A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and...A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and development of the NMI model and then emphasize that the NMI model represents a new tool for identifying the basic physics of how climate change influences mid-to-high latitude weather extremes.The building of the NMI model took place over three main periods.In the 1990s,a nonlinear Schr?dinger(NLS)equation model was presented to describe atmospheric blocking as a wave packet;however,it could not depict the lifetime(10-20 days)of atmospheric blocking.In the 2000s,we proposed an NMI model of atmospheric blocking in a uniform basic flow by making a scale-separation assumption and deriving an eddyforced NLS equation.This model succeeded in describing the life cycle of atmospheric blocking.In the 2020s,the NMI model was extended to include the impact of a changing climate mainly by altering the basic zonal winds and the magnitude of the meridional background potential vorticity gradient(PVy).Model results show that when PVy is smaller,blocking has a weaker dispersion and a stronger nonlinearity,so blocking can be more persistent and have a larger zonal scale and weaker eastward movement,thus favoring stronger weather extremes.However,when PVy is much smaller and below a critical threshold under much stronger winter Arctic warming of global warming,atmospheric blocking becomes locally less persistent and shows a much stronger westward movement,which acts to inhibit local cold extremes.Such a case does not happen in summer under global warming because PVy fails to fall below the critical threshold.Thus,our theory indicates that global warming can render summer-blocking anticyclones and mid-to-high latitude heatwaves more persistent,intense,and widespread.展开更多
Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic re...Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic resin and n-octanol were used to synthesize the main agent SCA-2.Hexamethylenetetramine and vinyl carbonate were selected to prepare the curing agent YGA-1,which was then compounded with SCA-2 to develop a sand fixation and water plugging system.Firstly,single-factor experiments were conducted to determine the optimal concentrations of SCA-2 and YGA-1,subsequently,the system’s sand fixation and water blocking performance were evaluated.Finally,a pilot test was carried out in the mining site.Experimental results showed that the optimal formula composition of the system was 10%SCA-2+5%YGA-1.The gelation time of the system was 180 minutes and the viscosity after gelation could reach 108.4 mPa·s.When the dosage of the drug system was 0.6 PV,the sand production rate remained below 0.08%.Dual-tube parallel experiments showed that the sand fixation and water plugging system had a water flow channel plugging rate of 87.5%,while the oil flow channel plugging rate was only 11.3%,indicating minimal damage to the oil-bearing reservoir.The field test showed that after the measures taken in Well M of X oilfield,the sand free oil recovery period exceeded 360 days,the water content decreased by 5.0%and the cumulative oil production increased by 7092 m^(3).This study provides new ideas for efficient development of loose sandstone reservoirs.展开更多
Seawater is the most abundant source of molecular hydrogen.Utilizing the hydrogen reserves present in the seawater may inaugurate innovative strategies aimed at advancing sustainable energy and environmental preservat...Seawater is the most abundant source of molecular hydrogen.Utilizing the hydrogen reserves present in the seawater may inaugurate innovative strategies aimed at advancing sustainable energy and environmental preservation endeavors in the future.Recently,there has been a surge in study in the field addressing the production of hydrogen through the electrochemical seawater splitting.However,the performance and durability of the electrode have limitations due to the fact that there are a few challenges that need to be addressed in order to make the technology suitable for the industrial purpose.The active site blockage caused by chloride ions that are prevalent in seawater and chloride corrosion is the most significant issue;it has a negative impact on both the activity and the durability of the anode component.Addressing this particular issue is of upmost importance in the seawater splitting area.This review concentrates on the newly developed materials and techniques for inhibiting chloride ions by blocking the active sites,simultaneously preventing the chloride corrosion.It is anticipated that the concept will be advantageous for a large audience and will inspire researchers to study on this particular area of concern.展开更多
White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual healt...White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual health.In this study,yellow-emitting carbon dots(CDs)with a quantum yield exceeding 94%were synthesized using citric acid and urea.These CDs effectively absorb blue light.By incorporating them into polystyrene,multiple films termed CDs-based blue light blocking films(CBFs)were developed,each offering different levels of blue light absorption.These CBFs exhibited excellent transparency and efficient blue light filtering capabilities.This study highlights the potential of high quantum yield CDs,which specifically absorb blue light,as foundational materials for developing light-blocking solutions against highenergy short-wavelength light.展开更多
BACKGROUND A major cause of mortality in the coronavirus disease 2019(COVID-19)pandemic was acute respiratory distress syndrome(ARDS).Currently,moderate to severe ARDS induced by COVID-19(COVID ARDS)and other viral an...BACKGROUND A major cause of mortality in the coronavirus disease 2019(COVID-19)pandemic was acute respiratory distress syndrome(ARDS).Currently,moderate to severe ARDS induced by COVID-19(COVID ARDS)and other viral and non-viral etiologies are treated by traditional ARDS protocols that recommend 12-16 hours of prone position ventilation(PPV)with neuromuscular blocking agents(NMBA)and a trial of inhaled vasodilators(IVd)if oxygenation does not improve.However,debate on the efficacy of adjuncts to PPV and low tidal volume ventilation persists and evidence about the benefits of IVd/NMBA in COVID ARDS is sparse.In our multi-center retrospective review,we evaluated the impact of PPV,IVd,and NMBA on outcomes and lung mechanics in COVID ARDS patients with moderate to severe ARDS.AIM To evaluate the impact of PPV used alone or in combination with pulmonary IVd and/or NMBA in mechanically ventilated patients with moderate to severe ARDS during the COVID-19 pandemic.METHODS A retrospective study at two tertiary academic medical centers compared outcomes between COVID ARDS patients receiving PPV and patients in the supine position.PPV patients were divided based on concurrent use of ARDS adjunct therapies resulting in four subgroups:(1)PPV alone;(2)PPV and IVd;(3)PPV and NMBA;and(4)PPV,IVd,and NMBA.Primary outcomes were hospital and intensive care unit(ICU)length of stay(LOS),mortality,and venovenous extracorporeal membrane oxygenation(VV-ECMO)status.Secondary outcomes included changes in lung mechanics at 24-hour intervals for 7 days.RESULTS Total 114 patients were included in this study.Baseline respiratory parameters and Sequential Organ Failure Assessment scores were significantly worse in the PPV group.ICU LOS and LOS were significantly longer for patients who were proned,but no mortality benefit or difference in VV-ECMO status was found.Among the subgroups,no difference in primary outcomes were found.In the secondary analysis,PPV was associated with a significant improvement in arterial oxygen partial pressure(PaO_(2))/fractional inspired oxygen(FiO_(2))(P/F)ratio from day 1 to day 4(P<0.05)and higher driving pressures day 5 to day 7(P<0.05).The combination of PPV and IVd together resulted in improvements in P/F ratio from day 1 to day 7 and plateau pressure on day 4 and day 6(P<0.05).PPV with NMBA was not associated with improvements in any of the secondary outcomes.The use of all three rescue therapies together resulted in improvements in lung compliance on day 2(P<0.05)but no other improvements.CONCLUSION In mechanically ventilated patients diagnosed with moderate to severe COVID ARDS,PPV and PPV with the addition of IVd produced a significant and sustained increase in P/F ratio.The combination of PPV,IVd and NMBA improved compliance however this did not reach significance.Mortality and LOS did not improve with adjunct therapies.Further research is warranted to determine the efficacy of these therapies alone and in combination in the treatment of COVID ARDS.展开更多
Three extreme cold events occurred in eastern Asia in January 2016,January 2021,and December 2023.As important factors in atmospheric circulation anomalies,the Blocking High and East Asian Trough(BH-ET)structure playe...Three extreme cold events occurred in eastern Asia in January 2016,January 2021,and December 2023.As important factors in atmospheric circulation anomalies,the Blocking High and East Asian Trough(BH-ET)structure played key roles during these three extreme cold wave events.Among these two dynamic patterns,the BH affected the development of the cold waves in two different ways:(1)before the cold waves in 2016 and 2023,the BH pushed the cold air southward,resulting in a slow and gradual cooling,with a cooling rate(CR)in eastern Asia of 1.34℃d^(-1)and 1.2℃d^(-1),respectively,and(2)in January 2021,the sudden collapse of BH caused the cold air to rapidly attack mid-latitude regions,with a CR of 1.87℃d^(-1).In terms of the spatial CR,the temperature drop in 2021 occurred 38.8%and 55%faster than those in 2016 and 2023,respectively.At the same time,the ET influences the wind direction of cold waves by modulating the pressure gradient.Before the cold waves occurred,the meridional wind field near the ET showed negative values,forming northwesterly or northeasterly winds,which continued to affect the southern part of East Asia.The meridional wind in January 2021 was stronger than those in 2016 and 2023,which is thought to be the reason for the strength of the 2021 cold wave.Finally,results from the temperature Empirical Orthogonal Function(EOF)analysis from 1980-2023 verify an obvious BH-ET structure in the three cold wave events,which suggests that this particular climatological state provides a climatic background for the occurrence of cold waves.展开更多
This paper investigates a distributed heterogeneous hybrid blocking flow-shop scheduling problem(DHHBFSP)designed to minimize the total tardiness and total energy consumption simultaneously,and proposes an improved pr...This paper investigates a distributed heterogeneous hybrid blocking flow-shop scheduling problem(DHHBFSP)designed to minimize the total tardiness and total energy consumption simultaneously,and proposes an improved proximal policy optimization(IPPO)method to make real-time decisions for the DHHBFSP.A multi-objective Markov decision process is modeled for the DHHBFSP,where the reward function is represented by a vector with dynamic weights instead of the common objectiverelated scalar value.A factory agent(FA)is formulated for each factory to select unscheduled jobs and is trained by the proposed IPPO to improve the decision quality.Multiple FAs work asynchronously to allocate jobs that arrive randomly at the shop.A two-stage training strategy is introduced in the IPPO,which learns from both single-and dual-policy data for better data utilization.The proposed IPPO is tested on randomly generated instances and compared with variants of the basic proximal policy optimization(PPO),dispatch rules,multi-objective metaheuristics,and multi-agent reinforcement learning methods.Extensive experimental results suggest that the proposed strategies offer significant improvements to the basic PPO,and the proposed IPPO outperforms the state-of-the-art scheduling methods in both convergence and solution quality.展开更多
Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. M...Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.展开更多
Some novel techniques of computational fluid dynamics are used to establish a mathematical model for the open diversion channel with two embankments in river blocking.The technique of boundary fitted coordinate syste...Some novel techniques of computational fluid dynamics are used to establish a mathematical model for the open diversion channel with two embankments in river blocking.The technique of boundary fitted coordinate system is used to overcome the difficulties resulting from the complicated shapes of natural river boundaries;the method of alternating direction implicit finite difference scheme is used to solve the partial differential equations in the transformed plane;and the technique of moving boundary is used to deal with the river bed exposed to water surface.This model has been used to predict the flow characteristics in the blocking of the Yangtz river in the Three Gorge Project (TGP).Comparison between the computed and experimental data shows a satisfactory agreement.展开更多
In this paper,we present a necessary and sufficient condition for hyponormal block Toeplitz operators T on the vector-valued weighted Bergman space with symbolsΦ(z)=G^(*)(z)+F(z),where F(z)=∑^(N)_(i)=1 A_(i)z^(i)and...In this paper,we present a necessary and sufficient condition for hyponormal block Toeplitz operators T on the vector-valued weighted Bergman space with symbolsΦ(z)=G^(*)(z)+F(z),where F(z)=∑^(N)_(i)=1 A_(i)z^(i)and G(z)=∑^(N)_(i)=1 A_(−i)z^(i),A_(i)ae culants.展开更多
When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can off...When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.展开更多
The diagnostic efficacy of contemporary bioimaging technologies remains constrained by inherent limitations of conventional imaging agents,including suboptimal sensitivity,off-target biodistribution,and inherent cytot...The diagnostic efficacy of contemporary bioimaging technologies remains constrained by inherent limitations of conventional imaging agents,including suboptimal sensitivity,off-target biodistribution,and inherent cytotoxicity.These limitations have catalyzed the development of intelligent stimuli-responsive block copolymers-based bioimaging agents,which was engineered to dynamically respond to endogenous biochemical cues(e.g.,p H gradients,redox potential,enzyme activity,hypoxia environment) or exogenous physical triggers(e.g.,photoirradiation,thermal gradients,ultrasound(US)/magnetic stimuli).Through spatiotemporally controlled structural transformations,stimuli-responsive block copolymers enable precise contrast targeting,activatable signal amplification,and theranostic integration,thereby substantially enhancing signal-to-noise ratios of bioimaging and diagnostic specificity.Hence,this mini-review systematically examines molecular engineering principles for designing p H-,redox-,enzyme-,light-,thermo-,and US/magnetic-responsive polymers,with emphasis on structure-property relationships governing imaging performance modulation.Furthermore,we critically analyze emerging strategies for optical imaging,US synergies,and magnetic resonance imaging(MRI).Multimodal bioimaging has also been elaborated,which could overcome the inherent trade-offs between resolution,penetration depth,and functional specificity in single-modal approaches.By elucidating mechanistic insights and translational challenges,this mini-review aims to establish a design framework of stimuli-responsive block copolymersbased for high fidelity bioimaging agents and accelerate their clinical translation in precise diagnosis and therapy.展开更多
In the image fusion field,fusing infrared images(IRIs)and visible images(VIs)excelled is a key area.The differences between IRIs and VIs make it challenging to fuse both types into a high-quality image.Accordingly,eff...In the image fusion field,fusing infrared images(IRIs)and visible images(VIs)excelled is a key area.The differences between IRIs and VIs make it challenging to fuse both types into a high-quality image.Accordingly,efficiently combining the advantages of both images while overcoming their shortcomings is necessary.To handle this challenge,we developed an end-to-end IRI andVI fusionmethod based on frequency decomposition and enhancement.By applying concepts from frequency domain analysis,we used the layering mechanism to better capture the salient thermal targets from the IRIs and the rich textural information from the VIs,respectively,significantly boosting the image fusion quality and effectiveness.In addition,the backbone network combined Restormer Blocks and Dense Blocks;Restormer blocks utilize global attention to extract shallow features.Meanwhile,Dense Blocks ensure the integration between shallow and deep features,thereby avoiding the loss of shallow attributes.Extensive experiments on TNO and MSRS datasets demonstrated that the suggested method achieved state-of-the-art(SOTA)performance in various metrics:Entropy(EN),Mutual Information(MI),Standard Deviation(SD),The Structural Similarity Index Measure(SSIM),Fusion quality(Qabf),MI of the pixel(FMI_(pixel)),and modified Visual Information Fidelity(VIF_(m)).展开更多
The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well underst...The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well understood.We conducted fission track age analysis on zircon grains(n=441)from the Cretaceous and Paleogene strata in the western Jianghan Basin.The Radial Plotter software is utilized to identify peak ages that indicate thermal events and the history of exhumation.The oldest peak at 810 Ma records the Neoproterozoic collisional orogeny between the Yangtze Craton and Cathaysian Block.Ages of 645-558 Ma reflect the convergence between the South China Block and Gondwana.Early Paleozoic ages document the collision leading to the exhumation of the western Jiangnan Orogenic Belt.Late Paleozoic to early Mesozoic peak ages correspond to the Indosinian orogeny.During the Mesozoic,the subduction of the Paleo-Pacific Plate resulted in further exhumation.The absence of Paleogene zircon fission track peak ages in the basin strata suggests limited exhumation during this period,likely due to tectonic quiescence and arid climatic conditions.展开更多
Debate has persisted over whether the metamorphic basement of the Zhoushan Islands,easternmost Cathaysia Block,is Precambrian.Here,representative metamorphic rocks from the Qushan Islands were investigated using petro...Debate has persisted over whether the metamorphic basement of the Zhoushan Islands,easternmost Cathaysia Block,is Precambrian.Here,representative metamorphic rocks from the Qushan Islands were investigated using petrography,mineral chemistry,phase equilibria modeling and SHRIMP zircon U-Pb dating to constrain their metamorphic evolution and tectonic significance.Both the pelitic granulites(garnet-kyanite-perthite-biotite-quartz)and the mafic granulites(garnet-clinopyroxene-amphibole-plagioclase-quartz)reached high-pressure granulite-facies conditions of 1.2-1.4 GPa/820-900℃,and recorded three metamorphic stages along a clockwise P-T path with post-peak isothermal decompression.This trajectory indicated rapid exhumation of thickened continental crust during collisional orogeny.Metamorphic ages of 254±3 Ma,262±4 Ma and 259±3 Ma were obtained for mafic granulite,pelitic granulite and marble,respectively,and were consistent with the emplacement age of 259±4 Ma for a pegmatite vein.Detrital zircons in metasediments spanned 2706-330 Ma,which constrained the latest deposition to~330 Ma;thus represented mid-Paleozoic sediment metamorphosed during the late Paleozoic rather than Precambrian basement.We conclude that the Indosinian tectonothermal event in the Cathaysia Block had originated from late Paleozoic-early Mesozoic collisional orogeny between the South China Plate to the north and the Indochina Block to the south.展开更多
The accretion of the Panama-ChocóBlock to the South American Plate partially drove the geological setting of the northern Andes.This event occurred in different collisional stages that are recorded in Oligocene-m...The accretion of the Panama-ChocóBlock to the South American Plate partially drove the geological setting of the northern Andes.This event occurred in different collisional stages that are recorded in Oligocene-middle Miocene deformed rocks of the inter-Andean valley between the Western and Central Cordilleras of Colombia.However,uncertainty remains about the age of the latest accretionary phases of the Panama-ChocóBlock.Poorly studied late Miocene volcanic rocks within the northern inter-Andean valley may provide key information to constrain the temporality of that final collision.Here,we study the deformational features of the~12-6 Ma extrusive rocks of the Combia Volcanic Province located in the northwestern Andes(Colombia).We present anisotropy of magnetic susceptibility(AMS)data for pyroclastic and volcanic rocks within the AmagáBasin,an inter-Andean depression with Oligocene-middle Miocene sedimentary rocks that recorded NW-SE compression and NE-SW simple shear caused by the Panama-ChocóBlock collision.We identified that the magnetic fabrics of the extrusive rocks of the Combia Volcanic Province reveal flow directions that indicate the occurrence of ancient volcanoes in the central axis of the AmagáBasin.Some of these fabrics do not contain any deformational features,whereas others record the same structural regime as the Oligocene-middle Miocene sedimentary rocks.We infer that variations in the intensity of the deformation promoted late Miocene local fault reactivations that,in contrast to the Oligocene-middle Miocene deformational events,did not affect the entire AmagáBasin.Age differences among the studied sections can also explain the different deformational patterns identified in the basin.Both interpretations suggest that the most significant collisional events of the Panama-ChocóBlock occurred in the Oligocene-middle Miocene,whereas the formation of the Combia Volcanic Province may have either followed or coincided with the latest stages of the accretion.展开更多
Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To a...Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To address this challenge,guided by the gas-liquid two-phase flow theory in ultra-low permeability reservoirs,and integrating theoretical analysis,numerical simulation,and insights from production practices,this study classifies the flowback and production stages of deep CBM well considering the Daning-Jixian Block,Eastern Ordos Basin as a representative case.We summarize the flowback characteristics for each stage and establish a standard flowback production type curve,aiming to guide field operations.The results indicate that:(a)The production process of deep CBM horizontal wells can be divided into five distinct stages:initial single-phase water dewatering stage,initial gas appearance to peak water production stage,gas breakthrough to peak gas production stage,stable production and decline stage,and low-rate production stage.(b)Based on reservoir energy,two standard type curves for horizontal well flowback production are established:the‘Sufficient Reservoir Energy’type and the‘Insufficient Reservoir Energy’type.The former achieves a higher initial gas rate(up to 12×10^(4)m^(3)/d)but exhibits poorer stability,while the latter achieves a lower stable rate(up to 8×10^(4)m^(3)/d)but demonstrates stronger stability.Numerical simulation confirms these behavioral patterns and reveals the underlying mechanisms related to the effectively drained area where pressure is significantly depleted.The findings from this study have guided the flowback production operations in 53 deep CBM wells with positive results,demonstrating high potential for broad application.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.42150204 and 2288101)supported by the China National Postdoctoral Program for Innovative Talents(BX20230045)the China Postdoctoral Science Foundation(2023M730279)。
文摘A nonlinear multi-scale interaction(NMI)model was proposed and developed by the first author for nearly 30 years to represent the evolution of atmospheric blocking.In this review paper,we first review the creation and development of the NMI model and then emphasize that the NMI model represents a new tool for identifying the basic physics of how climate change influences mid-to-high latitude weather extremes.The building of the NMI model took place over three main periods.In the 1990s,a nonlinear Schr?dinger(NLS)equation model was presented to describe atmospheric blocking as a wave packet;however,it could not depict the lifetime(10-20 days)of atmospheric blocking.In the 2000s,we proposed an NMI model of atmospheric blocking in a uniform basic flow by making a scale-separation assumption and deriving an eddyforced NLS equation.This model succeeded in describing the life cycle of atmospheric blocking.In the 2020s,the NMI model was extended to include the impact of a changing climate mainly by altering the basic zonal winds and the magnitude of the meridional background potential vorticity gradient(PVy).Model results show that when PVy is smaller,blocking has a weaker dispersion and a stronger nonlinearity,so blocking can be more persistent and have a larger zonal scale and weaker eastward movement,thus favoring stronger weather extremes.However,when PVy is much smaller and below a critical threshold under much stronger winter Arctic warming of global warming,atmospheric blocking becomes locally less persistent and shows a much stronger westward movement,which acts to inhibit local cold extremes.Such a case does not happen in summer under global warming because PVy fails to fall below the critical threshold.Thus,our theory indicates that global warming can render summer-blocking anticyclones and mid-to-high latitude heatwaves more persistent,intense,and widespread.
文摘Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic resin and n-octanol were used to synthesize the main agent SCA-2.Hexamethylenetetramine and vinyl carbonate were selected to prepare the curing agent YGA-1,which was then compounded with SCA-2 to develop a sand fixation and water plugging system.Firstly,single-factor experiments were conducted to determine the optimal concentrations of SCA-2 and YGA-1,subsequently,the system’s sand fixation and water blocking performance were evaluated.Finally,a pilot test was carried out in the mining site.Experimental results showed that the optimal formula composition of the system was 10%SCA-2+5%YGA-1.The gelation time of the system was 180 minutes and the viscosity after gelation could reach 108.4 mPa·s.When the dosage of the drug system was 0.6 PV,the sand production rate remained below 0.08%.Dual-tube parallel experiments showed that the sand fixation and water plugging system had a water flow channel plugging rate of 87.5%,while the oil flow channel plugging rate was only 11.3%,indicating minimal damage to the oil-bearing reservoir.The field test showed that after the measures taken in Well M of X oilfield,the sand free oil recovery period exceeded 360 days,the water content decreased by 5.0%and the cumulative oil production increased by 7092 m^(3).This study provides new ideas for efficient development of loose sandstone reservoirs.
基金supported by the Nano&Material Technology Development Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(RS-2024-00436563)supported by Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(Grant No.RS-2023-00284361).
文摘Seawater is the most abundant source of molecular hydrogen.Utilizing the hydrogen reserves present in the seawater may inaugurate innovative strategies aimed at advancing sustainable energy and environmental preservation endeavors in the future.Recently,there has been a surge in study in the field addressing the production of hydrogen through the electrochemical seawater splitting.However,the performance and durability of the electrode have limitations due to the fact that there are a few challenges that need to be addressed in order to make the technology suitable for the industrial purpose.The active site blockage caused by chloride ions that are prevalent in seawater and chloride corrosion is the most significant issue;it has a negative impact on both the activity and the durability of the anode component.Addressing this particular issue is of upmost importance in the seawater splitting area.This review concentrates on the newly developed materials and techniques for inhibiting chloride ions by blocking the active sites,simultaneously preventing the chloride corrosion.It is anticipated that the concept will be advantageous for a large audience and will inspire researchers to study on this particular area of concern.
基金supported by Medical Science and Technology Research Project of Henan Province(Joint Construction Project)(No.LHGJ20200433)National Natural Science Foundation of China(No.52122308)。
文摘White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual health.In this study,yellow-emitting carbon dots(CDs)with a quantum yield exceeding 94%were synthesized using citric acid and urea.These CDs effectively absorb blue light.By incorporating them into polystyrene,multiple films termed CDs-based blue light blocking films(CBFs)were developed,each offering different levels of blue light absorption.These CBFs exhibited excellent transparency and efficient blue light filtering capabilities.This study highlights the potential of high quantum yield CDs,which specifically absorb blue light,as foundational materials for developing light-blocking solutions against highenergy short-wavelength light.
文摘BACKGROUND A major cause of mortality in the coronavirus disease 2019(COVID-19)pandemic was acute respiratory distress syndrome(ARDS).Currently,moderate to severe ARDS induced by COVID-19(COVID ARDS)and other viral and non-viral etiologies are treated by traditional ARDS protocols that recommend 12-16 hours of prone position ventilation(PPV)with neuromuscular blocking agents(NMBA)and a trial of inhaled vasodilators(IVd)if oxygenation does not improve.However,debate on the efficacy of adjuncts to PPV and low tidal volume ventilation persists and evidence about the benefits of IVd/NMBA in COVID ARDS is sparse.In our multi-center retrospective review,we evaluated the impact of PPV,IVd,and NMBA on outcomes and lung mechanics in COVID ARDS patients with moderate to severe ARDS.AIM To evaluate the impact of PPV used alone or in combination with pulmonary IVd and/or NMBA in mechanically ventilated patients with moderate to severe ARDS during the COVID-19 pandemic.METHODS A retrospective study at two tertiary academic medical centers compared outcomes between COVID ARDS patients receiving PPV and patients in the supine position.PPV patients were divided based on concurrent use of ARDS adjunct therapies resulting in four subgroups:(1)PPV alone;(2)PPV and IVd;(3)PPV and NMBA;and(4)PPV,IVd,and NMBA.Primary outcomes were hospital and intensive care unit(ICU)length of stay(LOS),mortality,and venovenous extracorporeal membrane oxygenation(VV-ECMO)status.Secondary outcomes included changes in lung mechanics at 24-hour intervals for 7 days.RESULTS Total 114 patients were included in this study.Baseline respiratory parameters and Sequential Organ Failure Assessment scores were significantly worse in the PPV group.ICU LOS and LOS were significantly longer for patients who were proned,but no mortality benefit or difference in VV-ECMO status was found.Among the subgroups,no difference in primary outcomes were found.In the secondary analysis,PPV was associated with a significant improvement in arterial oxygen partial pressure(PaO_(2))/fractional inspired oxygen(FiO_(2))(P/F)ratio from day 1 to day 4(P<0.05)and higher driving pressures day 5 to day 7(P<0.05).The combination of PPV and IVd together resulted in improvements in P/F ratio from day 1 to day 7 and plateau pressure on day 4 and day 6(P<0.05).PPV with NMBA was not associated with improvements in any of the secondary outcomes.The use of all three rescue therapies together resulted in improvements in lung compliance on day 2(P<0.05)but no other improvements.CONCLUSION In mechanically ventilated patients diagnosed with moderate to severe COVID ARDS,PPV and PPV with the addition of IVd produced a significant and sustained increase in P/F ratio.The combination of PPV,IVd and NMBA improved compliance however this did not reach significance.Mortality and LOS did not improve with adjunct therapies.Further research is warranted to determine the efficacy of these therapies alone and in combination in the treatment of COVID ARDS.
基金supported by the National Natural Science Foundation of China under Grant No.41821004,the National Key Research and Development Program of China under contract No.2022YFE0140500the National Key R&D Program of China under contract No.2022YFA1004403+2 种基金the Laoshan Laboratory Science and Technology Innovation Project No.LSKJ202202104the National Nature Science Foundation of China No.42130406the Project of Doctoral Found of Qingdao University of Science and Technology under contract No.210010022746.
文摘Three extreme cold events occurred in eastern Asia in January 2016,January 2021,and December 2023.As important factors in atmospheric circulation anomalies,the Blocking High and East Asian Trough(BH-ET)structure played key roles during these three extreme cold wave events.Among these two dynamic patterns,the BH affected the development of the cold waves in two different ways:(1)before the cold waves in 2016 and 2023,the BH pushed the cold air southward,resulting in a slow and gradual cooling,with a cooling rate(CR)in eastern Asia of 1.34℃d^(-1)and 1.2℃d^(-1),respectively,and(2)in January 2021,the sudden collapse of BH caused the cold air to rapidly attack mid-latitude regions,with a CR of 1.87℃d^(-1).In terms of the spatial CR,the temperature drop in 2021 occurred 38.8%and 55%faster than those in 2016 and 2023,respectively.At the same time,the ET influences the wind direction of cold waves by modulating the pressure gradient.Before the cold waves occurred,the meridional wind field near the ET showed negative values,forming northwesterly or northeasterly winds,which continued to affect the southern part of East Asia.The meridional wind in January 2021 was stronger than those in 2016 and 2023,which is thought to be the reason for the strength of the 2021 cold wave.Finally,results from the temperature Empirical Orthogonal Function(EOF)analysis from 1980-2023 verify an obvious BH-ET structure in the three cold wave events,which suggests that this particular climatological state provides a climatic background for the occurrence of cold waves.
基金partially supported by the National Key Research and Development Program of the Ministry of Science and Technology of China(2022YFE0114200)the National Natural Science Foundation of China(U20A6004).
文摘This paper investigates a distributed heterogeneous hybrid blocking flow-shop scheduling problem(DHHBFSP)designed to minimize the total tardiness and total energy consumption simultaneously,and proposes an improved proximal policy optimization(IPPO)method to make real-time decisions for the DHHBFSP.A multi-objective Markov decision process is modeled for the DHHBFSP,where the reward function is represented by a vector with dynamic weights instead of the common objectiverelated scalar value.A factory agent(FA)is formulated for each factory to select unscheduled jobs and is trained by the proposed IPPO to improve the decision quality.Multiple FAs work asynchronously to allocate jobs that arrive randomly at the shop.A two-stage training strategy is introduced in the IPPO,which learns from both single-and dual-policy data for better data utilization.The proposed IPPO is tested on randomly generated instances and compared with variants of the basic proximal policy optimization(PPO),dispatch rules,multi-objective metaheuristics,and multi-agent reinforcement learning methods.Extensive experimental results suggest that the proposed strategies offer significant improvements to the basic PPO,and the proposed IPPO outperforms the state-of-the-art scheduling methods in both convergence and solution quality.
文摘Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.
文摘Some novel techniques of computational fluid dynamics are used to establish a mathematical model for the open diversion channel with two embankments in river blocking.The technique of boundary fitted coordinate system is used to overcome the difficulties resulting from the complicated shapes of natural river boundaries;the method of alternating direction implicit finite difference scheme is used to solve the partial differential equations in the transformed plane;and the technique of moving boundary is used to deal with the river bed exposed to water surface.This model has been used to predict the flow characteristics in the blocking of the Yangtz river in the Three Gorge Project (TGP).Comparison between the computed and experimental data shows a satisfactory agreement.
文摘In this paper,we present a necessary and sufficient condition for hyponormal block Toeplitz operators T on the vector-valued weighted Bergman space with symbolsΦ(z)=G^(*)(z)+F(z),where F(z)=∑^(N)_(i)=1 A_(i)z^(i)and G(z)=∑^(N)_(i)=1 A_(−i)z^(i),A_(i)ae culants.
基金Military Healthcare Special Scientific Research Project(25BJZ31, awarded to SHI XM)。
文摘When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.
基金supported by the National Natural Science Foundation of China (Nos.22208218,22078196,and 22278268)the Natural Science Foundation of Shanghai (No.22ZR1460400)Collaborative Innovation Center of Fragrance Flavour and Cosmetics,and Collaborative Innovation Project of Shanghai Institute of Technology (No.XTCX2023-07)。
文摘The diagnostic efficacy of contemporary bioimaging technologies remains constrained by inherent limitations of conventional imaging agents,including suboptimal sensitivity,off-target biodistribution,and inherent cytotoxicity.These limitations have catalyzed the development of intelligent stimuli-responsive block copolymers-based bioimaging agents,which was engineered to dynamically respond to endogenous biochemical cues(e.g.,p H gradients,redox potential,enzyme activity,hypoxia environment) or exogenous physical triggers(e.g.,photoirradiation,thermal gradients,ultrasound(US)/magnetic stimuli).Through spatiotemporally controlled structural transformations,stimuli-responsive block copolymers enable precise contrast targeting,activatable signal amplification,and theranostic integration,thereby substantially enhancing signal-to-noise ratios of bioimaging and diagnostic specificity.Hence,this mini-review systematically examines molecular engineering principles for designing p H-,redox-,enzyme-,light-,thermo-,and US/magnetic-responsive polymers,with emphasis on structure-property relationships governing imaging performance modulation.Furthermore,we critically analyze emerging strategies for optical imaging,US synergies,and magnetic resonance imaging(MRI).Multimodal bioimaging has also been elaborated,which could overcome the inherent trade-offs between resolution,penetration depth,and functional specificity in single-modal approaches.By elucidating mechanistic insights and translational challenges,this mini-review aims to establish a design framework of stimuli-responsive block copolymersbased for high fidelity bioimaging agents and accelerate their clinical translation in precise diagnosis and therapy.
基金funded by Anhui Province University Key Science and Technology Project(2024AH053415)Anhui Province University Major Science and Technology Project(2024AH040229)+3 种基金Talent Research Initiation Fund Project of Tongling University(2024tlxyrc019)Tongling University School-Level Scientific Research Project(2024tlxyptZD07)TheUniversity Synergy Innovation Programof Anhui Province(GXXT-2023-050)Tongling City Science and Technology Major Special Project(Unveiling and Commanding Model)(200401JB004).
文摘In the image fusion field,fusing infrared images(IRIs)and visible images(VIs)excelled is a key area.The differences between IRIs and VIs make it challenging to fuse both types into a high-quality image.Accordingly,efficiently combining the advantages of both images while overcoming their shortcomings is necessary.To handle this challenge,we developed an end-to-end IRI andVI fusionmethod based on frequency decomposition and enhancement.By applying concepts from frequency domain analysis,we used the layering mechanism to better capture the salient thermal targets from the IRIs and the rich textural information from the VIs,respectively,significantly boosting the image fusion quality and effectiveness.In addition,the backbone network combined Restormer Blocks and Dense Blocks;Restormer blocks utilize global attention to extract shallow features.Meanwhile,Dense Blocks ensure the integration between shallow and deep features,thereby avoiding the loss of shallow attributes.Extensive experiments on TNO and MSRS datasets demonstrated that the suggested method achieved state-of-the-art(SOTA)performance in various metrics:Entropy(EN),Mutual Information(MI),Standard Deviation(SD),The Structural Similarity Index Measure(SSIM),Fusion quality(Qabf),MI of the pixel(FMI_(pixel)),and modified Visual Information Fidelity(VIF_(m)).
基金the financial support provided by the National Natural Science Foundation of China(Grant No.41972212)the Hubei Chutian Scholars Talent Program(Grant No.8210403)。
文摘The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well understood.We conducted fission track age analysis on zircon grains(n=441)from the Cretaceous and Paleogene strata in the western Jianghan Basin.The Radial Plotter software is utilized to identify peak ages that indicate thermal events and the history of exhumation.The oldest peak at 810 Ma records the Neoproterozoic collisional orogeny between the Yangtze Craton and Cathaysian Block.Ages of 645-558 Ma reflect the convergence between the South China Block and Gondwana.Early Paleozoic ages document the collision leading to the exhumation of the western Jiangnan Orogenic Belt.Late Paleozoic to early Mesozoic peak ages correspond to the Indosinian orogeny.During the Mesozoic,the subduction of the Paleo-Pacific Plate resulted in further exhumation.The absence of Paleogene zircon fission track peak ages in the basin strata suggests limited exhumation during this period,likely due to tectonic quiescence and arid climatic conditions.
基金supported by the National Natural Science Foundation of China(42072223)Geological Survey project(DD20221649,DD20231429).
文摘Debate has persisted over whether the metamorphic basement of the Zhoushan Islands,easternmost Cathaysia Block,is Precambrian.Here,representative metamorphic rocks from the Qushan Islands were investigated using petrography,mineral chemistry,phase equilibria modeling and SHRIMP zircon U-Pb dating to constrain their metamorphic evolution and tectonic significance.Both the pelitic granulites(garnet-kyanite-perthite-biotite-quartz)and the mafic granulites(garnet-clinopyroxene-amphibole-plagioclase-quartz)reached high-pressure granulite-facies conditions of 1.2-1.4 GPa/820-900℃,and recorded three metamorphic stages along a clockwise P-T path with post-peak isothermal decompression.This trajectory indicated rapid exhumation of thickened continental crust during collisional orogeny.Metamorphic ages of 254±3 Ma,262±4 Ma and 259±3 Ma were obtained for mafic granulite,pelitic granulite and marble,respectively,and were consistent with the emplacement age of 259±4 Ma for a pegmatite vein.Detrital zircons in metasediments spanned 2706-330 Ma,which constrained the latest deposition to~330 Ma;thus represented mid-Paleozoic sediment metamorphosed during the late Paleozoic rather than Precambrian basement.We conclude that the Indosinian tectonothermal event in the Cathaysia Block had originated from late Paleozoic-early Mesozoic collisional orogeny between the South China Plate to the north and the Indochina Block to the south.
基金supported financially by the National Natural Science Foundation of China (Grants W2433104 to V.A.P. and42225402 to J.L.)the China Postdoctoral Science Foundation(Grant 2024M753205 to V.A.P.)+4 种基金the Institute of Geology and Geophysics of the Chinese Academy of Sciences (International Fellowship for Postdoctoral Researchers, Grant 2025PD02 to V.A.P.)an association between ECOS-NORD (France)Colciencias/Icetex (Colombia)(Grant C12U01 to M.I.M.)a junior fellowship scheme of Colciencias (Colombia)(Grant 706-2015 to V.A.P.)supported the undergraduate final project of A.T
文摘The accretion of the Panama-ChocóBlock to the South American Plate partially drove the geological setting of the northern Andes.This event occurred in different collisional stages that are recorded in Oligocene-middle Miocene deformed rocks of the inter-Andean valley between the Western and Central Cordilleras of Colombia.However,uncertainty remains about the age of the latest accretionary phases of the Panama-ChocóBlock.Poorly studied late Miocene volcanic rocks within the northern inter-Andean valley may provide key information to constrain the temporality of that final collision.Here,we study the deformational features of the~12-6 Ma extrusive rocks of the Combia Volcanic Province located in the northwestern Andes(Colombia).We present anisotropy of magnetic susceptibility(AMS)data for pyroclastic and volcanic rocks within the AmagáBasin,an inter-Andean depression with Oligocene-middle Miocene sedimentary rocks that recorded NW-SE compression and NE-SW simple shear caused by the Panama-ChocóBlock collision.We identified that the magnetic fabrics of the extrusive rocks of the Combia Volcanic Province reveal flow directions that indicate the occurrence of ancient volcanoes in the central axis of the AmagáBasin.Some of these fabrics do not contain any deformational features,whereas others record the same structural regime as the Oligocene-middle Miocene sedimentary rocks.We infer that variations in the intensity of the deformation promoted late Miocene local fault reactivations that,in contrast to the Oligocene-middle Miocene deformational events,did not affect the entire AmagáBasin.Age differences among the studied sections can also explain the different deformational patterns identified in the basin.Both interpretations suggest that the most significant collisional events of the Panama-ChocóBlock occurred in the Oligocene-middle Miocene,whereas the formation of the Combia Volcanic Province may have either followed or coincided with the latest stages of the accretion.
基金supported by the National Science and Technology Major Project of China(No.2025ZD1405702)the Scientific Research and Technology Development Project of PetroChina Coalbed Methane Co.,Ltd.(Project No.25MQCTSG010)Applied Science and Technology Project of PetroChina Company Limited(2023ZZ18YJ04).
文摘Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To address this challenge,guided by the gas-liquid two-phase flow theory in ultra-low permeability reservoirs,and integrating theoretical analysis,numerical simulation,and insights from production practices,this study classifies the flowback and production stages of deep CBM well considering the Daning-Jixian Block,Eastern Ordos Basin as a representative case.We summarize the flowback characteristics for each stage and establish a standard flowback production type curve,aiming to guide field operations.The results indicate that:(a)The production process of deep CBM horizontal wells can be divided into five distinct stages:initial single-phase water dewatering stage,initial gas appearance to peak water production stage,gas breakthrough to peak gas production stage,stable production and decline stage,and low-rate production stage.(b)Based on reservoir energy,two standard type curves for horizontal well flowback production are established:the‘Sufficient Reservoir Energy’type and the‘Insufficient Reservoir Energy’type.The former achieves a higher initial gas rate(up to 12×10^(4)m^(3)/d)but exhibits poorer stability,while the latter achieves a lower stable rate(up to 8×10^(4)m^(3)/d)but demonstrates stronger stability.Numerical simulation confirms these behavioral patterns and reveals the underlying mechanisms related to the effectively drained area where pressure is significantly depleted.The findings from this study have guided the flowback production operations in 53 deep CBM wells with positive results,demonstrating high potential for broad application.
