Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key componen...Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.展开更多
Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infecte...Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite.In immune-competent individuals,T.展开更多
This article presents a novel electrical/mechanical hybrid 4-redundancy brushless DC torque motor （BLDCM）, which has found applications in direct drive actuators （DDA） of aerial vehicles. This motor is characteris...This article presents a novel electrical/mechanical hybrid 4-redundancy brushless DC torque motor （BLDCM）, which has found applications in direct drive actuators （DDA） of aerial vehicles. This motor is characteristic of electrical/mechanical hybrid 4-redundancy by securing two stators along with two rotors on the same shaft. Each stator contains two sets of windings embed- ded in separated slots. Furthermore, compared to the scheme of two electrical dual-redundancy BLDCMs linked by a mechanical transmission, the proposed motor has lower volume and lighter weight, eliminates the nonlinearity caused by the gap of the me- chanical transmission, moderates the requirement for the torque balance between redundancies and reduces the cogging torque by shifting the magnets. Both magnetic circuit calculation and the finite element analysis （FEA） of the electromagnetic field are conducted to optimize the design process. A prototype motor has been produced and tested. The results indicate that its perform- ances comply with the requirements presented by designers. Moreover, the position frequency response of the prototype in the DDA＇s unloaded situation has also demonstrated the fulfillment of desired dynamic characteristics.展开更多
The hard support vector regression attracts little attention owing to the overfitting phenomenon. Recently, a fast offiine method has been proposed to approximately train the hard support vector regression with the ge...The hard support vector regression attracts little attention owing to the overfitting phenomenon. Recently, a fast offiine method has been proposed to approximately train the hard support vector regression with the generation performance comparable to the soft support vector regression. Based on this achievement, this article advances a fast online approximation called the hard sup- port vector regression （FOAHSVR for short）. By adopting the greedy stagewise and iterative strategies, it is capable of online estimating parameters of complicated systems. In order to verify the effectiveness of the FOAHSVR, an FOAHSVR-based analytical redundancy for aeroengines is developed. Experiments on the sensor failure and drift evidence the viability and feasibility of the analytical redundancy for aeroengines together with its base--FOAHSVR. In addition, the FOAHSVR is anticipated to find applications in other scientific-technical fields.展开更多
The redundancy technology for the aircraft multi-channel DC electrical power supply system is studied. In this system, the key loads can obtain power from seven sources. The direct current bus power control unit （DC ...The redundancy technology for the aircraft multi-channel DC electrical power supply system is studied. In this system, the key loads can obtain power from seven sources. The direct current bus power control unit （DC BPCU） is put forward to manage the power supply system automatically. The redundancy innovation is also applied in both hardware and software of DC BPCU. Furthermore, redundancy fault diagnosis is discussed through the existing parts. Experiments and applications show that the proposed aircraft DC power supply system possesses many advantages of high reliability, high automation and so on.展开更多
Analytic redundancy-based fault diagnosis technique （ARFDT） is applied to onboard maintenance system （OMS）. The principle of the proposed ARFDT scheme is to design a redundancy configuration using ARFDT to enhance...Analytic redundancy-based fault diagnosis technique （ARFDT） is applied to onboard maintenance system （OMS）. The principle of the proposed ARFDT scheme is to design a redundancy configuration using ARFDT to enhance the functions of redundancy management and built in test equipment （BITE） monitor. Redundancy configuration for dual-redundancy and analytic redundancy is proposed, in which, the fault diagnosis includes detection and isolation. In order to keep the balance between rapid diagnosis and binary hypothesis, a filter together with an elapsed time limit is designed for sequential probability ratio test （SPRT） in the process of isolation. Diagnosis results would be submitted to central maintenance computer （CMC） together with BITE information. Moreover, by adopting reconstruction, the designed method not only provides analytic redundancy to help redundancy management, but also compensates the output when both of the sensors of the same type are faulty. Our scheme is applied to an aircraft’s sensors in a simulation experiment, and the results show that the proposed filter SPRT （FSPRT） saves at least 50% of isolation time than Wald SPRT （WSPRT）. Also, effectiveness, practicability and rapidity of the proposed scheme can be successfully achieved in OMS.展开更多
Actuation system is a vital system in an aircraft, providing the force necessary to move flight control surfaces. The system has a significant influence on the overall aircraft performance and its safety. In order to ...Actuation system is a vital system in an aircraft, providing the force necessary to move flight control surfaces. The system has a significant influence on the overall aircraft performance and its safety. In order to further increase already high reliability and safety, Airbus has imple- mented a dissimilar redundancy actuation system （DRAS） in its aircraft. The DRAS consists of a hydraulic actuation system （HAS） and an electro-hydrostatic actuation system （EHAS）, in which the HAS utilizes a hydraulic source （HS） to move the control surface and the EHAS utilizes an elec- trical supply （ES） to provide the motion force. This paper focuses on the performance degradation processes and fault monitoring strategies of the DRAS, establishes its reliability model based on the generalized stochastic Petri nets （GSPN）, and carries out a reliability assessment considering the fault monitoring coverage rate and the false alarm rate. The results indicate that the proposed reli- ability model of the DRAS, considering the fault and redundancy degradation process and identify monitoring, can express its fault logical relation potential safety hazards.展开更多
This paper deals with the dynamics and control of a novel 3-degrees-of-freedom （DOF） parallel manipulator with actuation redundancy. According to the kinematics of the redundant manipulator, the inverse dynamic equa...This paper deals with the dynamics and control of a novel 3-degrees-of-freedom （DOF） parallel manipulator with actuation redundancy. According to the kinematics of the redundant manipulator, the inverse dynamic equation is formulated in the task space by using the Lagrangian formalism, and the driving force is optimized by utilizing the minimal 2-norm method. Based on the dynamic model, a synchronized sliding mode control scheme based on contour error is proposed to implement accurate motion tracking control. Additionally, an adaptive method is introduced to approximate the lumped uncertainty of the system and provide a chattering-free control. The simulation results indicate the effectiveness of the proposed approaches and demonstrate the satisfactory tracking performance compared to the conventional controller in the presence of the parameter uncertainties and un-modelled dynamics for the motion control of manipulators.展开更多
Structural redundancy elimination in case resource pools （CRP） is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this pape...Structural redundancy elimination in case resource pools （CRP） is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this paper proposes a novel approach to ensure redundancy elimination of a reasoning system in CRP. By using α entropy and mutual information, functional measures to eliminate redundancy of a system are developed with respect to a set of outputs. These measures help to distinguish both the optimal feature and the relations among the nodes in reasoning networks from the redundant ones with the elimination criterion. Based on the optimal feature and its harmonic weight, a model for knowledge reasoning in CRP （CRPKR） is built to complete the task of query matching, and the missing values are estimated with Bayesian networks. Moreover, the robustness of decisions is verified through parameter analyses. This approach is validated by the simulation with benchmark data sets using cloud SQL. Compared with several state-of-the-art techniques, the results show that the proposed approach has a good performance and boosts the robustness of decisions.展开更多
Gene knockdown approaches using antisense oligo nucleotides or analogs such as siRNAs and morpholinos have been widely adopted to study gene functions although the off-target issue has been always a concern in these s...Gene knockdown approaches using antisense oligo nucleotides or analogs such as siRNAs and morpholinos have been widely adopted to study gene functions although the off-target issue has been always a concern in these studies.On the other hand,classic genetic analysis relies on the availability of loss-offunction or gain-of-function mutants.The fast development of genome editing technologies such as TALEN and CRISPR/Cas9 has greatly facilitated the generation of null mutants for the functional studies of target genes in a variety of organisms such as zebrafish.Surprisingly,an unexpected discrepancy was observed between morphant phenotype and mutant phenotype for many genes in zebrafish,i.e.,while the morphant often displays an obvious phenotype,the corresponding null mutant appears relatively normal or only exhibits a mild phenotype due to gene compensation.Two recent reports have partially answered this intriguing question by showing that a pre-mature termination codon and homologous sequence are required to elicit the gene compensation and the histone modifying complex COMPASS is involved in activating the expression of the compensatory genes.Here,I summarize these exciting new progress and try to redefine the concept of genetic compensation and gene compensation.展开更多
This paper presents a trinal-branch space robotic manipulator with redundancy, due to hash application environments, such as in the station. One end-effector of the manipulator can be attached to the base, and other t...This paper presents a trinal-branch space robotic manipulator with redundancy, due to hash application environments, such as in the station. One end-effector of the manipulator can be attached to the base, and other two be controlled to accomplish tasks. The manipulator permits operation of science payload, during periods when astronauts may not be present. In order to provide theoretic basis for kinematics optimization, dynamics optimization and fault-tolerant control, its inverse kinematics is analyzed by using screw theory, and its unified formulation is established. Base on closed-form resolution of spherical wrist, a simplified inverse kinematics is proposed. Computer simulation results demonstrate the validity of the proposed inverse kinematics.展开更多
The high redundancy actuator(HRA)concept is a novel approach to fault tolerant actuation that uses a high number of small actuation elements,assembled in series and parallel in order to form a single actuator which ha...The high redundancy actuator(HRA)concept is a novel approach to fault tolerant actuation that uses a high number of small actuation elements,assembled in series and parallel in order to form a single actuator which has intrinsic fault tolerance.Whilst this structure afords resilience under passive control methods alone,active control approaches are likely to provide higher levels of performance.A multiple-model control scheme for an HRA applied through the framework of multi-agent control is presented here.The application of this approach to a 10×10 HRA is discussed and consideration of reconfguration delays and fault detection errors are made.The example shows that multi-agent control can provide tangible performance improvements and increase fault tolerance in comparison to a passive fault tolerant approach.Reconfguration delays are shown to be tolerable,and a strategy for handling false fault detections is detailed.展开更多
The enhanced variable rate codec (EVRC) is a standard for the 'Speech ServiceOption 3 for Wideband Spread Spectrum Digital System,' which has been employed in both IS-95cellular systems and ANSI J-STC-008 PCS ...The enhanced variable rate codec (EVRC) is a standard for the 'Speech ServiceOption 3 for Wideband Spread Spectrum Digital System,' which has been employed in both IS-95cellular systems and ANSI J-STC-008 PCS (personal communications systems). This paper concentrateson channel decoders that exploit the residual redundancy inherent in the enhanced variable ratecodec bitstream. This residual redundancy is quantified by modeling the parameters as first orderMarkov chains and computing the entropy rate based on the relative frequencies of transitions.Moreover, this residual redundancy can be exploited by an appropriately 'tuned' channel decoder toprovide substantial coding gain when compared with the decoders that do not exploit it. Channelcoding schemes include convolutional codes, and iteratively decoded parallel concatenatedconvolutional 'turbo' codes.展开更多
Wireless sensor networks （WSNs） consist of sensor nodes that broadcast a message within a network. Efficient broadcasting is a key requirement in sensor networks and has been a focal point of research over the last ...Wireless sensor networks （WSNs） consist of sensor nodes that broadcast a message within a network. Efficient broadcasting is a key requirement in sensor networks and has been a focal point of research over the last few years. There are many challenging tasks in the network, including redundancy control and sensor node localization that mainly depend on broadcasting. In this paper, we propose a broadcasting algorithm to control redundancy and improve localization （BACRIL） in WSNs. The proposed algorithm incorporates the benefits of the gossip protocol for optimizing message broadcasting within the network. Simulation results show a controlled level of redundancy, which is up to 57.6% if the number of sensor nodes deployed in a 500 m×500 m area are increased from 50 to 500.展开更多
Feature selection is an important problem in pattern classification systems. High dimension fisher criterion（HDF） is a good indicator of class separability. However, calculating the high dimension fisher ratio is di...Feature selection is an important problem in pattern classification systems. High dimension fisher criterion（HDF） is a good indicator of class separability. However, calculating the high dimension fisher ratio is difficult. A new feature selection method, called fisher-and-correlation （FC）, is proposed. The proposed method is combining fisher criterion and correlation criterion based on the analysis of feature relevance and redundancy. The proposed methodology is tested in five different classification applications. The presented resuits confirm that FC performs as well as HDF does at much lower computational complexity.展开更多
Although it is common to eliminate the singularity of parallel mechanism by adding the branched chain with actuation redundancy, there is no theory and method for the configuration synthesis of the branched chain with...Although it is common to eliminate the singularity of parallel mechanism by adding the branched chain with actuation redundancy, there is no theory and method for the configuration synthesis of the branched chain with actuation redundancy in parallel mechanism. Branched chains with actuation redundancy are synthesized for eliminating interior singularity of 3-translational and 1-rotational（3T1R） parallel mechanisms. Guided by the discriminance method of hybrid screw group according to Grassmann line geometry, all the possibilities are listed for the occurrence of interior singularities in 3T1R parallel mechanism. Based on the linear relevance of screw system and the principles of eliminating parallel mechanism singularity with actuation redundancy, different types of branched chains with actuation redundancy are synthesized systematically to indicate the layout and the number of the branched chainsinterior with actuation redundancy. A general method is proposed for the configuration synthesis of the branched chains with actuation redundancy of the redundant parallel mechanism, and it builds a solid foundation for the subsequent performance optimization of the redundant actuation parallel mechanism.展开更多
This study provides new insights into the comparison of cable-stayed and extradosed bridges based on the safety assessment of their stay cables.These bridges are often regarded as identical structures owing to the use...This study provides new insights into the comparison of cable-stayed and extradosed bridges based on the safety assessment of their stay cables.These bridges are often regarded as identical structures owing to the use of inclined cables;however,the international standards for bridge design stipulate different safety factors for stay cables of both types of bridges.To address this misconception,a comparative study was carried out on the safety factors of stay cables under fatigue and ultimate limit states by considering the effects of various untoward and damaging factors,such as overloading,cable loss,and corrosion.The primary goal of this study is to describe the structural disparities between both types of bridges and evaluate their structural redundancies by employing deterministic and nondeterministic methods.To achieve this goal,three-dimensional finite-element models of both bridges were developed based on the current design guidelines for stay cables in Japan.After the balanced states of the bridge models were achieved,static analyses were performed for different safety factors of stay cables in a parametric manner.Finally,the first-order reliability method and Monte Carlo method were applied to determine the reliability index of stay cables.The analysis results show that cable-stayed and extradosed bridges exhibit different structural redundancies for different safety factors under the same loading conditions.Moreover,a significant increase in structural redundancy occurs with an incremental increase in the safety factors of stay cables.展开更多
基金supported by National Key Research and Development Program of China(No.2023YFB 4404200).
文摘Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.
基金supported by the National Natural Sci ence Foundation of China(No.31672543)the Zhejiang Province“Sannongliufang”Science and Technology Coopera tion Project(No.2020SNLF007),China.
文摘Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite.In immune-competent individuals,T.
基金New Century Program For Excellent Talents of Ministry of Education of China (NCET-04-0163)
文摘This article presents a novel electrical/mechanical hybrid 4-redundancy brushless DC torque motor （BLDCM）, which has found applications in direct drive actuators （DDA） of aerial vehicles. This motor is characteristic of electrical/mechanical hybrid 4-redundancy by securing two stators along with two rotors on the same shaft. Each stator contains two sets of windings embed- ded in separated slots. Furthermore, compared to the scheme of two electrical dual-redundancy BLDCMs linked by a mechanical transmission, the proposed motor has lower volume and lighter weight, eliminates the nonlinearity caused by the gap of the me- chanical transmission, moderates the requirement for the torque balance between redundancies and reduces the cogging torque by shifting the magnets. Both magnetic circuit calculation and the finite element analysis （FEA） of the electromagnetic field are conducted to optimize the design process. A prototype motor has been produced and tested. The results indicate that its perform- ances comply with the requirements presented by designers. Moreover, the position frequency response of the prototype in the DDA＇s unloaded situation has also demonstrated the fulfillment of desired dynamic characteristics.
基金National Natural Science Foundation of China (50576033)Aeronautical Science Foundation of China (04C52019)
文摘The hard support vector regression attracts little attention owing to the overfitting phenomenon. Recently, a fast offiine method has been proposed to approximately train the hard support vector regression with the generation performance comparable to the soft support vector regression. Based on this achievement, this article advances a fast online approximation called the hard sup- port vector regression （FOAHSVR for short）. By adopting the greedy stagewise and iterative strategies, it is capable of online estimating parameters of complicated systems. In order to verify the effectiveness of the FOAHSVR, an FOAHSVR-based analytical redundancy for aeroengines is developed. Experiments on the sensor failure and drift evidence the viability and feasibility of the analytical redundancy for aeroengines together with its base--FOAHSVR. In addition, the FOAHSVR is anticipated to find applications in other scientific-technical fields.
文摘The redundancy technology for the aircraft multi-channel DC electrical power supply system is studied. In this system, the key loads can obtain power from seven sources. The direct current bus power control unit （DC BPCU） is put forward to manage the power supply system automatically. The redundancy innovation is also applied in both hardware and software of DC BPCU. Furthermore, redundancy fault diagnosis is discussed through the existing parts. Experiments and applications show that the proposed aircraft DC power supply system possesses many advantages of high reliability, high automation and so on.
基金Aeronautical Science Foundation of China (20100753009)
文摘Analytic redundancy-based fault diagnosis technique （ARFDT） is applied to onboard maintenance system （OMS）. The principle of the proposed ARFDT scheme is to design a redundancy configuration using ARFDT to enhance the functions of redundancy management and built in test equipment （BITE） monitor. Redundancy configuration for dual-redundancy and analytic redundancy is proposed, in which, the fault diagnosis includes detection and isolation. In order to keep the balance between rapid diagnosis and binary hypothesis, a filter together with an elapsed time limit is designed for sequential probability ratio test （SPRT） in the process of isolation. Diagnosis results would be submitted to central maintenance computer （CMC） together with BITE information. Moreover, by adopting reconstruction, the designed method not only provides analytic redundancy to help redundancy management, but also compensates the output when both of the sensors of the same type are faulty. Our scheme is applied to an aircraft’s sensors in a simulation experiment, and the results show that the proposed filter SPRT （FSPRT） saves at least 50% of isolation time than Wald SPRT （WSPRT）. Also, effectiveness, practicability and rapidity of the proposed scheme can be successfully achieved in OMS.
基金supported by the National Basic Research and Development Program of China(No.2014CB046402)the National Natural Science Foundation of China(No.51175014)‘‘111" Program of China
文摘Actuation system is a vital system in an aircraft, providing the force necessary to move flight control surfaces. The system has a significant influence on the overall aircraft performance and its safety. In order to further increase already high reliability and safety, Airbus has imple- mented a dissimilar redundancy actuation system （DRAS） in its aircraft. The DRAS consists of a hydraulic actuation system （HAS） and an electro-hydrostatic actuation system （EHAS）, in which the HAS utilizes a hydraulic source （HS） to move the control surface and the EHAS utilizes an elec- trical supply （ES） to provide the motion force. This paper focuses on the performance degradation processes and fault monitoring strategies of the DRAS, establishes its reliability model based on the generalized stochastic Petri nets （GSPN）, and carries out a reliability assessment considering the fault monitoring coverage rate and the false alarm rate. The results indicate that the proposed reli- ability model of the DRAS, considering the fault and redundancy degradation process and identify monitoring, can express its fault logical relation potential safety hazards.
基金supported by National Natural Science Foundation of China(Nos.51075222 and E050101)Priority Academic Program Development of Jiangsu Higher Education Institutions(No.6,2011)+1 种基金Zhenjiang Municipal Key Technology R&D Program(No.NY2011013)Postgraduate Research and Innovation Program of Jiangsu Higher Education Institutions(No.1221140046)
文摘This paper deals with the dynamics and control of a novel 3-degrees-of-freedom （DOF） parallel manipulator with actuation redundancy. According to the kinematics of the redundant manipulator, the inverse dynamic equation is formulated in the task space by using the Lagrangian formalism, and the driving force is optimized by utilizing the minimal 2-norm method. Based on the dynamic model, a synchronized sliding mode control scheme based on contour error is proposed to implement accurate motion tracking control. Additionally, an adaptive method is introduced to approximate the lumped uncertainty of the system and provide a chattering-free control. The simulation results indicate the effectiveness of the proposed approaches and demonstrate the satisfactory tracking performance compared to the conventional controller in the presence of the parameter uncertainties and un-modelled dynamics for the motion control of manipulators.
基金supported by the National Natural Science Foundation of China (7117114371201087)+1 种基金the Tianjin Municipal Research Program of Application Foundation and Advanced Technology of China (10JCY-BJC07300)the Science and Technology Program of FOXCONN Group (120024001156)
文摘Structural redundancy elimination in case resource pools （CRP） is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this paper proposes a novel approach to ensure redundancy elimination of a reasoning system in CRP. By using α entropy and mutual information, functional measures to eliminate redundancy of a system are developed with respect to a set of outputs. These measures help to distinguish both the optimal feature and the relations among the nodes in reasoning networks from the redundant ones with the elimination criterion. Based on the optimal feature and its harmonic weight, a model for knowledge reasoning in CRP （CRPKR） is built to complete the task of query matching, and the missing values are estimated with Bayesian networks. Moreover, the robustness of decisions is verified through parameter analyses. This approach is validated by the simulation with benchmark data sets using cloud SQL. Compared with several state-of-the-art techniques, the results show that the proposed approach has a good performance and boosts the robustness of decisions.
基金supported by National Key R&D Program of China (2018YFA0800501)National Natural Science Foundation of China (Nos.31571495, 31830113 and 31330050)
文摘Gene knockdown approaches using antisense oligo nucleotides or analogs such as siRNAs and morpholinos have been widely adopted to study gene functions although the off-target issue has been always a concern in these studies.On the other hand,classic genetic analysis relies on the availability of loss-offunction or gain-of-function mutants.The fast development of genome editing technologies such as TALEN and CRISPR/Cas9 has greatly facilitated the generation of null mutants for the functional studies of target genes in a variety of organisms such as zebrafish.Surprisingly,an unexpected discrepancy was observed between morphant phenotype and mutant phenotype for many genes in zebrafish,i.e.,while the morphant often displays an obvious phenotype,the corresponding null mutant appears relatively normal or only exhibits a mild phenotype due to gene compensation.Two recent reports have partially answered this intriguing question by showing that a pre-mature termination codon and homologous sequence are required to elicit the gene compensation and the histone modifying complex COMPASS is involved in activating the expression of the compensatory genes.Here,I summarize these exciting new progress and try to redefine the concept of genetic compensation and gene compensation.
文摘This paper presents a trinal-branch space robotic manipulator with redundancy, due to hash application environments, such as in the station. One end-effector of the manipulator can be attached to the base, and other two be controlled to accomplish tasks. The manipulator permits operation of science payload, during periods when astronauts may not be present. In order to provide theoretic basis for kinematics optimization, dynamics optimization and fault-tolerant control, its inverse kinematics is analyzed by using screw theory, and its unified formulation is established. Base on closed-form resolution of spherical wrist, a simplified inverse kinematics is proposed. Computer simulation results demonstrate the validity of the proposed inverse kinematics.
基金supported by UK s Engineering and Physical Sciences Research Council(EPSRC)(No.EP/D078350/1)
文摘The high redundancy actuator(HRA)concept is a novel approach to fault tolerant actuation that uses a high number of small actuation elements,assembled in series and parallel in order to form a single actuator which has intrinsic fault tolerance.Whilst this structure afords resilience under passive control methods alone,active control approaches are likely to provide higher levels of performance.A multiple-model control scheme for an HRA applied through the framework of multi-agent control is presented here.The application of this approach to a 10×10 HRA is discussed and consideration of reconfguration delays and fault detection errors are made.The example shows that multi-agent control can provide tangible performance improvements and increase fault tolerance in comparison to a passive fault tolerant approach.Reconfguration delays are shown to be tolerable,and a strategy for handling false fault detections is detailed.
文摘The enhanced variable rate codec (EVRC) is a standard for the 'Speech ServiceOption 3 for Wideband Spread Spectrum Digital System,' which has been employed in both IS-95cellular systems and ANSI J-STC-008 PCS (personal communications systems). This paper concentrateson channel decoders that exploit the residual redundancy inherent in the enhanced variable ratecodec bitstream. This residual redundancy is quantified by modeling the parameters as first orderMarkov chains and computing the entropy rate based on the relative frequencies of transitions.Moreover, this residual redundancy can be exploited by an appropriately 'tuned' channel decoder toprovide substantial coding gain when compared with the decoders that do not exploit it. Channelcoding schemes include convolutional codes, and iteratively decoded parallel concatenatedconvolutional 'turbo' codes.
文摘Wireless sensor networks （WSNs） consist of sensor nodes that broadcast a message within a network. Efficient broadcasting is a key requirement in sensor networks and has been a focal point of research over the last few years. There are many challenging tasks in the network, including redundancy control and sensor node localization that mainly depend on broadcasting. In this paper, we propose a broadcasting algorithm to control redundancy and improve localization （BACRIL） in WSNs. The proposed algorithm incorporates the benefits of the gossip protocol for optimizing message broadcasting within the network. Simulation results show a controlled level of redundancy, which is up to 57.6% if the number of sensor nodes deployed in a 500 m×500 m area are increased from 50 to 500.
基金the Ministerial Level Advanced Research Foundation(66830202)
文摘Feature selection is an important problem in pattern classification systems. High dimension fisher criterion（HDF） is a good indicator of class separability. However, calculating the high dimension fisher ratio is difficult. A new feature selection method, called fisher-and-correlation （FC）, is proposed. The proposed method is combining fisher criterion and correlation criterion based on the analysis of feature relevance and redundancy. The proposed methodology is tested in five different classification applications. The presented resuits confirm that FC performs as well as HDF does at much lower computational complexity.
基金Supported by Research Fund for the Doctoral Program of Higher Education,China(Grant No.20131333110008)
文摘Although it is common to eliminate the singularity of parallel mechanism by adding the branched chain with actuation redundancy, there is no theory and method for the configuration synthesis of the branched chain with actuation redundancy in parallel mechanism. Branched chains with actuation redundancy are synthesized for eliminating interior singularity of 3-translational and 1-rotational（3T1R） parallel mechanisms. Guided by the discriminance method of hybrid screw group according to Grassmann line geometry, all the possibilities are listed for the occurrence of interior singularities in 3T1R parallel mechanism. Based on the linear relevance of screw system and the principles of eliminating parallel mechanism singularity with actuation redundancy, different types of branched chains with actuation redundancy are synthesized systematically to indicate the layout and the number of the branched chainsinterior with actuation redundancy. A general method is proposed for the configuration synthesis of the branched chains with actuation redundancy of the redundant parallel mechanism, and it builds a solid foundation for the subsequent performance optimization of the redundant actuation parallel mechanism.
文摘This study provides new insights into the comparison of cable-stayed and extradosed bridges based on the safety assessment of their stay cables.These bridges are often regarded as identical structures owing to the use of inclined cables;however,the international standards for bridge design stipulate different safety factors for stay cables of both types of bridges.To address this misconception,a comparative study was carried out on the safety factors of stay cables under fatigue and ultimate limit states by considering the effects of various untoward and damaging factors,such as overloading,cable loss,and corrosion.The primary goal of this study is to describe the structural disparities between both types of bridges and evaluate their structural redundancies by employing deterministic and nondeterministic methods.To achieve this goal,three-dimensional finite-element models of both bridges were developed based on the current design guidelines for stay cables in Japan.After the balanced states of the bridge models were achieved,static analyses were performed for different safety factors of stay cables in a parametric manner.Finally,the first-order reliability method and Monte Carlo method were applied to determine the reliability index of stay cables.The analysis results show that cable-stayed and extradosed bridges exhibit different structural redundancies for different safety factors under the same loading conditions.Moreover,a significant increase in structural redundancy occurs with an incremental increase in the safety factors of stay cables.
