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A peridynamics modeling approach for pre-cracked rock cracking processes under impact by integrating Drucker-Prager plasticity model and efficient contact model
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作者 Jingzhi Tu Nengxiong Xu Gang Mei 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期179-195,共17页
In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical propert... In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical properties of rocks,the cracking processes of pre-cracked rocks have been extensively studied using numerical modeling methods.The peridynamics(PD)exhibits advantages over other numerical methods due to the absence of the requirements for remeshing and external crack growth criterion.However,for modeling pre-cracked rock cracking processes under impact,current PD implementations lack generally applicable rock constitutive models and impact contact models,which leads to difficulties in determining rock material parameters and efficiently calculating impact loads.This paper proposes a non-ordinary state-based peridynamics(NOSBPD)modeling method integrating the Drucker-Prager(DP)plasticity model and an efficient contact model to address the above problems.In the proposed method,the Drucker-Prager plasticity model is integrated into the NOSBPD,thereby equipping NOSBPD with the capability to accurately characterize the nonlinear stress-strain relationship inherent in rocks.An efficient contact model between particles and meshes is designed to calculate the impact loads,which is essentially a coupling method of PD with the finite element method(FEM).The effectiveness of the proposed NOSBPD modeling method is verified by comparison with other numerical methods and experiments.Experimental results indicate that the proposed method can effectively and accurately predict the 3D cracking processes of pre-cracked cracks under impact loading,and the maximum principal stress is the key driver behind wing crack formation in pre-cracked rocks. 展开更多
关键词 Pre-cracked rocks Cracking processes Non-ordinary state-based peridynamics (NOSBPD) Drucker-Prager plasticity model Efficient contact model
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Plasticity meets regeneration during innate spinal cord repair
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作者 Amruta Tendolkar Mayssa H.Mokalled 《Neural Regeneration Research》 2026年第3期1136-1137,共2页
Regenerative capacity of the central nervous system(CNS)is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative... Regenerative capacity of the central nervous system(CNS)is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative vertebrates including urodele amphibians and teleost fish spontaneously reverse CNS damage.Teletost zebrafish(danio rerio)are tropical freshwater fish that proved to be an excellent vertebrate model of successful CNS regeneration.Differential neuronal,glial,and immune injury responses underlie disparate injury outcomes between highly regenerative zebrafish and poorly regenerative mammals.This article describes complications associated with neuronal repair following spinal cord injury(SCI)in poorly regenerative mammals and highlights intersecting modes of plasticity and regeneration in highly regenerative zebrafish(Figures 1 and 2).Comparative approaches evaluating immunoglial SCI responses were recently reviewed elsewhere(Reyes and Mokalled,2024). 展开更多
关键词 urodele amphibians central nervous system central nervous system cns REGENERATION vertebrate model plasticity vertebrates teleost fish
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Investigation of non-Schmid effects in dual-phase steels using a dislocation density-based crystal plasticity model
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作者 Jianchang Zhu Mohamed Ben Bettaieb +2 位作者 Zhenhuan Li Farid Abed-Meraim Minsheng Huang 《Acta Mechanica Sinica》 2025年第11期101-120,共20页
Non-Schmid(NS)effects in body-centered cubic(BCC)single-phase metals have received special attention in recent years.However,a deep understanding of these effects in the BCC phase of dual-phase(DP)steels has not yet b... Non-Schmid(NS)effects in body-centered cubic(BCC)single-phase metals have received special attention in recent years.However,a deep understanding of these effects in the BCC phase of dual-phase(DP)steels has not yet been reached.This study explores the NS effects in ferrite-martensite DP steels,where the ferrite phase has a BCC crystallographic structure and exhibits NS effects.The influences of NS stress components on the mechanical response of DP steels are studied,including stress/strain partitioning,plastic flow,and yield surface.To this end,the mechanical behavior of the two phases is described by dislocation density-based crystal plasticity constitutive models,with the NS effect only incorporated into the ferrite phase modeling.The NS stress contribution is revealed for two types of microstructures commonly observed in DP steels:equiaxed phases with random grain orientations,and elongated phases with preferred grain orientations.Our results show that,in the case of a microstructure with equiaxed phases,the normal NS stress components play significant roles in tension-compression asymmetry.By contrast,in microstructures with elongated phases,a combined influence of crystallographic texture and NS effect is evident.These findings advance our knowledge of the intricate interplay between microstructural features and NS effects and help to elucidate the mechanisms underlying anisotropic-asymmetric plastic behavior of DP steels. 展开更多
关键词 DP steels Non-Schmid effects Crystal plasticity modeling Tension-compression asymmetry
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Solid solution dependence of the deformation behavior in Mg-xZn(x=0,1,2 wt%)alloys:In-situ neutron diffraction and crystal plasticity modeling
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作者 Huai Wang Soo Yeol Lee +3 位作者 You Sub Kim Huamiao Wang Wanchuck Woo Ke An 《Journal of Magnesium and Alloys》 2025年第2期823-838,共16页
The effects of solid solution on the deformation behavior of binary Mg-xZn(x=0,1,2 wt%)alloys featuring a designated texture that enables extension twinning under tension parallel to the basal pole in most grains,were... The effects of solid solution on the deformation behavior of binary Mg-xZn(x=0,1,2 wt%)alloys featuring a designated texture that enables extension twinning under tension parallel to the basal pole in most grains,were investigated using in-situ neutron diffraction and the EVPSC-TDT model.Neutron diffraction was used to quantitatively track grain-level lattice strains and diffraction intensity changes(related to mechanical twinning)in differently oriented grains of each alloy during cyclic tensile/compressive loadings.These measurements were accurately captured by the model.The stress-strain curves of Mg-1 wt%Zn and Mg-2 wt%Zn alloys show as-expected solid solution strengthening from the addition of Zn compared to pure Mg.The macroscopic yielding and hardening behaviors are explained by alternating slip and twinning modes as calculated by the model.The solid solution's influence on individual deformation modes,including basal〈a〉slip,prismatic〈a〉slip,and extension twinning,was then quantitatively assessed in terms of activity,yielding behavior,and hardening response by combining neutron diffraction results with crystal plasticity predictions.The Mg-1 wt%Zn alloy displays distinct yielding and hardening behavior due to solid solution softening of prismatic〈a〉slip.Additionally,the dependence of extension twinning,in terms of the twinning volume fraction,on Zn content exhibits opposite trends under tensile and compressive loadings. 展开更多
关键词 Magnesium alloy Deformation behavior Solid solution Crystal plasticity modeling Neutron diffraction
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Coarse grain non-uniform refinement simulation in multi-directional forging of titanium alloys based on macro-deformation and crystal plasticity modelling
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作者 Shiqi Guo Liang Huang +1 位作者 Kezhuo Liu Changmin Li 《Journal of Materials Science & Technology》 2025年第34期128-144,共17页
The complex grain fragmentation mechanisms of coarse grains in titanium alloys under multi-directional forging(MDF)directly influence the optimization and control of primary hot working processes.This study conducted ... The complex grain fragmentation mechanisms of coarse grains in titanium alloys under multi-directional forging(MDF)directly influence the optimization and control of primary hot working processes.This study conducted MDF experiments onβ-phase as-cast Ti-6554 alloy and simulated non-uniform deformation during cyclic multi-directional compression through macro-and micro-deformation modeling.The results revealed that friction and surface cooling caused low strain and tensile stress concentration at billet edges,leading to mixed grain structures.In contrast,high strain and triaxial compressive stress at billet centers facilitated uniform grain refinement.After 14 compressions and 4 intermediate reheating processes,coarse grains of the billet were refined from 2-5 mm to 0.25-0.50 mm,achieving uniform grain sizes across different regions.For the first time,the orientation evolution of grains with different morphologies during multi-directional compressions was visualized microscopically.Columnar grains were found to be more easily subdivided than equiaxed grains due to local strain accumulation.Under cumulative compressions,grain orientations gradually rotated from uniform to random,driving continuous dynamic recrystallization(CDRX).Slip system interactions and concentrated misorientation led to the formation and extension of transition and shear bands,inducing grain fragmentation dominated by transgranular subdivided CDRX.Smooth grain boundaries transformed into serrated ones after multiple passes,providing additional nucleation sites for discontinuous dynamic recrystallization(DDRX)and facilitating boundary expand CDRX.The interaction of diverse DRX mechanisms was the fundamental cause of grain refinement.This study clarified the principles of refining and homogenizing millimeter-grade coarse grains under increasing forging strain,offering valuable insights for the development of primary hot processing techniques for as-castβtitanium alloys. 展开更多
关键词 Titanium alloy Multi-directional forging Coarse grain refinement Crystal plasticity modeling Grain orientation evolution
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Deformation mechanisms of Mg-3Al-1Zn alloy by polycrystal plasticity modeling 被引量:2
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作者 尹德良 刘金强 吴冰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第7期2188-2194,共7页
A polycrystal plasticity model was developed to analyze the room-temperature deformation behaviors of Mg-3A1-1Zn alloy(AZ31).The uniaxial tension and compression tests at room temperature were conducted using cast a... A polycrystal plasticity model was developed to analyze the room-temperature deformation behaviors of Mg-3A1-1Zn alloy(AZ31).The uniaxial tension and compression tests at room temperature were conducted using cast and extruded AZ31 rods with different textures and combined with the proposed model to reveal the deformation mechanisms.It is shown that,different flow curves of two specimens under tension and compression tests can be simulated by this model.The flow curves of AZ31 extrusions exhibit different shapes for tension and compression due to different activities of tensile twinning and pyramidalc+a slip.The metallographic and TEM observations showed the equal twinning activities at the initial stage in tension and compression tests and the occurrence of pyramidalc+a slip in compression of as-cast Mg-3A1-1Zn alloy with increasing the strain,which is consistent with the simulated results by the proposed model. 展开更多
关键词 Mg alloy deformation mechanism polycrystal plasticity model TEXTURE
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Review on cyclic plasticity of magnesium alloys:Experiments and constitutive models 被引量:12
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作者 Guo-zheng Kang Hang Li 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2021年第4期567-589,共23页
Fatigue analysis has always been a concern in the design and assessment of Mg alloy structure components subjected to cyclic loading,and research on the cyclic plasticity is fundamental to investigate the correspondin... Fatigue analysis has always been a concern in the design and assessment of Mg alloy structure components subjected to cyclic loading,and research on the cyclic plasticity is fundamental to investigate the corresponding fatigue failure.Thus,this work reviews the progress in the cyclic plasticity of Mg alloys.First,the existing macroscopic and microscopic experimental results of Mg alloys are summarized.Then,corresponding macroscopic phenomenological constitutive models and crystal plasticity-based models are reviewed.Finally,some conclusions and recommended topics on the cyclic plasticity of Mg alloys are provided to boost the further development and application of Mg alloys. 展开更多
关键词 magnesium alloy cyclic plasticity macroscopic experiments microscopic observations constitutive model
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A Multi-mechanism Model Describing Reorientation and Reorientation-Induced Plasticity of NiTi Shape Memory Alloy 被引量:5
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作者 Xiang Xu Bo Xu +2 位作者 Han M. Jiang Guo-zheng Kang Qian-hua Kan 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2018年第4期445-458,共14页
The recovery force or recovery strain is an important indicator of NiTi-based shape memory alloy devices. However, the restoring force or recoverable strain is partially restrained due to an interaction between reorie... The recovery force or recovery strain is an important indicator of NiTi-based shape memory alloy devices. However, the restoring force or recoverable strain is partially restrained due to an interaction between reorientation and reorientation-induced plasticity. Therefore, a macroscopic multi-mechanism constitutive model was constructed to describe the degeneration of shape memory effect based on the phase diagram. The residual strain after cooling consists of reorientation strain and reorientation-induced plastic strain. An internal variable, i.e., the detwinned stress, and its evolution equation were introduced into the transformation kinetics equation to describe the nonlinear hardening characteristics induced by the combined reorien- ration and detwinning mechanisms during mechanical loading. Finally, the proposed model was numerically implemented to simulate the experiments of shape memory effect at different peak strains. Comparisons between the experimental and simulated results show that the proposed model can reasonably describe the degeneration of shape memory effect. 展开更多
关键词 Shape memory alloy Shape memory effect Residual strain Constitutive model plastic strain
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Origins of high ductility exhibited by an extruded magnesium alloy Mg-1.8Zn-0.2Ca:Experiments and crystal plasticity modeling 被引量:6
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作者 Jie Wang Gaoming Zhu +5 位作者 Leyun Wang Evgenii Vasilev Jun-Sang Park Gang Sha Xiaoqin Zeng Marko Knezevic 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第25期27-42,共16页
Low ductility and strength are major bottlenecks against Mg alloys’wide applications.In this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can ... Low ductility and strength are major bottlenecks against Mg alloys’wide applications.In this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can be extruded at low temperatures(~250℃)and high speeds(~2 mm/s).After the extrusion,this alloy exhibits a substantially weakened basal texture,relatively small grain size,very high tensile elongation(~30%),and good strength.The origin of the considerably improved ductility was studied using a combination of three-dimensional atom probe tomography(3D-APT),transmission electron microscopy(TEM),electron backscattered diffraction(EBSD)in conjunction with surface slip trace analysis,in-situ synchrotron X-ray diffraction,and elasto-plastic self-consistent(EPSC)modeling.Co-segregation of Zn and Ca atoms at a grain boundary is observed and associated with texture weakening and grain boundary mediated plasticity,both improving the ductility.While basal slip and prismatic slip are identified as the dominant deformation systems in the alloy,the ratio between their slip resistances is substantially reduced relative to pure Mg and most other Mg alloys,significantly contributing to the improved ductility of the alloy.This Mg-Zn-Ca alloy exhibiting excellent mechanical properties and low fabrication cost is a promising candidate for industrial productions. 展开更多
关键词 Mg-Zn-Ca alloy DUCTILITY Deformation mechanisms Crystal plasticity modeling Grain boundary mediated plasticity
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Adiabatic shear localization evolution for steel based on the Johnson-Cook model and gradient-dependent plasticity 被引量:4
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作者 Xuebin Wang 《Journal of University of Science and Technology Beijing》 CSCD 2006年第4期313-318,共6页
Gradient-dependent plasticity is introduced into the phenomenological Johnson-Cook model to study the effects of strainhardening, strain rate sensitivity, thermal-softening, and microstructure. The microstructural eff... Gradient-dependent plasticity is introduced into the phenomenological Johnson-Cook model to study the effects of strainhardening, strain rate sensitivity, thermal-softening, and microstructure. The microstructural effect (interactions and interplay among microstructures) due to heterogeneity of texture plays an important role in the process of development or evolution of an adiabatic shear band with a certain thickness depending on the grain diameter. The distributed plastic shear strain and deformation in the shear band are derived and depend on the critical plastic shear strain corresponding to the peak flow shear stress, the coordinate or position, the internal length parameter, and the average plastic shear strain or the flow shear stress. The critical plastic shear strain, the distributed plastic shear strain, and deformation in the shear band are numerically predicted for a kind of steel deformed at a constant shear strain rate. Beyond the peak shear stress, the local plastic shear strain in the shear band is highly nonuniform and the local plastic shear deformation in the band is highly nonlinear. Shear localization is more apparent with the increase of the average plastic shear strain. The calculated distributions of the local plastic shear strain and deformation agree with the previous numerical and experimental results. 展开更多
关键词 adiabatic shear band STEEL STRAIN-HARDENING gradient-dependent plasticity Johnson-Cook model
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3D Crystal Plasticity Finite Element Modeling of the Tensile Deformation of Polycrystalline Ferritic Stainless Steel 被引量:3
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作者 Chi Zhang Li-Wen Zhang +2 位作者 Wen-Fei Shen Ying-Nan Xia Yu-Tan Yan 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2017年第1期79-88,共10页
A mesoscale model of plastic deformation of ferritic stainless steels (FSSs) is formulated by combining a crystal plasticity finite element model with 3D cellular automaton algorithm. The actual grain orientations o... A mesoscale model of plastic deformation of ferritic stainless steels (FSSs) is formulated by combining a crystal plasticity finite element model with 3D cellular automaton algorithm. The actual grain orientations of FSS cold rolling and annealing sheet have been detected by electron backscatter diffraction and selected to be assigned to the polycrystal model. The simulation results have been validated by comparing the calculated true stress-strain response with the experimental one. For the lack of considering the interactions of dislocations with impurities, there are no upper and lower yield points in the simulation stress-strain curves. However, the calculated yield strength and the stress-strain response after yielding agree well with the real material. The local stress and strain fields show inhomogeneous at mesoscale. The plastic deformations of the grains with typical orientations have been characterized. The analysis reveals that the grains with fiber texture show higher thickness reduction ratio as compared to others. The deformation behaviors of the grains in polycrystal are not only related to the orientations but also to the interactions from adjacent grains. 展开更多
关键词 Ferritic steels Crystallographic orientation Polycrystal plasticity modeling Cellular automaton
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Recent developments of generalized plasticity models for saturated and unsaturated soils 被引量:2
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作者 Hong-en LI Yong-jun HE +2 位作者 Guang-ya FAN Tong-chun LI Manuel PASTOR 《Water Science and Engineering》 EI CAS 2011年第3期329-344,共16页
Soil undergoes both elastic and plastic deformations under different loading conditions. A relatively accurate constitutive model of soil behaviors should be capable of predicting the elastic and plastic deformations ... Soil undergoes both elastic and plastic deformations under different loading conditions. A relatively accurate constitutive model of soil behaviors should be capable of predicting the elastic and plastic deformations properly. Among a large number of elastoplastic constitutive models developed over the last several decades, constitutive models based on generalized plasticity have been successfully utilized in modeling the mechanical behavior of various soils. This paper attempts to present a review of the most recent developments of generalized plasticity models for geotechnical problems. After a brief review of generalized plasticity theories and constitutive models, limitations of the original Pastor-Zienkiewicz model in practical application are summarized. Afterwards, recent achievements in the generalized plasticity models for both saturated and unsaturated soils and their applicability are analyzed, and a general approach for modification of generalized plasticity models is highlighted. 展开更多
关键词 generalized plasticity constitutive model Pastor-Zienkiewicz model saturated and unsaturated soils
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Evaluation of Blast-Resistant Performance Predicted by Damaged Plasticity Model for Concrete 被引量:8
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作者 还毅 方秦 +1 位作者 陈力 张亚栋 《Transactions of Tianjin University》 EI CAS 2008年第6期414-421,共8页
in order to evaluate the capacity of reinforced concrete (RC) structures subjected to blast Ioadings, the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC st... in order to evaluate the capacity of reinforced concrete (RC) structures subjected to blast Ioadings, the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC structures, and all three failure modes were numerically simulated by the finite element software ABAQUS. Simulation results agree with the experimental observations. It is demonstrated that the damaged plasticity model for concrete in the finite element software ABAQUS can predict dynamic responses and typical flexure, flexure-shear and direct shear failure modes of the blast-loaded RC structures. 展开更多
关键词 ABAQUS damaged plasticity model for concrete blast loading reinforced concrete structure failure mode
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Adiabatic Shear Localization for Steels Based on Johnson-Cook Model and Second-and Fourth-Order Gradient Plasticity Models 被引量:2
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作者 WANG Xue-bin 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2007年第5期56-61,共6页
To consider the effects of the interactions and interplay among microstructures, gradient-dependent models of second- and fourth-order are included in the widely used phenomenological Johnson-Cook model where the effe... To consider the effects of the interactions and interplay among microstructures, gradient-dependent models of second- and fourth-order are included in the widely used phenomenological Johnson-Cook model where the effects of strain-hardening, strain rate sensitivity, and thermal-softening are successfully described. The various parameters for 1006 steel, 4340 steel and S-7 tool steel are assigned. The distributions and evolutions of the local plastic shear strain and deformation in adiabatic shear band (ASB) are predicted. The calculated results of the second- and fourth- order gradient plasticity models are compared. S-7 tool steel possesses the steepest profile of local plastic shear strain in ASB, whereas 1006 steel has the least profile. The peak local plastic shear strain in ASB for S-7 tool steel is slightly higher than that for 4340 steel and is higher than that for 1006 steel. The extent of the nonlinear distribution of the local plastic shear deformation in ASB is more apparent for the S-7 tool steel, whereas it is the least apparent for 1006 steel. In fourth-order gradient plasticity model, the profile of the local plastic shear strain in the middle of ASB has a pronounced plateau whose width decreases with increasing average plastic shear strain, leading to a shrink of the portion of linear distribution of the profile of the local plastic shear deformation. When compared with the sec- ond-order gradient plasticity model, the fourth-order gradient plasticity model shows a lower peak local plastic shear strain in ASB and a higher magnitude of plastic shear deformation at the top or base of ASB, which is due to wider ASB. The present numerical results of the second- and fourth-order gradient plasticity models are consistent with the previous numerical and experimental results at least qualitatively. 展开更多
关键词 adiabatic shear band steel gradient-dependent plasticity Johnson-Cook model second-order gradient fourth-order gradient
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General Model of Fuzzy Plasticity 被引量:1
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作者 ZHANG Chunliang ZHANG Liangchi 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第4期496-504,共9页
The transition between the elastic and plastic states is sharp in the classical plasticity theory. To overcome this problem, many constitutive models, such as multi-yield-surface model and two-surface model, have been... The transition between the elastic and plastic states is sharp in the classical plasticity theory. To overcome this problem, many constitutive models, such as multi-yield-surface model and two-surface model, have been developed. However, these models can not represent the true deformation process in a material. In order to capture nonlinear hardening behavior and smooth transition from elastic to plastic state, a general model of fuzzy plasticity is developed. On the basis of the theory of fuzzy sets and TAKAGI-SUGENO fuzzy model, a fuzzy plastic model for monotonic and cyclic loadings in one dimension is established and it is generalized to six dimensions and unsymmetric cycles. The proposed model uses a set of surfaces to partition the stress space with individual plastic modulus. The plastic modulus between two adjacent surfaces is determined by a membership function. By means of a finite number of partitioning surfaces, the fuzzy plastic model can provide with a more realistic and practical description of the materials behavior than the classical plasticity model. The validity of the fuzzy plastic model is investigated by comparing the predicted and experimental stress-strain responses of steels. It was found that the fuzzy plasticity has the ability to handle many practical problems that cannot be adequately analyzed by the conventional theory of plasticity. 展开更多
关键词 plasticity theory fuzzy model membership function plastic modulus stress-strain curve
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Short-term versus long-term water maze training effects on hippocampal neuronal synaptic plasticity in a rat model of senile dementia 被引量:1
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作者 Guogui Li 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第9期929-932,共4页
BACKGROUND: Changes in synaptic plasticity might underlie senile dementia, and might be the neurobiological basis for learning and memory dysfunctions in patients with Alzheimer's Disease. OBJECTIVE: To investigate... BACKGROUND: Changes in synaptic plasticity might underlie senile dementia, and might be the neurobiological basis for learning and memory dysfunctions in patients with Alzheimer's Disease. OBJECTIVE: To investigate the effects of water maze training on hippocampal neuronal synaptic plasticity in rats with senile dementia, and to compare changes in synaptic plasticity between short- and long-term water maze training sessions. DESIGN, TIME AND SETTING: A randomized, controlled, neuromorphological observation with animal models of senile dementia was performed at the laboratory of College of Pharmacy, Chongqing Medical University between November 2006 and April 2007. MATERIALS: Fifty male, Sprague Dawley rats were randomized into five groups, with 10 rats per group: model, control, sham-operated, short-term water maze training, and long-term water maze training. METHODS: In the model group, senile dementia was induced by fimbria-fornix lesion method. The control rats remained untreated. In the sham-operated group, water maze training was performed without fimbria-fomix lesion induction. Rats from the short-term water maze training group underwent 20-day water maze training from day 26 after fimbria-fornix lesion induction. The long-term water maze training group underwent 40-day water maze training beginning at day 6 following fimbria-fornix lesion induction. Beginning at day 41, each group underwent 5-day spatial learning and memory training. MAIN OUTCOME MEASURES: Following experimentation, the morphological parameters of synapses, including synaptic numerical density, synaptic surface density, and the average synapse size were stereologically measured. Through the use of an electron microscope, synaptic morphological changes in the hippocampal CA3 region were observed. RESULTS: Compared with the control group, synaptic numerical and surface densities were significantly decreased in the model group (P 〈 0.01). Synaptic numerical and surface densities significantly increased in the short- and long-term water maze training groups, compared with the model group (P 〈 0.01 ), and these values were also significantly greater in the long-term water maze training group than in the short-term water maze training group. The model group exhibited larger average sizes of synaptic conjunctions, compared with the control group (P 〈 0.01). Synaptic conjunction size was significantly less in the short- and long-term water maze training groups than in the model group (P 〈 0.01 ), and the long-term water maze training group exhibited smaller synaptic conjunction sizes compared with the short-term water maze training group (P 〈 0.05). Synaptic morphological changes in the hippocampal neurons were in accordance with stereological measurements. CONCLUSION: Water maze training increased synaptic numerical and surface densities in the hippocampal CA3 region, resulting in numerical and functional changes in synaptic plasticity in rats with senile dementia. Long-term water maze training resulted in better therapeutic effects than short-term water mate training. 展开更多
关键词 Alzheimer's disease HIPPOCAMPUS memory model plasticity rats SYNAPSE
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INVESTIGATION ON GRADIENT-DEPENDENT NONLOCAL CONSTITUTIVE MODELS FOR ELASTO-PLASTICITY COUPLED WITH DAMAGE 被引量:1
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作者 沈新普 沈国晓 +1 位作者 陈立新 杨璐 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2005年第2期218-233,共16页
Firstly, typical) gradient-dependent nonlocal inelastic models were briefly reviewed. Secondly, based on the principle of ‘gradient-dependent energy dissipation', a gradient-dependent constitutive model for plast... Firstly, typical) gradient-dependent nonlocal inelastic models were briefly reviewed. Secondly, based on the principle of ‘gradient-dependent energy dissipation', a gradient-dependent constitutive model for plasticity coupled with isotropic damage was presented in the framework of continuum thermodynamics. Numerical scheme for calculation of Laplacian term of damage field with the numerical results obtained by FEM calculation was proposed. Equations have been presented on the basis of Taylor series for both 2-dimensional and 3-dimensional cases, respectively. Numerical results have indicated the validity of the proposed gradient-dependent model and corresponding numerical scheme. 展开更多
关键词 DAMAGE plasticity NONLOCAL constitutive model gradient-dependent
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A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity 被引量:1
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作者 Yao He Don Kulasiri Jingyi Liang 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第4期621-631,共11页
Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional im... Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data. 展开更多
关键词 SYNAPSE SHORT-TERM plasticity SHORT-TERM FACILITATION and depression MATHEMATICAL model low-frequency STIMULATION high-frequency STIMULATION
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Crystal-Plasticity-Based Dynamic Constitutive Model of AZ31B Magnesium Alloy at Elevated Temperature and with Explicit Plastic-Strain-Rate Control 被引量:2
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作者 Qijun Xie Zhiwu Zhu Guozheng Kang 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2020年第1期31-50,共20页
In this study,a series of experiments were carried out on the AZ31B magnesium alloy,including both a macro-experiment(mechanical experiment)and a micro-experiment(dislocation observation).Next,based on the considerati... In this study,a series of experiments were carried out on the AZ31B magnesium alloy,including both a macro-experiment(mechanical experiment)and a micro-experiment(dislocation observation).Next,based on the consideration of the deformation mechanism of magnesium alloys(dislocation slip and twinning),a dynamic constitutive model of the magnesium alloy was established.In the developed model,the strain-rate-sensitivity control and the effect of temperature on the dynamic mechanical performance of the alloy were also investigated.The model parameters were determined by fitting the macroscopic experimental results.Next,the evolution of the micro-deformation mechanism was calculated by the developed model,and the trend of macro-mechanical behavior was also discussed. 展开更多
关键词 Magnesium alloy Constitutive model Microscopic mechanism Dynamic test Crystal plasticity
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Texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr dual-phase alloy during cold rolling based on multiscale crystal plasticity finite element model 被引量:2
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作者 Duoduo Wang Qunbo Fan +9 位作者 Xingwang Cheng Yu Zhou Ran Shi Yan Qian Le Wang Xinjie Zhu Haichao Gong Kai Chen Jingjiu Yuan Liu Yang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第16期76-87,共12页
The complex micromechanical response among grains remains a persistent challenge to understand the deformation mechanism of titanium alloys during cold rolling.Therefore,in this work,a multiscale crystal plasticity fi... The complex micromechanical response among grains remains a persistent challenge to understand the deformation mechanism of titanium alloys during cold rolling.Therefore,in this work,a multiscale crystal plasticity finite element method of dual-phase alloy was proposed and secondarily developed based on LS-DYNA software.Afterward,the texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr alloy,based on the realistic 3D microstructure,during cold rolling(20%thickness reduction)were systematically investigated.The relative activity of the■slip system in theαphase gradually increased,and then served as the main slip mode at lower Schmid factor(<0.2).In contrast,the contribution of the■slip system to the overall plastic deformation was relatively limited.For theβphase,the relative activity of the<111>{110}slip system showed an upward tendency,indicating the important role of the critical resolved shear stress relationship in the relative activity evolutions.Furthermore,the abnormally high strain of very fewβgrains was found,which was attributed to their severe rotations compelled by the neighboring pre-deformedαgrains.The calculated pole figures,rotation axes,and compelled rotation behavior exhibited good agreement to the experimental results. 展开更多
关键词 Titanium alloy Multiscale crystal plasticity finite element model Texture evolution Slip mode
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