Heterotrimeric G proteins,composed of the α,β,and subunits,mediate cellular signal pathways in response to external stimuli.The Gαsubunit is traditionally viewed as a molecular switch,cycling between a GDP-bound in...Heterotrimeric G proteins,composed of the α,β,and subunits,mediate cellular signal pathways in response to external stimuli.The Gαsubunit is traditionally viewed as a molecular switch,cycling between a GDP-bound inactive state,where it forms a stable heterotrimer with Gβy,and a GTP-bound active state,which promotes the dissociation of the heterotrimer into two active signaling components:GTP-bound Gαand the Gβ dimer.展开更多
文摘Heterotrimeric G proteins,composed of the α,β,and subunits,mediate cellular signal pathways in response to external stimuli.The Gαsubunit is traditionally viewed as a molecular switch,cycling between a GDP-bound inactive state,where it forms a stable heterotrimer with Gβy,and a GTP-bound active state,which promotes the dissociation of the heterotrimer into two active signaling components:GTP-bound Gαand the Gβ dimer.
