BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s...BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.展开更多
Background:The aim of this study was to investigate the influence of marking meth-ods on the outcomes of body composition analysis and provide guidance for the se-lection of marking methods in mouse body composition a...Background:The aim of this study was to investigate the influence of marking meth-ods on the outcomes of body composition analysis and provide guidance for the se-lection of marking methods in mouse body composition analysis.Methods:Male C57BL/6J mice aged 6 weeks were randomly assigned for pre-and post-ear tagging measurements.The body composition of the mice was measured using a small animal body composition analyzer,which provided measurements of the mass of fat,lean,and free fluid.Then,the mass of fat,lean and free fluid to body weight ratio was gained.Further data analysis was conducted to obtain the range and coeffi-cient of variation in body composition measurements for each mouse.The distribution of fat and lean tissue in the mice was also analyzed by comparing the fat-to-lean ratio.Results:(1)The mass of all body composition components in the ear tagging group was significantly lower than that in the control group.(2)There was a significant in-crease in the range and coefficient of variation of body composition measurements between the ear tagging group and the control group.(3)The fat-to-lean ratio in the ear tagging group was significantly lower than that in the control group.Conclusions:Ear tagging significantly lowered the results of body composition analy-sis in mice and higher the results of measurement error.Therefore,ear tagging should be avoided as much as possible when conducting body composition analysis experi-ments in mice.展开更多
Objective There is strong evidence that the body composition can affect the progression-free survival(PFS)and overall survival(OS)in patients with a variety of cancers.The main objective of this study was to investiga...Objective There is strong evidence that the body composition can affect the progression-free survival(PFS)and overall survival(OS)in patients with a variety of cancers.The main objective of this study was to investigate the effect of body composition on the prognosis of patients with advanced gastrointestinal and colorectal cancers who received first-line palliative chemotherapy.Methods Patients who were newly-diagnosed with advanced gastrointestinal or colorectal cancer and received standard first-line palliative chemotherapy from January 2017 to December 2018 were included in this retrospective study.An analysis of computed tomography images was performed to determine the skeletal muscle index(SMI),which reflects the skeletal muscle mass and skeletal muscle density(SMD)related to muscle strength.A Kaplan-Meier survival analysis and log-rank test were used to compare the survival relationships among groups stratified by the SMI,and a Cox proportional hazard model was used for a multivariate analysis.Results A total of 108 patients met the inclusion criteria,including 41 cases of gastric cancer,46 cases of left colorectal cancer,and 21 cases of right colon cancer.In patients with gastric cancer,the OS of women was significantly shorter than that of men.The OS of patients with a low SMI,low SMD,and low phase angle(PA)was significantly shorter than that of patients with high values(P≤0.05).In the multivariate analysis,the SMD was significantly associated with the patients'long-term survival[Hazard Ratio(HR)=0.904,95%CI:0.840~0.974,P=0.008].For patients with a low SMI and PA,the PFS was significantly shorter than that of patients with high values(P≤0.05).In patients with left colon cancer,the PA and SMD were both independent risk factors for a poorer long-term prognosis(HR=0.375,95%CI:=0.167~0.840,P=0.017;HR=0.887,95%CI:0.824~0.954,P=0.001).Among right colon cancer patients,the PFS and OS of those with a low SMD were significantly lower than those for patients with high values(P≤0.05).Conclusion The PA is an independent risk factor for the OS of left colon cancer patients;the SMD is an independent risk factor for the survival of patients with gastric cancer,left colon cancer,and right colon cancer.展开更多
Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patient...Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis.展开更多
Background and Objectives:Sarcopenia is the progressive loss of muscle mass and strength that can adversely affect an individual’s health and quality of life.The objective of this study was to evaluate the effectiven...Background and Objectives:Sarcopenia is the progressive loss of muscle mass and strength that can adversely affect an individual’s health and quality of life.The objective of this study was to evaluate the effectiveness of a combined nutritional and exercise intervention among older adults who were at risk of sarcopenia.Methods and Study Design:46 older adults were included in a 30±3 days intervention that combined oral nutritional supple ments with resistance exercise.Parameters were measured at baseline(day 0)and after intervention(day 30±3),including routine parameters of sarcopenia,blood tests,and body measurements.The ITT analysis method was used,and the data were analysed using paired t-tests/paired Wilcoxon test,and ANOVA.Results:Among the 46 participants,there were no significant changes in hip circumference(HC),muscle mass of both lower limbs,ap pendicular skeletal muscle mass index(ASMI),and hemoglobin(Hb)after intervention.However,both hand grip strength(GS)significantly increased,as did muscle mass of both upper limbs and the total muscle strength.Blood tests showed a slight increase in albumin(ALB)levels and a significant increase in 25-OH-D levels,while the waist(WC)and calf circumferences(CC)also increased significantly after intervention.Somatic motor per formance improved significantly in the 6-meter walk and 5 sit-ups tests.Conclusions:The combined nutritional and exercise intervention was feasible and effective in improving muscle mass and strength,especially in the up per limbs,as well as somatic motor performance among older adults at risk of sarcopenia.It could be beneficial among three stages of sarcopenia.展开更多
Background and Objectives:Elderly patients with chronic heart failure(CHF)are at high risk of malnutrition and sarcopenia.Therefore,nutritional screening,assessment,diagnosis,and management are particularly crucial fo...Background and Objectives:Elderly patients with chronic heart failure(CHF)are at high risk of malnutrition and sarcopenia.Therefore,nutritional screening,assessment,diagnosis,and management are particularly crucial for elderly CHF patients.Our study aims to investigate the nutritional status and the incidence characteristics and influencing factors of sarcopenia in elderly CHF patients.Methods and Study Design:A total of 122 elderly CHF patients admitted to The First Hospital of Hebei Medical University from March 2023 to January 2024 were enrolled.Within 24 hours after admission,demographic data,body composition analysis,nutritional status assessments,and laboratory parameter testing were conducted for all participants.Patients were divided into sarcopenia and non-sarcopenia groups.Results:A total of 122 patients were included,among whom 37(30.33%)were diagnosed with sarcopenia.The prevalence of malnutrition was significantly higher in sarcopenia group(p<0.05).Patients with sarcopenia exhibited lower levels of albumin and hemoglobin,along with elevated Interleukin-6(IL-6),Systemic Immune-Inflammation Index(SII),Neutrophil-to-Lymphocyte-Ratio(NLR),and Plateletto-Lymphocyte-Ratio(PLR)(p<0.05).Additionally,the sarcopenia group showed reduced fat-free mass,muscle mass,upper arm circumference,Phase Angle,and grip strength(p<0.05).Multivariate logistic regression analysis revealed that BMI,protein,mineral,and triceps skinfold thickness were protective factors for sarcopenia in elderly CHF patients,after adjusting for confounding factors.Conclusions:Elderly CHF patients exhibit a higher risk of malnutrition and sarcopenia.There exists a correlation between age/BMI/protein/mineral and sarcopenia.The presence of sarcopenia correlates with poorer body composition outcomes and elevated inflammatory markers.展开更多
基金Supported by Science and Technology Bureau of Quzhou,No.2022079.
文摘BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.
文摘Background:The aim of this study was to investigate the influence of marking meth-ods on the outcomes of body composition analysis and provide guidance for the se-lection of marking methods in mouse body composition analysis.Methods:Male C57BL/6J mice aged 6 weeks were randomly assigned for pre-and post-ear tagging measurements.The body composition of the mice was measured using a small animal body composition analyzer,which provided measurements of the mass of fat,lean,and free fluid.Then,the mass of fat,lean and free fluid to body weight ratio was gained.Further data analysis was conducted to obtain the range and coeffi-cient of variation in body composition measurements for each mouse.The distribution of fat and lean tissue in the mice was also analyzed by comparing the fat-to-lean ratio.Results:(1)The mass of all body composition components in the ear tagging group was significantly lower than that in the control group.(2)There was a significant in-crease in the range and coefficient of variation of body composition measurements between the ear tagging group and the control group.(3)The fat-to-lean ratio in the ear tagging group was significantly lower than that in the control group.Conclusions:Ear tagging significantly lowered the results of body composition analy-sis in mice and higher the results of measurement error.Therefore,ear tagging should be avoided as much as possible when conducting body composition analysis experi-ments in mice.
文摘Objective There is strong evidence that the body composition can affect the progression-free survival(PFS)and overall survival(OS)in patients with a variety of cancers.The main objective of this study was to investigate the effect of body composition on the prognosis of patients with advanced gastrointestinal and colorectal cancers who received first-line palliative chemotherapy.Methods Patients who were newly-diagnosed with advanced gastrointestinal or colorectal cancer and received standard first-line palliative chemotherapy from January 2017 to December 2018 were included in this retrospective study.An analysis of computed tomography images was performed to determine the skeletal muscle index(SMI),which reflects the skeletal muscle mass and skeletal muscle density(SMD)related to muscle strength.A Kaplan-Meier survival analysis and log-rank test were used to compare the survival relationships among groups stratified by the SMI,and a Cox proportional hazard model was used for a multivariate analysis.Results A total of 108 patients met the inclusion criteria,including 41 cases of gastric cancer,46 cases of left colorectal cancer,and 21 cases of right colon cancer.In patients with gastric cancer,the OS of women was significantly shorter than that of men.The OS of patients with a low SMI,low SMD,and low phase angle(PA)was significantly shorter than that of patients with high values(P≤0.05).In the multivariate analysis,the SMD was significantly associated with the patients'long-term survival[Hazard Ratio(HR)=0.904,95%CI:0.840~0.974,P=0.008].For patients with a low SMI and PA,the PFS was significantly shorter than that of patients with high values(P≤0.05).In patients with left colon cancer,the PA and SMD were both independent risk factors for a poorer long-term prognosis(HR=0.375,95%CI:=0.167~0.840,P=0.017;HR=0.887,95%CI:0.824~0.954,P=0.001).Among right colon cancer patients,the PFS and OS of those with a low SMD were significantly lower than those for patients with high values(P≤0.05).Conclusion The PA is an independent risk factor for the OS of left colon cancer patients;the SMD is an independent risk factor for the survival of patients with gastric cancer,left colon cancer,and right colon cancer.
基金Science and Technology Department of Jilin Provincial(No.3D5204167428 for Dr.Nan Ya Wang).
文摘Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis.
基金supported by China National Key R&D Pro gram during the 13th Five-year Plan Period(No.2020YFC2005605)China National Key R&D Program during the 13th Five-year Plan Period(No.2020YFC2005604)the Comprehensive intervention technology and product develop ment for sarcopenia in the elderly National Project of Multidis ciplinary Management of Major Diseases,2020.(No.2199000764).
文摘Background and Objectives:Sarcopenia is the progressive loss of muscle mass and strength that can adversely affect an individual’s health and quality of life.The objective of this study was to evaluate the effectiveness of a combined nutritional and exercise intervention among older adults who were at risk of sarcopenia.Methods and Study Design:46 older adults were included in a 30±3 days intervention that combined oral nutritional supple ments with resistance exercise.Parameters were measured at baseline(day 0)and after intervention(day 30±3),including routine parameters of sarcopenia,blood tests,and body measurements.The ITT analysis method was used,and the data were analysed using paired t-tests/paired Wilcoxon test,and ANOVA.Results:Among the 46 participants,there were no significant changes in hip circumference(HC),muscle mass of both lower limbs,ap pendicular skeletal muscle mass index(ASMI),and hemoglobin(Hb)after intervention.However,both hand grip strength(GS)significantly increased,as did muscle mass of both upper limbs and the total muscle strength.Blood tests showed a slight increase in albumin(ALB)levels and a significant increase in 25-OH-D levels,while the waist(WC)and calf circumferences(CC)also increased significantly after intervention.Somatic motor per formance improved significantly in the 6-meter walk and 5 sit-ups tests.Conclusions:The combined nutritional and exercise intervention was feasible and effective in improving muscle mass and strength,especially in the up per limbs,as well as somatic motor performance among older adults at risk of sarcopenia.It could be beneficial among three stages of sarcopenia.
基金funded by the Medical Science Research Project of Hebei(No.20250014)Young Elite Scientists Sponsorship Program by CAST(grant no.2022QNRC001).
文摘Background and Objectives:Elderly patients with chronic heart failure(CHF)are at high risk of malnutrition and sarcopenia.Therefore,nutritional screening,assessment,diagnosis,and management are particularly crucial for elderly CHF patients.Our study aims to investigate the nutritional status and the incidence characteristics and influencing factors of sarcopenia in elderly CHF patients.Methods and Study Design:A total of 122 elderly CHF patients admitted to The First Hospital of Hebei Medical University from March 2023 to January 2024 were enrolled.Within 24 hours after admission,demographic data,body composition analysis,nutritional status assessments,and laboratory parameter testing were conducted for all participants.Patients were divided into sarcopenia and non-sarcopenia groups.Results:A total of 122 patients were included,among whom 37(30.33%)were diagnosed with sarcopenia.The prevalence of malnutrition was significantly higher in sarcopenia group(p<0.05).Patients with sarcopenia exhibited lower levels of albumin and hemoglobin,along with elevated Interleukin-6(IL-6),Systemic Immune-Inflammation Index(SII),Neutrophil-to-Lymphocyte-Ratio(NLR),and Plateletto-Lymphocyte-Ratio(PLR)(p<0.05).Additionally,the sarcopenia group showed reduced fat-free mass,muscle mass,upper arm circumference,Phase Angle,and grip strength(p<0.05).Multivariate logistic regression analysis revealed that BMI,protein,mineral,and triceps skinfold thickness were protective factors for sarcopenia in elderly CHF patients,after adjusting for confounding factors.Conclusions:Elderly CHF patients exhibit a higher risk of malnutrition and sarcopenia.There exists a correlation between age/BMI/protein/mineral and sarcopenia.The presence of sarcopenia correlates with poorer body composition outcomes and elevated inflammatory markers.
