Two new triterpenoid glycosides, hederagenin-3-O-b-D-xylopyranoside (1), dodecandral 3-O-b-D-xylopyranoside(2), were isolated from Elsholtzia bodinieri Vant. The structures of 1 and 2 were established by spectroscopi...Two new triterpenoid glycosides, hederagenin-3-O-b-D-xylopyranoside (1), dodecandral 3-O-b-D-xylopyranoside(2), were isolated from Elsholtzia bodinieri Vant. The structures of 1 and 2 were established by spectroscopic and chemical methods.展开更多
Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one k...Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.展开更多
文摘Two new triterpenoid glycosides, hederagenin-3-O-b-D-xylopyranoside (1), dodecandral 3-O-b-D-xylopyranoside(2), were isolated from Elsholtzia bodinieri Vant. The structures of 1 and 2 were established by spectroscopic and chemical methods.
基金financially supported by the National Natural Science Foundation of China(Nos.81422046 and 21762048)the Yunnan Applicative and Basic Research Program(Nos.2015BC002,2018FY001 and 2018FA048)+4 种基金the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94)the Key Program of Natural Science of Yunnan Province to W.L.Xiaothe Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02)the Natural Science Foundation of Yunnan University(No.2017YDQN03)the Foundation of Yunnan Educational Committee(No.2018JS002)。
文摘Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.
