1WI three-dimensional magnetization prepared rapid acquisition gradient echo(T1WI-3D-MP RAGE)sequence.Herein,we investigated the difference in brain microstructural changes in patients with AD and MCI using QSM and VBM,combined with neuropsychological test results,to evaluate the diagnostic value of QSM and VBM.展开更多
基金supported by“1+X”program for Clinical Competency Enhancement–Improvement of Clinical Technology Project,The Second Hospital of Dalian Medical University(No.2022LCJSGC04)“Xingliao Talent Plan”Medical Master Project of Liaoning Province(No.YXMJ-QN-16)Fundamental Scientific Research Project of Liaoning Provincial Department of Education(No.LJ212410161028).
文摘To the Editor:With the aging of the population,the prevalence of Alzheimer’s disease(AD)has increased significantly.Mild cognitive impairment(MCI)is the transition period between normal aging and dementia.[1]Quantitative susceptibility mapping(QSM)allows for the direct measurement of iron metabolism disorders and iron deposition in AD brain tissue,represented as susceptibility(SUS).Voxel-based morphometry(VBM)is widely applied to evaluate gray and white matter lesions in the brain,reflecting differences in the corresponding anatomical structures by quantitatively calculating and analyzing the density or volume of brain gray/white matter for each voxel in the T1WI three-dimensional magnetization prepared rapid acquisition gradient echo(T1WI-3D-MP RAGE)sequence.Herein,we investigated the difference in brain microstructural changes in patients with AD and MCI using QSM and VBM,combined with neuropsychological test results,to evaluate the diagnostic value of QSM and VBM.
