With the development of embodied cognitive science,the embodiment of human high-level psychological processes such as language and emotions has been paid more and more attention.The importance of body and situation in...With the development of embodied cognitive science,the embodiment of human high-level psychological processes such as language and emotions has been paid more and more attention.The importance of body and situation in the understanding of emotional experience is the core content of the embodied emotion.This article aims to review the current hypotheses and empirical evidence of embodied emotions,explains the significance and value of embodied emotion research,and thinks about the research prospects and research ideas of embodied emotion.At the same time,as a new theoretical point of view,emotional embodied view provides a new perspective for emotional research.展开更多
Under the influence of European rationalism,which holds that human rationality is higher than,or at least independent of human sensory cognition,the first generation of cognitive science advocates for disembodied cogn...Under the influence of European rationalism,which holds that human rationality is higher than,or at least independent of human sensory cognition,the first generation of cognitive science advocates for disembodied cognition,manifesting the concept of dualism of mind and body.With the development of cognitive science in the 1980s,the second generation of cognitive science redefines the relationship between mind and body,thought and behavior,and reason and feeling and puts forward the concept of embodied cognition,representing monism of mind and body.It is claimed that the formation of concepts,categorical cognition and the evolution of rational thinking are characterized by embodiment,which is the necessary condition and basis for the formation of human rationality.The current study traces the shift of cognitive science from dualism to monism of mind and body and explores the relationship between rationality and sensibility from the perspective of philosophical basis and interpretations,with an aim to achieve a better understanding and thorough interpretation of human rationality.In this heated discussion about embodied cognition,there are still some fundamental questions that need to be further clarified,such as the essence and mechanism of human cognition,the ways that human body participates in cognitive activities,especially imagination and reasoning.The research paradigm of embodied cognition and its relevant theory have not been established and developed yet,and empirical research from interdisciplinary perspectives is far from enough to provide hard evidence for embodied cognition.展开更多
As a recurring pattern of sensory-motor-affective experience, image schema is not only a concept discussed in linguistics and psychology, but also a significant one in the study of embodied cognition. Through analyzi...As a recurring pattern of sensory-motor-affective experience, image schema is not only a concept discussed in linguistics and psychology, but also a significant one in the study of embodied cognition. Through analyzing the features of image schema considered by the authors as embodiment, recessiveness, sedimentation, logicality, scientificity, and dependency to cognitive metaphors and reviewing the definition of embodied cognition, the paper argues that image schema is an integration of bodily property and mental property, and accordingly a core and inseparable concept of embodied cognition by bridging body and mind. Image schema can help to explain how abstraction and inference generate from body-environment interactions, thus making the theory of embodied cognition more persuasive and reliable.展开更多
Embodied intelligence emphasizes the synergy between body,mind,and environment,offering a powerful framework for building more adaptive and interactive intelligent systems.Over the past decade,rapid advancements in ar...Embodied intelligence emphasizes the synergy between body,mind,and environment,offering a powerful framework for building more adaptive and interactive intelligent systems.Over the past decade,rapid advancements in artificial intelligence have driven remarkable achievements in perception,planning,and control tasks,particularly through the rise of deep learning.However,embodied intelligence–the integration of AI with a physical body interacting in real environments–remains a relatively underexplored frontier.Unlike disembodied systems that rely solely on static datasets,embodied agents learn through real-time interaction with their surroundings,leveraging perception-action loops to adaptively understand and manipulate the world.Inspired by human cognition,embodied intelligence emphasizes learning by doing,thereby offering the potential to generalize knowledge across tasks,environments,and sensorimotor experiences.展开更多
Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between c...Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between coarse cereals consumption and body fat percentage(BFP)in Chinese children and adolescents.Methods The study included 48,305 children aged 6–17 years from 28 districts/counties in 14 provinces across seven regions of China(24,152 girls and 24,153 boys).BFP was examined using bioelectrical impedance analysis in the early morning.Coarse cereals consumption was assessed using a Food Frequency Questionnaire and categorized into three groups:0 g/1,000 kcal per day,0–10 g/1,000kcal per day,and>10 g/1,000 kcal per day(daily consumption of coarse cereals×1,000/total energy consumption).Quantile regression model was used to analyze the association between coarse cereals and BFP,adjusting for potential confounders such as age,pubertal development stage,urban/rural and regional factors,total daily dietary energy consumption,sedentary time,moderate-to-high physical activity,household income,parental education,and consumption of other foods.Results Boys aged 6–10,11–14,and 15–17 years had median daily coarse cereals consumptions of6.6 g,7.1 g,and 5.7 g,with BFP of 19.6%,19.5%,and 17.5%(all P<0.05).Girls in the same age groups showed consumption of 7.1 g,8.4 g,and 6.7 g,with BFP of 20.3%,26.4%,and 31.0%(all P<0.05).The quantile regression results for boys showed that daily consumption of coarse cereals was significantly correlated with their BFP in the 0.15,0.25,and 0.50 quartiles,with regression coefficients of-0.257,-0.221,and-0.330,respectively,after adjusting for potential confounders(P<0.05).For girls,there was a significant correlation with PBF at the 0.05,0.15,0.25,0.50,0.75,and 0.85 quartiles,with regression coefficients of-0.258,-0.366,-0.372,-0.431,-0.472,and-0.503(P<0.05 for all).Conclusions Coarse cereals consumption among Chinese children and adolescents remains relatively low.Higher consumption was inversely associated with BFP in children aged 6–17 years.Future interventional studies should assess how increased coarse cereals consumption prevents childhood obesity.展开更多
Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions i...Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions in Positive and Negative Syndrome Scale positive symptoms than 40 mg/day,without higher discontinuations for adverse events or a metabolic penalty over 6 weeks.These data support an individualized approach:Start at 80 mg/day when rapid control of positive symptoms or agitation is needed and tolerance permits;start at 40 mg/day when akathisia risk or patient preference argues for caution,with a planned day-7 review for up-titration.The open-label design,dose convergence after week 1,and the lack of stratified randomization limit attribution of longer-term advantages to starting dose.Even so,the trial reframes initial dose as a modifiable lever for the early course rather than a one-size-fits-all rule and warrants confirmation in larger,double-blind randomized trials.展开更多
Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss...Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.展开更多
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates ...The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials.While these failures have many possible explanations,it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.In other words,the lack of adequate animal models of Parkinson's disease currently represents the main barrier to preclinical identification of potential disease-modifying therapies likely to succeed in clinical trials.However,this barrier may be overcome by the recent introduction of novel generations of viral vectors coding for different forms of alpha-synuclein species and related genes.Although still facing several limitations,these models have managed to mimic the known neuropathological hallmarks of Parkinson's disease with unprecedented accuracy,delineating a more optimistic scenario for the near future.展开更多
Pelagic appendicularians,known for their rapid bloom capability,are important secondary producers and play essential roles in marine ecosystems.To assess the environmental adaptation of the most common appendicularian...Pelagic appendicularians,known for their rapid bloom capability,are important secondary producers and play essential roles in marine ecosystems.To assess the environmental adaptation of the most common appendicularian species Oikopleura dioica in Jiaozhou Bay,Shandong,China,its annual variations in abundance and body size were investigated monthly at 12 stations in 2011,and the relationship between somatic growth and gonadal development was compared with previously published laboratory data.Oikopleura dioica exhibited distinct seasonal abundance patterns,peaking in summer and autumn,particularly in the inner bay,reflecting its adaptation to the eutrophic conditions and high food availability.Compared to laboratory results,O.dioica in Jiaozhou Bay exhibited shorter body lengths,smaller gonad volumes,and earlier maturation at reduced body sizes,despite high natural chlorophyll-a concentration,suggesting that factors beyond food availability,such as resource competition and environmental stressors,may limit its growth in natural settings.Correlation analysis indicated that the somatic growth of natural O.dioica was primarily influenced by temperature,while gonadal development was related to chlorophyll-a concentration,and its population abundance was linked to food availability and the abundance of other zooplankton,such as copepods and jellyfish.It was suggested that the growth and recruitment of O.dioica were constrained by resource limitations in natural environments,further exacerbated by interactions with other zooplankton,including predation and competition.This study provides valuable data on the mechanisms underlying bio-environmental interactions and their spatiotemporal variations,offering critical insights into the ecological roles of appendicularians in marine ecosystems.展开更多
Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^(...Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.展开更多
Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association betw...Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.展开更多
Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia ...Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia by Arnold Pick in the same years,and Lewy bodies by Friedrich Lewy in 1912.These foundational studies laid the groundwork for the classification of what we now recognize as distinct neurodegenerative entities(Allali,2024).展开更多
Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly b...Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.展开更多
Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-...Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-mediated e–h recombination the dominant decay pathway.In this work,nonradiative e–h recombination within excitons in monolayer MoS2 is investigated using first-principles simulations that combine nonadiabatic molecular dynamics with𝐺𝑊and real-time Bethe–Salpeter equation(BSE)propagation.A two-step process is identified:rapid intervalley redistribution induced by exchange interaction,followed by slower phonon-assisted recombination facilitated by exciton binding.By selectively removing the screened Coulomb and exchange terms from the BSE Hamiltonian,their respective contributions are disentangled—exchange interaction is found to increase the number of accessible recombination pathways,while binding reduces the excitation energy and enhances nonradiative decay.A reduction in recombination lifetime by over an order of magnitude is observed due to the excitonic many-body effects.These findings provide microscopic insights for understanding and tuning exciton lifetimes in 2D transition-metal dichalcogenides.展开更多
Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic ...Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic targets. Apolipoprotein E(APOE) genotypes and their corresponding protein(Apo E) isoforms may influence the biophysical properties of the cell membrane lipid bilayer. However, the role of APOE in central nervous system pathophysiology extended beyond its lipid transport function. In the present review article, we analyzed the links existing between APOE genotypes and the neurobiology of neuropsychiatric symptoms in neurodegenerative and vascular diseases. APOE genotypes(APOE ε2, APOE ε3, and APOE ε4) were implicated in common mechanisms underlying a wide spectrum of neurodegenerative diseases, including sporadic Alzheimer's disease, synucleinopathies such as Parkinson's disease and Lewy body disease, stroke, and traumatic brain injury. These shared pathways often involved neuroinflammation, abnormal protein accumulation, or responses to acute detrimental events. Across these conditions, APOE variants are believed to contribute to the modulation of inflammatory responses, the regulation of amyloid and tau pathology, as well as the clearance of proteins such as α-synuclein. The bidirectional interactions among Apo E, amyloid and mitochondrial metabolism, immunomodulatory effects, neuronal repair, and remodeling underscored the complexity of Apo E's role in neuropsychiatric symptoms associated with these conditions since from early phases of cognitive impairment such as mild cognitive impairment and mild behavioral impairment. Besides Apo E-specific isoforms' link to increased neuropsychiatric symptoms in Alzheimer's disease(depression, psychosis, aberrant motor behaviors, and anxiety, not apathy), the APOE ε4 genotype was also considered a significant genetic risk factor for Lewy body disease and its worse cognitive outcomes. Conversely, the APOE ε2 variant has been observed not to exert a protective effect equally in all neurodegenerative diseases. Specifically, in Lewy body disease, this variant may delay disease onset, paralleling its protective role in Alzheimer's disease, although its role in frontotemporal dementia is uncertain. The APOE ε4 genotype has been associated with adverse cognitive outcomes across other various neurodegenerative conditions. In Parkinson's disease, the APOE ε4 allele significantly impacted cognitive performance, increasing the risk of developing dementia, even in cases of pure synucleinopathies with minimal co-pathology from Alzheimer's disease. Similarly, in traumatic brain injury, recovery rates varied, with APOE ε4 carriers demonstrating a greater risk of poor long-term cognitive outcomes and elevated levels of neuropsychiatric symptoms. Furthermore, APOE ε4 influenced the age of onset and severity of stroke, as well as the likelihood of developing stroke-associated dementia, potentially due to its role in compromising endothelial integrity and promoting blood–brain barrier dysfunction.展开更多
The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral bloo...The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral blood biomarkers in neurological and psychiatric disorders based on the assertion that disease pathology is limited to the brain.The discovery that all tissues,including the brain,release extracellular vesicles(Raposo and Stoorvogel,2013)and cell free DNAs(Chan et al.,2013)into various body fluids has provided a potential way to measure activity from inaccessible tissues like the central nervous system(CNS)and has given rise to the term“liquid biopsy.”The development of liquid biopsies that can diagnose and predict the course of psychiatric and neurological disorders would be transformative.The ability to predict episodic events such as mania,depression,and risk for suicide would be particularly useful for psychiatric care as it would enable the development of interventions that prevent mortality and improve outcomes.Additionally,biomarkers that are informative about drug response and aid in treatment decisions would be a significant advance in psychiatric care as it would prevent patients from having to endure multiple courses of ineffective treatments and side effects.展开更多
The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines...The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.展开更多
With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of th...With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of these biological processes do not fully explain the onset,progression,and development of these conditions.Therefore,exploration of the pathogenesis of neurodegenerative diseases remains a valuable area of research.This review summarizes the potential common pathogeneses of Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,Huntington’s disease,frontotemporal lobar dementia,and Lewy body disease.Research findings have indicated that several common biological processes,including aging,genetic factors,progressive neuronal dysfunction,neuronal death and apoptosis,protein misfolding and aggregation,neuroinflammation,mitochondrial dysfunction,axonal transport defects,and gut microbiota dysbiosis,are involved in the pathogenesis of these six neurodegenerative diseases.Based on current information derived from diverse areas of research,these biological processes may form complex pathogenic networks that lead to distinctive types of neuronal death in neurodegenerative diseases.Furthermore,promoting the regeneration of damaged neurons may be achievable through the repair of affected neural cells if the underlying pathogenesis can be prevented or reversed.Hence,these potential common biological processes may represent only very small,limited elements within numerous intricate pathogenic networks associated with neurodegenerative diseases.In clinical treatment,interfering with any single biological process has proven insufficient to completely halt the progression of neurodegenerative diseases.Therefore,future research on the pathogenesis of neurodegenerative diseases should focus on uncovering the complex pathogenic networks,rather than isolating individual biological processes.Based on this,therapies that aim to block or reverse various targets involved in the potential pathogenic mechanisms of neurodegenerative diseases may be promising directions,as current treatment methods that focus on halting a single pathogenic factor have not achieved satisfactory efficacy.展开更多
In the interpretation of the body in the 20th century, philosophy placed less emphasis than before on its natural composition and sought to integrate value judgements from different perspectives. The philosophy of the...In the interpretation of the body in the 20th century, philosophy placed less emphasis than before on its natural composition and sought to integrate value judgements from different perspectives. The philosophy of the body addresses the deepest essential problems of human society and culture, it generates a uniquely detailed analysis of human nature and its various roles and performances in social operations, and it reveals contemporary society's operating mechanisms and deep internal contradictions. Accordingly, philosophy no longer gives the mind any priority or superiority in terms of cognition, and the focus of research has moved away from pure consciousness and towards the body. Contemporary philosophical exploration of the body covers both the concept of belongingness and the feasibility of bodily freedom. It not only foregrounds the impossibility of viewing the body and the mind as separate entities but also leads us to examine the connections between humans and the world, taking meaning, reason and the body as their basis. This paper explores the connections between body and thought in modern philosophy, traces the development of philosophy's increasing concern with the body, elucidates the main contributions of representative figures in the field of philosophy of the body, and analyses the methodological significance and influence of the philosophy of the body as a contemporary philosophical trend.展开更多
The analogy between the human body and architectural structures dates all the way back to ancient times and has significantly shaped the design of buildings and structures.The article examines the body’s historical i...The analogy between the human body and architectural structures dates all the way back to ancient times and has significantly shaped the design of buildings and structures.The article examines the body’s historical influence on how structures are perceived and designed,demonstrating how the body shapes the"technical truth"dimension of structural design while oblivious to the importance of an"artistic truth"or perceptual dimension.This article aims to connect recent neuroscience findings and their implications for structural design through graphic statics and its design methods.Finally,this article proposes an equilibrium-based structural design approach for designing embodied structures based on graphic statics.展开更多
文摘With the development of embodied cognitive science,the embodiment of human high-level psychological processes such as language and emotions has been paid more and more attention.The importance of body and situation in the understanding of emotional experience is the core content of the embodied emotion.This article aims to review the current hypotheses and empirical evidence of embodied emotions,explains the significance and value of embodied emotion research,and thinks about the research prospects and research ideas of embodied emotion.At the same time,as a new theoretical point of view,emotional embodied view provides a new perspective for emotional research.
文摘Under the influence of European rationalism,which holds that human rationality is higher than,or at least independent of human sensory cognition,the first generation of cognitive science advocates for disembodied cognition,manifesting the concept of dualism of mind and body.With the development of cognitive science in the 1980s,the second generation of cognitive science redefines the relationship between mind and body,thought and behavior,and reason and feeling and puts forward the concept of embodied cognition,representing monism of mind and body.It is claimed that the formation of concepts,categorical cognition and the evolution of rational thinking are characterized by embodiment,which is the necessary condition and basis for the formation of human rationality.The current study traces the shift of cognitive science from dualism to monism of mind and body and explores the relationship between rationality and sensibility from the perspective of philosophical basis and interpretations,with an aim to achieve a better understanding and thorough interpretation of human rationality.In this heated discussion about embodied cognition,there are still some fundamental questions that need to be further clarified,such as the essence and mechanism of human cognition,the ways that human body participates in cognitive activities,especially imagination and reasoning.The research paradigm of embodied cognition and its relevant theory have not been established and developed yet,and empirical research from interdisciplinary perspectives is far from enough to provide hard evidence for embodied cognition.
文摘As a recurring pattern of sensory-motor-affective experience, image schema is not only a concept discussed in linguistics and psychology, but also a significant one in the study of embodied cognition. Through analyzing the features of image schema considered by the authors as embodiment, recessiveness, sedimentation, logicality, scientificity, and dependency to cognitive metaphors and reviewing the definition of embodied cognition, the paper argues that image schema is an integration of bodily property and mental property, and accordingly a core and inseparable concept of embodied cognition by bridging body and mind. Image schema can help to explain how abstraction and inference generate from body-environment interactions, thus making the theory of embodied cognition more persuasive and reliable.
文摘Embodied intelligence emphasizes the synergy between body,mind,and environment,offering a powerful framework for building more adaptive and interactive intelligent systems.Over the past decade,rapid advancements in artificial intelligence have driven remarkable achievements in perception,planning,and control tasks,particularly through the rise of deep learning.However,embodied intelligence–the integration of AI with a physical body interacting in real environments–remains a relatively underexplored frontier.Unlike disembodied systems that rely solely on static datasets,embodied agents learn through real-time interaction with their surroundings,leveraging perception-action loops to adaptively understand and manipulate the world.Inspired by human cognition,embodied intelligence emphasizes learning by doing,thereby offering the potential to generalize knowledge across tasks,environments,and sensorimotor experiences.
基金supported by the Special Project of National Science and Technology Basic Resources Survey(Grant No.2017FY101100)。
文摘Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between coarse cereals consumption and body fat percentage(BFP)in Chinese children and adolescents.Methods The study included 48,305 children aged 6–17 years from 28 districts/counties in 14 provinces across seven regions of China(24,152 girls and 24,153 boys).BFP was examined using bioelectrical impedance analysis in the early morning.Coarse cereals consumption was assessed using a Food Frequency Questionnaire and categorized into three groups:0 g/1,000 kcal per day,0–10 g/1,000kcal per day,and>10 g/1,000 kcal per day(daily consumption of coarse cereals×1,000/total energy consumption).Quantile regression model was used to analyze the association between coarse cereals and BFP,adjusting for potential confounders such as age,pubertal development stage,urban/rural and regional factors,total daily dietary energy consumption,sedentary time,moderate-to-high physical activity,household income,parental education,and consumption of other foods.Results Boys aged 6–10,11–14,and 15–17 years had median daily coarse cereals consumptions of6.6 g,7.1 g,and 5.7 g,with BFP of 19.6%,19.5%,and 17.5%(all P<0.05).Girls in the same age groups showed consumption of 7.1 g,8.4 g,and 6.7 g,with BFP of 20.3%,26.4%,and 31.0%(all P<0.05).The quantile regression results for boys showed that daily consumption of coarse cereals was significantly correlated with their BFP in the 0.15,0.25,and 0.50 quartiles,with regression coefficients of-0.257,-0.221,and-0.330,respectively,after adjusting for potential confounders(P<0.05).For girls,there was a significant correlation with PBF at the 0.05,0.15,0.25,0.50,0.75,and 0.85 quartiles,with regression coefficients of-0.258,-0.366,-0.372,-0.431,-0.472,and-0.503(P<0.05 for all).Conclusions Coarse cereals consumption among Chinese children and adolescents remains relatively low.Higher consumption was inversely associated with BFP in children aged 6–17 years.Future interventional studies should assess how increased coarse cereals consumption prevents childhood obesity.
文摘Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions in Positive and Negative Syndrome Scale positive symptoms than 40 mg/day,without higher discontinuations for adverse events or a metabolic penalty over 6 weeks.These data support an individualized approach:Start at 80 mg/day when rapid control of positive symptoms or agitation is needed and tolerance permits;start at 40 mg/day when akathisia risk or patient preference argues for caution,with a planned day-7 review for up-titration.The open-label design,dose convergence after week 1,and the lack of stratified randomization limit attribution of longer-term advantages to starting dose.Even so,the trial reframes initial dose as a modifiable lever for the early course rather than a one-size-fits-all rule and warrants confirmation in larger,double-blind randomized trials.
基金supported by the National Institutes of Health for the Kansas Center for Metabolism and Obesity Research(award No.P20GM144269)support from the Center for Advancing Translational Sciences of the National Institutes of Health(award No.KL2TR002367)supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(award No.TL1TR002368)。
文摘Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.
基金supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research+1 种基金by CiberNed Intramural Collaborative Projects(ref.PI2020/09)by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
文摘The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials.While these failures have many possible explanations,it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.In other words,the lack of adequate animal models of Parkinson's disease currently represents the main barrier to preclinical identification of potential disease-modifying therapies likely to succeed in clinical trials.However,this barrier may be overcome by the recent introduction of novel generations of viral vectors coding for different forms of alpha-synuclein species and related genes.Although still facing several limitations,these models have managed to mimic the known neuropathological hallmarks of Parkinson's disease with unprecedented accuracy,delineating a more optimistic scenario for the near future.
基金Supported by the National Key Research and Development Program of China(Nos.2023YFC3108205,2023YFC3108201)the National Natural Science Foundation of China(No.42306153)。
文摘Pelagic appendicularians,known for their rapid bloom capability,are important secondary producers and play essential roles in marine ecosystems.To assess the environmental adaptation of the most common appendicularian species Oikopleura dioica in Jiaozhou Bay,Shandong,China,its annual variations in abundance and body size were investigated monthly at 12 stations in 2011,and the relationship between somatic growth and gonadal development was compared with previously published laboratory data.Oikopleura dioica exhibited distinct seasonal abundance patterns,peaking in summer and autumn,particularly in the inner bay,reflecting its adaptation to the eutrophic conditions and high food availability.Compared to laboratory results,O.dioica in Jiaozhou Bay exhibited shorter body lengths,smaller gonad volumes,and earlier maturation at reduced body sizes,despite high natural chlorophyll-a concentration,suggesting that factors beyond food availability,such as resource competition and environmental stressors,may limit its growth in natural settings.Correlation analysis indicated that the somatic growth of natural O.dioica was primarily influenced by temperature,while gonadal development was related to chlorophyll-a concentration,and its population abundance was linked to food availability and the abundance of other zooplankton,such as copepods and jellyfish.It was suggested that the growth and recruitment of O.dioica were constrained by resource limitations in natural environments,further exacerbated by interactions with other zooplankton,including predation and competition.This study provides valuable data on the mechanisms underlying bio-environmental interactions and their spatiotemporal variations,offering critical insights into the ecological roles of appendicularians in marine ecosystems.
文摘Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.
基金supported by the Yanzhao Gold Talent Project of Hebei Province(NO.HJZD202506)。
文摘Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.
文摘Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia by Arnold Pick in the same years,and Lewy bodies by Friedrich Lewy in 1912.These foundational studies laid the groundwork for the classification of what we now recognize as distinct neurodegenerative entities(Allali,2024).
基金supported by the National Natural Science Foundation of China (Nos.22234005,22494632,22404081)the Natural Science Foundation of Jiangsu Province (Nos.BK20222015,BK20240534)。
文摘Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.
基金supported by the National Key Research and Development Program of China (Grant Nos.2024YFA1409800 for J.Z.and2024YFA1408603 for Q.Z.)the National Natural Science Foundation of China (Grant Nos.12125408,12334004for J.Z.,and 12174363 for Q.Z.)+1 种基金the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0303306 for J.Z.)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0450101 for J.Z.)。
文摘Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-mediated e–h recombination the dominant decay pathway.In this work,nonradiative e–h recombination within excitons in monolayer MoS2 is investigated using first-principles simulations that combine nonadiabatic molecular dynamics with𝐺𝑊and real-time Bethe–Salpeter equation(BSE)propagation.A two-step process is identified:rapid intervalley redistribution induced by exchange interaction,followed by slower phonon-assisted recombination facilitated by exciton binding.By selectively removing the screened Coulomb and exchange terms from the BSE Hamiltonian,their respective contributions are disentangled—exchange interaction is found to increase the number of accessible recombination pathways,while binding reduces the excitation energy and enhances nonradiative decay.A reduction in recombination lifetime by over an order of magnitude is observed due to the excitonic many-body effects.These findings provide microscopic insights for understanding and tuning exciton lifetimes in 2D transition-metal dichalcogenides.
文摘Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic targets. Apolipoprotein E(APOE) genotypes and their corresponding protein(Apo E) isoforms may influence the biophysical properties of the cell membrane lipid bilayer. However, the role of APOE in central nervous system pathophysiology extended beyond its lipid transport function. In the present review article, we analyzed the links existing between APOE genotypes and the neurobiology of neuropsychiatric symptoms in neurodegenerative and vascular diseases. APOE genotypes(APOE ε2, APOE ε3, and APOE ε4) were implicated in common mechanisms underlying a wide spectrum of neurodegenerative diseases, including sporadic Alzheimer's disease, synucleinopathies such as Parkinson's disease and Lewy body disease, stroke, and traumatic brain injury. These shared pathways often involved neuroinflammation, abnormal protein accumulation, or responses to acute detrimental events. Across these conditions, APOE variants are believed to contribute to the modulation of inflammatory responses, the regulation of amyloid and tau pathology, as well as the clearance of proteins such as α-synuclein. The bidirectional interactions among Apo E, amyloid and mitochondrial metabolism, immunomodulatory effects, neuronal repair, and remodeling underscored the complexity of Apo E's role in neuropsychiatric symptoms associated with these conditions since from early phases of cognitive impairment such as mild cognitive impairment and mild behavioral impairment. Besides Apo E-specific isoforms' link to increased neuropsychiatric symptoms in Alzheimer's disease(depression, psychosis, aberrant motor behaviors, and anxiety, not apathy), the APOE ε4 genotype was also considered a significant genetic risk factor for Lewy body disease and its worse cognitive outcomes. Conversely, the APOE ε2 variant has been observed not to exert a protective effect equally in all neurodegenerative diseases. Specifically, in Lewy body disease, this variant may delay disease onset, paralleling its protective role in Alzheimer's disease, although its role in frontotemporal dementia is uncertain. The APOE ε4 genotype has been associated with adverse cognitive outcomes across other various neurodegenerative conditions. In Parkinson's disease, the APOE ε4 allele significantly impacted cognitive performance, increasing the risk of developing dementia, even in cases of pure synucleinopathies with minimal co-pathology from Alzheimer's disease. Similarly, in traumatic brain injury, recovery rates varied, with APOE ε4 carriers demonstrating a greater risk of poor long-term cognitive outcomes and elevated levels of neuropsychiatric symptoms. Furthermore, APOE ε4 influenced the age of onset and severity of stroke, as well as the likelihood of developing stroke-associated dementia, potentially due to its role in compromising endothelial integrity and promoting blood–brain barrier dysfunction.
基金supported by Department of Defense grant HT9425-24-1-0030 a grant from the Stanley Medical Research Institute(to SS).
文摘The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral blood biomarkers in neurological and psychiatric disorders based on the assertion that disease pathology is limited to the brain.The discovery that all tissues,including the brain,release extracellular vesicles(Raposo and Stoorvogel,2013)and cell free DNAs(Chan et al.,2013)into various body fluids has provided a potential way to measure activity from inaccessible tissues like the central nervous system(CNS)and has given rise to the term“liquid biopsy.”The development of liquid biopsies that can diagnose and predict the course of psychiatric and neurological disorders would be transformative.The ability to predict episodic events such as mania,depression,and risk for suicide would be particularly useful for psychiatric care as it would enable the development of interventions that prevent mortality and improve outcomes.Additionally,biomarkers that are informative about drug response and aid in treatment decisions would be a significant advance in psychiatric care as it would prevent patients from having to endure multiple courses of ineffective treatments and side effects.
基金Supported by Discipline Construction Project of Shanxi University of Chinese Medicine—Internal Medicine of Traditional Chinese Medicine(2025XK02).
文摘The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.
基金supported by the National Natural Science Foundation of China,No.82160255(to RX)the Natural Science Foundation of Jiangxi Province,No.20212BAB216026(to HL)+2 种基金Science and Technology Plan Project of Health Commission of Jiangxi Province,No.202110016(to HL)Science and Technology Plan Project of Jiangxi Provincial Administration of Traditional Chinese Medicine,No.2022B975(to HL)a grant from Jiangxi Province Key Laboratory of Neurology,No.2024SSY06081(to RX).
文摘With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of these biological processes do not fully explain the onset,progression,and development of these conditions.Therefore,exploration of the pathogenesis of neurodegenerative diseases remains a valuable area of research.This review summarizes the potential common pathogeneses of Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,Huntington’s disease,frontotemporal lobar dementia,and Lewy body disease.Research findings have indicated that several common biological processes,including aging,genetic factors,progressive neuronal dysfunction,neuronal death and apoptosis,protein misfolding and aggregation,neuroinflammation,mitochondrial dysfunction,axonal transport defects,and gut microbiota dysbiosis,are involved in the pathogenesis of these six neurodegenerative diseases.Based on current information derived from diverse areas of research,these biological processes may form complex pathogenic networks that lead to distinctive types of neuronal death in neurodegenerative diseases.Furthermore,promoting the regeneration of damaged neurons may be achievable through the repair of affected neural cells if the underlying pathogenesis can be prevented or reversed.Hence,these potential common biological processes may represent only very small,limited elements within numerous intricate pathogenic networks associated with neurodegenerative diseases.In clinical treatment,interfering with any single biological process has proven insufficient to completely halt the progression of neurodegenerative diseases.Therefore,future research on the pathogenesis of neurodegenerative diseases should focus on uncovering the complex pathogenic networks,rather than isolating individual biological processes.Based on this,therapies that aim to block or reverse various targets involved in the potential pathogenic mechanisms of neurodegenerative diseases may be promising directions,as current treatment methods that focus on halting a single pathogenic factor have not achieved satisfactory efficacy.
基金supported by a major project of the National Social Science Fund of China,‘Contemporary Approaches to Personal Identity’(grant no.18ZDA029)
文摘In the interpretation of the body in the 20th century, philosophy placed less emphasis than before on its natural composition and sought to integrate value judgements from different perspectives. The philosophy of the body addresses the deepest essential problems of human society and culture, it generates a uniquely detailed analysis of human nature and its various roles and performances in social operations, and it reveals contemporary society's operating mechanisms and deep internal contradictions. Accordingly, philosophy no longer gives the mind any priority or superiority in terms of cognition, and the focus of research has moved away from pure consciousness and towards the body. Contemporary philosophical exploration of the body covers both the concept of belongingness and the feasibility of bodily freedom. It not only foregrounds the impossibility of viewing the body and the mind as separate entities but also leads us to examine the connections between humans and the world, taking meaning, reason and the body as their basis. This paper explores the connections between body and thought in modern philosophy, traces the development of philosophy's increasing concern with the body, elucidates the main contributions of representative figures in the field of philosophy of the body, and analyses the methodological significance and influence of the philosophy of the body as a contemporary philosophical trend.
基金This study was funded by the China Scholarship Council(Grant No.202008170012).
文摘The analogy between the human body and architectural structures dates all the way back to ancient times and has significantly shaped the design of buildings and structures.The article examines the body’s historical influence on how structures are perceived and designed,demonstrating how the body shapes the"technical truth"dimension of structural design while oblivious to the importance of an"artistic truth"or perceptual dimension.This article aims to connect recent neuroscience findings and their implications for structural design through graphic statics and its design methods.Finally,this article proposes an equilibrium-based structural design approach for designing embodied structures based on graphic statics.
