Diabetic patients often suffer higher orthopedic implant failure rates due to high blood sugar causing inflammation and oxidative stress.While molecular hydrogen(H_(2))shows anti-inflammatory and antioxidant promise,c...Diabetic patients often suffer higher orthopedic implant failure rates due to high blood sugar causing inflammation and oxidative stress.While molecular hydrogen(H_(2))shows anti-inflammatory and antioxidant promise,current delivery methods lack precision for sustained implantsite treatment.A collaborative team led by Prof.展开更多
Objective:To investigate the clinical efficacy of the Shaoyang Zhugu Formula based on the“Shaoyang Governing Bones”theory in treating residual pain after vertebroplasty.Methods:A total of 60 outpatients and inpatien...Objective:To investigate the clinical efficacy of the Shaoyang Zhugu Formula based on the“Shaoyang Governing Bones”theory in treating residual pain after vertebroplasty.Methods:A total of 60 outpatients and inpatients from the Second Orthopedics Ward and Preventive Treatment Center of Chuxiong Prefecture Hospital of Traditional Chinese Medicine between January 2024 and December 2024 were selected and randomly divided into a control group(celecoxib capsules,30 cases)and an observation group(Shaoyang Zhugu Formula+celecoxib capsules,30 cases)using a lottery method.Postoperative pain levels,TCM symptom scores,Japanese Orthopaedic Association(JOA)scores for the lumbar spine,and adverse reactions were compared between the two groups.Results:The observation group showed better pain relief than the control group(P<0.05).The TCM symptom efficacy in the observation group was superior to that of the control group(P<0.05).After two treatment courses,both groups exhibited improved JOA scores,but the observation group demonstrated significantly better postoperative JOA scores(P<0.05).Additionally,the observation group had fewer adverse reactions(P<0.05).Conclusion:The Shaoyang Zhugu Formula,based on the“Shaoyang Governing Bones”theory,effectively alleviates residual pain after vertebroplasty,improves TCM symptoms and lumbar function,and demonstrates high safety.展开更多
Introduction: Pseudarthrosis (PSA) of the diaphysis of long bones still remains a current problem, despite improvements in the treatment of these fractures. Our study aims to study the epidemiological and therapeutic ...Introduction: Pseudarthrosis (PSA) of the diaphysis of long bones still remains a current problem, despite improvements in the treatment of these fractures. Our study aims to study the epidemiological and therapeutic aspects of PSA of the diaphysis of long bones. Method: This retrospective work concerns 30 cases of non-union of the diaphysis of long bones treated in the orthopedic and trauma surgery department at Donka National Hospital, during a period of 18 months from January 1, 2019 to June 30, 2020. Results: We recruited 30 patients, 80% of whom were male, with an average age of 39.9 years. Public road accidents (AVP) represented the main cause of fractures of the diaphysis of long bones 87%, they were open in 25 cases or 83%. The fractures were located in the middle 1/3 of the diaphysis of the long bones in 50% of cases. Treatment of initial fractures was traditional in 21 cases, orthopedic in 2 cases and surgical in 7 cases. It was aseptic nonunion in 28 cases (93%) and septic nonunion in 2 cases. They were hypertrophic in 7 cases, slightly hypertrophic in 5 cases, oligotrophic in 11 cases, atrophic in 6 cases and with bone defect in 1 case. The treatment was based on osteosynthesis including 16 cases of screwed “PV” plate: 7 cases of centromedullary “ECM” nailing, 2 cases of external fixator, 1 case of broaching and 4 cases of Plastering. The results according to ASAMI criteria on an anatomical level were excellent in 19 cases, good in 3 cases and poor in 3 cases, with a union rate of 76%. And 5 patients undergoing consolidation. Conclusion: Based on the literature data and the experience of our department, the true treatment of PSA requires correct management of the initial fracture without forgetting the interest in preventing AVP which appears to be an element essential, making it possible to reduce the incidence of fractures of the diaphysis.展开更多
After Hurricane Katrina in 2005,literary works related to such a crisis sprouted the southern America,which are known as Post-Katrina Literature.This thesis,taking Salvage the Bones and The Not Yet as examples,scrutin...After Hurricane Katrina in 2005,literary works related to such a crisis sprouted the southern America,which are known as Post-Katrina Literature.This thesis,taking Salvage the Bones and The Not Yet as examples,scrutinizes how writers respond to the Post-Katrina environmental crisis in different ways.In Salvage the Bones,Jesmyn Ward employs a biographical genre to record the Katrina disaster,thereby,writings serving as a way of healing the psychic trauma of the writer herself;and in The Not Yet,Moira Crone presents a post-natural world by the employment of the Cli-Fi genre.Both writers enrich the tradition of Southern literature as well as American eco-literature.展开更多
Objective: To investigate the effectiveness of the plate screw internal fixation technique on the clinical outcomes of patients with traumatic fractures of long bones in the lower extremities. Methods: From January 20...Objective: To investigate the effectiveness of the plate screw internal fixation technique on the clinical outcomes of patients with traumatic fractures of long bones in the lower extremities. Methods: From January 2022 to December 2023, 70 patients with traumatic fractures of long bones in the lower extremities were admitted to the hospital and randomly divided into two groups: the control group and the observation group, each consisting of 35 cases. The control group underwent traditional closed interlocking intramedullary nailing, while the observation group received internal fixation with steel plates and screws. Relevant surgical indicators, treatment effectiveness, and postoperative complication rates were compared between the two groups. Results: The observation group exhibited significantly short surgical duration (80.65 ± 5.01 vs. 88.36 ± 5.26 minutes), fracture healing time (13.27 ± 0.32 vs. 15.52 ± 0.48 weeks), and hospitalization days (10.49 ± 1.13 vs. 16.57 ± 1.15 days) compared to the control group (P = 0.000). The effective treatment rate was significantly higher in the observation group (29/82.86%) than in the control group (21/60.00%), with a significant difference observed (χ2 = 4.480, P = 0.034). Additionally, the complication rate in the observation group (2/5.71%) was significantly lower than that in the control group (8/22.86%), with a correlated difference (χ2 = 4.200, P = 0.040). Conclusion: The plate screw internal fixation technique demonstrates significant clinical efficacy in treating traumatic fractures of long bones in the lower extremities. It improves the healing rate, reduces complications, and represents a safe and effective treatment strategy worthy of widespread use and application.展开更多
Ovine bones are the major by-products after slaughtered. The present study was conducted to extract and characterize acid soluble collagens （ASC） and pepsin soluble collagens （PSC） from ovine bones （Ujumuqin shee...Ovine bones are the major by-products after slaughtered. The present study was conducted to extract and characterize acid soluble collagens （ASC） and pepsin soluble collagens （PSC） from ovine bones （Ujumuqin sheep）. Ovine bones collagen were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE） and liquid chromatography-tan- dem mass spectrometry （LC-MS/MS） as type I collagen. The results of Fourier transform infrared （FTIR） spectra analysis testified the existence of triple superhelical structure in both ASC and PSC, showing pepsin did not disrupt the triple helical structure of ovine bones collagen. Glycine, accounting for one-third of total amino acids, was the major amino acid for ovine bones collagen. Higher imino acid content was responsible for higher thermal denaturation temperature of ovine bones collagen compared to fish collagens. The isoelectric point of ASC was lower than PSC due to the higher content of acidic amino acids. Therefore, this study provides the potential reference for collagen extraction and application of ovine bones by-procduct.展开更多
Objective To investigate the effect of oral administration of arginine on linear growth of long bones in male pubertal rats and the underlying mechanisms, focusing on expression of genes related to the hypothalamus-pi...Objective To investigate the effect of oral administration of arginine on linear growth of long bones in male pubertal rats and the underlying mechanisms, focusing on expression of genes related to the hypothalamus-pituitary growth axis and the nitric oxide （NO）-cyclic guanosine monophosphate （cGMP） pathway. Methods Rats were randomly divided into control and intervention groups. In the intervention group, arginine was solved in water （0.045 g L-arginine was mixed with 1 mL water） and administered in rats （10 mL/kg） through gastric perfusion once per day, for totally 28 d. Rats in the control group received normal saline treatment. Bone histomorphometry analysis was used to measure growth plate width and mineral apposition rate of the tibia, as well as trabecular bone volume fraction, osteoblast surface and osteo- clast surface of the femur. Serum growth hormone （GH） concentration was determined by radioimmunoassay. Real-time PCR was used to measure the expression of neuronal nitric oxide synthase （nNOS）, soluble guanylyl cyclases （sGCal and sGCfll）, growth hormone-releasing hormone （Ghrh） and somatostatin （SS） in hypothalamus, as well as Gh in pituitary. Western blot was used to detect the protein levels ofnNOS, sGCα1 and sGCβ1 in hypothalamus. Results After treat- ment with arginine, the growth plate width of tibia and osteoblast surface of femur were increased （P 〈 0.05）, and serum GH concentration was elevated （P 〈 0.05）. Besides, mRNA and protein levels ofnNOS and sGCα1 （P 〈 0.05）, as well as the expression of Gh mRNA （P 〈 0.01）, were significantly up-regulated, while the expression of SS mRNA was down- regulated （P 〈 0.05）. Conclusion Oral administration ofarginine could improve linear growth of long bones by regulating mRNA expression of SS and Gh and inducing GH secretion, possibly via nNOS-NO-sGC-cGMP signal transduction pathway.展开更多
A case of florid reactive periostitis ossificans(RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less than 100 cases have been described in the litera...A case of florid reactive periostitis ossificans(RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less than 100 cases have been described in the literature with far fewer outside the bones of the hand, feet, fingers, and toes. Although the etiology is unknown, a relationship to preceding trauma is suggested. The imaging and histologic features show an overlap with other bone lesions including bizarre parosteal osteochondromatous proliferation, subungual exostosis, and malignant surface tumors of bone and cartilage which include, periosteal and parosteal osteosarcoma. It is important to recognize the clinical presentation and diagnostic features of RPO as a benign entity so that it is not mistaken for a more aggressive neoplasm. We present a case of a right distal humeral lesion that on histopathological review revealed florid RPO. This diagnosis was not suspected on imaging studies, but was made on open biopsy of the mass. The patient remains disease free, years postoperatively. In addition to presenting this unique case report, we review the pertinent literature, and offer a differential diagnosis and treatment strategy for its management.展开更多
Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment,which can not only efficiently against tumor,but also can offer precise treatment window and real-time monitoring of the treatment ...Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment,which can not only efficiently against tumor,but also can offer precise treatment window and real-time monitoring of the treatment efficiency.In our work,polydopamine(PDA)-coated gold nanobones(AuNBs@PDA nanocomplexes)were designed for this approach.The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared(NIR)region and higher photothermal conversion efficiency(75.48%)than gold nanobones alone,which was facilitated for photoacoustic imaging and photothermal therapy.Besides,the loading efficiency of doxorubicin(DOX)by AuNBs@PDA nanocomplexes could be up to about 70%and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation,which makes them become the excellent nano-carrier for the delivery of chemotherapy drug.In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects.Meanwhile,the nanoplatform was also successfully employed for computed tomography(CT)imaging,attributing to the high atomic number and high X-ray attenuation coefficient of gold.Therefore,we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer.展开更多
The Salp Swarm Algorithm(SSA)may have trouble in dropping into stagnation as a kind of swarm intelligence method.This paper developed an adaptive barebones salp swarm algorithm with quasi-oppositional-based learning t...The Salp Swarm Algorithm(SSA)may have trouble in dropping into stagnation as a kind of swarm intelligence method.This paper developed an adaptive barebones salp swarm algorithm with quasi-oppositional-based learning to compensate for the above weakness called QBSSA.In the proposed QBSSA,an adaptive barebones strategy can help to reach both accurate convergence speed and high solution quality;quasi-oppositional-based learning can make the population away from traping into local optimal and expand the search space.To estimate the performance of the presented method,a series of tests are performed.Firstly,CEC 2017 benchmark test suit is used to test the ability to solve the high dimensional and multimodal problems;then,based on QBSSA,an improved Kernel Extreme Learning Machine(KELM)model,named QBSSA–KELM,is built to handle medical disease diagnosis problems.All the test results and discussions state clearly that the QBSSA is superior to and very competitive to all the compared algorithms on both convergence speed and solutions accuracy.展开更多
In the prosthetic socket design, aimed at the high cost and radiation deficiency caused by CT scanning which is a routine technique to obtain the cross-sectional image of the residual limb, a new ultrasonic scanning m...In the prosthetic socket design, aimed at the high cost and radiation deficiency caused by CT scanning which is a routine technique to obtain the cross-sectional image of the residual limb, a new ultrasonic scanning method is developed to acquire the bones and skin contours of the residual limb. Using a pig fore-leg as the scanning object, an overlapping algorithm is designed to reconstruct the 2D cross-sectional image, the contours of the bone and skin are extracted using edge detection algorithm and the 3D model of the pig fore-leg is reconstructed by using reverse engineering technology. The results of checking the accuracy of the image by scanning a cylinder work pieces show that the extracted contours of the cylinder are quite close to the standard circumference. So it is feasible to get the contours of bones and skin by ultrasonic scanning. The ultrasonic scanning system featuring no radiation and low cost is a kind of new means of cross section scanning for medical images.展开更多
美国作家捷思名·伍尔德的作品《salvage the bones》以其别具一格的叙事角度、"黑人性"之语言、自传之内容和断续的叙事方法,形象地描绘了美国南方农村社会下层黑人的穷困生活以及黑人们的生活体验,展示了美国社会仍然...美国作家捷思名·伍尔德的作品《salvage the bones》以其别具一格的叙事角度、"黑人性"之语言、自传之内容和断续的叙事方法,形象地描绘了美国南方农村社会下层黑人的穷困生活以及黑人们的生活体验,展示了美国社会仍然存在种族主义且给黑人群体有巨大伤害的真实社会状况。展开更多
The Lovely Bones written by Alice Sebold is about a 14-year-old girl Susie who,as a ghost,tells her story as well as her family's after her death.Tiffs paper focuses on the characteristics of the first-person retr...The Lovely Bones written by Alice Sebold is about a 14-year-old girl Susie who,as a ghost,tells her story as well as her family's after her death.Tiffs paper focuses on the characteristics of the first-person retrospective narrative in The Lovely Bones.Firstly,this paper introduces the story,the double focalizations of the first--person retrospective narrative and the purpose of the paper.It then discusses the three functions of the first-person retrospective narrative:enhancing authenticity,intensifying intimacy and contributing to the love theme of the story.Besides,the thesis points out the limitation of the first-person retrospective narrative:monotonous.Therefore,a shift of the narrative perspective is put forwards as the solution to the problem.展开更多
A data-driven method was proposed to realistically animate garments on human poses in reduced space. Firstly, a gradient based method was extended to generate motion sequences and garments were simulated on the sequen...A data-driven method was proposed to realistically animate garments on human poses in reduced space. Firstly, a gradient based method was extended to generate motion sequences and garments were simulated on the sequences as our training data. Based on the examples, the proposed method can fast output realistic garments on new poses. Our framework can be mainly divided into offline phase and online phase. During the offline phase, based on linear blend skinning(LBS), rigid bones and flex bones were estimated for human bodies and garments, respectively. Then, rigid bone weight maps on garment vertices were learned from examples. In the online phase, new human poses were treated as input to estimate rigid bone transformations. Then, both rigid bones and flex bones were used to drive garments to fit the new poses. Finally, a novel formulation was also proposed to efficiently deal with garment-body penetration. Experiments manifest that our method is fast and accurate. The intersection artifacts are fast removed and final garment results are quite realistic.展开更多
Background: Rapid urbanization and increasing fleet in low-income countries are the basis of the higher rate of trauma and fractures. In a post conflict environment, the abnormal movement of firearms and poverty from ...Background: Rapid urbanization and increasing fleet in low-income countries are the basis of the higher rate of trauma and fractures. In a post conflict environment, the abnormal movement of firearms and poverty from them may change the configuration’s epidemiological, anatomical and clinical fractures of the limbs bones as well as their care. Goal: To make an inventory on the fractures of the limb bones in Bukavu town, a town in post armed conflict. Method: This work is transversal, retrospective and descriptive on 500 fractures of the limbs bones recorded on a period of 3 months from 1st June to 31st August 2013. Twenty investigators went around different places of Bukavu town to interview and complete a research protocol ad hoc. In total, we recorded 500 subjects with 570 fractures of the limb bones. Results: The average age is 29.4 years old and 37% are male fractured. The main circumstances of occurrence of the fracture of the limbs bones are the falls (31.7%), firearms (22.2%) followed closely by road traffic accidents (21.9%). Students (38.6%) and the unemployed (29.4%) are most victims’ fractures of limb bones. The forearm bones (31.7%) and leg bones (27.2%) are most concerned, 52.2% fractured turned to modern medicine against 41.8% for traditional medicine. Conclusion: The fractures of the limbs bones in Bukavu mainly concern young male subjects. They occur with the waning of a fall and preferentially affect the bones of the forearm. Good governance would reduce the incidence of fractures of the limbs bones and their assessment.展开更多
Brachydactyly is a general term that refers to disproportionately short fingers and toes and forms a part of the group of limb malformations characterized by bone dysostosis. Brachydactyly usually occurs either as an ...Brachydactyly is a general term that refers to disproportionately short fingers and toes and forms a part of the group of limb malformations characterized by bone dysostosis. Brachydactyly usually occurs either as an isolated malformation or as a part of a complex malformation syndrome. Brachydactyly is classified as types A, B, C, D, or E;brachymetatarsus IV;Sugarman brachydactyly;or Kirner deformity. Various types of isolated brachydactyly are rare, except for types A3 and D. We describe a 15-year-old girl with isolated brachyphalangism of the basal finger bones of the little finger with symptoms of tenosynovitis. Tenosynovitis might be caused by growth deviation between the flexor digitorum superficialis and the flexor digitorum profundus. The patient responded very well to surgical treatment.展开更多
The use of computed microtomography （p.CT） has revolutionized many areas of research, such as noninvasive, fast and high precision techniques, which allows immediate visualization of internal structures without any ...The use of computed microtomography （p.CT） has revolutionized many areas of research, such as noninvasive, fast and high precision techniques, which allows immediate visualization of internal structures without any risk to the object of study. ~tCT is widely accepted for medical diagnostics, is also important for purposes of zoological research and paleontological. In this work, we used the μCT to investigate the internal structure of bones from mammalian and poultry. We studied the bones of rats and quail. Through microtomography images, we observed that the bones of the poultry have a bony structure in the form of a trellis that is not present in bones of mammals. These trellises bony is an evolutionary adaptation that allowed the bones of the birds to become longer and lighter maintaining its strength. It was also observed that the percentage of the trabecular area in poultry is almost half of that observed in mammals. The results obtained validate the use of μCT as a technique that allows the study of bone structures in small samples, enabling to explore the morphological differences between the bones of those species.展开更多
Age of African pike Hepsetus odoe from Ado Ekiti Reservoir Ekiti State, Nigeria was studied. Annuli on the opercula bones and scales were used to determine the age. The standard length of specimens examined varied bet...Age of African pike Hepsetus odoe from Ado Ekiti Reservoir Ekiti State, Nigeria was studied. Annuli on the opercula bones and scales were used to determine the age. The standard length of specimens examined varied between 12.50 and 29.80 cm and body weight 10-385 g. Annuli （growth rings） observed on the opercula bones of specimens with mean standard lengths 21.70 ± 1.4 cm had one real annulus, 24.80 ± 1.1 cm had two real annuli, 27.4 ± 0.9 cm had three real annuli indicating age one, two, and three （1 ＋, 2＋, 3＋ ） respectively. Growth rings observed on scales appeared as interruptions in the normal pattems of scales. Specimens with mean standard lengths of 21.3 ± 1.5 cm, 24.7 ± 0.8 cm and 27.35 ± 11 cm were interpreted to be ages 1＋, 2＋, and 3＋ respectively. The maximum age of samples, derived from annuli on both opercula bones and scales was 3 years. Specimens below 18 cm standard length did not register any growth mark. The mean lengths at the estimated ages obtained using both opercula bones and scales were not significantly different （P 〉 0.05, P 〉 0.01）.展开更多
文摘Diabetic patients often suffer higher orthopedic implant failure rates due to high blood sugar causing inflammation and oxidative stress.While molecular hydrogen(H_(2))shows anti-inflammatory and antioxidant promise,current delivery methods lack precision for sustained implantsite treatment.A collaborative team led by Prof.
基金Therapeutic Effect of Shaoyang Zhugu Formula on Residual Pain After Vertebroplasty Based on the Theory of Shaoyang Governing Bones(Project No.:XYLH202369)。
文摘Objective:To investigate the clinical efficacy of the Shaoyang Zhugu Formula based on the“Shaoyang Governing Bones”theory in treating residual pain after vertebroplasty.Methods:A total of 60 outpatients and inpatients from the Second Orthopedics Ward and Preventive Treatment Center of Chuxiong Prefecture Hospital of Traditional Chinese Medicine between January 2024 and December 2024 were selected and randomly divided into a control group(celecoxib capsules,30 cases)and an observation group(Shaoyang Zhugu Formula+celecoxib capsules,30 cases)using a lottery method.Postoperative pain levels,TCM symptom scores,Japanese Orthopaedic Association(JOA)scores for the lumbar spine,and adverse reactions were compared between the two groups.Results:The observation group showed better pain relief than the control group(P<0.05).The TCM symptom efficacy in the observation group was superior to that of the control group(P<0.05).After two treatment courses,both groups exhibited improved JOA scores,but the observation group demonstrated significantly better postoperative JOA scores(P<0.05).Additionally,the observation group had fewer adverse reactions(P<0.05).Conclusion:The Shaoyang Zhugu Formula,based on the“Shaoyang Governing Bones”theory,effectively alleviates residual pain after vertebroplasty,improves TCM symptoms and lumbar function,and demonstrates high safety.
文摘Introduction: Pseudarthrosis (PSA) of the diaphysis of long bones still remains a current problem, despite improvements in the treatment of these fractures. Our study aims to study the epidemiological and therapeutic aspects of PSA of the diaphysis of long bones. Method: This retrospective work concerns 30 cases of non-union of the diaphysis of long bones treated in the orthopedic and trauma surgery department at Donka National Hospital, during a period of 18 months from January 1, 2019 to June 30, 2020. Results: We recruited 30 patients, 80% of whom were male, with an average age of 39.9 years. Public road accidents (AVP) represented the main cause of fractures of the diaphysis of long bones 87%, they were open in 25 cases or 83%. The fractures were located in the middle 1/3 of the diaphysis of the long bones in 50% of cases. Treatment of initial fractures was traditional in 21 cases, orthopedic in 2 cases and surgical in 7 cases. It was aseptic nonunion in 28 cases (93%) and septic nonunion in 2 cases. They were hypertrophic in 7 cases, slightly hypertrophic in 5 cases, oligotrophic in 11 cases, atrophic in 6 cases and with bone defect in 1 case. The treatment was based on osteosynthesis including 16 cases of screwed “PV” plate: 7 cases of centromedullary “ECM” nailing, 2 cases of external fixator, 1 case of broaching and 4 cases of Plastering. The results according to ASAMI criteria on an anatomical level were excellent in 19 cases, good in 3 cases and poor in 3 cases, with a union rate of 76%. And 5 patients undergoing consolidation. Conclusion: Based on the literature data and the experience of our department, the true treatment of PSA requires correct management of the initial fracture without forgetting the interest in preventing AVP which appears to be an element essential, making it possible to reduce the incidence of fractures of the diaphysis.
文摘After Hurricane Katrina in 2005,literary works related to such a crisis sprouted the southern America,which are known as Post-Katrina Literature.This thesis,taking Salvage the Bones and The Not Yet as examples,scrutinizes how writers respond to the Post-Katrina environmental crisis in different ways.In Salvage the Bones,Jesmyn Ward employs a biographical genre to record the Katrina disaster,thereby,writings serving as a way of healing the psychic trauma of the writer herself;and in The Not Yet,Moira Crone presents a post-natural world by the employment of the Cli-Fi genre.Both writers enrich the tradition of Southern literature as well as American eco-literature.
文摘Objective: To investigate the effectiveness of the plate screw internal fixation technique on the clinical outcomes of patients with traumatic fractures of long bones in the lower extremities. Methods: From January 2022 to December 2023, 70 patients with traumatic fractures of long bones in the lower extremities were admitted to the hospital and randomly divided into two groups: the control group and the observation group, each consisting of 35 cases. The control group underwent traditional closed interlocking intramedullary nailing, while the observation group received internal fixation with steel plates and screws. Relevant surgical indicators, treatment effectiveness, and postoperative complication rates were compared between the two groups. Results: The observation group exhibited significantly short surgical duration (80.65 ± 5.01 vs. 88.36 ± 5.26 minutes), fracture healing time (13.27 ± 0.32 vs. 15.52 ± 0.48 weeks), and hospitalization days (10.49 ± 1.13 vs. 16.57 ± 1.15 days) compared to the control group (P = 0.000). The effective treatment rate was significantly higher in the observation group (29/82.86%) than in the control group (21/60.00%), with a significant difference observed (χ2 = 4.480, P = 0.034). Additionally, the complication rate in the observation group (2/5.71%) was significantly lower than that in the control group (8/22.86%), with a correlated difference (χ2 = 4.200, P = 0.040). Conclusion: The plate screw internal fixation technique demonstrates significant clinical efficacy in treating traumatic fractures of long bones in the lower extremities. It improves the healing rate, reduces complications, and represents a safe and effective treatment strategy worthy of widespread use and application.
基金funded by the emarked fund for China Agriculture Research System (CARS-39)the National Agricultural Science and Technology Innovation Program
文摘Ovine bones are the major by-products after slaughtered. The present study was conducted to extract and characterize acid soluble collagens （ASC） and pepsin soluble collagens （PSC） from ovine bones （Ujumuqin sheep）. Ovine bones collagen were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE） and liquid chromatography-tan- dem mass spectrometry （LC-MS/MS） as type I collagen. The results of Fourier transform infrared （FTIR） spectra analysis testified the existence of triple superhelical structure in both ASC and PSC, showing pepsin did not disrupt the triple helical structure of ovine bones collagen. Glycine, accounting for one-third of total amino acids, was the major amino acid for ovine bones collagen. Higher imino acid content was responsible for higher thermal denaturation temperature of ovine bones collagen compared to fish collagens. The isoelectric point of ASC was lower than PSC due to the higher content of acidic amino acids. Therefore, this study provides the potential reference for collagen extraction and application of ovine bones by-procduct.
文摘Objective To investigate the effect of oral administration of arginine on linear growth of long bones in male pubertal rats and the underlying mechanisms, focusing on expression of genes related to the hypothalamus-pituitary growth axis and the nitric oxide （NO）-cyclic guanosine monophosphate （cGMP） pathway. Methods Rats were randomly divided into control and intervention groups. In the intervention group, arginine was solved in water （0.045 g L-arginine was mixed with 1 mL water） and administered in rats （10 mL/kg） through gastric perfusion once per day, for totally 28 d. Rats in the control group received normal saline treatment. Bone histomorphometry analysis was used to measure growth plate width and mineral apposition rate of the tibia, as well as trabecular bone volume fraction, osteoblast surface and osteo- clast surface of the femur. Serum growth hormone （GH） concentration was determined by radioimmunoassay. Real-time PCR was used to measure the expression of neuronal nitric oxide synthase （nNOS）, soluble guanylyl cyclases （sGCal and sGCfll）, growth hormone-releasing hormone （Ghrh） and somatostatin （SS） in hypothalamus, as well as Gh in pituitary. Western blot was used to detect the protein levels ofnNOS, sGCα1 and sGCβ1 in hypothalamus. Results After treat- ment with arginine, the growth plate width of tibia and osteoblast surface of femur were increased （P 〈 0.05）, and serum GH concentration was elevated （P 〈 0.05）. Besides, mRNA and protein levels ofnNOS and sGCα1 （P 〈 0.05）, as well as the expression of Gh mRNA （P 〈 0.01）, were significantly up-regulated, while the expression of SS mRNA was down- regulated （P 〈 0.05）. Conclusion Oral administration ofarginine could improve linear growth of long bones by regulating mRNA expression of SS and Gh and inducing GH secretion, possibly via nNOS-NO-sGC-cGMP signal transduction pathway.
基金Supported by The University of Alabama at Birmingham,Alabama and The Orthopaedic Center,Birmingham,AL,United States
文摘A case of florid reactive periostitis ossificans(RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less than 100 cases have been described in the literature with far fewer outside the bones of the hand, feet, fingers, and toes. Although the etiology is unknown, a relationship to preceding trauma is suggested. The imaging and histologic features show an overlap with other bone lesions including bizarre parosteal osteochondromatous proliferation, subungual exostosis, and malignant surface tumors of bone and cartilage which include, periosteal and parosteal osteosarcoma. It is important to recognize the clinical presentation and diagnostic features of RPO as a benign entity so that it is not mistaken for a more aggressive neoplasm. We present a case of a right distal humeral lesion that on histopathological review revealed florid RPO. This diagnosis was not suspected on imaging studies, but was made on open biopsy of the mass. The patient remains disease free, years postoperatively. In addition to presenting this unique case report, we review the pertinent literature, and offer a differential diagnosis and treatment strategy for its management.
基金financially supported by the National Key R&D Program of China(No.2018YFB1105700)the National Natural Science Foundation of China(Nos.81902913,81930048 and 81627805)+9 种基金the Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars(No.2020B1515020027)the Fundamental Research Funds for the Central Universities(No.19ykpy108)the Natural Science Foundation of Jiangsu Province(No.BK20190821)the Postdoctoral Science Foundation of China(No.2019M651953)the Open Project Program of the State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK1201909)the Guangdong Science and Technology Department(No.2020B1212060018)the Science and Technology Project from Suzhou City Commission of Health and Family Planning(No.LCZX201712)the grants from Guangzhou Science and Technology Bureau(202002020070,201902020015)Opening Foundation of Hubei Province Key Laboratory of Molecular Imaginga Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment,which can not only efficiently against tumor,but also can offer precise treatment window and real-time monitoring of the treatment efficiency.In our work,polydopamine(PDA)-coated gold nanobones(AuNBs@PDA nanocomplexes)were designed for this approach.The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared(NIR)region and higher photothermal conversion efficiency(75.48%)than gold nanobones alone,which was facilitated for photoacoustic imaging and photothermal therapy.Besides,the loading efficiency of doxorubicin(DOX)by AuNBs@PDA nanocomplexes could be up to about 70%and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation,which makes them become the excellent nano-carrier for the delivery of chemotherapy drug.In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects.Meanwhile,the nanoplatform was also successfully employed for computed tomography(CT)imaging,attributing to the high atomic number and high X-ray attenuation coefficient of gold.Therefore,we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer.
基金supported by the National Natural Science Foundation of China(62076185,U1809209)supported by Zhejiang Provincial Natural Science Foundation of China(LY21F020030)+1 种基金Wenzhou Major Scientific and Technological Innovation Project(ZY2019019)Wenzhou Science and Technology Bureau(2018ZG016)。
文摘The Salp Swarm Algorithm(SSA)may have trouble in dropping into stagnation as a kind of swarm intelligence method.This paper developed an adaptive barebones salp swarm algorithm with quasi-oppositional-based learning to compensate for the above weakness called QBSSA.In the proposed QBSSA,an adaptive barebones strategy can help to reach both accurate convergence speed and high solution quality;quasi-oppositional-based learning can make the population away from traping into local optimal and expand the search space.To estimate the performance of the presented method,a series of tests are performed.Firstly,CEC 2017 benchmark test suit is used to test the ability to solve the high dimensional and multimodal problems;then,based on QBSSA,an improved Kernel Extreme Learning Machine(KELM)model,named QBSSA–KELM,is built to handle medical disease diagnosis problems.All the test results and discussions state clearly that the QBSSA is superior to and very competitive to all the compared algorithms on both convergence speed and solutions accuracy.
基金This project is supported by National Hi-tech Research and Development Program of China(863 Program, No.2002AA421130)Excellent Doctoral Dissertation Fund(No.200026).
文摘In the prosthetic socket design, aimed at the high cost and radiation deficiency caused by CT scanning which is a routine technique to obtain the cross-sectional image of the residual limb, a new ultrasonic scanning method is developed to acquire the bones and skin contours of the residual limb. Using a pig fore-leg as the scanning object, an overlapping algorithm is designed to reconstruct the 2D cross-sectional image, the contours of the bone and skin are extracted using edge detection algorithm and the 3D model of the pig fore-leg is reconstructed by using reverse engineering technology. The results of checking the accuracy of the image by scanning a cylinder work pieces show that the extracted contours of the cylinder are quite close to the standard circumference. So it is feasible to get the contours of bones and skin by ultrasonic scanning. The ultrasonic scanning system featuring no radiation and low cost is a kind of new means of cross section scanning for medical images.
文摘The Lovely Bones written by Alice Sebold is about a 14-year-old girl Susie who,as a ghost,tells her story as well as her family's after her death.Tiffs paper focuses on the characteristics of the first-person retrospective narrative in The Lovely Bones.Firstly,this paper introduces the story,the double focalizations of the first--person retrospective narrative and the purpose of the paper.It then discusses the three functions of the first-person retrospective narrative:enhancing authenticity,intensifying intimacy and contributing to the love theme of the story.Besides,the thesis points out the limitation of the first-person retrospective narrative:monotonous.Therefore,a shift of the narrative perspective is put forwards as the solution to the problem.
基金Project(20104307110003)supported by the Research Fund for the Doctoral Program of Higher Education of ChinaProjects(61379103,61202333,61303185)supported by the National Natural Science Foundation of China+1 种基金Project(2012M520392)supported by the China Postdoctoral Science FoundationProject(CX2012B027)supported by the Hunan Province Graduate Student Innovation Program,China
文摘A data-driven method was proposed to realistically animate garments on human poses in reduced space. Firstly, a gradient based method was extended to generate motion sequences and garments were simulated on the sequences as our training data. Based on the examples, the proposed method can fast output realistic garments on new poses. Our framework can be mainly divided into offline phase and online phase. During the offline phase, based on linear blend skinning(LBS), rigid bones and flex bones were estimated for human bodies and garments, respectively. Then, rigid bone weight maps on garment vertices were learned from examples. In the online phase, new human poses were treated as input to estimate rigid bone transformations. Then, both rigid bones and flex bones were used to drive garments to fit the new poses. Finally, a novel formulation was also proposed to efficiently deal with garment-body penetration. Experiments manifest that our method is fast and accurate. The intersection artifacts are fast removed and final garment results are quite realistic.
文摘Background: Rapid urbanization and increasing fleet in low-income countries are the basis of the higher rate of trauma and fractures. In a post conflict environment, the abnormal movement of firearms and poverty from them may change the configuration’s epidemiological, anatomical and clinical fractures of the limbs bones as well as their care. Goal: To make an inventory on the fractures of the limb bones in Bukavu town, a town in post armed conflict. Method: This work is transversal, retrospective and descriptive on 500 fractures of the limbs bones recorded on a period of 3 months from 1st June to 31st August 2013. Twenty investigators went around different places of Bukavu town to interview and complete a research protocol ad hoc. In total, we recorded 500 subjects with 570 fractures of the limb bones. Results: The average age is 29.4 years old and 37% are male fractured. The main circumstances of occurrence of the fracture of the limbs bones are the falls (31.7%), firearms (22.2%) followed closely by road traffic accidents (21.9%). Students (38.6%) and the unemployed (29.4%) are most victims’ fractures of limb bones. The forearm bones (31.7%) and leg bones (27.2%) are most concerned, 52.2% fractured turned to modern medicine against 41.8% for traditional medicine. Conclusion: The fractures of the limbs bones in Bukavu mainly concern young male subjects. They occur with the waning of a fall and preferentially affect the bones of the forearm. Good governance would reduce the incidence of fractures of the limbs bones and their assessment.
文摘Brachydactyly is a general term that refers to disproportionately short fingers and toes and forms a part of the group of limb malformations characterized by bone dysostosis. Brachydactyly usually occurs either as an isolated malformation or as a part of a complex malformation syndrome. Brachydactyly is classified as types A, B, C, D, or E;brachymetatarsus IV;Sugarman brachydactyly;or Kirner deformity. Various types of isolated brachydactyly are rare, except for types A3 and D. We describe a 15-year-old girl with isolated brachyphalangism of the basal finger bones of the little finger with symptoms of tenosynovitis. Tenosynovitis might be caused by growth deviation between the flexor digitorum superficialis and the flexor digitorum profundus. The patient responded very well to surgical treatment.
文摘The use of computed microtomography （p.CT） has revolutionized many areas of research, such as noninvasive, fast and high precision techniques, which allows immediate visualization of internal structures without any risk to the object of study. ~tCT is widely accepted for medical diagnostics, is also important for purposes of zoological research and paleontological. In this work, we used the μCT to investigate the internal structure of bones from mammalian and poultry. We studied the bones of rats and quail. Through microtomography images, we observed that the bones of the poultry have a bony structure in the form of a trellis that is not present in bones of mammals. These trellises bony is an evolutionary adaptation that allowed the bones of the birds to become longer and lighter maintaining its strength. It was also observed that the percentage of the trabecular area in poultry is almost half of that observed in mammals. The results obtained validate the use of μCT as a technique that allows the study of bone structures in small samples, enabling to explore the morphological differences between the bones of those species.
文摘Age of African pike Hepsetus odoe from Ado Ekiti Reservoir Ekiti State, Nigeria was studied. Annuli on the opercula bones and scales were used to determine the age. The standard length of specimens examined varied between 12.50 and 29.80 cm and body weight 10-385 g. Annuli （growth rings） observed on the opercula bones of specimens with mean standard lengths 21.70 ± 1.4 cm had one real annulus, 24.80 ± 1.1 cm had two real annuli, 27.4 ± 0.9 cm had three real annuli indicating age one, two, and three （1 ＋, 2＋, 3＋ ） respectively. Growth rings observed on scales appeared as interruptions in the normal pattems of scales. Specimens with mean standard lengths of 21.3 ± 1.5 cm, 24.7 ± 0.8 cm and 27.35 ± 11 cm were interpreted to be ages 1＋, 2＋, and 3＋ respectively. The maximum age of samples, derived from annuli on both opercula bones and scales was 3 years. Specimens below 18 cm standard length did not register any growth mark. The mean lengths at the estimated ages obtained using both opercula bones and scales were not significantly different （P 〉 0.05, P 〉 0.01）.
