Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting sin...Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon detectors.Here,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding attacks.Our strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding attacks.By integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding attacks.This method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security.展开更多
In a practical quantum key distribution（QKD） system, imperfect equipment, especially the single-photon detector,can be eavesdropped on by a blinding attack. However, the original blinding attack may be discovered by...In a practical quantum key distribution（QKD） system, imperfect equipment, especially the single-photon detector,can be eavesdropped on by a blinding attack. However, the original blinding attack may be discovered by directly detecting the current. In this paper, we propose a probabilistic blinding attack model, where Eve probabilistically applies a blinding attack without being caught by using only an existing intuitive countermeasure. More precisely, our countermeasure solves the problem of how to define the bound in the limitation of precision of current detection, and then we prove security of the practical system by considering the current parameter. Meanwhile, we discuss the bound of the quantum bit error rate（QBER） introduced by Eve, by which Eve can acquire information without the countermeasure.展开更多
As one of the key components of clinical trials, blinding, if successfully implemented, can help to mitigate the risks of implementation bias and measurement bias, consequently improving the validity and reliability o...As one of the key components of clinical trials, blinding, if successfully implemented, can help to mitigate the risks of implementation bias and measurement bias, consequently improving the validity and reliability of the trial results. However, successful blinding in clinical trials of traditional Chinese medicine(TCM) is hard to achieve, and the evaluation of blinding success through blinding assessment lacks established guidelines. Taking into account the challenges associated with blinding in the TCM field, here we present a framework for assessing blinding. Further, this study proposes a blinding assessment protocol for TCM clinical trials, building upon the framework and the existing methods. An assessment report checklist and an approach for evaluating the assessment results are presented based on the proposed protocol. It is anticipated that these improvements to blinding assessment will generate greater awareness among researchers, facilitate the standardization of blinding, and augment the blinding effectiveness. The use of this blinding assessment may further advance the quality and precision of TCM clinical trials and improve the accuracy of the trial results. The blinding assessment protocol will undergo continued optimization and refinement, drawing upon expert consensus and experience derived from clinical trials.展开更多
The way of ventilation in all its forms and characteristics in the blinding heading was studied.On the basis of computational fluid dynamics (CFD) the turbulence model of restrained ventilation in blinding heading was...The way of ventilation in all its forms and characteristics in the blinding heading was studied.On the basis of computational fluid dynamics (CFD) the turbulence model of restrained ventilation in blinding heading was set up,and the calculation boundary condi- tions were analyzed.According to the practice application the three-dimensional flow field of ventilation in blinding heading was simulated by the computational fluid dynamics soft- ware.The characteristics of the ventilation flow field such as the temperature field zone and the flow filed zone and the rule of the flow velocity were obtained.The ventilation in blinding heading under certain circumstances was calculated and simulated for optimiza- tion.The optimal ventilation form and related parameters under given condition were ob- tained.The rule of the ventilation in blinding heading was theoretical analyzed,which pro- vided reference for the research on the process of mass transfer,the rule of hazardous substances transportation and ventilation efficiency,provided a new method for the study of reasonable and effective ventilation in blinding heading.展开更多
The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding prob...The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding problem were presented.展开更多
Objective:Fu's subcutaneous needling(FSN)has been shown potential positive effectiveness in clinical practice.However,its specific effects are still not clear.This study aims to evaluate the blinding effect of a n...Objective:Fu's subcutaneous needling(FSN)has been shown potential positive effectiveness in clinical practice.However,its specific effects are still not clear.This study aims to evaluate the blinding effect of a non-penetrating sham FSN needle,developed for the first time by the authors'research team in healthy participants.Furthermore,to provide a reliable control tool to assess the specific effects of FSN.Methods:We conducted a randomized,sham-controlled trial in 60 healthy participants divided into FSN group and sham FSN group in a 1:1 ratio.The participants were assessed according to blinding index(BI),pain intensity,sensation type and acceptability of needling.Results:The James'BI was(0.56,95%CI[0.45,0.67])for two groups.The Bang's BI was(0.50,95%CI[0.24,0.76])in the FSN group and(-0.36,95%CI[-0.67,-0.07])in the sham FSN group.There was no significant difference between needling pain intensity(P>0.05)and type of needling sensation.A total of 96.6%participants who received sham FSN and 86.6%participants who received FSN considered the needling acceptable or better.Conclusion:This study confirmed the effective blinding capability of the sham FSN needles in healthy participants,indicating that the novel non-penetrating sham FSN needle can be served as eligible control to evaluatethe specific effects of FSN.展开更多
In our highly globalized but culturally divided world whereby so-called defense industry is implied as both innovative and progressive, as contemporaneously the international legal doctrine is conceived to be static a...In our highly globalized but culturally divided world whereby so-called defense industry is implied as both innovative and progressive, as contemporaneously the international legal doctrine is conceived to be static and conservative. This doubly bound narrative itself is almost as old as international law wherein the most striking contradictory moments happened in the era of, and between two world wars： In such a way that our thinking of legal and other fields owe much more thereto than we realize today. In this study, it is purported to call attention to some key understandings which may be termed as militarist humanitarianism, humanitarian militarism, or, optimist scientism, and pessimist humanitarianism. As such, it is intended to examine international issues pertaining to humanitarianism and militarism through the lens of different perspectives, doctrine-itself and their history as enshrined in the Protocol IV on Blinding Laser Weapons, issues which are almost totally neglected in the mainstream media and academia.展开更多
Objective:To determine the prevalence of blinding trachoma among refugees in South Western Ethiopia.Methods:A cross-sectional outreach clinic based descriptive study was conducted on 1054 refugees in Southwest Ethiopi...Objective:To determine the prevalence of blinding trachoma among refugees in South Western Ethiopia.Methods:A cross-sectional outreach clinic based descriptive study was conducted on 1054 refugees in Southwest Ethiopia.A basic eyelid and cornea examination for signs of trachoma was done by using 2.5× binocular magnifying loupe.The findings were classified by using the World Health Digitization simplified trachoma grading system and data were analyzed by using SPSS version 16.0.Results:A total of 1054 refugee patients were examined for trachoma.179(16.98%) of them had clinical signs of trachoma.About 6(3.35%) patients had active trachoma with trachomatous trichiasis(TT),47(26.26%) patients had TT only and the rest 126(70.39%)patients had TT with trachomatous corneal opacity.All of the trachoma patients had blinding trachoma(TT with or without trachomatous corneal opacity),and about 60.89% of them had visual impairment.Blinding trachoma was significantly more common among females.patients in age group of 16-59 years,married patients,illiterates and Fugnido camp settlers(P<0.05).Conclusions:There is a very high burden of blinding trachoma among refugees.Urgent surgical intervention is needed to prevent blindness and low vision in the study subjects,and targeted regular outreach-based eye care service should be commenced.展开更多
Partial key exposure attacks present a signifcant threat to RSA-type cryptosystems. These attacks factorize the RSA modulus by utilizing partial knowledge of the decryption exponent, which is typically revealed by sid...Partial key exposure attacks present a signifcant threat to RSA-type cryptosystems. These attacks factorize the RSA modulus by utilizing partial knowledge of the decryption exponent, which is typically revealed by side-channel attacks, cold boot attacks, etc. In practice, the RSA implementations typically employ countermeasures to resist physi-calattacks, such as additive exponent blinding d′ = d + rϕ(N) with unknown random blinding factor r. Although there are a couple of partial key exposure attacks on blinding RSA, these attacks require a considerable amount of leakage and fail to work when e is up to full size. In this paper, we propose new partial key exposure attacks on RSA with additive exponent blinding, focusing on leakage scenarios where the Most Signifcant Bits (MSBs) or Least Sig-nifcantBits (LSBs) of d′ are revealed. For the case where e is small, we frst recover partial information of p by solving the quadratic congruence equation, and then fnd the small roots of the integer equation to recover entire private key. Our method relaxes the attack requirements, for instance, we reduce the amount of MSBs for a successful attack from 75 to 25% when e ≈ N0.25 and r ≈ N0 . Furthermore, we propose new attacks using the unique algebraic rela-tionshipin blinding RSA, which extend the attack to the case where e is of full size.展开更多
Calcium (Ca^(2+)) is a key intracellular messenger involved in a variety of cellular functions.Intracellular Ca^(2+)dysregulation drives neuron cell death in multiple degenerative diseases and traumatic conditions.Ret...Calcium (Ca^(2+)) is a key intracellular messenger involved in a variety of cellular functions.Intracellular Ca^(2+)dysregulation drives neuron cell death in multiple degenerative diseases and traumatic conditions.Retinal ganglion cell(RGC) degeneration occurs in blinding diseases such as glaucoma and other optic neuropathies.展开更多
The revision of CONSORT guidelines for reporting blinding in randomised controlled trials is the subject of controversy and criticism. To determine whether the criticism is justified, in this short communication paper...The revision of CONSORT guidelines for reporting blinding in randomised controlled trials is the subject of controversy and criticism. To determine whether the criticism is justified, in this short communication paper we discuss the problems encountered in the methodology of the assessment of blinding, and the reporting of blinding in randomised controlled trials and the standards of reporting on blinding with reference to their usage in clinical trials of acupuncture for chronic pain. To conclude we recommend two simple guidelines： the development of sound clinical protocols that anticipate potential difficulties and reinforce overall internal validity, and secondly. the accurate reporting of the methodologies used to ensure a clear view of blinding procedures.展开更多
Trachoma is a blinding eye disease caused by Chlamydia trachomatis infection.Trachoma was pandemic in the 19th century and rampant around the world,and was a widely prevalent infectious eye disease.
Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are...Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are consequently lacking.The microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a host.The intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other factors.Such dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many diseases.In recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the brain.Indeed,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease.Similarly,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular disorders.Moreover,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable etiologies.As such,the intestinal flora may play an important role in age-related macular degeneration.Given the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic strategies.Currently,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular degeneration.Organ-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the intestinal flora with research on metabolites through metabolomics and other techniques is crucial for understanding their potential mechanisms.展开更多
The advancement in endoscopic technology and techniques has increased its use in the diagnosis and treatment of gastrointestinal diseases.Reprocessing of reusable endoscopes remains a challenge.Inadequate reprocessing...The advancement in endoscopic technology and techniques has increased its use in the diagnosis and treatment of gastrointestinal diseases.Reprocessing of reusable endoscopes remains a challenge.Inadequate reprocessing leads to bacterial contamination of the endoscope,a significant cause of endoscope-related infections.To thoroughly address the complexities of cleaning a flexible endo-scope,various cleaning methods have been devised and tested across different studies.This letter evaluates one such method,spray flushing for flexible gastro-scopes,developed and tested in a randomized controlled trial by Du et al.Based on the post-processing test results for this method,Du et al conclude that there is improved cleaning efficacy and reduced damage compared to manual brush cleaning.The validity and reliability of the results could be further enhanced by carefully considering the study design and a few underlying concepts that contribute to the reprocessing quality of different types of endoscopes.展开更多
AIM:To evaluate the prevalence and the causes of blindness,severe visual impairment(SVI),and visual impairment(VI)and to investigate the frequency of cataract surgery in people aged≥50y in Yueqing,Zhejiang Province,C...AIM:To evaluate the prevalence and the causes of blindness,severe visual impairment(SVI),and visual impairment(VI)and to investigate the frequency of cataract surgery in people aged≥50y in Yueqing,Zhejiang Province,China.METHODS:A population-based,cross-sectional study was performed using the Rapid Assessment of Avoidable Blindness technique.Eight-seven clusters,each consisting of 50 people aged≥50y,were selected by probabilityproportionate-to-size sampling.Three outreach teams conducted door-to-door visits.Visual acuity(VA)was measured using a tumbling E chart.Lens status and causes of VI were assessed by ophthalmologists for individuals with a VA of<6/12 in either eye.A standardized questionnaire was used to collect information about cataract surgeries.RESULTS:Of 4350 eligible individuals,4120 were examined with a 94.7%response rate.Age-and genderadjusted prevalence of blindness,SVI,and VI were 0.5%(95%CI,0.3%–0.7%),0.7%(95%CI,0.4%–1.0%),and 4.8%(95%CI,4.2%–5.5%),respectively.Age was associated with an increased prevalence of VI,and the most common cause of VI was untreated cataracts,with the main barriers to cataract surgery being a lack of knowledge or awareness about cataracts.Of the 415 eyes operated on for cataracts,68(16.4%)eyes had a poor outcomes(VA<6/60)and 303(73.0%)had a good outcomes(VA>6/18).CONCLUSION:Prevalence rates of blindness,SVI,and VI in Yueqing are lower than other reported Chinese population-based studies.Cataracts remain the most common cause of blindness and VI.展开更多
Objective:This study aimed to investigate the prevalence,causes,and influencing factors of vision impairment in the elderly population aged 60 years and above in Mangxin Town,Kashgar region,Xinjiang,China.Located in a...Objective:This study aimed to investigate the prevalence,causes,and influencing factors of vision impairment in the elderly population aged 60 years and above in Mangxin Town,Kashgar region,Xinjiang,China.Located in a region characterized by intense ultraviolet radiation and arid climatic conditions,Mangxin Town presents unique environmental challenges that may exacerbate ocular health issues.Despite the global emphasis on addressing vision impairment among aging populations,there remains a paucity of updated and region-specific data in Xinjiang,necessitating this comprehensive assessment to inform targeted interventions.Methods:A cross-sectional study was conducted from May to June 2024,involving 1,311 elderly participants(76.76%participation rate)out of a total eligible population of 1,708 individuals aged≥60 years.Participants underwent detailed ocular examinations,including assessments of uncorrected visual acuity(UVA)and best-corrected visual acuity(BCVA)using standard logarithmic charts,slit-lamp biomicroscopy,optical coherence tomography(OCT,Topcon DRI OCT Triton),fundus photography,and intraocular pressure measurement(Canon TX-20 Tonometer).A multidisciplinary team of 10 ophthalmologists and 2 local village doctors,trained rigorously in standardized protocols,ensured consistent data collection.Demographic,lifestyle,and medical history data were collected via questionnaires.Statistical analyses,performed using STATA 16,included multivariate logistic regression to identify risk factors,with significance defined as P<0.05.Results:The overall prevalence of vision impairment was 13.21%(95%CI:11.37%-15.04%),with low vision at 11.76%(95%CI:10.01%-13.50%)and blindness at 1.45%(95%CI:0.80%-2.10%).Cataract emerged as the leading cause,responsible for 68.20%of cases,followed by glaucoma(5.80%),optic atrophy(5.20%),and age-related macular degeneration(2.90%).Vision impairment prevalence escalated significantly with age:7.74%in the 60–69 age group,17.79%in 70–79,and 33.72%in those≥80.Males exhibited higher prevalence than females(15.84%vs.10.45%,P=0.004).Multivariate analysis revealed age≥80 years(OR=6.43,95%CI:3.79%-10.90%),male sex(OR=0.53,95%CI:0.34%-0.83%),and daily exercise(OR=0.44,95%CI:0.20%-0.95%)as significant factors.History of eye disease showed a non-significant trend toward increased risk(OR=1.49,P=0.107).Education level,income,and smoking status showed no significant associations.Conclusions:This study underscores cataract as the predominant cause of vision impairment in Mangxin Town’s elderly population,with age and sex as critical determinants.The findings align with global patterns but highlight region-specific challenges,such as environmental factors contributing to cataract prevalence.Public health strategies should prioritize improving access to cataract surgery,enhancing grassroots ophthalmic infrastructure,and integrating portable screening technologies for early detection of fundus diseases.Additionally,promoting health education on UV protection and lifestyle modifications,such as regular exercise,may mitigate risks.Future research should expand to broader regions in Xinjiang,employ advanced diagnostic tools for complex conditions like glaucoma,and explore longitudinal trends to refine intervention strategies.These efforts are vital to reducing preventable blindness and improving quality of life for aging populations in underserved areas.展开更多
This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system ci...This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system circuit is designed and fabricated,enabling the detection,acquisition,and calibration of weak solar-blind UV signals.Experimental results demonstrate that under zero bias conditions,with a UV light power density of 3.45μW/cm^(2) at 260 nm,the sample achieves a peak responsivity(R)of 0.085 A·W^(−1),an external quantum efficiency(EQE)of 40.7%,and a detectivity(D^(*))of 7.46×10^(12) cm·Hz^(1/2)·W^(−1).The system exhibits a bandpass characteristic within the 240–280 nm wavelength range,coupled with a high signal-to-noise ratio(SNR)of 39.74 dB.展开更多
My parents and I lived upstairs over my aged and infirm paternal grandparents.All of us helped make the grandparentsday⁃to⁃day lives as comfortable as possible.But Granny was gradually going blind and Gramps suffered ...My parents and I lived upstairs over my aged and infirm paternal grandparents.All of us helped make the grandparentsday⁃to⁃day lives as comfortable as possible.But Granny was gradually going blind and Gramps suffered from the effects of two strokes(中风).Grannys mind was sharp.展开更多
Blockchain-enabled Internet of Medical Things (BIoMT) has attracted significant attention from academia and healthcare organizations. However, the large amount of medical data involved in BIoMT has also raised concern...Blockchain-enabled Internet of Medical Things (BIoMT) has attracted significant attention from academia and healthcare organizations. However, the large amount of medical data involved in BIoMT has also raised concerns about data security and personal privacy protection. To alleviate these concerns, blind signature technology has emerged as an effective method to solve blindness and unforgeability. Unfortunately, most existing blind signature schemes suffer from the security risk of key leakage. In addition, traditional blind signature schemes are also vulnerable to quantum computing attacks. Therefore, it remains a crucial and ongoing challenge to explore the construction of key-secure, quantum-resistant blind signatures. In this paper, we introduce lattice-based forward-secure blind signature (LFSBS), a lattice-based forward-secure blind signature scheme for medical privacy preservation in BIoMT. LFSBS achieves forward security by constructing a key evolution mechanism using a binary tree structure. This mechanism ensures that even if future encryption keys are leaked, past data can still remain secure. Meanwhile, LFSBS realizes post-quantum security based on the hardness assumption of small integer solution (SIS), making it resistant to potential quantum computing attacks. In addition, we formally define and prove the security of LFSBS in a random oracle model, including blindness and forward-secure unforgeability. Comprehensive performance evaluation shows that LFSBS performs well in terms of computational overhead, with a reduction of 22%–73% compared to previous schemes.展开更多
Dogs make great pets,and some are also good workers.Some dogs help blind people.They lead blind people around and help them get to places safely.Police dogs help officers.They can find bad guys or look for drugs and o...Dogs make great pets,and some are also good workers.Some dogs help blind people.They lead blind people around and help them get to places safely.Police dogs help officers.They can find bad guys or look for drugs and other dangerous things.展开更多
基金This work was supported by the Major Scientific and Technological Special Project of Anhui Province(202103a13010004)the Major Scientific and Technological Special Project of Hefei City(2021DX007)+1 种基金the Key R&D Plan of Shandong Province(2020CXGC010105)the China Postdoctoral Science Foundation(2021M700315).
文摘Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon detectors.Here,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding attacks.Our strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding attacks.By integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding attacks.This method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security.
基金Project supported by the National Basic Research Program of China(Grant Nos.2011CBA00200 and 2011CB921200)the National Natural Science Foundation of China(Grant Nos.61475148,61201239,61205118,and 11304397)the China Postdoctoral Science Foundation(Grant No.2013M540514)
文摘In a practical quantum key distribution（QKD） system, imperfect equipment, especially the single-photon detector,can be eavesdropped on by a blinding attack. However, the original blinding attack may be discovered by directly detecting the current. In this paper, we propose a probabilistic blinding attack model, where Eve probabilistically applies a blinding attack without being caught by using only an existing intuitive countermeasure. More precisely, our countermeasure solves the problem of how to define the bound in the limitation of precision of current detection, and then we prove security of the practical system by considering the current parameter. Meanwhile, we discuss the bound of the quantum bit error rate（QBER） introduced by Eve, by which Eve can acquire information without the countermeasure.
基金supported by the National Natural Science Foundation of China(No.82174530).
文摘As one of the key components of clinical trials, blinding, if successfully implemented, can help to mitigate the risks of implementation bias and measurement bias, consequently improving the validity and reliability of the trial results. However, successful blinding in clinical trials of traditional Chinese medicine(TCM) is hard to achieve, and the evaluation of blinding success through blinding assessment lacks established guidelines. Taking into account the challenges associated with blinding in the TCM field, here we present a framework for assessing blinding. Further, this study proposes a blinding assessment protocol for TCM clinical trials, building upon the framework and the existing methods. An assessment report checklist and an approach for evaluating the assessment results are presented based on the proposed protocol. It is anticipated that these improvements to blinding assessment will generate greater awareness among researchers, facilitate the standardization of blinding, and augment the blinding effectiveness. The use of this blinding assessment may further advance the quality and precision of TCM clinical trials and improve the accuracy of the trial results. The blinding assessment protocol will undergo continued optimization and refinement, drawing upon expert consensus and experience derived from clinical trials.
基金the National Scientific and Technological Support Plan of China(2006BAK05B04-03)
文摘The way of ventilation in all its forms and characteristics in the blinding heading was studied.On the basis of computational fluid dynamics (CFD) the turbulence model of restrained ventilation in blinding heading was set up,and the calculation boundary condi- tions were analyzed.According to the practice application the three-dimensional flow field of ventilation in blinding heading was simulated by the computational fluid dynamics soft- ware.The characteristics of the ventilation flow field such as the temperature field zone and the flow filed zone and the rule of the flow velocity were obtained.The ventilation in blinding heading under certain circumstances was calculated and simulated for optimiza- tion.The optimal ventilation form and related parameters under given condition were ob- tained.The rule of the ventilation in blinding heading was theoretical analyzed,which pro- vided reference for the research on the process of mass transfer,the rule of hazardous substances transportation and ventilation efficiency,provided a new method for the study of reasonable and effective ventilation in blinding heading.
文摘The agglomeration of moist fine coal and the mechanism of aperture blinding in screening were analyzed. The theoretical analysis and a pilot test on that the elastic screen mesh can overcome the aperture blinding problem were presented.
基金Supported by Guangdong Key Laboratory of Acupuncture and Moxibustion:202,101.
文摘Objective:Fu's subcutaneous needling(FSN)has been shown potential positive effectiveness in clinical practice.However,its specific effects are still not clear.This study aims to evaluate the blinding effect of a non-penetrating sham FSN needle,developed for the first time by the authors'research team in healthy participants.Furthermore,to provide a reliable control tool to assess the specific effects of FSN.Methods:We conducted a randomized,sham-controlled trial in 60 healthy participants divided into FSN group and sham FSN group in a 1:1 ratio.The participants were assessed according to blinding index(BI),pain intensity,sensation type and acceptability of needling.Results:The James'BI was(0.56,95%CI[0.45,0.67])for two groups.The Bang's BI was(0.50,95%CI[0.24,0.76])in the FSN group and(-0.36,95%CI[-0.67,-0.07])in the sham FSN group.There was no significant difference between needling pain intensity(P>0.05)and type of needling sensation.A total of 96.6%participants who received sham FSN and 86.6%participants who received FSN considered the needling acceptable or better.Conclusion:This study confirmed the effective blinding capability of the sham FSN needles in healthy participants,indicating that the novel non-penetrating sham FSN needle can be served as eligible control to evaluatethe specific effects of FSN.
文摘In our highly globalized but culturally divided world whereby so-called defense industry is implied as both innovative and progressive, as contemporaneously the international legal doctrine is conceived to be static and conservative. This doubly bound narrative itself is almost as old as international law wherein the most striking contradictory moments happened in the era of, and between two world wars： In such a way that our thinking of legal and other fields owe much more thereto than we realize today. In this study, it is purported to call attention to some key understandings which may be termed as militarist humanitarianism, humanitarian militarism, or, optimist scientism, and pessimist humanitarianism. As such, it is intended to examine international issues pertaining to humanitarianism and militarism through the lens of different perspectives, doctrine-itself and their history as enshrined in the Protocol IV on Blinding Laser Weapons, issues which are almost totally neglected in the mainstream media and academia.
文摘Objective:To determine the prevalence of blinding trachoma among refugees in South Western Ethiopia.Methods:A cross-sectional outreach clinic based descriptive study was conducted on 1054 refugees in Southwest Ethiopia.A basic eyelid and cornea examination for signs of trachoma was done by using 2.5× binocular magnifying loupe.The findings were classified by using the World Health Digitization simplified trachoma grading system and data were analyzed by using SPSS version 16.0.Results:A total of 1054 refugee patients were examined for trachoma.179(16.98%) of them had clinical signs of trachoma.About 6(3.35%) patients had active trachoma with trachomatous trichiasis(TT),47(26.26%) patients had TT only and the rest 126(70.39%)patients had TT with trachomatous corneal opacity.All of the trachoma patients had blinding trachoma(TT with or without trachomatous corneal opacity),and about 60.89% of them had visual impairment.Blinding trachoma was significantly more common among females.patients in age group of 16-59 years,married patients,illiterates and Fugnido camp settlers(P<0.05).Conclusions:There is a very high burden of blinding trachoma among refugees.Urgent surgical intervention is needed to prevent blindness and low vision in the study subjects,and targeted regular outreach-based eye care service should be commenced.
基金supported in part by National Key R&D Program of China(No.2022YFB3103800)National Natural Science Foundation of China(No.U1936209,No.62002353,No.62202231 and No.62202230)+1 种基金China Postdoc-toral Science Foundation(No.2021M701726)Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB270)。
文摘Partial key exposure attacks present a signifcant threat to RSA-type cryptosystems. These attacks factorize the RSA modulus by utilizing partial knowledge of the decryption exponent, which is typically revealed by side-channel attacks, cold boot attacks, etc. In practice, the RSA implementations typically employ countermeasures to resist physi-calattacks, such as additive exponent blinding d′ = d + rϕ(N) with unknown random blinding factor r. Although there are a couple of partial key exposure attacks on blinding RSA, these attacks require a considerable amount of leakage and fail to work when e is up to full size. In this paper, we propose new partial key exposure attacks on RSA with additive exponent blinding, focusing on leakage scenarios where the Most Signifcant Bits (MSBs) or Least Sig-nifcantBits (LSBs) of d′ are revealed. For the case where e is small, we frst recover partial information of p by solving the quadratic congruence equation, and then fnd the small roots of the integer equation to recover entire private key. Our method relaxes the attack requirements, for instance, we reduce the amount of MSBs for a successful attack from 75 to 25% when e ≈ N0.25 and r ≈ N0 . Furthermore, we propose new attacks using the unique algebraic rela-tionshipin blinding RSA, which extend the attack to the case where e is of full size.
文摘Calcium (Ca^(2+)) is a key intracellular messenger involved in a variety of cellular functions.Intracellular Ca^(2+)dysregulation drives neuron cell death in multiple degenerative diseases and traumatic conditions.Retinal ganglion cell(RGC) degeneration occurs in blinding diseases such as glaucoma and other optic neuropathies.
基金Hugh MacPherson is supported by a Career Scientist Award from the National Institute for Health Research,UK
文摘The revision of CONSORT guidelines for reporting blinding in randomised controlled trials is the subject of controversy and criticism. To determine whether the criticism is justified, in this short communication paper we discuss the problems encountered in the methodology of the assessment of blinding, and the reporting of blinding in randomised controlled trials and the standards of reporting on blinding with reference to their usage in clinical trials of acupuncture for chronic pain. To conclude we recommend two simple guidelines： the development of sound clinical protocols that anticipate potential difficulties and reinforce overall internal validity, and secondly. the accurate reporting of the methodologies used to ensure a clear view of blinding procedures.
文摘Trachoma is a blinding eye disease caused by Chlamydia trachomatis infection.Trachoma was pandemic in the 19th century and rampant around the world,and was a widely prevalent infectious eye disease.
基金supported by the National Natural Science Foundation of China,No.82171080Nanjing Medical Science and Technology Development Project,No.YKK23264Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。
文摘Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are consequently lacking.The microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a host.The intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other factors.Such dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many diseases.In recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the brain.Indeed,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease.Similarly,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular disorders.Moreover,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable etiologies.As such,the intestinal flora may play an important role in age-related macular degeneration.Given the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic strategies.Currently,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular degeneration.Organ-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the intestinal flora with research on metabolites through metabolomics and other techniques is crucial for understanding their potential mechanisms.
文摘The advancement in endoscopic technology and techniques has increased its use in the diagnosis and treatment of gastrointestinal diseases.Reprocessing of reusable endoscopes remains a challenge.Inadequate reprocessing leads to bacterial contamination of the endoscope,a significant cause of endoscope-related infections.To thoroughly address the complexities of cleaning a flexible endo-scope,various cleaning methods have been devised and tested across different studies.This letter evaluates one such method,spray flushing for flexible gastro-scopes,developed and tested in a randomized controlled trial by Du et al.Based on the post-processing test results for this method,Du et al conclude that there is improved cleaning efficacy and reduced damage compared to manual brush cleaning.The validity and reliability of the results could be further enhanced by carefully considering the study design and a few underlying concepts that contribute to the reprocessing quality of different types of endoscopes.
基金Supported by Zhejiang Province Science and Technology Benefiting Project(No.2014H01007)Wenzhou Municipal Basic Research Project(No.Y20210208).
文摘AIM:To evaluate the prevalence and the causes of blindness,severe visual impairment(SVI),and visual impairment(VI)and to investigate the frequency of cataract surgery in people aged≥50y in Yueqing,Zhejiang Province,China.METHODS:A population-based,cross-sectional study was performed using the Rapid Assessment of Avoidable Blindness technique.Eight-seven clusters,each consisting of 50 people aged≥50y,were selected by probabilityproportionate-to-size sampling.Three outreach teams conducted door-to-door visits.Visual acuity(VA)was measured using a tumbling E chart.Lens status and causes of VI were assessed by ophthalmologists for individuals with a VA of<6/12 in either eye.A standardized questionnaire was used to collect information about cataract surgeries.RESULTS:Of 4350 eligible individuals,4120 were examined with a 94.7%response rate.Age-and genderadjusted prevalence of blindness,SVI,and VI were 0.5%(95%CI,0.3%–0.7%),0.7%(95%CI,0.4%–1.0%),and 4.8%(95%CI,4.2%–5.5%),respectively.Age was associated with an increased prevalence of VI,and the most common cause of VI was untreated cataracts,with the main barriers to cataract surgery being a lack of knowledge or awareness about cataracts.Of the 415 eyes operated on for cataracts,68(16.4%)eyes had a poor outcomes(VA<6/60)and 303(73.0%)had a good outcomes(VA>6/18).CONCLUSION:Prevalence rates of blindness,SVI,and VI in Yueqing are lower than other reported Chinese population-based studies.Cataracts remain the most common cause of blindness and VI.
基金supported by Science and Technology Planning Project of Guangzhou City(2024A04J4474).
文摘Objective:This study aimed to investigate the prevalence,causes,and influencing factors of vision impairment in the elderly population aged 60 years and above in Mangxin Town,Kashgar region,Xinjiang,China.Located in a region characterized by intense ultraviolet radiation and arid climatic conditions,Mangxin Town presents unique environmental challenges that may exacerbate ocular health issues.Despite the global emphasis on addressing vision impairment among aging populations,there remains a paucity of updated and region-specific data in Xinjiang,necessitating this comprehensive assessment to inform targeted interventions.Methods:A cross-sectional study was conducted from May to June 2024,involving 1,311 elderly participants(76.76%participation rate)out of a total eligible population of 1,708 individuals aged≥60 years.Participants underwent detailed ocular examinations,including assessments of uncorrected visual acuity(UVA)and best-corrected visual acuity(BCVA)using standard logarithmic charts,slit-lamp biomicroscopy,optical coherence tomography(OCT,Topcon DRI OCT Triton),fundus photography,and intraocular pressure measurement(Canon TX-20 Tonometer).A multidisciplinary team of 10 ophthalmologists and 2 local village doctors,trained rigorously in standardized protocols,ensured consistent data collection.Demographic,lifestyle,and medical history data were collected via questionnaires.Statistical analyses,performed using STATA 16,included multivariate logistic regression to identify risk factors,with significance defined as P<0.05.Results:The overall prevalence of vision impairment was 13.21%(95%CI:11.37%-15.04%),with low vision at 11.76%(95%CI:10.01%-13.50%)and blindness at 1.45%(95%CI:0.80%-2.10%).Cataract emerged as the leading cause,responsible for 68.20%of cases,followed by glaucoma(5.80%),optic atrophy(5.20%),and age-related macular degeneration(2.90%).Vision impairment prevalence escalated significantly with age:7.74%in the 60–69 age group,17.79%in 70–79,and 33.72%in those≥80.Males exhibited higher prevalence than females(15.84%vs.10.45%,P=0.004).Multivariate analysis revealed age≥80 years(OR=6.43,95%CI:3.79%-10.90%),male sex(OR=0.53,95%CI:0.34%-0.83%),and daily exercise(OR=0.44,95%CI:0.20%-0.95%)as significant factors.History of eye disease showed a non-significant trend toward increased risk(OR=1.49,P=0.107).Education level,income,and smoking status showed no significant associations.Conclusions:This study underscores cataract as the predominant cause of vision impairment in Mangxin Town’s elderly population,with age and sex as critical determinants.The findings align with global patterns but highlight region-specific challenges,such as environmental factors contributing to cataract prevalence.Public health strategies should prioritize improving access to cataract surgery,enhancing grassroots ophthalmic infrastructure,and integrating portable screening technologies for early detection of fundus diseases.Additionally,promoting health education on UV protection and lifestyle modifications,such as regular exercise,may mitigate risks.Future research should expand to broader regions in Xinjiang,employ advanced diagnostic tools for complex conditions like glaucoma,and explore longitudinal trends to refine intervention strategies.These efforts are vital to reducing preventable blindness and improving quality of life for aging populations in underserved areas.
基金supported by the Director’s Fund for the‘Climbing Plan’of the National Space Science Centre of the Chinese Academy of Sciences(No.E2PD10011S)the National Engineering Research Centre for Mobile Private Networks Project(No.BJTU20221102).
文摘This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system circuit is designed and fabricated,enabling the detection,acquisition,and calibration of weak solar-blind UV signals.Experimental results demonstrate that under zero bias conditions,with a UV light power density of 3.45μW/cm^(2) at 260 nm,the sample achieves a peak responsivity(R)of 0.085 A·W^(−1),an external quantum efficiency(EQE)of 40.7%,and a detectivity(D^(*))of 7.46×10^(12) cm·Hz^(1/2)·W^(−1).The system exhibits a bandpass characteristic within the 240–280 nm wavelength range,coupled with a high signal-to-noise ratio(SNR)of 39.74 dB.
文摘My parents and I lived upstairs over my aged and infirm paternal grandparents.All of us helped make the grandparentsday⁃to⁃day lives as comfortable as possible.But Granny was gradually going blind and Gramps suffered from the effects of two strokes(中风).Grannys mind was sharp.
基金funded by the Yunnan Key Laboratory of Blockchain Application Technology(202105AG070005,202305AG340008)&YNB202301,NSFC(Grant Nos.72293583,72293580,62476007,62176273,62271234)the Open Foundation of State Key Laboratory of Networking and Switching Technology(Beijing University of Posts and Telecommunications)(SKLNST-2024-1-06)+2 种基金the Project of Science and Technology Major Project of Yunnan Province(202302AF080006)Open Foundation of State Key Laboratory of Public Big Data(Guizhou University)under Grant No.PBD2022-16Double First-Class Project for Collaborative Innovation Achievements inDisciplines Construction in Heilongjiang Province under Grant No.GXCG2022-054.
文摘Blockchain-enabled Internet of Medical Things (BIoMT) has attracted significant attention from academia and healthcare organizations. However, the large amount of medical data involved in BIoMT has also raised concerns about data security and personal privacy protection. To alleviate these concerns, blind signature technology has emerged as an effective method to solve blindness and unforgeability. Unfortunately, most existing blind signature schemes suffer from the security risk of key leakage. In addition, traditional blind signature schemes are also vulnerable to quantum computing attacks. Therefore, it remains a crucial and ongoing challenge to explore the construction of key-secure, quantum-resistant blind signatures. In this paper, we introduce lattice-based forward-secure blind signature (LFSBS), a lattice-based forward-secure blind signature scheme for medical privacy preservation in BIoMT. LFSBS achieves forward security by constructing a key evolution mechanism using a binary tree structure. This mechanism ensures that even if future encryption keys are leaked, past data can still remain secure. Meanwhile, LFSBS realizes post-quantum security based on the hardness assumption of small integer solution (SIS), making it resistant to potential quantum computing attacks. In addition, we formally define and prove the security of LFSBS in a random oracle model, including blindness and forward-secure unforgeability. Comprehensive performance evaluation shows that LFSBS performs well in terms of computational overhead, with a reduction of 22%–73% compared to previous schemes.
文摘Dogs make great pets,and some are also good workers.Some dogs help blind people.They lead blind people around and help them get to places safely.Police dogs help officers.They can find bad guys or look for drugs and other dangerous things.
