Chronic fluoride(F^(-))toxicity has been endemic at least 25 countries around the world due to prolonged consumption of contaminated water,posing a great threat to human health.Rapid and convenient visual methods for ...Chronic fluoride(F^(-))toxicity has been endemic at least 25 countries around the world due to prolonged consumption of contaminated water,posing a great threat to human health.Rapid and convenient visual methods for F^(-)ion detection are hence needed for public safety.In this work,we show a series of novel mixed lanthanide-organic frameworks,namely{[Eu_(x)Tb_(2-x)(BIPA)_(3)(DMF)(H_(2)O)_(3)]·2DMF·3H_(2)O}_(n)(H_(2)BIPA=5-boronoisophthalic acid;x=0,0.12,0.28,0.30,0.68,1.04 and 2 for 1-7,respectively),with abundant recognition sites of borono groups for convenient and visual detection of excess F^(-)ions in river water.Wide linear range for F^(-)ion detection can be obtained through systematic optimization of sensing materials.A rare double dynamic sensing process between F^(-)ions and lanthanide-organic frameworks was clearly revealed though single-crystal X-ray diffraction and transient fluorescence techniques.展开更多
Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have previously developed a deterministic parsing model to determine the Compound Biological Effectiveness (CBE) factor in ...Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have previously developed a deterministic parsing model to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate that the CBE factor is directly and unambiguously derivable by the new formula for any case of intracellular 10Boron (10B) distribution, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derive the following new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax. where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density in tissues and tumor. In order to determine these constants and the eigen values, iterative calculation technique was employed for the CEB factor and Nmax data set previously reported. Results and Conclusion: From the iterative calculation results, it is clear that the calculated CBE factor values obtained are almost identical to the original CBE factors and there is a good correlation between the original CBE factors and Nth/Nmax, when CBE0, F and n are given as 0.5, 8 and 3, respectively. These constants provide a better understanding of different types of intracellular10B distribution.展开更多
Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CB...Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate a specific method of how the application of the case of application to actual patient data, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derived the following new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax.? (1), where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density and CBE0, F and n are given as 0.5, 8 and 3, respectively. In order to determine Nth and Nmax in the formula, sigmoid logistic function was employed for 10B concentration data, Db(t) obtained by dynamic PET technique. (2), where, A, a and t0 are constants. Results and Conclusion: From the application of sigmoid function to dynamic PET data, it is concluded that the Nth and Nmax for tissue and tumor are identified with the parameter constants in the sigmoid function in Equation (2) as: (3). And the calculated CBE factor values obtained from Equation (1), with Nth/Nmax.展开更多
基金supported by the National Natural Science Foundation of China(grant number 22121005)open-ended fund of Hubei Key Laboratory of Pollutant Analysis&Reuse Technology(grant number PA230212)talent introduction project of Hubei Normal University(grant number HS2023RC072).
文摘Chronic fluoride(F^(-))toxicity has been endemic at least 25 countries around the world due to prolonged consumption of contaminated water,posing a great threat to human health.Rapid and convenient visual methods for F^(-)ion detection are hence needed for public safety.In this work,we show a series of novel mixed lanthanide-organic frameworks,namely{[Eu_(x)Tb_(2-x)(BIPA)_(3)(DMF)(H_(2)O)_(3)]·2DMF·3H_(2)O}_(n)(H_(2)BIPA=5-boronoisophthalic acid;x=0,0.12,0.28,0.30,0.68,1.04 and 2 for 1-7,respectively),with abundant recognition sites of borono groups for convenient and visual detection of excess F^(-)ions in river water.Wide linear range for F^(-)ion detection can be obtained through systematic optimization of sensing materials.A rare double dynamic sensing process between F^(-)ions and lanthanide-organic frameworks was clearly revealed though single-crystal X-ray diffraction and transient fluorescence techniques.
文摘Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have previously developed a deterministic parsing model to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate that the CBE factor is directly and unambiguously derivable by the new formula for any case of intracellular 10Boron (10B) distribution, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derive the following new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax. where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density in tissues and tumor. In order to determine these constants and the eigen values, iterative calculation technique was employed for the CEB factor and Nmax data set previously reported. Results and Conclusion: From the iterative calculation results, it is clear that the calculated CBE factor values obtained are almost identical to the original CBE factors and there is a good correlation between the original CBE factors and Nth/Nmax, when CBE0, F and n are given as 0.5, 8 and 3, respectively. These constants provide a better understanding of different types of intracellular10B distribution.
文摘Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate a specific method of how the application of the case of application to actual patient data, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derived the following new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax.? (1), where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density and CBE0, F and n are given as 0.5, 8 and 3, respectively. In order to determine Nth and Nmax in the formula, sigmoid logistic function was employed for 10B concentration data, Db(t) obtained by dynamic PET technique. (2), where, A, a and t0 are constants. Results and Conclusion: From the application of sigmoid function to dynamic PET data, it is concluded that the Nth and Nmax for tissue and tumor are identified with the parameter constants in the sigmoid function in Equation (2) as: (3). And the calculated CBE factor values obtained from Equation (1), with Nth/Nmax.
