Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epitheli...Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epithelial repair.Methods:The affected eyes of 90 patients with blepharitis-associated dry eye disease admitted to our hospital were selected,and the optimal parameters of enhanced pulsed light technology for dry eye syndrome were selected by L_(9)(3^(4))orthogonal experimental design with pulse width,pulse delay and energy gradient as the influencing factors,and the meibomian gland function was used as the evaluation index.The effect on meibomian gland f unction and corneal epithelial repair in patients with dry eye inflammation of the palpebral margin was observed.Results:The analysis of variance(ANOVA)results for the response surface methodology experiment demonstrated that the established model(R1=+0.92+0.38×energy gradient-0.33×pulse duration-0.10×pulse delay+0.65×energy gradient×pulse duration+1.30×energy gradient×pulse delay+0.100×pulse duration×pulse delay+1.37×energy gradient^(2)+0.065×pulse duration^(2)-0.58×pulse delay^(2))showed statistical significance(P<0.05),and the lack-of-fit term was non-significant(P>0.05),indicating that high reliability and successful modeling.The optimal parameters of the three factors appeared in the energy gradient pulse width of 14 J,10.82 ms,and pulse delay of 40.14 ms.After optimization with reference to the above parameters,the difference in meibomian gland function grade in 45 patients was significantly higher than that of the patients before optimization(P<0.05).Conclusion:The optimized IPL technology demonstrotes a significant improvement in blepharitis-associated dry eye disease,which can improve meibomian gland function,but still cannot promote corneal epithelial repair,so other treatment regimens can be considered.展开更多
文摘Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epithelial repair.Methods:The affected eyes of 90 patients with blepharitis-associated dry eye disease admitted to our hospital were selected,and the optimal parameters of enhanced pulsed light technology for dry eye syndrome were selected by L_(9)(3^(4))orthogonal experimental design with pulse width,pulse delay and energy gradient as the influencing factors,and the meibomian gland function was used as the evaluation index.The effect on meibomian gland f unction and corneal epithelial repair in patients with dry eye inflammation of the palpebral margin was observed.Results:The analysis of variance(ANOVA)results for the response surface methodology experiment demonstrated that the established model(R1=+0.92+0.38×energy gradient-0.33×pulse duration-0.10×pulse delay+0.65×energy gradient×pulse duration+1.30×energy gradient×pulse delay+0.100×pulse duration×pulse delay+1.37×energy gradient^(2)+0.065×pulse duration^(2)-0.58×pulse delay^(2))showed statistical significance(P<0.05),and the lack-of-fit term was non-significant(P>0.05),indicating that high reliability and successful modeling.The optimal parameters of the three factors appeared in the energy gradient pulse width of 14 J,10.82 ms,and pulse delay of 40.14 ms.After optimization with reference to the above parameters,the difference in meibomian gland function grade in 45 patients was significantly higher than that of the patients before optimization(P<0.05).Conclusion:The optimized IPL technology demonstrotes a significant improvement in blepharitis-associated dry eye disease,which can improve meibomian gland function,but still cannot promote corneal epithelial repair,so other treatment regimens can be considered.
