Immune imbalance is a critical factor in the occurrence and progression of cancers because it disrupts the immune system's ability to detect and eliminate abnormal cells.Restoring immune balance and reactivating i...Immune imbalance is a critical factor in the occurrence and progression of cancers because it disrupts the immune system's ability to detect and eliminate abnormal cells.Restoring immune balance and reactivating immune cells remain major challenges in cancer immunotherapy.Current immunoregulatory strategies,such as immune checkpoint blockade,adoptive cell therapy,and therapeutic vaccines,aim to influence key immune cells,such as T cells,dendritic cells,and macrophages,to boost anticancer responses.However,conventional material design in immunotherapy usually emphasizes chemical composition and physical morphology,while neglecting the critical role of stereochemistry in immune cell recognition and activation.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant Nos.U23A20591,52273158,52273159,and W2421115)the Science and Technology Department Project of Jilin Province(Grant No.20250204068YY)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.Y2023066).
文摘Immune imbalance is a critical factor in the occurrence and progression of cancers because it disrupts the immune system's ability to detect and eliminate abnormal cells.Restoring immune balance and reactivating immune cells remain major challenges in cancer immunotherapy.Current immunoregulatory strategies,such as immune checkpoint blockade,adoptive cell therapy,and therapeutic vaccines,aim to influence key immune cells,such as T cells,dendritic cells,and macrophages,to boost anticancer responses.However,conventional material design in immunotherapy usually emphasizes chemical composition and physical morphology,while neglecting the critical role of stereochemistry in immune cell recognition and activation.
