Summary： The changes in excitability and autorhthmicity of bladder detrusor in experimental non- insulin dependent diabetes mellitus （NIDDM） rats were observed. Sixty-nine NIDDM rats as NIDDM group and 69 normal ra...Summary： The changes in excitability and autorhthmicity of bladder detrusor in experimental non- insulin dependent diabetes mellitus （NIDDM） rats were observed. Sixty-nine NIDDM rats as NIDDM group and 69 normal rats as control group were enrolled into this experimental study. At 6th, 10th, 14th, 18th, 22nd and 26th week after the rats were iniected last time, the changes in the excitability and autorhthmicity of detrusor strips in vitro were observed. The results showed that the threshold of the tension which made the detrusor strips contract was significantly higher in NIDDM group （0.716±0.325 g） than in control group （0.323±0. 177 g）（F=59.63, P〈0.001）. At different stages, the threshold of the tension resulting the contract of the detrusor strips in NIDDM group was also higher than in control group. At 18th week after STZ iniection, the frequency of spontaneous contract of the detrusor strips in NIDDM was significantly higher than in control group （P〈0.05）, whereas at 22nd week, that in NIDDM group was significantly lower than in control group （P〈0. 05）. It was concluded that the decreased excitability of the bladder detrusor was the earliest and most obvious changes in bladder function in diabetes rats and the autorhthmicity had also changed at the early stage of diabetic bladder.展开更多
Purpose To observe the effect of acupuncturing different points on unstable bladder.Method Fifty-one patients of unstable bladder were divided randomly into Shu-point group, Mu-point group, He-point group, observe the...Purpose To observe the effect of acupuncturing different points on unstable bladder.Method Fifty-one patients of unstable bladder were divided randomly into Shu-point group, Mu-point group, He-point group, observe the change of symptom score and urodynamics.Results Puncturing these points can improve the symptom score and urodynamics, but the different points can get different effect, and the effect of Shu-point and He-point is superior to that of Mu-point.Conclusion The different points of bladder have different adjusting function and that function relates with nerves locating in points. Key words Urodynamics - Acupuncture Therapy - Bladder Disease - Syndrome Founhdation Item: Clinical Study and Neural Receptor Mechanism of Lumbosacral acupoints Regulating Unstable Bladder (02CK02), supported by the Education Committee of Shanghai City.Translator: CHEN Yue-lai展开更多
The bladder plays a critical role in maintaining homeostasis and overall health within the human body.Monitoring bladder conditions is essential for facilitating bladder control,evaluating wound healing,and other diag...The bladder plays a critical role in maintaining homeostasis and overall health within the human body.Monitoring bladder conditions is essential for facilitating bladder control,evaluating wound healing,and other diagnosis functions.Recent advancements in soft bioelectronics for sensing have introduced promising capabilities for monitoring bladder conditions including strain,pressure,volume,and other physiological properties,offering crucial feedback that enables adaptive therapeutic interventions.Meanwhile,minimally invasive drug delivery to the bladder is essential for treating various bladder diseases such as interstitial cystitis and bladder cancer with minimized side effect.This review highlights the latest innovations in soft bioelectronics including wearable,implantable,and intravesical devices for bladder condition monitoring and intravesical drug delivery systems for minimally invasive long-term treatment.We further provide perspective on the potential of integrating soft bioelectronics with drug delivery systems to facilitate closed-loop therapeutic functions for bladder disease management,improving patient outcomes and quality of life.展开更多
文摘Summary： The changes in excitability and autorhthmicity of bladder detrusor in experimental non- insulin dependent diabetes mellitus （NIDDM） rats were observed. Sixty-nine NIDDM rats as NIDDM group and 69 normal rats as control group were enrolled into this experimental study. At 6th, 10th, 14th, 18th, 22nd and 26th week after the rats were iniected last time, the changes in the excitability and autorhthmicity of detrusor strips in vitro were observed. The results showed that the threshold of the tension which made the detrusor strips contract was significantly higher in NIDDM group （0.716±0.325 g） than in control group （0.323±0. 177 g）（F=59.63, P〈0.001）. At different stages, the threshold of the tension resulting the contract of the detrusor strips in NIDDM group was also higher than in control group. At 18th week after STZ iniection, the frequency of spontaneous contract of the detrusor strips in NIDDM was significantly higher than in control group （P〈0.05）, whereas at 22nd week, that in NIDDM group was significantly lower than in control group （P〈0. 05）. It was concluded that the decreased excitability of the bladder detrusor was the earliest and most obvious changes in bladder function in diabetes rats and the autorhthmicity had also changed at the early stage of diabetic bladder.
基金Clinical Study and Neural Receptor Mechanism of Lumbosacral acupoints Regulating Unstable Bladder，上海市教委资助项目
文摘Purpose To observe the effect of acupuncturing different points on unstable bladder.Method Fifty-one patients of unstable bladder were divided randomly into Shu-point group, Mu-point group, He-point group, observe the change of symptom score and urodynamics.Results Puncturing these points can improve the symptom score and urodynamics, but the different points can get different effect, and the effect of Shu-point and He-point is superior to that of Mu-point.Conclusion The different points of bladder have different adjusting function and that function relates with nerves locating in points. Key words Urodynamics - Acupuncture Therapy - Bladder Disease - Syndrome Founhdation Item: Clinical Study and Neural Receptor Mechanism of Lumbosacral acupoints Regulating Unstable Bladder (02CK02), supported by the Education Committee of Shanghai City.Translator: CHEN Yue-lai
文摘The bladder plays a critical role in maintaining homeostasis and overall health within the human body.Monitoring bladder conditions is essential for facilitating bladder control,evaluating wound healing,and other diagnosis functions.Recent advancements in soft bioelectronics for sensing have introduced promising capabilities for monitoring bladder conditions including strain,pressure,volume,and other physiological properties,offering crucial feedback that enables adaptive therapeutic interventions.Meanwhile,minimally invasive drug delivery to the bladder is essential for treating various bladder diseases such as interstitial cystitis and bladder cancer with minimized side effect.This review highlights the latest innovations in soft bioelectronics including wearable,implantable,and intravesical devices for bladder condition monitoring and intravesical drug delivery systems for minimally invasive long-term treatment.We further provide perspective on the potential of integrating soft bioelectronics with drug delivery systems to facilitate closed-loop therapeutic functions for bladder disease management,improving patient outcomes and quality of life.
