AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the disease.METHODS:Sixteen patients(16 eyes)with BKC complicated by corneal perf...AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the disease.METHODS:Sixteen patients(16 eyes)with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively analyzed.All patients received PKP.Participants were assessed for symptoms,clinical manifestations,the activity and damage grading of BKC.A paired t-test was used to compare the uncorrected visual acuity(UCVA)before and after surgery for the perforated eye.RESULTS:The mean age of the patients was 16.3y.Blurred vision is the most common discomfort,followed by redness,and then photophobia.The duration of ocular discomfort lasted for 3.2y,on average.Three(18.8%)participants were associated with rosacea,while 11(68.8%)patients had recurrent chalazion or hordeolum.Demodex in eyelash follicles was positive in 11(68.8%)cases.All corneal perforations were≤3.0 mm in diameter.The perforation was located mainly in the inferior cornea(68.8%).The mean area of corneal vascularisation was 3.0 quadrants.All patients manifested bilateral BKC,with the perforated eyes ranked as severely damaged and presenting with severe inflammation.Most contralateral eyes manifested mild damage with no active inflammation.Majority(68.8%)of the perforated eyes were treated with PKP using a minimal graft.The UCVA increased significantly at the final follow-up(mean,21mo;P<0.001),with the manifestation of BKC alleviated greatly.None of the patients developed immune rejection or other serious complications.CONCLUSION:BKC combined with corneal perforation occurs mainly among young people with a long history of ocular discomfort.PKP,especially using a minimal graft,is an effective and safe option for treating the disease.展开更多
This article reported a case of acne associated blepharokeratoconjunctivitis(BKC)in a young woman.During her pregnancy,to reduce the systemic use of drugs due to its side effect,localized eye drop,oral administration ...This article reported a case of acne associated blepharokeratoconjunctivitis(BKC)in a young woman.During her pregnancy,to reduce the systemic use of drugs due to its side effect,localized eye drop,oral administration of Chinese medicine,and fumigation treatment were adopted.In integrated Chinese and Western medicine treatments,localized treatment simultaneously with the intrinsic conditioning of the patient’s physique could treat both the symptoms and root causes of disease.It can effectively improve clinical efficacy,shorten the course of the disease,and reduce patient suffering and recurrence.展开更多
AIM:To evaluate the efficacy and safety of cyclosporine 1%(CsA)eye drops in patients affected by pediatric blepharokeratoconjunctivitis(PBKC).METHODS:This was a retrospective,single arm study of pediatric patients wit...AIM:To evaluate the efficacy and safety of cyclosporine 1%(CsA)eye drops in patients affected by pediatric blepharokeratoconjunctivitis(PBKC).METHODS:This was a retrospective,single arm study of pediatric patients with PBKC.All patients received topical CsA 1%eye drops,administered three times daily for 2mo and then tapered during the third month.In the first treatment week,chloramphenicol and betamethasone eye drops were also given three times daily.Patients were examined at baseline(T0),4wk(T1),3mo(T2),and 12mo(T3).At each visit,slit-lamp evaluation of the anterior segment and anterior segment photography were performed.Disease activity and damage were assessed using the modified Hamada bimodal scoring system.Mean PBKC scores across time points were compared using oneway ANOVA,followed by Tukey’s HSD post-hoc test.RESULTS:Thirty-six pediatric patients with PBKC were enrolled,six are excluded for incomplete follow-up,leaving 30 patients(11 males,19 females;mean age 7.71±3.86y)for analysis.The baseline activity score was 1.60±0.62 and decreased significantly at all time points(T1:0.53±0.51;T2:0.34±0.76;T3:0.47±0.86;P<0.001).Damage scores declined by 52%at T1,53%at T2,and 70%at T3,with significant reductions at T2 and T3 versus baseline(P<0.01).No adverse events occur during the follow-up.CONCLUSION:CsA 1%eye drops effectively control the signs and symptoms of PBKC in pediatric patients and demonstrate a favorable safety profile,supporting their used as a valid therapeutic option in clinical practice.展开更多
Background and Objective:Pediatric blepharokeratoconjunctivitis(PBKC),while carrying the risk of severe ocular morbidity,remains underdiagnosed and inadequately treated.This narrative literature review aims to provide...Background and Objective:Pediatric blepharokeratoconjunctivitis(PBKC),while carrying the risk of severe ocular morbidity,remains underdiagnosed and inadequately treated.This narrative literature review aims to provide a comprehensive overview of what the medical community has learned and understood to date with regard to PBKC.Additionally,the potential role for imaging modalities and emerging therapies is presented.Methods:A literature search was conducted utilizing the PubMed database.The search was conducted with the following terms:“pediatric blepharokeratoconjunctivitis”,“pediatric blepharitis”,and“pediatric blepharoconjunctivitis”.The search yielded articles published between 2005 and 2025.Key Content and Findings:The 2024 PBKC Study Group’s proposed standardized definition and diagnostic criteria of PBKC are highlighted as a significant step forward in achieving more timely diagnosis and treatment of PBKC.Vision loss in PBKC primarily stems from corneal involvement and its chronic,recurrent inflammatory nature with the potential to cause irreversible visual impairment or even blindness.There may be a role for meibography and anterior segment optical coherence tomography(AS-OCT)in diagnosing PBKC and monitoring response to treatment.Conclusions:In recent years,PBKC has attracted significant attention within the ophthalmologic community in efforts to better understand the complex etiology,pathogenesis,and clinical picture so as to successfully treat this challenging and potentially vision-threatening childhood ocular disease.Timely diagnosis and effective treatment remain a challenge;further investigation is critical to advance care and improve visual outcomes in patients affected by PBKC.展开更多
基金Supported by Key Technology Research and Development Program of Shandong Province(No.2022CXGC010505)Natural Science Foundation of Shandong Province(No.ZR2019BH065)+1 种基金Taishan Scholars Program(No.20221110)the Innovation Project of Shandong Academy of Medical Sciences.
文摘AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the disease.METHODS:Sixteen patients(16 eyes)with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively analyzed.All patients received PKP.Participants were assessed for symptoms,clinical manifestations,the activity and damage grading of BKC.A paired t-test was used to compare the uncorrected visual acuity(UCVA)before and after surgery for the perforated eye.RESULTS:The mean age of the patients was 16.3y.Blurred vision is the most common discomfort,followed by redness,and then photophobia.The duration of ocular discomfort lasted for 3.2y,on average.Three(18.8%)participants were associated with rosacea,while 11(68.8%)patients had recurrent chalazion or hordeolum.Demodex in eyelash follicles was positive in 11(68.8%)cases.All corneal perforations were≤3.0 mm in diameter.The perforation was located mainly in the inferior cornea(68.8%).The mean area of corneal vascularisation was 3.0 quadrants.All patients manifested bilateral BKC,with the perforated eyes ranked as severely damaged and presenting with severe inflammation.Most contralateral eyes manifested mild damage with no active inflammation.Majority(68.8%)of the perforated eyes were treated with PKP using a minimal graft.The UCVA increased significantly at the final follow-up(mean,21mo;P<0.001),with the manifestation of BKC alleviated greatly.None of the patients developed immune rejection or other serious complications.CONCLUSION:BKC combined with corneal perforation occurs mainly among young people with a long history of ocular discomfort.PKP,especially using a minimal graft,is an effective and safe option for treating the disease.
文摘This article reported a case of acne associated blepharokeratoconjunctivitis(BKC)in a young woman.During her pregnancy,to reduce the systemic use of drugs due to its side effect,localized eye drop,oral administration of Chinese medicine,and fumigation treatment were adopted.In integrated Chinese and Western medicine treatments,localized treatment simultaneously with the intrinsic conditioning of the patient’s physique could treat both the symptoms and root causes of disease.It can effectively improve clinical efficacy,shorten the course of the disease,and reduce patient suffering and recurrence.
文摘AIM:To evaluate the efficacy and safety of cyclosporine 1%(CsA)eye drops in patients affected by pediatric blepharokeratoconjunctivitis(PBKC).METHODS:This was a retrospective,single arm study of pediatric patients with PBKC.All patients received topical CsA 1%eye drops,administered three times daily for 2mo and then tapered during the third month.In the first treatment week,chloramphenicol and betamethasone eye drops were also given three times daily.Patients were examined at baseline(T0),4wk(T1),3mo(T2),and 12mo(T3).At each visit,slit-lamp evaluation of the anterior segment and anterior segment photography were performed.Disease activity and damage were assessed using the modified Hamada bimodal scoring system.Mean PBKC scores across time points were compared using oneway ANOVA,followed by Tukey’s HSD post-hoc test.RESULTS:Thirty-six pediatric patients with PBKC were enrolled,six are excluded for incomplete follow-up,leaving 30 patients(11 males,19 females;mean age 7.71±3.86y)for analysis.The baseline activity score was 1.60±0.62 and decreased significantly at all time points(T1:0.53±0.51;T2:0.34±0.76;T3:0.47±0.86;P<0.001).Damage scores declined by 52%at T1,53%at T2,and 70%at T3,with significant reductions at T2 and T3 versus baseline(P<0.01).No adverse events occur during the follow-up.CONCLUSION:CsA 1%eye drops effectively control the signs and symptoms of PBKC in pediatric patients and demonstrate a favorable safety profile,supporting their used as a valid therapeutic option in clinical practice.
文摘Background and Objective:Pediatric blepharokeratoconjunctivitis(PBKC),while carrying the risk of severe ocular morbidity,remains underdiagnosed and inadequately treated.This narrative literature review aims to provide a comprehensive overview of what the medical community has learned and understood to date with regard to PBKC.Additionally,the potential role for imaging modalities and emerging therapies is presented.Methods:A literature search was conducted utilizing the PubMed database.The search was conducted with the following terms:“pediatric blepharokeratoconjunctivitis”,“pediatric blepharitis”,and“pediatric blepharoconjunctivitis”.The search yielded articles published between 2005 and 2025.Key Content and Findings:The 2024 PBKC Study Group’s proposed standardized definition and diagnostic criteria of PBKC are highlighted as a significant step forward in achieving more timely diagnosis and treatment of PBKC.Vision loss in PBKC primarily stems from corneal involvement and its chronic,recurrent inflammatory nature with the potential to cause irreversible visual impairment or even blindness.There may be a role for meibography and anterior segment optical coherence tomography(AS-OCT)in diagnosing PBKC and monitoring response to treatment.Conclusions:In recent years,PBKC has attracted significant attention within the ophthalmologic community in efforts to better understand the complex etiology,pathogenesis,and clinical picture so as to successfully treat this challenging and potentially vision-threatening childhood ocular disease.Timely diagnosis and effective treatment remain a challenge;further investigation is critical to advance care and improve visual outcomes in patients affected by PBKC.
