Quantitative assessment of myocardial perfusion by myocardial blush grade(MBG) is an angiographic computer-assisted method to assess myocardial tissue-level reperfusion in patients with acute coronary syndromes and mi...Quantitative assessment of myocardial perfusion by myocardial blush grade(MBG) is an angiographic computer-assisted method to assess myocardial tissue-level reperfusion in patients with acute coronary syndromes and microvascular integrity in heart transplant recipients with suspected cardiac allograft vasculopathy. This review describes the ability of quantitative MBG as a simple, fast and cost effective modality for the prompt diagnosis of impaired microvascular integrity during routine cardiac catheterization. Herein, we summarize the existing evidence, its usefulness in the clinical routine, and compare this method to other techniques which can be used for the assessment of myocardial perfusion.展开更多
BACKGROUND Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy trauma.Increase of the elderly population with age related comorbidities further complicates the management.Ab...BACKGROUND Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy trauma.Increase of the elderly population with age related comorbidities further complicates the management.Abdominal organ injuries are kindred with PF due to the proximity to pelvic bones.Presence of contrast blush(CB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is debatable.AIM To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast blush.METHODS This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(MOI),injury severity score(ISS),Glasgow coma scale(GCS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and mortality.The study compared geriatric and non-geriatric patients,patients with and without CB and abdominal co-injuries.Propensity score matching was implemented in comparison groups.RESULTS PF comprised 4%of all trauma admissions.89 patients had CB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal co-injuries.Geriatric patients compared to non-geriatric had more falls as MOI,lower ISS and AIS pelvis,higher GCS,less abdominal co-injuries,similar CB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher mortality.After propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,P<0.001),hospital length of stay shorter,and mortality higher(13%vs 4%,P<0.001)in geriatric patients.Out of 89 patients with CB,45(51%)were embolized.After propensity matching,patients with CB compared to without CB had more pelvic angiography(71%vs 12%,P<0.001),higher embolization rates(64%vs 22%,P=0.02)and comparable mortality.CONCLUSION Half of the patients with PF had concomitant co-injuries,including abdominal co-injuries in 17%.Similarly injured geriatric patients had higher mortality.Half of the patients with CB required an embolization.展开更多
为探究NUDIX(nucleoside diphosphates linked to other moieties X)基因家族在月月粉月季(Rosa chinensis‘Old Blush’)中的功能及潜在应用,本研究利用生物信息学方法,共鉴定出41个月月粉月季NUDIX基因家族成员,并对其系统发育关系、...为探究NUDIX(nucleoside diphosphates linked to other moieties X)基因家族在月月粉月季(Rosa chinensis‘Old Blush’)中的功能及潜在应用,本研究利用生物信息学方法,共鉴定出41个月月粉月季NUDIX基因家族成员,并对其系统发育关系、基因结构和表达模式等进行了分析。构建月月粉月季与野蔷薇、玫瑰、光叶蔷薇、草莓、苹果、拟南芥、水稻的NUDIX蛋白系统发育树,结果发现,NUDIX蛋白可分成13个亚家族,其中NUDIX1、NUDIX2、NUDIX4、NUDIX11亚家族成员数量较多。基因共线性分析发现,月月粉月季NUDIX基因发生了全基因组复制事件,并产生2对共线性基因对。染色体定位结果显示,月月粉月季NUDIX基因发生多次串联重复事件,这些重复事件大多经历了纯化选择。转录组数据分析表明,RcNUDIX1a/1b/1d/1e在花瓣组织中特异性表达,Rc NUDIX1b/1e/4c/9/11d可能参与叶片的胁迫响应,RcIDI可能参与植物组织幼根的发育和早期花发育,RcNUDIX2b/2d/2h可能参与花器官的衰老调控。综上所述,月月粉月季NUDIX基因的数量扩增主要由串联重复事件引起,NUDIX基因家族可能对月月粉月季次生代谢、生长发育和叶片胁迫响应等生理过程发挥着重要的调控作用。本研究为进一步探究月月粉月季NUDIX基因功能提供了理论依据。展开更多
目的:评价在急性心肌梗死(AMI)的经皮冠脉介入治疗(PCI)过程中,应用远端保护装置Guard Wire Plus TM的安全性及有效性。方法:自2004年9月至2006年5月共72例急性心肌梗死接受急诊PCI治疗的患者随机分为远端保护组(GW组)和非远端保护组(NG...目的:评价在急性心肌梗死(AMI)的经皮冠脉介入治疗(PCI)过程中,应用远端保护装置Guard Wire Plus TM的安全性及有效性。方法:自2004年9月至2006年5月共72例急性心肌梗死接受急诊PCI治疗的患者随机分为远端保护组(GW组)和非远端保护组(NGW组),其中GW组38例,NGW组34例。比较两组间的基础临床状况、造影情况、ST段回落情况、术后TIMI分级、TIMI记帧、和心肌blush分级以及术后一周内及3个月后左室射血分数(LVEF)。结果:两组全部病例均成功地置入支架,GW组全部成功放置GuardWire PlusTM保护装置,GW组ST段回落□50%的百分比明显高于NGW组(68．4%vs41．2%,p＜0．05)。术后TIMI分级两组没有明显差别,TIMI记帧(p=0．043)和心肌blush分级有明显差别(p=0．000)。GW组的左室射血分数(LVEF)明显高于NGW组。结论:急性心肌梗死急诊PCI中联合应用远端保护装置可以有效的预防远端血栓栓塞,缩小梗死面积,改善LVEF。展开更多
目的对盐酸替罗非班治疗冠心病患者的有效性探究。方法随机选择2019年12月—2020年12月于莱州市人民医院心内科就诊的冠心病患者90例作为研究对象,进行前瞻性随机对照研究,分为观察组(盐酸替罗非班+直接PCI,45例)和对照组(直接PCI,45例...目的对盐酸替罗非班治疗冠心病患者的有效性探究。方法随机选择2019年12月—2020年12月于莱州市人民医院心内科就诊的冠心病患者90例作为研究对象,进行前瞻性随机对照研究,分为观察组(盐酸替罗非班+直接PCI,45例)和对照组(直接PCI,45例)。分析比较两组患者经皮冠状动脉支架植入(percutaneous coronary inter vention,PCI)术后即刻血流分级(thrombolysis in myocardial infarction,TIMI),术后6、12 h肌酸激酶同工酶变化,术后7 d左室射血分数,术后1个月内不良心血管事件。结果观察组PCI术后即刻TIMI1、2、3级血流优于对照组,差异有统计学意义(Z=-4.493,P<0.001);观察组心血管不良事件发生率(2.22%)低于对照组(22.22%),差异有统计学意义(χ^(2)=8.389,P=0.004)。结论盐酸替罗非班在治疗冠心病患者治疗中起到有效作用,能降低冠心病患者的不良反应发生率,其安全性较高。展开更多
文摘Quantitative assessment of myocardial perfusion by myocardial blush grade(MBG) is an angiographic computer-assisted method to assess myocardial tissue-level reperfusion in patients with acute coronary syndromes and microvascular integrity in heart transplant recipients with suspected cardiac allograft vasculopathy. This review describes the ability of quantitative MBG as a simple, fast and cost effective modality for the prompt diagnosis of impaired microvascular integrity during routine cardiac catheterization. Herein, we summarize the existing evidence, its usefulness in the clinical routine, and compare this method to other techniques which can be used for the assessment of myocardial perfusion.
文摘BACKGROUND Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy trauma.Increase of the elderly population with age related comorbidities further complicates the management.Abdominal organ injuries are kindred with PF due to the proximity to pelvic bones.Presence of contrast blush(CB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is debatable.AIM To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast blush.METHODS This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(MOI),injury severity score(ISS),Glasgow coma scale(GCS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and mortality.The study compared geriatric and non-geriatric patients,patients with and without CB and abdominal co-injuries.Propensity score matching was implemented in comparison groups.RESULTS PF comprised 4%of all trauma admissions.89 patients had CB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal co-injuries.Geriatric patients compared to non-geriatric had more falls as MOI,lower ISS and AIS pelvis,higher GCS,less abdominal co-injuries,similar CB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher mortality.After propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,P<0.001),hospital length of stay shorter,and mortality higher(13%vs 4%,P<0.001)in geriatric patients.Out of 89 patients with CB,45(51%)were embolized.After propensity matching,patients with CB compared to without CB had more pelvic angiography(71%vs 12%,P<0.001),higher embolization rates(64%vs 22%,P=0.02)and comparable mortality.CONCLUSION Half of the patients with PF had concomitant co-injuries,including abdominal co-injuries in 17%.Similarly injured geriatric patients had higher mortality.Half of the patients with CB required an embolization.
文摘为探究NUDIX(nucleoside diphosphates linked to other moieties X)基因家族在月月粉月季(Rosa chinensis‘Old Blush’)中的功能及潜在应用,本研究利用生物信息学方法,共鉴定出41个月月粉月季NUDIX基因家族成员,并对其系统发育关系、基因结构和表达模式等进行了分析。构建月月粉月季与野蔷薇、玫瑰、光叶蔷薇、草莓、苹果、拟南芥、水稻的NUDIX蛋白系统发育树,结果发现,NUDIX蛋白可分成13个亚家族,其中NUDIX1、NUDIX2、NUDIX4、NUDIX11亚家族成员数量较多。基因共线性分析发现,月月粉月季NUDIX基因发生了全基因组复制事件,并产生2对共线性基因对。染色体定位结果显示,月月粉月季NUDIX基因发生多次串联重复事件,这些重复事件大多经历了纯化选择。转录组数据分析表明,RcNUDIX1a/1b/1d/1e在花瓣组织中特异性表达,Rc NUDIX1b/1e/4c/9/11d可能参与叶片的胁迫响应,RcIDI可能参与植物组织幼根的发育和早期花发育,RcNUDIX2b/2d/2h可能参与花器官的衰老调控。综上所述,月月粉月季NUDIX基因的数量扩增主要由串联重复事件引起,NUDIX基因家族可能对月月粉月季次生代谢、生长发育和叶片胁迫响应等生理过程发挥着重要的调控作用。本研究为进一步探究月月粉月季NUDIX基因功能提供了理论依据。
文摘目的:评价在急性心肌梗死(AMI)的经皮冠脉介入治疗(PCI)过程中,应用远端保护装置Guard Wire Plus TM的安全性及有效性。方法:自2004年9月至2006年5月共72例急性心肌梗死接受急诊PCI治疗的患者随机分为远端保护组(GW组)和非远端保护组(NGW组),其中GW组38例,NGW组34例。比较两组间的基础临床状况、造影情况、ST段回落情况、术后TIMI分级、TIMI记帧、和心肌blush分级以及术后一周内及3个月后左室射血分数(LVEF)。结果:两组全部病例均成功地置入支架,GW组全部成功放置GuardWire PlusTM保护装置,GW组ST段回落□50%的百分比明显高于NGW组(68．4%vs41．2%,p＜0．05)。术后TIMI分级两组没有明显差别,TIMI记帧(p=0．043)和心肌blush分级有明显差别(p=0．000)。GW组的左室射血分数(LVEF)明显高于NGW组。结论:急性心肌梗死急诊PCI中联合应用远端保护装置可以有效的预防远端血栓栓塞,缩小梗死面积,改善LVEF。
文摘目的对盐酸替罗非班治疗冠心病患者的有效性探究。方法随机选择2019年12月—2020年12月于莱州市人民医院心内科就诊的冠心病患者90例作为研究对象,进行前瞻性随机对照研究,分为观察组(盐酸替罗非班+直接PCI,45例)和对照组(直接PCI,45例)。分析比较两组患者经皮冠状动脉支架植入(percutaneous coronary inter vention,PCI)术后即刻血流分级(thrombolysis in myocardial infarction,TIMI),术后6、12 h肌酸激酶同工酶变化,术后7 d左室射血分数,术后1个月内不良心血管事件。结果观察组PCI术后即刻TIMI1、2、3级血流优于对照组,差异有统计学意义(Z=-4.493,P<0.001);观察组心血管不良事件发生率(2.22%)低于对照组(22.22%),差异有统计学意义(χ^(2)=8.389,P=0.004)。结论盐酸替罗非班在治疗冠心病患者治疗中起到有效作用,能降低冠心病患者的不良反应发生率,其安全性较高。
