The purpose of this study was to review the magnitude of contribution of chemotherapy(CT) in the local control of muscle invasive bladder carcinoma in the studies where a combined radio-chemotherapy(RCT) was used(how ...The purpose of this study was to review the magnitude of contribution of chemotherapy(CT) in the local control of muscle invasive bladder carcinoma in the studies where a combined radio-chemotherapy(RCT) was used(how much higher local control rates are obtained with RCT compared to RT alone).Studies on radiotherapy(RT) and combined RCT,neo-adjuvant,concurrent,adjuvant or combinations,reported after 1990 were reviewed.The mean complete response(CR) rates were significantly higher for the RCT studies compared to RT-alone studies:75.9% vs 64.4%(Wilcoxon ranksum test,P = 0.001).Eleven of the included RCT studies involved 2-3 cycles of neo-adjuvant CT,in addition to concurrent RCT.The RCT studies included the onephase type(where a full dose of RCT was given and then assessment of response and cystectomy for nonresponders followed) and the two-phase types(where an assessment of response was undertaken after an initial RCT course,followed 6 wk later by a consolidation RCT for those patients with a CR).CR rates between the two subgroups of RCT studies were 79.6%(one phase) vs 71.6%(two-phase)(P = 0.015).Theaverage achievable tumour control rates,with an acceptable rate of side effects have been around 70%,which may represent a plateau.Further increase in CR response rates demands for new chemotherapeutic agents,targeted therapies,or modified fractionation in various combinations.Quantification of RT and CT contribution to local control using radiobiological modelling in trial designs would enhance the potential for both improved outcomes and the estimation of the potential gain.展开更多
Aiming at realizing monitoring of tyre bladder vulcanizer operating process, a master-slave control system was composed of configuration software and Mitsubishi FX2N series PLC. PLC was taken as slave machine to opera...Aiming at realizing monitoring of tyre bladder vulcanizer operating process, a master-slave control system was composed of configuration software and Mitsubishi FX2N series PLC. PLC was taken as slave machine to operating process of tyre bladder vulcanizer. Configuration software monitored the running state of the tyre bladder vulcanizer realtimely, showed data in real time and recorded data in upper machine. The test results indicate that the system with friendly interface can be operated conveniently for automation management. The system can increase the tyre bladder quality successfully for production requirement.展开更多
Underactive bladder(UAB)patients experience straining to void and typically cannot sense bladder fullness.Previous closed-loop bladder volume control systems are limited in neurogenic UAB patients and face infection r...Underactive bladder(UAB)patients experience straining to void and typically cannot sense bladder fullness.Previous closed-loop bladder volume control systems are limited in neurogenic UAB patients and face infection risk due to wired connections.Here,we propose an intelligent bladder volume control system(IBCS)combining an implantable meshed magnetic soft robot(MMR)with a wearable magnetic field sensor.The MMR,tightly sutured to the bladder,compresses the bladder to facilitate urination under magnetic actuation,achieving a voiding efficiency of 94.8%.The wearable magnetic field sensor outside the abdomen achieves continuous and wireless monitoring of bladder volume with a 4.8%error in time.The MMR was validated on a UAB pig model,demonstrating a pressure increase of up to 33 cmH_(2)O and voiding efficiency of over 83%.Our IBCS provides a biocompatible solution for wireless and continuous bladder volume management by integrating wearable sensors and magnetic robotics.展开更多
文摘The purpose of this study was to review the magnitude of contribution of chemotherapy(CT) in the local control of muscle invasive bladder carcinoma in the studies where a combined radio-chemotherapy(RCT) was used(how much higher local control rates are obtained with RCT compared to RT alone).Studies on radiotherapy(RT) and combined RCT,neo-adjuvant,concurrent,adjuvant or combinations,reported after 1990 were reviewed.The mean complete response(CR) rates were significantly higher for the RCT studies compared to RT-alone studies:75.9% vs 64.4%(Wilcoxon ranksum test,P = 0.001).Eleven of the included RCT studies involved 2-3 cycles of neo-adjuvant CT,in addition to concurrent RCT.The RCT studies included the onephase type(where a full dose of RCT was given and then assessment of response and cystectomy for nonresponders followed) and the two-phase types(where an assessment of response was undertaken after an initial RCT course,followed 6 wk later by a consolidation RCT for those patients with a CR).CR rates between the two subgroups of RCT studies were 79.6%(one phase) vs 71.6%(two-phase)(P = 0.015).Theaverage achievable tumour control rates,with an acceptable rate of side effects have been around 70%,which may represent a plateau.Further increase in CR response rates demands for new chemotherapeutic agents,targeted therapies,or modified fractionation in various combinations.Quantification of RT and CT contribution to local control using radiobiological modelling in trial designs would enhance the potential for both improved outcomes and the estimation of the potential gain.
文摘Aiming at realizing monitoring of tyre bladder vulcanizer operating process, a master-slave control system was composed of configuration software and Mitsubishi FX2N series PLC. PLC was taken as slave machine to operating process of tyre bladder vulcanizer. Configuration software monitored the running state of the tyre bladder vulcanizer realtimely, showed data in real time and recorded data in upper machine. The test results indicate that the system with friendly interface can be operated conveniently for automation management. The system can increase the tyre bladder quality successfully for production requirement.
基金supported by the National Natural Science Foundation of China(nos.T2350001,52173280)the China Postdoctoral Science Foundation(no.2022M711256)+2 种基金the HUST Interdisciplinary Research Project(no.2023JCYJ044)the Taihu Lake Innovation Fund for Future Technology,HUST(no.2023A3)conducted by protocols approved by the Committee on Animal Care of Hubei Yizhicheng Biotechnology Co.Ltd.(Approval No.WDRM-202403003).
文摘Underactive bladder(UAB)patients experience straining to void and typically cannot sense bladder fullness.Previous closed-loop bladder volume control systems are limited in neurogenic UAB patients and face infection risk due to wired connections.Here,we propose an intelligent bladder volume control system(IBCS)combining an implantable meshed magnetic soft robot(MMR)with a wearable magnetic field sensor.The MMR,tightly sutured to the bladder,compresses the bladder to facilitate urination under magnetic actuation,achieving a voiding efficiency of 94.8%.The wearable magnetic field sensor outside the abdomen achieves continuous and wireless monitoring of bladder volume with a 4.8%error in time.The MMR was validated on a UAB pig model,demonstrating a pressure increase of up to 33 cmH_(2)O and voiding efficiency of over 83%.Our IBCS provides a biocompatible solution for wireless and continuous bladder volume management by integrating wearable sensors and magnetic robotics.
