Elliptic curve(EC)based cryptosystems gained more attention due to enhanced security than the existing public key cryptosystems.A substitution box(S-box)plays a vital role in securing modern symmetric key cryptosystem...Elliptic curve(EC)based cryptosystems gained more attention due to enhanced security than the existing public key cryptosystems.A substitution box(S-box)plays a vital role in securing modern symmetric key cryptosystems.However,the recently developed EC based algorithms usually trade off between computational efficiency and security,necessitating the design of a new algorithm with the desired cryptographic strength.To address these shortcomings,this paper proposes a new scheme based onMordell elliptic curve(MEC)over the complex field for generating distinct,dynamic,and highly uncorrelated S-boxes.Furthermore,we count the exact number of the obtained S-boxes,and demonstrate that the permuted version of the presented S-box is statistically optimal.The nonsingularity of the presented algorithm and the injectivity of the resultant output are explored.Rigorous theoretical analysis and experimental results demonstrate that the proposedmethod is highly effective in generating a large number of dynamic S-boxes with adequate cryptographic properties,surpassing current state-of-the-art S-box generation algorithms in terms of security.Apart fromthis,the generated S-box is benchmarked using side-channel attacks,and its performance is compared with highly nonlinear S-boxes,demonstrating comparable results.In addition,we present an application of our proposed S-box generator by incorporating it into an image encryption technique.The encrypted and decrypted images are tested by employing extensive standard security metrics,including the Number of Pixel Change Rate,the Unified Average Changing Intensity,information entropy,correlation coefficient,and histogram analysis.Moreover,the analysis is extended beyond conventional metrics to validate the new method using advanced tests,such as the NIST statistical test suite,robustness analysis,and noise and cropping attacks.Experimental outcomes show that the presented algorithm strengthens the existing encryption scheme against various well-known cryptographic attacks.展开更多
The axle box bearings of high-speed trains often operate in extremely harsh environments,bearing loads from different directions.Long-term operation and frequent changes in working conditions can easily lead to axle b...The axle box bearings of high-speed trains often operate in extremely harsh environments,bearing loads from different directions.Long-term operation and frequent changes in working conditions can easily lead to axle box bearing failures.Therefore,it is extremely important to study the mechanism of axle box bearings.Firstly,the medium of thermal deformation establishes a coupling relationship between the system dynamics model and the thermal grid model,and then obtains the thermal force coupling model of the high-speed train axle box bearing.The coupling model is validated from the perspectives of system dynamics response and temperature response,proving its effectiveness in system dynamics response and temperature characteristic response.Comparing the coupling model with the dynamics model,it is found that thermal deformation complicates the dynamic re-sponse.Finally,using the Lundberg-Palmgren(L-P)bearing fatigue calculation method and damage accumu-lation theory,the bearing fatigue life is calculated,and it is found that thermal deformation deteriorates the bearing operating environment,reducing the bearing fatigue life.Finally,by comparing the bearing fatigue life under different working conditions,it is concluded that the faster the vehicle speed,the greater the load,and the smaller the initial radial clearance of the bearing,the fatigue life of the bearing is reduced.The shorter the lifespan.展开更多
The optimization of wings typically relies on computationally intensive high-fidelity simulations,which restrict the quick exploration of design spaces.To address this problem,this paper introduces a methodology dedic...The optimization of wings typically relies on computationally intensive high-fidelity simulations,which restrict the quick exploration of design spaces.To address this problem,this paper introduces a methodology dedicated to optimizing box wing configurations using low-fidelity data driven machine learning approach.This technique showcases its practicality through the utilization of a tailored low-fidelity machine learning technique,specifically designed for early-stage wing configuration.By employing surrogate model trained on small dataset derived from low-fidelity simulations,our method aims to predict outputs within an acceptable range.This strategy significantly mitigates computational costs and expedites the design exploration process.The methodology's validation relies on its successful application in optimizing the box wing of PARSIFAL,serving as a benchmark,while the primary focus remains on optimizing the newly designed box wing by Bionica.Applying this method to the Bionica configuration led to a notable 14%improvement in overall aerodynamic effciency.Furthermore,all the optimized results obtained from machine learning model undergo rigorous assessments through the high-fidelity RANS analysis for confirmation.This methodology introduces innovative approach that aims to streamline computational processes,potentially reducing the time and resources required compared to traditional optimization methods.展开更多
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex...High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.展开更多
The parachute deployment conditions during the terminal entry phase in Mars landing missions exhibit critical impact on landing precision.In this article,aiming at the requirements of safe parachute deployment and acc...The parachute deployment conditions during the terminal entry phase in Mars landing missions exhibit critical impact on landing precision.In this article,aiming at the requirements of safe parachute deployment and accurate landing,a multidimensional parachute deployment box for determining deployment condition during Mars landing was proposed.First,an extremerange optimization model was established,synthesizing the dynamics and constraints of both parachute descent and powered descent phases.Then,on the basis of the two-dimensional altitude-velocity deployment box,a multi-dimensional parachute deployment box characterized by altitude,velocity,flight-path angle,and extreme range was constructed through the integration of extreme range information.Furthermore,an evaluation index for landing precision was formulated and a deployment control logic was proposed for minimizing landing deviation.Finally,the proposed deployment box was simulated in a Mars landing mission.The results demonstrate that the proposed box effectively satisfies safe deployment and landing precision demands,eliminating the range-to-go error at the terminal of the entry phase.展开更多
Axle box bearings are critical components of high-speed trains.Localized defects,such as pitting and spalling,on raceways or rollers pose significant threats to the operational safety of railway vehicles.In this work,...Axle box bearings are critical components of high-speed trains.Localized defects,such as pitting and spalling,on raceways or rollers pose significant threats to the operational safety of railway vehicles.In this work,a novel bearing-flexible axle boxvehicle coupling model is established to explore the vibration characteristics of axle box bearings with irregular localized defects.First,based on the contact and kinematic relationship between rollers and raceways,the three-dimensional(3D)bearing force elements are analyzed and formulated.Second,the established model and a flexible axle box are integrated into the vehicle,and the responses of the normal and faulty bearings under the combined excitations of wheel roughness and track irregularities are simulated.Third,the simulation results are verified through a rolling-vibrating test bench for full-scale wheelsets of high-speed trains.The comparisons of the fault-induced repetitive transients in the time-domain and the fault characteristic frequencies in the envelope spectra demonstrate the efficiency of the proposed model.Finally,based on the flexible axle box model,a sensitivity analysis of the accelerometer placements to the bearing faults is carried out,and the optimal one is identified based on both the time-domain and frequency-domain signal-to-noise ratios(SNRs)for engineering applications.展开更多
BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer pro...BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer prognoses of colorectal cancer(CRC).AIM This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis(LNM)of CRC.METHODS Firstly,we designed an investigation with 1003 CRC patients and 1303 cancer-free controls to observe whether HMGB1 rs1412125 T>C and rs1045411 C>T SNPs could influence the risk of cancer.Subsequently,we carried out a correlation-analysis to assess whether these SNPs could alter the risk of LNM.RESULTS The current investigation suggested a relationship of HMGB1 rs1412125 SNP with the increased susceptibility of CRC.In a subgroup analysis,our findings suggested that this SNP could enhance an occurrence of CRC in≥61 years,non-drinker and body mass index<24 kg/m2 subgroups.However,we found that there was null association between HMGB1 rs1412125 SNP and LNM,even in different CRC region.These observations were confirmed by calculating the power value(more than 0.8).The association of HMGB1 rs1045411 C>T SNP with CRC risk and LNM was not found in any compare.CONCLUSION This study highlights a possible association between HMGB1 rs1412125 polymorphism and the increased risk of CRC.In the future,more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.展开更多
Streamlined box girders serve as a prevalent choice for the primary structural elements in large-span suspension bridge designs.With the increase in traffic demands,the design of such girders is evolving towards wider...Streamlined box girders serve as a prevalent choice for the primary structural elements in large-span suspension bridge designs.With the increase in traffic demands,the design of such girders is evolving towards wider bridge decks and larger aspect ratios(B/D).To obtain more effective and aerodynamic design shapes for streamlined box girders,it is essential to investigate the impact of B/D on their aerodynamic performance.Accordingly,in this study we investigate the buffeting responses of large-span suspension bridges using girders of varying aspect ratios(B/D of 7.5,9.3,and 12.7).First,the aerodynamic coefficients of these girders are estimated using computational fluid dynamics(CFD)simulations.Subsequently,spatial finite element(FE)models of three long-span suspension bridges with different girders(B/D of 7.5,9.3,and 12.7)are established in Ansys software,and the dynamic characteristics of these bridges are obtained.Then,the time-domain buffeting analysis is performed by simulating the fluctuating wind fields acting on the bridge through the spectral representation method.Ultimately,the buffeting responses are computed using Ansys software,and the impact of B/D on these responses is assessed.The results reveal that the root mean square(RMS)values of the main girder’s buffeting displacement are highest at the midspan position and are lowest at the ends of the bridge.A decrease in B/D of the main girder leads to a more severe buffeting response because both the range and the effective value of the displacement increase with the decreasing B/D.Comparing the buffeting displacements in three directions,B/D plays a significant role in the vertical buffeting displacement,moderately impacts the torsional displacement,and has the least effect on the lateral displacement.The findings of this study may help wind resistance analysis and design optimization for bridges.展开更多
This study examines the temperature field distribution characteristics and temperature effects during the prefabrication of composite box girders with corrugated steel webs(CBGCSWs),aiming to provide practical recomme...This study examines the temperature field distribution characteristics and temperature effects during the prefabrication of composite box girders with corrugated steel webs(CBGCSWs),aiming to provide practical recommendations for controlling temperature-induced cracking and technical guidance for concrete mix proportions and placement processes.Based on field measurement data,a three-dimensional finite element model was developed to simulate the temperature effects at critical locations during the prefabrication phase.By varying the concrete mix proportions,initial casting temperature,and ambient temperature,the study elucidates the variation patterns of the temperature field during precast placement.The results show that the temperature rise caused by hydration heat increases with higher cement and fly ash content,whereas reducing cement and using minimal fly ash effectively lower the hydration temperature.However,the influence of fly ash on prestress losses should be carefully evaluated during the design phase.Higher initial casting temperatures accelerate hydration rates,leading to a rapid temperature rise.Significant differences between the initial casting and ambient temperatures result in larger residual temperature stresses.Based on concrete mix proportions,curing conditions,and ambient temperatures,three recommended casting temperature ranges were identified:5℃–10℃,10℃–25℃,and 25℃–30℃.Variations in the average ambient temperature affect the peak temperature of the hydration reaction and indirectly influence the final temperature distribution of the concrete structure.Optimizing the demolding time and applying geotextiles and water curing effectively reduces the peak temperature,maximum internal-to-surface temperature gradients,and surface tensile stresses,thereby mitigating the risk of temperature-induced cracking.展开更多
Accurately predicting the overlying pressure is crucial for determining an appropriate cover depth of underwater box tunnels to avoid the uplifting failure.Based on the project of box jacking crossing the Beijing-Hang...Accurately predicting the overlying pressure is crucial for determining an appropriate cover depth of underwater box tunnels to avoid the uplifting failure.Based on the project of box jacking crossing the Beijing-Hangzhou Grand Canal in Suzhou,the characteristics of overlying pressure variation during tunneling are investigated.The monitoring results reveal that the fluctuation of overlying pressure is weakened during the rapid tunneling process.A modified analytical model for vertical earth pressure is conceived,in which the active and passive limit states for multi-layered soils are both considered.The probable range of overlying pressure obtained by the proposed model is suitable to cover the actual values.The anti-floating behavior of underwater box tunnels for two different working conditions is discussed by calculating the minimum cover depth.Using the calibrated analytical models,a parametric study is conducted to explore the influence of injection pressure,hardened slurry unit weight,soil internal friction angle,soil cohesion,and tunnel geometry.It is found that the injection pressure during the construction process is crucial for determining the necessary cover depth,and the change of box tunnel height makes it easier to trigger the variation of minimum cover depth.展开更多
Objective:In recent decades,studies have underscored nuclear proteins and signaling pathways in prostate cancer(PCa)development.Key biomarkers like Enhancer of zeste homolog 2(EZH2)and Forkhead box M1(FOXM1)are expres...Objective:In recent decades,studies have underscored nuclear proteins and signaling pathways in prostate cancer(PCa)development.Key biomarkers like Enhancer of zeste homolog 2(EZH2)and Forkhead box M1(FOXM1)are expressed in both healthy and malignant prostate cells.This study aimed to demonstrate the relationship between pathological characteristics,survival,recurrence,and tissue expression of EZH2 and FOXM1 in high-risk PCa patients.Methods:PCa tissues were used in a retrospective analysis that spanned from September 2009 to August 2019.Inclusion criteria comprised pathological tumor stage(pT)3 patients with positive surgical margins or tumor proximity to inked margins within 5 mm.After case selection,tissue slides were stained for EZH2 and FOXM1 antibodies,and Allred scores were calculated.Patients or relatives of deceased patients were contacted for signed agreements and disease follow-ups.Results:The pT3b,ductal carcinoma component,and moderate EZH2 expression were associated with relapse(odds ratio[OR]6.21,95%confidence interval[CI]1.41-27.27,p=0.016;OR 7.29,95%CI 1.03-51.43,p=0.046;OR 5.96,95%CI 1.09-32.48,p=0.039;respectively).The unilateral and bilateral seminal vesicle invasion increased the likelihood of recurrence by 9.98 times and 5.36 times,and the risk of death by around 9.78 times and 10.79 times,respectively.The pT3b was linked to higher death likelihood(OR 7.16,95%CI 1.38-37.23,p=0.019),while moderate EZH2 expression did not show statistical significance(OR 4.54,95%CI 0.87-23.60,p=0.072,marginally).Pathological regional lymph node stage(pN)1 had significantly higher probability of mortality than pN unknown(3.9%vs.27%,p<0.001).PCa in the neck and apex of the prostate gland increased death risk tenfold.Conclusion:Sufficient immunoexpression of EZH2,ductal carcinoma component,and neoplastic proliferation in the seminal vesicles,apex and neck of the prostate gland correlates with elevated risks of recurrence and mortality.Clinicians should use these criteria for appropriate patient referrals,and a multicenter trial could provide accurate classifications.展开更多
Axle box bearings serve as crucial components within the transmission system of high-speed trains.Their failure can directly impact the operational safety of these trains.Accurately determining the dynamic load experi...Axle box bearings serve as crucial components within the transmission system of high-speed trains.Their failure can directly impact the operational safety of these trains.Accurately determining the dynamic load experienced by bearings during the operation of high-speed trains can provide valuable boundary inputs for the study of bearing fatigue life and service performance,thereby holding significant engineering implications.In this study,we propose a high-speed train axle box bearing load estimation method(FMCC-DKF).This method is founded on the Kalman filtering technique of the Maximum Correntropy Criterion(MCC)and employs dummy measurement technology to enhance the stability of estimated loads.We develop a kernel size update algorithm to address the challenges associated with obtaining the key parameter,kernel size of MCC.Comparative analysis of the vertical and lateral loads of the axle box bearing obtained using FMCC-DKF,DKF,and AMCC-DKF,under both measurement noise-free and non-Gaussian noise conditions,is conducted to demonstrate the superiority of the proposed estimation method.The results indicate that the proposed FMCC-DKF method exhibits high estimation accuracy under both measurement noise-free and non-Gaussian noise interference,and maintains its high estimation accuracy despite changes in train speed.The proposed load estimation method demonstrates reliable performance within the low-frequency domain below 70 Hz.展开更多
Considering the characteristics of deep thick top coal roadway,in which the high ground stress,coal seam with low strength,and a large range of surrounding rock fragmentation,the pressure relief anchor box beam suppor...Considering the characteristics of deep thick top coal roadway,in which the high ground stress,coal seam with low strength,and a large range of surrounding rock fragmentation,the pressure relief anchor box beam support system with high strength is developed.The high-strength bearing characteristics and coupling yielding support mechanism of this support system are studied by the mechanical tests of composite members and the combined support system.The test results show that under the coupling effect of support members,the peak stress of the box-shaped support beam in the anchor box beam is reduced by 21.9%,and the average deformation is increased by 135.0%.The ultimate bending bearing capacity of the box-shaped support beam is 3.5 times that of traditional channel beam.The effective compressive stress zone applied by the high prestressed cable is expanded by 26.4%.On this basis,the field support comparison test by the anchor channel beam,the anchor I-shaped beam and the anchor box beam are carried out.Compared with those of the previous two,the surrounding rock convergence of the latter is decreased by 41.2%and 22.2%,respectively.The field test verifies the effectiveness of the anchor box beam support system.展开更多
High mobility group box 1(HMGB1),when released extracellularly,plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system.In experimental auto...High mobility group box 1(HMGB1),when released extracellularly,plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system.In experimental autoimmune encephalomyelitis(EAE),a condition that models multiple sclerosis,the levels of extracellular HMGB1 and interleukin-33(IL-33)have been found to be inversely correlated.However,the mechanism by which IL-33 deficiency enhances HMGB1 release during EAE remains elusive.Our study elucidates a potential signaling pathway whereby the absence of IL-33 leads to increased binding of P300/CBP-associated factor with HMGB1 in the nuclei of astrocytes,upregulating HMGB1 acetylation and promoting its release from astrocyte nuclei in the spinal cord of EAE mice.Conversely,the addition of IL-33 counteracts the TNF-α-induced increase in HMGB1 and acetylated HMGB1 levels in primary astrocytes.These findings underscore the potential of IL-33-associated signaling pathways as a therapeutic target for EAE treatment.展开更多
To investigate the influence of the shear lag effect on the bending shear stress of single-box multicell box gird-ers(MCBG),the shear lag warping additional deflection is selected as the generalized displacement.The g...To investigate the influence of the shear lag effect on the bending shear stress of single-box multicell box gird-ers(MCBG),the shear lag warping additional deflection is selected as the generalized displacement.The governing dif-ferential equations and boundary conditions for the shear lag of the MCBG are derived using the energy variational method.Based on the shear lag warping deformation state of the MCBG and by employing the microelement equilib-rium differential equation and the coordination conditions for shear lag warping deformation,the calculation method for the bending-warping shear stress of the MCBG is de-rived,and the influence of the width-to-span and height-to span ratios on bending-warping shear stress is analyzed.Ex-ample analysis shows that the bending-warping shear stress of the MCBG calculated by the proposed calculation method coincides with the finite element solution,and the warping shear stress satisfies the self-balancing condition of shear warping,thus verifying the accuracy of the proposed method.The warping shear stress exhibits an antisymmetric distribution about the vertical axis of symmetry and has a weakening effect on the shear stress of the elementary beam(EB).The larger the width-to-span ratio is,the larger the proportion of the warping shear stress of the EB.The larger the height-to-span ratio is,the smaller the proportion of the warping shear stress and the more significant the influence of the width-to-span ratio.The more the number of cells is,the smaller the influence of the warping shear stress on the total bending shear stress.The influence of the shear lag ef-fect can be ignored in the calculation of the bending shear stress of three or more cells in the MCBG.展开更多
A grey-box modelling framework was developed for the estimation of cut point temperature of a crude distillation unit(CDU)under uncertainty in crude composition and process conditions.First principle(FP)model of CDU w...A grey-box modelling framework was developed for the estimation of cut point temperature of a crude distillation unit(CDU)under uncertainty in crude composition and process conditions.First principle(FP)model of CDU was developed for Pakistani crudes from Zamzama and Kunnar fields.A hybrid methodology based on the integration of Taguchi method and genetic algorithm(GA)was employed to estimate the optimal cut point temperature for various sets of process variables.Optimised datasets were utilised to develop an artificial neural networks(ANN)model for the prediction of optimum values of cut points.The ANN model was then used to replace the hybrid framework of the Taguchi method and the GA.The integration of the ANN and FP model makes it a grey-box(GB)model.For the case of Zamama crude,the GB model helped in the decrease of up to 38.93%in energy required per kilo barrel of diesel and an 8.2%increase in diesel production compared to the stand-alone FP model under uncertainty.Similarly,for Kunnar crude,up to 18.87%decrease in energy required per kilo barrel of diesel and a 33.96%increase in diesel production was observed in comparison to the stand-alone FP model.展开更多
BACKGROUND Type 2 diabetes mellitus is characterized by pancreaticβ-cell dysfunction and insulin resistance.Studies have suggested thatβ-cell dedifferentiation is one of the pathogeneses ofβ-cell dysfunction,but th...BACKGROUND Type 2 diabetes mellitus is characterized by pancreaticβ-cell dysfunction and insulin resistance.Studies have suggested thatβ-cell dedifferentiation is one of the pathogeneses ofβ-cell dysfunction,but the detailed mechanism is still unclear.Most studies ofβ-cell dedifferentiation rely on rodent models and human pathological specimens.The development of in vitro systems can facilitate the exploration ofβ-cell dedifferentiation.AIM To investigate the molecular mechanism ofβ-cell dedifferentiation.Hence,an in vitro model ofβ-cell dedifferentiation induced by palmitic acid and high glucose was established using the INS-1832/13 cell line.METHODS The study was further analyzed using RNA-sequencing,transmission electron microscopy,quantitative real-time polymerase chain reaction and Western blot.RESULTS Results showed that the treatment of palmitic acid and high glucose significantly up-regulatedβ-cell forbidden genes and endocrine precursor cell marker genes,and down-regulated the expression ofβ-cell specific markers.Data showed that dedifferentiated INS-1 cells up-regulated the expression of endoplasmic reticulum(ER)stressrelated genes.Moreover,the results also showed that forkhead box O1(Foxo1)inhibition potentiated genetic changes inβ-cell dedifferentiation induced by palmitic acid and high glucose.CONCLUSION ER stress is sufficient to triggerβ-cell dedifferentiation and is necessary for palmitic acid and high glucose-inducedβ-cell dedifferentiation.Foxo1 inhibition can further enhance these phenomena.展开更多
文摘Elliptic curve(EC)based cryptosystems gained more attention due to enhanced security than the existing public key cryptosystems.A substitution box(S-box)plays a vital role in securing modern symmetric key cryptosystems.However,the recently developed EC based algorithms usually trade off between computational efficiency and security,necessitating the design of a new algorithm with the desired cryptographic strength.To address these shortcomings,this paper proposes a new scheme based onMordell elliptic curve(MEC)over the complex field for generating distinct,dynamic,and highly uncorrelated S-boxes.Furthermore,we count the exact number of the obtained S-boxes,and demonstrate that the permuted version of the presented S-box is statistically optimal.The nonsingularity of the presented algorithm and the injectivity of the resultant output are explored.Rigorous theoretical analysis and experimental results demonstrate that the proposedmethod is highly effective in generating a large number of dynamic S-boxes with adequate cryptographic properties,surpassing current state-of-the-art S-box generation algorithms in terms of security.Apart fromthis,the generated S-box is benchmarked using side-channel attacks,and its performance is compared with highly nonlinear S-boxes,demonstrating comparable results.In addition,we present an application of our proposed S-box generator by incorporating it into an image encryption technique.The encrypted and decrypted images are tested by employing extensive standard security metrics,including the Number of Pixel Change Rate,the Unified Average Changing Intensity,information entropy,correlation coefficient,and histogram analysis.Moreover,the analysis is extended beyond conventional metrics to validate the new method using advanced tests,such as the NIST statistical test suite,robustness analysis,and noise and cropping attacks.Experimental outcomes show that the presented algorithm strengthens the existing encryption scheme against various well-known cryptographic attacks.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12393780,12032017,12302067)College Education Scientific Research Project of Hebei Province(Grant No.JZX2024006)Hebei Provincial S&T Program(Grant No.21567622 H).
文摘The axle box bearings of high-speed trains often operate in extremely harsh environments,bearing loads from different directions.Long-term operation and frequent changes in working conditions can easily lead to axle box bearing failures.Therefore,it is extremely important to study the mechanism of axle box bearings.Firstly,the medium of thermal deformation establishes a coupling relationship between the system dynamics model and the thermal grid model,and then obtains the thermal force coupling model of the high-speed train axle box bearing.The coupling model is validated from the perspectives of system dynamics response and temperature response,proving its effectiveness in system dynamics response and temperature characteristic response.Comparing the coupling model with the dynamics model,it is found that thermal deformation complicates the dynamic re-sponse.Finally,using the Lundberg-Palmgren(L-P)bearing fatigue calculation method and damage accumu-lation theory,the bearing fatigue life is calculated,and it is found that thermal deformation deteriorates the bearing operating environment,reducing the bearing fatigue life.Finally,by comparing the bearing fatigue life under different working conditions,it is concluded that the faster the vehicle speed,the greater the load,and the smaller the initial radial clearance of the bearing,the fatigue life of the bearing is reduced.The shorter the lifespan.
基金The funding for this publication was provided by Johannes Kepler University(JKU),Linz.Special thanks to Prof.Zongmin DENG from Beihang University for his invaluable guidance,insightful feedback,and constructive criticism,which greatly enhanced the quality of this manuscript.We extend our heartfelt gratitude to the PARSIFAL team for providing the supporting materials,which inspired this study.
文摘The optimization of wings typically relies on computationally intensive high-fidelity simulations,which restrict the quick exploration of design spaces.To address this problem,this paper introduces a methodology dedicated to optimizing box wing configurations using low-fidelity data driven machine learning approach.This technique showcases its practicality through the utilization of a tailored low-fidelity machine learning technique,specifically designed for early-stage wing configuration.By employing surrogate model trained on small dataset derived from low-fidelity simulations,our method aims to predict outputs within an acceptable range.This strategy significantly mitigates computational costs and expedites the design exploration process.The methodology's validation relies on its successful application in optimizing the box wing of PARSIFAL,serving as a benchmark,while the primary focus remains on optimizing the newly designed box wing by Bionica.Applying this method to the Bionica configuration led to a notable 14%improvement in overall aerodynamic effciency.Furthermore,all the optimized results obtained from machine learning model undergo rigorous assessments through the high-fidelity RANS analysis for confirmation.This methodology introduces innovative approach that aims to streamline computational processes,potentially reducing the time and resources required compared to traditional optimization methods.
基金supported by a grant of the M.D.-Ph.D./Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(to HK)+3 种基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSITMinistry of Science and ICT)(NRF2019R1A5A2026045 and NRF-2021R1F1A1061819)a grant from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(HR21C1003)New Faculty Research Fund of Ajou University School of Medicine(to JYC)。
文摘High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.
基金Supported by the National Natural Science Foundation of China(62073034)。
文摘The parachute deployment conditions during the terminal entry phase in Mars landing missions exhibit critical impact on landing precision.In this article,aiming at the requirements of safe parachute deployment and accurate landing,a multidimensional parachute deployment box for determining deployment condition during Mars landing was proposed.First,an extremerange optimization model was established,synthesizing the dynamics and constraints of both parachute descent and powered descent phases.Then,on the basis of the two-dimensional altitude-velocity deployment box,a multi-dimensional parachute deployment box characterized by altitude,velocity,flight-path angle,and extreme range was constructed through the integration of extreme range information.Furthermore,an evaluation index for landing precision was formulated and a deployment control logic was proposed for minimizing landing deviation.Finally,the proposed deployment box was simulated in a Mars landing mission.The results demonstrate that the proposed box effectively satisfies safe deployment and landing precision demands,eliminating the range-to-go error at the terminal of the entry phase.
基金supported by the National Natural Science Foundation of China(Nos.12372056,12032017,12393783)the S&T Program of Hebei of China(No.24465001D)。
文摘Axle box bearings are critical components of high-speed trains.Localized defects,such as pitting and spalling,on raceways or rollers pose significant threats to the operational safety of railway vehicles.In this work,a novel bearing-flexible axle boxvehicle coupling model is established to explore the vibration characteristics of axle box bearings with irregular localized defects.First,based on the contact and kinematic relationship between rollers and raceways,the three-dimensional(3D)bearing force elements are analyzed and formulated.Second,the established model and a flexible axle box are integrated into the vehicle,and the responses of the normal and faulty bearings under the combined excitations of wheel roughness and track irregularities are simulated.Third,the simulation results are verified through a rolling-vibrating test bench for full-scale wheelsets of high-speed trains.The comparisons of the fault-induced repetitive transients in the time-domain and the fault characteristic frequencies in the envelope spectra demonstrate the efficiency of the proposed model.Finally,based on the flexible axle box model,a sensitivity analysis of the accelerometer placements to the bearing faults is carried out,and the optimal one is identified based on both the time-domain and frequency-domain signal-to-noise ratios(SNRs)for engineering applications.
基金Supported by the Major Project of Changzhou Science and Technology Bureau,No.CJ20220255.
文摘BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer prognoses of colorectal cancer(CRC).AIM This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis(LNM)of CRC.METHODS Firstly,we designed an investigation with 1003 CRC patients and 1303 cancer-free controls to observe whether HMGB1 rs1412125 T>C and rs1045411 C>T SNPs could influence the risk of cancer.Subsequently,we carried out a correlation-analysis to assess whether these SNPs could alter the risk of LNM.RESULTS The current investigation suggested a relationship of HMGB1 rs1412125 SNP with the increased susceptibility of CRC.In a subgroup analysis,our findings suggested that this SNP could enhance an occurrence of CRC in≥61 years,non-drinker and body mass index<24 kg/m2 subgroups.However,we found that there was null association between HMGB1 rs1412125 SNP and LNM,even in different CRC region.These observations were confirmed by calculating the power value(more than 0.8).The association of HMGB1 rs1045411 C>T SNP with CRC risk and LNM was not found in any compare.CONCLUSION This study highlights a possible association between HMGB1 rs1412125 polymorphism and the increased risk of CRC.In the future,more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.
基金funded by the National Natural Science Foundation of China(Grant No.52108435)the Science and Technology Research Program of Chongqing Municipal Education Commission(Grant No.KJQN202404320)+1 种基金Chongqing Jiaotong University Postgraduate Research and Innovation Project(2024S0013)Chongqing Jiaotong University Undergraduate Innovation and Entrepreneurship Project(S202410618019).
文摘Streamlined box girders serve as a prevalent choice for the primary structural elements in large-span suspension bridge designs.With the increase in traffic demands,the design of such girders is evolving towards wider bridge decks and larger aspect ratios(B/D).To obtain more effective and aerodynamic design shapes for streamlined box girders,it is essential to investigate the impact of B/D on their aerodynamic performance.Accordingly,in this study we investigate the buffeting responses of large-span suspension bridges using girders of varying aspect ratios(B/D of 7.5,9.3,and 12.7).First,the aerodynamic coefficients of these girders are estimated using computational fluid dynamics(CFD)simulations.Subsequently,spatial finite element(FE)models of three long-span suspension bridges with different girders(B/D of 7.5,9.3,and 12.7)are established in Ansys software,and the dynamic characteristics of these bridges are obtained.Then,the time-domain buffeting analysis is performed by simulating the fluctuating wind fields acting on the bridge through the spectral representation method.Ultimately,the buffeting responses are computed using Ansys software,and the impact of B/D on these responses is assessed.The results reveal that the root mean square(RMS)values of the main girder’s buffeting displacement are highest at the midspan position and are lowest at the ends of the bridge.A decrease in B/D of the main girder leads to a more severe buffeting response because both the range and the effective value of the displacement increase with the decreasing B/D.Comparing the buffeting displacements in three directions,B/D plays a significant role in the vertical buffeting displacement,moderately impacts the torsional displacement,and has the least effect on the lateral displacement.The findings of this study may help wind resistance analysis and design optimization for bridges.
基金supported by the National Natural Science Foundation of China(U22A20598,52279113)Key Research and Development Special Program of Henan Province(241111322500)Support Plan for University Science and Technology Innovation Team of Henan Province(24IRTSTHN009).
文摘This study examines the temperature field distribution characteristics and temperature effects during the prefabrication of composite box girders with corrugated steel webs(CBGCSWs),aiming to provide practical recommendations for controlling temperature-induced cracking and technical guidance for concrete mix proportions and placement processes.Based on field measurement data,a three-dimensional finite element model was developed to simulate the temperature effects at critical locations during the prefabrication phase.By varying the concrete mix proportions,initial casting temperature,and ambient temperature,the study elucidates the variation patterns of the temperature field during precast placement.The results show that the temperature rise caused by hydration heat increases with higher cement and fly ash content,whereas reducing cement and using minimal fly ash effectively lower the hydration temperature.However,the influence of fly ash on prestress losses should be carefully evaluated during the design phase.Higher initial casting temperatures accelerate hydration rates,leading to a rapid temperature rise.Significant differences between the initial casting and ambient temperatures result in larger residual temperature stresses.Based on concrete mix proportions,curing conditions,and ambient temperatures,three recommended casting temperature ranges were identified:5℃–10℃,10℃–25℃,and 25℃–30℃.Variations in the average ambient temperature affect the peak temperature of the hydration reaction and indirectly influence the final temperature distribution of the concrete structure.Optimizing the demolding time and applying geotextiles and water curing effectively reduces the peak temperature,maximum internal-to-surface temperature gradients,and surface tensile stresses,thereby mitigating the risk of temperature-induced cracking.
基金supported by the Natural Science Foundation of Jiangsu Province of China (Grant Nos.BK20230500 and BK20210721)the Young Talent Fund of Association for Science and Technology in Shaanxi,China (Grant No.20240722).
文摘Accurately predicting the overlying pressure is crucial for determining an appropriate cover depth of underwater box tunnels to avoid the uplifting failure.Based on the project of box jacking crossing the Beijing-Hangzhou Grand Canal in Suzhou,the characteristics of overlying pressure variation during tunneling are investigated.The monitoring results reveal that the fluctuation of overlying pressure is weakened during the rapid tunneling process.A modified analytical model for vertical earth pressure is conceived,in which the active and passive limit states for multi-layered soils are both considered.The probable range of overlying pressure obtained by the proposed model is suitable to cover the actual values.The anti-floating behavior of underwater box tunnels for two different working conditions is discussed by calculating the minimum cover depth.Using the calibrated analytical models,a parametric study is conducted to explore the influence of injection pressure,hardened slurry unit weight,soil internal friction angle,soil cohesion,and tunnel geometry.It is found that the injection pressure during the construction process is crucial for determining the necessary cover depth,and the change of box tunnel height makes it easier to trigger the variation of minimum cover depth.
文摘Objective:In recent decades,studies have underscored nuclear proteins and signaling pathways in prostate cancer(PCa)development.Key biomarkers like Enhancer of zeste homolog 2(EZH2)and Forkhead box M1(FOXM1)are expressed in both healthy and malignant prostate cells.This study aimed to demonstrate the relationship between pathological characteristics,survival,recurrence,and tissue expression of EZH2 and FOXM1 in high-risk PCa patients.Methods:PCa tissues were used in a retrospective analysis that spanned from September 2009 to August 2019.Inclusion criteria comprised pathological tumor stage(pT)3 patients with positive surgical margins or tumor proximity to inked margins within 5 mm.After case selection,tissue slides were stained for EZH2 and FOXM1 antibodies,and Allred scores were calculated.Patients or relatives of deceased patients were contacted for signed agreements and disease follow-ups.Results:The pT3b,ductal carcinoma component,and moderate EZH2 expression were associated with relapse(odds ratio[OR]6.21,95%confidence interval[CI]1.41-27.27,p=0.016;OR 7.29,95%CI 1.03-51.43,p=0.046;OR 5.96,95%CI 1.09-32.48,p=0.039;respectively).The unilateral and bilateral seminal vesicle invasion increased the likelihood of recurrence by 9.98 times and 5.36 times,and the risk of death by around 9.78 times and 10.79 times,respectively.The pT3b was linked to higher death likelihood(OR 7.16,95%CI 1.38-37.23,p=0.019),while moderate EZH2 expression did not show statistical significance(OR 4.54,95%CI 0.87-23.60,p=0.072,marginally).Pathological regional lymph node stage(pN)1 had significantly higher probability of mortality than pN unknown(3.9%vs.27%,p<0.001).PCa in the neck and apex of the prostate gland increased death risk tenfold.Conclusion:Sufficient immunoexpression of EZH2,ductal carcinoma component,and neoplastic proliferation in the seminal vesicles,apex and neck of the prostate gland correlates with elevated risks of recurrence and mortality.Clinicians should use these criteria for appropriate patient referrals,and a multicenter trial could provide accurate classifications.
基金National Key R&D Program of China(Grant numbers 2022YFB4301201-11,2022YFB4301203-05)National Natural Science Foundation of China(Grant number 52202464).
文摘Axle box bearings serve as crucial components within the transmission system of high-speed trains.Their failure can directly impact the operational safety of these trains.Accurately determining the dynamic load experienced by bearings during the operation of high-speed trains can provide valuable boundary inputs for the study of bearing fatigue life and service performance,thereby holding significant engineering implications.In this study,we propose a high-speed train axle box bearing load estimation method(FMCC-DKF).This method is founded on the Kalman filtering technique of the Maximum Correntropy Criterion(MCC)and employs dummy measurement technology to enhance the stability of estimated loads.We develop a kernel size update algorithm to address the challenges associated with obtaining the key parameter,kernel size of MCC.Comparative analysis of the vertical and lateral loads of the axle box bearing obtained using FMCC-DKF,DKF,and AMCC-DKF,under both measurement noise-free and non-Gaussian noise conditions,is conducted to demonstrate the superiority of the proposed estimation method.The results indicate that the proposed FMCC-DKF method exhibits high estimation accuracy under both measurement noise-free and non-Gaussian noise interference,and maintains its high estimation accuracy despite changes in train speed.The proposed load estimation method demonstrates reliable performance within the low-frequency domain below 70 Hz.
基金Project(2023YFC2907600)supported by the National Key Research and Development Program of ChinaProjects(42277174,42477166)supported by the National Natural Science Foundation of China+1 种基金Project(2024JCCXSB01)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(KFJJ24-01M)supported by the State Key Laboratory of Explosion Science and Safety Protection,Beijing Institute of Technology,China。
文摘Considering the characteristics of deep thick top coal roadway,in which the high ground stress,coal seam with low strength,and a large range of surrounding rock fragmentation,the pressure relief anchor box beam support system with high strength is developed.The high-strength bearing characteristics and coupling yielding support mechanism of this support system are studied by the mechanical tests of composite members and the combined support system.The test results show that under the coupling effect of support members,the peak stress of the box-shaped support beam in the anchor box beam is reduced by 21.9%,and the average deformation is increased by 135.0%.The ultimate bending bearing capacity of the box-shaped support beam is 3.5 times that of traditional channel beam.The effective compressive stress zone applied by the high prestressed cable is expanded by 26.4%.On this basis,the field support comparison test by the anchor channel beam,the anchor I-shaped beam and the anchor box beam are carried out.Compared with those of the previous two,the surrounding rock convergence of the latter is decreased by 41.2%and 22.2%,respectively.The field test verifies the effectiveness of the anchor box beam support system.
基金supported by the National Natural Science Foundation of China(82001281 and 82371195)Hubei Provincial Natural Science Foundation of China for Distinguished Young Scholars(2022CFA104)the Research Fund of Jianghan University(2022XKZX28).
文摘High mobility group box 1(HMGB1),when released extracellularly,plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system.In experimental autoimmune encephalomyelitis(EAE),a condition that models multiple sclerosis,the levels of extracellular HMGB1 and interleukin-33(IL-33)have been found to be inversely correlated.However,the mechanism by which IL-33 deficiency enhances HMGB1 release during EAE remains elusive.Our study elucidates a potential signaling pathway whereby the absence of IL-33 leads to increased binding of P300/CBP-associated factor with HMGB1 in the nuclei of astrocytes,upregulating HMGB1 acetylation and promoting its release from astrocyte nuclei in the spinal cord of EAE mice.Conversely,the addition of IL-33 counteracts the TNF-α-induced increase in HMGB1 and acetylated HMGB1 levels in primary astrocytes.These findings underscore the potential of IL-33-associated signaling pathways as a therapeutic target for EAE treatment.
基金The National Natural Science Foundation of China (No. 52368020)Gansu Provincial Universities Young Doctor Support Project (No. 2024QB-047)Gansu Province postdoctoral Fund (No. 386824)。
文摘To investigate the influence of the shear lag effect on the bending shear stress of single-box multicell box gird-ers(MCBG),the shear lag warping additional deflection is selected as the generalized displacement.The governing dif-ferential equations and boundary conditions for the shear lag of the MCBG are derived using the energy variational method.Based on the shear lag warping deformation state of the MCBG and by employing the microelement equilib-rium differential equation and the coordination conditions for shear lag warping deformation,the calculation method for the bending-warping shear stress of the MCBG is de-rived,and the influence of the width-to-span and height-to span ratios on bending-warping shear stress is analyzed.Ex-ample analysis shows that the bending-warping shear stress of the MCBG calculated by the proposed calculation method coincides with the finite element solution,and the warping shear stress satisfies the self-balancing condition of shear warping,thus verifying the accuracy of the proposed method.The warping shear stress exhibits an antisymmetric distribution about the vertical axis of symmetry and has a weakening effect on the shear stress of the elementary beam(EB).The larger the width-to-span ratio is,the larger the proportion of the warping shear stress of the EB.The larger the height-to-span ratio is,the smaller the proportion of the warping shear stress and the more significant the influence of the width-to-span ratio.The more the number of cells is,the smaller the influence of the warping shear stress on the total bending shear stress.The influence of the shear lag ef-fect can be ignored in the calculation of the bending shear stress of three or more cells in the MCBG.
基金Higher Education Commission,Pakistan,under the National Research Program for Universities Project,Grant/Award Number:NBU-FPEJ-2024-1243-02。
文摘A grey-box modelling framework was developed for the estimation of cut point temperature of a crude distillation unit(CDU)under uncertainty in crude composition and process conditions.First principle(FP)model of CDU was developed for Pakistani crudes from Zamzama and Kunnar fields.A hybrid methodology based on the integration of Taguchi method and genetic algorithm(GA)was employed to estimate the optimal cut point temperature for various sets of process variables.Optimised datasets were utilised to develop an artificial neural networks(ANN)model for the prediction of optimum values of cut points.The ANN model was then used to replace the hybrid framework of the Taguchi method and the GA.The integration of the ANN and FP model makes it a grey-box(GB)model.For the case of Zamama crude,the GB model helped in the decrease of up to 38.93%in energy required per kilo barrel of diesel and an 8.2%increase in diesel production compared to the stand-alone FP model under uncertainty.Similarly,for Kunnar crude,up to 18.87%decrease in energy required per kilo barrel of diesel and a 33.96%increase in diesel production was observed in comparison to the stand-alone FP model.
基金Supported by the Natural Science Foundation of China,No.81471081the Natural Science Foundation of Fujian Province,No.2023D009+1 种基金the Natural Science Foundation of Xiamen City,No.3502Z202373104 and No.3502Z20227162Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University,No.PM201809170005。
文摘BACKGROUND Type 2 diabetes mellitus is characterized by pancreaticβ-cell dysfunction and insulin resistance.Studies have suggested thatβ-cell dedifferentiation is one of the pathogeneses ofβ-cell dysfunction,but the detailed mechanism is still unclear.Most studies ofβ-cell dedifferentiation rely on rodent models and human pathological specimens.The development of in vitro systems can facilitate the exploration ofβ-cell dedifferentiation.AIM To investigate the molecular mechanism ofβ-cell dedifferentiation.Hence,an in vitro model ofβ-cell dedifferentiation induced by palmitic acid and high glucose was established using the INS-1832/13 cell line.METHODS The study was further analyzed using RNA-sequencing,transmission electron microscopy,quantitative real-time polymerase chain reaction and Western blot.RESULTS Results showed that the treatment of palmitic acid and high glucose significantly up-regulatedβ-cell forbidden genes and endocrine precursor cell marker genes,and down-regulated the expression ofβ-cell specific markers.Data showed that dedifferentiated INS-1 cells up-regulated the expression of endoplasmic reticulum(ER)stressrelated genes.Moreover,the results also showed that forkhead box O1(Foxo1)inhibition potentiated genetic changes inβ-cell dedifferentiation induced by palmitic acid and high glucose.CONCLUSION ER stress is sufficient to triggerβ-cell dedifferentiation and is necessary for palmitic acid and high glucose-inducedβ-cell dedifferentiation.Foxo1 inhibition can further enhance these phenomena.
