Introduction:Obesity,particularly central adiposity,has been associated with elevated cancer risk.However,longitudinal data on adiposity trajectories and cancer incidence in Chinese populations remain limited.Methods:...Introduction:Obesity,particularly central adiposity,has been associated with elevated cancer risk.However,longitudinal data on adiposity trajectories and cancer incidence in Chinese populations remain limited.Methods:We analyzed data from 25,653 adults with≥10 health check-ups in the West China Hospital Alliance Longitudinal Epidemiology Wellness(WHALE)Study(2010–2023).Five adiposity indicators—body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),BMIadjusted WC(WCadjBMI),and BMI-adjusted WHR(WHRadjBMI)—were evaluated using Poisson regression and generalized linear mixed-effects models.Latent class mixed modeling identified long-term adiposity trajectories.Analyses were stratified by sex and age(≥50 years).Results:Over 14 years,393 participants developed cancer.Higher BMI[risk ratio(RR)=0.873,P=0.019]was associated with lower cancer risk,whereas central adiposity indicators(e.g.,WCadjBMI,RR=1.175,P=0.001)showed positive associations,particularly among men and those aged≥50 years.WCadjBMI was significantly associated with lung cancer(RR=1.246,P=0.009),with similar trends for breast and liver cancers.Inverted U-shaped trajectories of BMIadjusted waist measures were linked to elevated cancer risk,highlighting the relevance of long-term fat distribution.Conclusions:Central adiposity and its trajectories are associated with cancer risk in Chinese adults,supporting dynamic obesity monitoring and targeted prevention in older adults and men.展开更多
基金Supported by the National Natural Science Foundation of China(32471519)National Natural Science Foundation of China(32171285)the 1.3.5 project for Disciplines of Excellence from West China Hospital of Sichuan University(ZYGD23039).
文摘Introduction:Obesity,particularly central adiposity,has been associated with elevated cancer risk.However,longitudinal data on adiposity trajectories and cancer incidence in Chinese populations remain limited.Methods:We analyzed data from 25,653 adults with≥10 health check-ups in the West China Hospital Alliance Longitudinal Epidemiology Wellness(WHALE)Study(2010–2023).Five adiposity indicators—body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),BMIadjusted WC(WCadjBMI),and BMI-adjusted WHR(WHRadjBMI)—were evaluated using Poisson regression and generalized linear mixed-effects models.Latent class mixed modeling identified long-term adiposity trajectories.Analyses were stratified by sex and age(≥50 years).Results:Over 14 years,393 participants developed cancer.Higher BMI[risk ratio(RR)=0.873,P=0.019]was associated with lower cancer risk,whereas central adiposity indicators(e.g.,WCadjBMI,RR=1.175,P=0.001)showed positive associations,particularly among men and those aged≥50 years.WCadjBMI was significantly associated with lung cancer(RR=1.246,P=0.009),with similar trends for breast and liver cancers.Inverted U-shaped trajectories of BMIadjusted waist measures were linked to elevated cancer risk,highlighting the relevance of long-term fat distribution.Conclusions:Central adiposity and its trajectories are associated with cancer risk in Chinese adults,supporting dynamic obesity monitoring and targeted prevention in older adults and men.
