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Inhibiting the bipolar effect via band gap engineering to improve the thermoelectric performance in n-type Bi_(2-x)Sb_(x)Te_(3)for solid-state refrigeration 被引量:4
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作者 Dongliang Su Jiahui Cheng +6 位作者 Shan Li Shengnan Zhang Tu Lyu Chaohua Zhang Junqin Li Fusheng Liu Lipeng Hu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第7期50-58,共9页
To date,the benchmark Bi_(2)Te_(3)-based alloys are still the only commercial material system used for ther-moelectric solid-state refrigeration.Nonetheless,the conspicuous performance imbalance between the p-type Bi_... To date,the benchmark Bi_(2)Te_(3)-based alloys are still the only commercial material system used for ther-moelectric solid-state refrigeration.Nonetheless,the conspicuous performance imbalance between the p-type Bi_(2-x)Sb_(x)Te_(3)and n-type Bi_(2)Te_(3-x)Se_(x) legs has become a major obstacle for the improvement of cooling devices to achieve higher efficiency.In our previous study,novel n-type Bi_(2-x)Sb_(x)Te_(3)alloy has been pro-posed via manipulating donor-like effect as an alternative to mainstream n-type Bi_(2)Te_(3-x)Se_(x).However,the narrow bandgap of Bi_(2-x)Sb_(x)Te_(3)provoked severe bipolar effect that constrained the further improvement of zT near room temperature.Herein,we have implemented band gap engineering in n-type Bi_(1.5)Sb_(0.5)Te_(3)by employing isovalent Se substitution to inhibit the undesired intrinsic excitation and achieve the dis-tinguished room-temperature zT.First,the preferential occupancy of Se at Te^(2)site appropriately enlarges the band gap,thereby concurrently improving the Seebeck coefficient and depressing the bipolar thermal conductivity.In addition,the Se alloying mildly suppresses the compensation mechanism and essentially preserves the already optimized carrier concentration,which maintains the peak zT near room tempera-ture.Moreover,the large strain field and mass fluctuation generated by Se alloying leads to the remark-able reduction of lattice thermal conductivity.Accordingly,the zT value of Bi_(1.5)Sb_(0.5)Te_(2.8)Se_(0.2)reaches 1.0 at 300 K and peaks 1.1 at 360 K,which surpasses that of most well-known room-temperature n-type thermoelectric materials.These results pave the way for n-type Bi_(2-x)Sb_(x)Te_(3)alloys to become a new and promising top candidate for large-scale solid-state cooling applications. 展开更多
关键词 Thermoelectric Bi_(2)Te_(3) Band gap bipolar effect Point defects
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New insight into the parasitic bipolar amplification effect in single event transient production 被引量:1
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作者 Chen Jian-Jun Chen Shu-Ming +1 位作者 Liang Bin Deng Ke-Feng 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第1期334-339,共6页
In this paper, a new method is proposed to study the mechanism of charge collection in single event transient (SET) production in 90 nm bulk complementary metal oxide semiconductor (CMOS) technology. We find that ... In this paper, a new method is proposed to study the mechanism of charge collection in single event transient (SET) production in 90 nm bulk complementary metal oxide semiconductor (CMOS) technology. We find that different from the case in the pMOSFET, the parasitic bipolar amplification effect (bipolar effect) in the balanced inverter does not exist in the nMOSFET after the ion striking. The influence of the suhstrate process on the bipolar effect is also studied in the pMOSFET. We find that the bipolar effect can be effectively mitigated by a buried deep P+-well layer and can be removed by a buried SO2 layer. 展开更多
关键词 parasitic bipolar amplification effect bipolar effect single event transient substrateprocess
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Experimental characterization of the bipolar effect on P-hit single-event transients in 65 nm twin-well and triple-well CMOS technologies 被引量:1
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作者 CHEN JianJun LIANG Bin CHI YaQing 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第3期488-493,共6页
Single-event charge collection is controlled by drift, diffusion and the bipolar effect. Previous work has established that the bipolar effect is significant in the p-type metal-oxide-semiconductor field-effect transi... Single-event charge collection is controlled by drift, diffusion and the bipolar effect. Previous work has established that the bipolar effect is significant in the p-type metal-oxide-semiconductor field-effect transistor(PMOS) in 90 nm technology and above. However, the consequences of the bipolar effect on P-hit single-event transients have still not completely been characterized in 65 nm technology. In this paper, characterization of the consequences of the bipolar effect on P-hit single-event transients is performed by heavy ion experiments in both 65 nm twin-well and triple-well complementary metal-oxide-semiconductor(CMOS) technologies. Two inverter chains with clever layout structures are explored for the characterization. Ge(linear energy transfer(LET) = 37.4 Me V cm^2/mg) and Ti(LET = 22.2 Me V cm^2/mg) particles are also employed. The experimental results show that with Ge(Ti) exposure, the average pulse reduction is 49 ps(45 ps) in triple-well CMOS technology and 42 ps(32 ps) in twin-well CMOS technology when the bipolar effect is efficiently mitigated. This characterization will provide an important reference for radiation hardening integrated circuit design. 展开更多
关键词 single event transient (SET) bipolar effect quantitative characterization
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Enhanced thermoelectric performance in Ga_(x)Co_(4)Sb_(12.3-y)Te_(y) skutterudites via suppressing bipolar effects for commercial application 被引量:1
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作者 Jing Jiang Rui Zhang +4 位作者 Chengcheng Yang Yi Niu Ting Zhou Yan Pan Chao Wang 《Journal of Materiomics》 SCIE EI 2020年第2期240-247,共8页
The n-type filled and doped skutterudites Ga_(x)Co_(4)Sb_(12.3) and Ga_(0.2)Co_(4)Sb_(11.3)Te composites with the welldistributed GaSb nanoinclusions are synthesized through the manipulating of metastable Ga fillers a... The n-type filled and doped skutterudites Ga_(x)Co_(4)Sb_(12.3) and Ga_(0.2)Co_(4)Sb_(11.3)Te composites with the welldistributed GaSb nanoinclusions are synthesized through the manipulating of metastable Ga fillers and enrichment of Sb by an in-situ method with a proper annealing procedure.Ga atoms can fill the icosahedron cages of skutterudite at high temperature,but at low temperature,they are driven out from the lattice voids and form the second phase of GaSb at grain boundaries.The presence of GaSb second phases reduces the thermal conductivity effectively.Te doping leads to a significant increase in carrier concentration of Ga_(0.2)Co_(4)Sb_(11.3)Te,thus largely suppresses the bipolar effect of Ga_(x)Co_(4)Sb_(12.3),resulting in a great enhancement in power factor.Moreover,Te doping induces mass and strain fluctuation,which decreases the lattice thermal conductivity further.Consequently,the maximum ZT is increased from 0.56 for Ga_(0.2)Co_(4)Sb_(12.3) at 573 K to 1.48 for Ga_(0.2)Co_(4)Sb_(11.3)Te at 873 K,which is advantageous to improve the thermoelectric conversion efficiency for commercial application. 展开更多
关键词 THERMOELECTRIC SKUTTERUDITE Second phase bipolar effect
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Effects of microwave pulse-width damage on a bipolar transistor 被引量:3
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作者 马振洋 柴常春 +3 位作者 任兴荣 杨银堂 陈斌 赵颖博 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第5期675-680,共6页
This paper presents a theoretical study of the pulse-width effects on the damage process of a typical bipolar transistor caused by high power microwaves(HPMs) through the injection approach.The dependences of the mi... This paper presents a theoretical study of the pulse-width effects on the damage process of a typical bipolar transistor caused by high power microwaves(HPMs) through the injection approach.The dependences of the microwave damage power,P,and the absorbed energy,E,required to cause the device failure on the pulse width τ are obtained in the nanosecond region by utilizing the curve fitting method.A comparison of the microwave pulse damage data and the existing dc pulse damage data for the same transistor is carried out.By means of a two-dimensional simulator,ISE-TCAD,the internal damage processes of the device caused by microwave voltage signals and dc pulse voltage signals are analyzed comparatively.The simulation results suggest that the temperature-rising positions of the device induced by the microwaves in the negative and positive half periods are different,while only one hot spot exists under the injection of dc pulses.The results demonstrate that the microwave damage power threshold and the absorbed energy must exceed the dc pulse power threshold and the absorbed energy,respectively.The dc pulse damage data may be useful as a lower bound for microwave pulse damage data. 展开更多
关键词 bipolar transistor high power microwave pulse width effects
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Substrate bias effects on collector resistance in SiGe heterojunction bipolar transistors on thin film silicon-on-insulator 被引量:1
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作者 徐小波 张鹤鸣 +2 位作者 胡辉勇 李妤晨 屈江涛 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第5期450-454,共5页
An analytical expression for the co/lector resistance of a novel vertical SiGe heterojunction bipolar transistor (HBT) on thin film silicon-on-insulator (SOI) is obtained with the substrate bias effects being cons... An analytical expression for the co/lector resistance of a novel vertical SiGe heterojunction bipolar transistor (HBT) on thin film silicon-on-insulator (SOI) is obtained with the substrate bias effects being considered. The resistance is found to decrease slowly and then quickly and to have kinks with the increase of the substrate-collector bias, which is quite different from that of a conventional bulk HBT. The model is consistent with the simulation result and the reported data and is useful to the frequency characteristic design of 0.13 μtm millimeter-wave SiGe SOI BiCMOS devices. 展开更多
关键词 collector resistance substrate bias effect SiGe heterojunction bipolar transistor thinfilm silicon-on-insulator
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A device model for thin silicon-on-insulator SiGe heterojunction bipolar transistors with saturation effects
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作者 徐小波 徐凯选 +1 位作者 张鹤鸣 秦珊珊 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第9期445-449,共5页
In this paper, we describe the saturation effect of a silicon germanium (SiGe) heterojunction bipolar transistor (HBT) fabricated on a thin silicon-on-insulator (SOI) with a step-by-step derivation of the model ... In this paper, we describe the saturation effect of a silicon germanium (SiGe) heterojunction bipolar transistor (HBT) fabricated on a thin silicon-on-insulator (SOI) with a step-by-step derivation of the model formulation. The collector injection width, the internal base-collector bias, and the hole density at the base-collector junction interface are analysed by considering the unique features of the internal and the external parts of the collector, as they are different from those of a bulk counterpart. 展开更多
关键词 saturation effect heterojunction bipolar transistor SIGE SILICON-ON-INSULATOR
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Early effect modeling of silicon-on-insulator SiGe heterojunction bipolar transistors 被引量:1
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作者 徐小波 张鹤鸣 +1 位作者 胡辉勇 马建立 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第5期444-449,共6页
Silicon germanium (SiGe) heterojunction bipolar transistor (HBT) on thin silicon-on-insulator (SOI) has recently been demonstrated and integrated into the latest SOI BiCMOS technology. The Early effect of the SO... Silicon germanium (SiGe) heterojunction bipolar transistor (HBT) on thin silicon-on-insulator (SOI) has recently been demonstrated and integrated into the latest SOI BiCMOS technology. The Early effect of the SOI SiGe HBT is analysed considering vertical and horizontal collector depletion, which is different from that of a bulk counterpart. A new compact formula of the Early voltage is presented and validated by an ISE TCAD simulation. The Early voltage shows a kink with the increase of the reverse base-collector bias. Large differences are observed between SOI devices and their bulk counterparts. The presented Early effect model can be employed for a fast evaluation of the Early voltage and is useful to the design, the simulation and the fabrication of high performance SOI SiCe devices and circuits. 展开更多
关键词 heterojunction bipolar transistor (HBT) SIGE SILICON-ON-INSULATOR Early effect
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Radiation effects on MOS and bipolar devices by 8 MeV protons,60 MeV Br ions and 1 MeV electrons
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作者 李兴冀 耿洪滨 +3 位作者 兰慕杰 杨德庄 何世禹 刘超铭 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第5期419-426,共8页
The radiation effects of the metal-oxide-semiconductor (MOS) and the bipolar devices are characterised using 8 MeV protons, 60 MeV Br ions and 1 MeV electrons. Key parameters are measured in-situ and compared for th... The radiation effects of the metal-oxide-semiconductor (MOS) and the bipolar devices are characterised using 8 MeV protons, 60 MeV Br ions and 1 MeV electrons. Key parameters are measured in-situ and compared for the devices. The ionising and nonionising energy losses of incident particles are calculated using the Geant4 and the stopping and range of ions in matter code. The results of the experiment and energy loss calculation for different particles show that different incident particles may give different contributions to MOS and bipolar devices. The irradiation particles, which cause a larger displacement dose within the same chip depth of bipolar devices at a given total dose, would generate more severe damage to the voltage parameters of the bipolar devices. On the contrary, the irradiation particles, which cause larger ionising damage in the gate oxide, would generate more severe damage to MOS devices. In this investigation, we attempt to analyse the sensitivity to radiation damage of the different parameter of the MOS and bipolar devices by comparing the irradiation experimental data and the calculated results using Geant4 and SRIM code. 展开更多
关键词 radiation effects MOS and bipolar devices ionisation damage displacement damage
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Experimental verification of the parasitic bipolar amplification effect in PMOS single event transients
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作者 何益百 陈书明 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第7期775-779,共5页
The contribution of parasitic bipolar amplification to SETs is experimentally verified using two P-hit target chains in the normal layout and in the special layout. For PMOSs in the normal layout, the single-event cha... The contribution of parasitic bipolar amplification to SETs is experimentally verified using two P-hit target chains in the normal layout and in the special layout. For PMOSs in the normal layout, the single-event charge collection is composed of diffusion, drift, and the parasitic bipolar effect, while for PMOSs in the special layout, the parasitic bipolar junction transistor cannot turn on. Heavy ion experimental results show that PMOSs without parasitic bipolar amplification have a 21.4% decrease in the average SET pulse width and roughly a 40.2% reduction in the SET cross-section. 展开更多
关键词 single event effect single event transient parasitic bipolar amplification heavy ion experiments
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共情理论的个性化干预措施对双相情感障碍患者情绪调节和康复的影响 被引量:5
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作者 李娇丽 魏小方 +3 位作者 张果 郭慧荣 崔坤 何丹丹 《中国健康心理学杂志》 2025年第2期177-181,共5页
目的:探讨基于共情理论的个性化干预措施对双相情感障碍(BD)患者情绪调节和康复的影响。方法:选取某院2022年3月—2024年3月收治的BD患者84例,根据随机数字表法将其分成对照组和观察组(各42例)。对照组给予常规干预措施,观察组在对照组... 目的:探讨基于共情理论的个性化干预措施对双相情感障碍(BD)患者情绪调节和康复的影响。方法:选取某院2022年3月—2024年3月收治的BD患者84例,根据随机数字表法将其分成对照组和观察组(各42例)。对照组给予常规干预措施,观察组在对照组基础上实施基于共情理论的个性化干预措施。比较两组应对方式[简易应对方式问卷(SCSQ)评分]、情绪状况[贝克-拉范森躁狂量表(BRMS)和抑郁自评量表(SDS)评分]、社会功能[社会功能缺陷筛选量表(SDSS)评分]、认知功能[蒙特利尔认知评估量表(MoCA)评分]、康复效果及睡眠质量[匹兹堡睡眠质量指数(PSQI)评分]。结果:干预后,观察组SCSQ中的积极应对评分高于对照组,消极应对评分低于对照组(t=4.910,8.327;P<0.05);观察组BRMS、SDS评分均低于对照组(t=8.365,2.949;P<0.05);观察组SDSS评分低于对照组,MoCA评分高于对照组(t=11.194,3.008;P<0.05);观察组总有效率高于对照组(χ^(2)=5.126;P<0.05);观察组PSQI各维度及总分均低于对照组(t=2.625,4.646,3.202,5.195,4.955,3.814,2.436,6.040;P<0.05)。结论:基于共情理论的个性化干预措施可改善BD患者应对方式和情绪状况,提高其社会功能、认知功能和睡眠质量,康复效果确切。 展开更多
关键词 双向情感障碍 共情理论 个性化干预 情绪调节 康复效果
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集成肖特基二极管的分裂栅碳化硅(SiC)MOSFET器件
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作者 马超 陈伟中 张波 《电子与信息学报》 北大核心 2025年第9期3346-3352,共7页
该文提出一种集成肖特基二极管结构的新型分裂栅碳化硅MOSFET器件,有效改善传统DT-MOS器件的反向恢复与开关特性。该新型结构首先采用元胞内集成肖特基二极管技术替代传统DT-MOS的右侧沟道,其次采用分裂栅极集成技术代替传统槽栅设计,... 该文提出一种集成肖特基二极管结构的新型分裂栅碳化硅MOSFET器件,有效改善传统DT-MOS器件的反向恢复与开关特性。该新型结构首先采用元胞内集成肖特基二极管技术替代传统DT-MOS的右侧沟道,其次采用分裂栅极集成技术代替传统槽栅设计,将栅极分成了栅极G和源极S两个部分,中间由二氧化硅进行介质隔离。其作用包括:集成肖特基二极管抑制体二极管导通并消除双极退化效应;集成分裂栅与源极短接,减小栅漏耦合面积来降低反馈电容与栅电荷,且在接入高电位时形成电子积累层以提高电子密度。其结果显示:反向导通状态下,电流将从肖特基二极管流出,连接源极的分裂栅极将提升电子浓度从而提高电流密度;动态开关状态下,分裂栅结构通过屏蔽设计减小了栅极与漏极的耦合面积,有效降低了米勒平台电荷QGD并改善了开关性能。 展开更多
关键词 肖特基二极管 碳化硅MOSFET双极退化效应 分裂栅极
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基于SDG MOS表面电势理论的PNP BJT过基极电流改进模型研究
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作者 刘帅 曹菲 +2 位作者 王祖军 邢嘉彬 秦建强 《电子元件与材料》 北大核心 2025年第8期919-927,共9页
电离总剂量(Total Ionizing Dose,TID)效应诱使PNP双极型晶体管(Bipolar Junction Transistors,BJTs)产生界面态电荷和氧化层俘获电荷,导致基极电流异常增大。鉴于传统解析模型的局限性,本文基于对称双栅MOSFET(Symmetric Double Gate M... 电离总剂量(Total Ionizing Dose,TID)效应诱使PNP双极型晶体管(Bipolar Junction Transistors,BJTs)产生界面态电荷和氧化层俘获电荷,导致基极电流异常增大。鉴于传统解析模型的局限性,本文基于对称双栅MOSFET(Symmetric Double Gate MOSFET,SDG MOS)表面电势理论,通过引入缺陷复合机制,提出了一种改进的PNP BJT过基极电流解析模型,并通过数值仿真揭示了不同界面态电荷密度(1×10^(11)~3×10^(12)cm^(2))和氧化层俘获电荷密度(1×10^(11)~1×10^(12)cm^(2))下的表面电势分布特征。3CK3B型晶体管在^(60)Coγ射线下的辐照试验(总剂量50/100 krad(Si))表明:改进模型计算结果与试验值的平均相对误差低至24.5%,较传统模型预测精度提升19%。理论分析表明,该模型可准确表征TID效应下双极晶体管表面电势的分布特征与过基极电流的关联机制,为抗辐射加固设计提供理论依据。 展开更多
关键词 电离总剂量效应 双极型晶体管 过基极电流 对称双栅MOSFET 表面电势理论
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SiGe-on-SOI HBT总剂量效应损伤研究
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作者 龙月得才 刘雪飞 +5 位作者 毕津顺 艾尔肯·阿不都瓦衣提 王珍 王刚 刘明强 王德贵 《微电子学》 北大核心 2025年第1期70-77,共8页
利用半导体器件仿真工具,针对SOI衬底锗硅异质结双极晶体管(SiGe-on-SOI HBT)的总剂量效应(TID)损伤机理与影响进行研究。STI与EB Spacer氧化层陷阱电荷和界面陷阱电荷引起额外的基极漏电流导致SiGe-on-SOI HBT器件电学参数退化。分析... 利用半导体器件仿真工具,针对SOI衬底锗硅异质结双极晶体管(SiGe-on-SOI HBT)的总剂量效应(TID)损伤机理与影响进行研究。STI与EB Spacer氧化层陷阱电荷和界面陷阱电荷引起额外的基极漏电流导致SiGe-on-SOI HBT器件电学参数退化。分析不同工作偏置和低温条件下的过剩基极电流和归一化电流增益,结果表明,截止偏置下退化最为严重,零偏其次,正向偏置和饱和偏置则表现出较好的抗辐照能力。低温条件下氧化层内电子空穴对的净产生率与传输时间降低,从而减少氧化层陷阱电荷和界面态陷阱,复合电流减小,因此Gummel特性显著改善。总剂量辐照1 Mrad(Si)后,fT和fmax分别增加了10%和8%,射频特性得到一定程度提升。本工作为SiGe-on-SOI HBT宇航器件的研发和应用提供了参考。 展开更多
关键词 锗硅异质结双极晶体管 绝缘体上硅 总剂量效应 陷阱电荷
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面积对垂直NPN结构探测器直流X射线响应特性的影响
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作者 王晶 欧阳晓平 +4 位作者 陈亮 王方宝 张雁霞 田耕 刘森 《强激光与粒子束》 北大核心 2025年第10期58-63,共6页
设计并制造了三种不同面积的双端SiC基NPN结构辐射探测器,并对其直流X射线响应特性进行了实验评估。实验结果表明,这些探测器在外加偏置电压和光伏电压的共同作用下工作,并存在四个拐点电压,将I-V特性曲线分为五个阶段。相比之下,在相... 设计并制造了三种不同面积的双端SiC基NPN结构辐射探测器,并对其直流X射线响应特性进行了实验评估。实验结果表明,这些探测器在外加偏置电压和光伏电压的共同作用下工作,并存在四个拐点电压,将I-V特性曲线分为五个阶段。相比之下,在相同的直流X射线照射条件下,面积较大的探测器能够吸收更多X射线能量,从而产生更强的输出信号。面积较小的探测器在I-V特性曲线上显示出更高的拐点电压,表现出更强的耐压能力。此外,探测器的响应时间与其面积大小密切相关,面积越大,开关下降时间越长,1 cm×1 cm探测器比0.25 cm×0.25 cm探测器的90%~10%下降时间要多约12.2 ms。这些发现强调了在辐射探测器设计中考虑面积的重要性,并指出了优化这一参数以提高探测器性能的必要性。 展开更多
关键词 X射线探测器 面积的影响 碳化硅探测器 双极型晶体管探测器 半导体辐射探测器
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哌罗匹隆联合拉莫三嗪治疗双相情感障碍抑郁发作的效果及安全性分析
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作者 张婷婷 《四川生理科学杂志》 2025年第2期356-358,432,共4页
目的:分析哌罗匹隆联合拉莫三嗪治疗双相情感障碍(Bipolar disorder,BPD)抑郁发作患者的效果及安全性。方法:回顾性分析2021年1月至2023年11月本院收治的82例BPD抑郁发作患者的临床资料。其中对照组(n=40)采用拉莫三嗪口服治疗,首次剂量... 目的:分析哌罗匹隆联合拉莫三嗪治疗双相情感障碍(Bipolar disorder,BPD)抑郁发作患者的效果及安全性。方法:回顾性分析2021年1月至2023年11月本院收治的82例BPD抑郁发作患者的临床资料。其中对照组(n=40)采用拉莫三嗪口服治疗,首次剂量25-50 mg·d^(-1),2次·d^(-1),观察组(n=42)基于对照组联用哌罗匹隆初始口服治疗,4 mg·d^(-1),1次·d^(-1),两组持续用药8 w。分析对比两组临床疗效,于治疗前后分别采用汉密尔顿抑郁量表-17项(Hamilton depression scale,HAMD-17)、临床总体印象⁃双相情感障碍病情程度量表(Clinical global impression scale-bipolar disorder,CGI-S-BP)、重复性成套神经心理状态测验(Repeatable battery for the assessment of neuropsychological status,RBANS)和世界卫生组织生存质量测定简表(The world health organization quality of life,WHOQOL-BREF)评估患者抑郁程度、BPD病情程度、心理认知和生存质量,同时采用酶联免疫吸附法检测5羟色胺(5-Hydroxytryptamine,5-HT)、谷氨酸(Glutamic acid,Glu)、血清γ氨基丁酸(γ-aminobutyric acid,GABA)水平,记录不良反应发生率。结果:观察组治疗总有效率显著高于对照组(P<0.05);与治疗前相比,两组治疗4 w、8 w后HAMD-17、CGI-S-BP评分均降低,RBANS、WHOQOL-BREF评分均提高,且观察组变化幅度均显著大于对照组(P<0.05);与对照组相比,观察组治疗4 w、8 w后的GABA、5-HT水平均显著升高,Glu水平显著降低(P<0.05);两组不良反应总发生率无显著差异(P>0.05)。结论:哌罗匹隆联合拉莫三嗪可有效改善BPD抑郁发作患者情绪,减轻抑郁症状,提高生存质量,且具有一定安全性。 展开更多
关键词 哌罗匹隆 拉莫三嗪 双相情感障碍 临床疗效
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集成JFET续流二极管的低开关损耗双沟槽SiC MOSFET
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作者 高升 章先锋 +2 位作者 陈秋锐 陈伟中 张红升 《电子与信息学报》 北大核心 2025年第9期3303-3311,共9页
传统双沟槽碳化硅金属氧化物半导体场效应晶体管(SiC MOSFET)在高频开关电路和反向续流应用中显现出显著的性能瓶颈,主要表现为开关损耗较高、反向导通电压偏大、反向恢复电荷过多,以及长时间反向续流易引发双极退化等问题。为突破这些... 传统双沟槽碳化硅金属氧化物半导体场效应晶体管(SiC MOSFET)在高频开关电路和反向续流应用中显现出显著的性能瓶颈,主要表现为开关损耗较高、反向导通电压偏大、反向恢复电荷过多,以及长时间反向续流易引发双极退化等问题。为突破这些技术限制,该文采用TCAD仿真技术,基于PN结空间电荷区内能带弯曲的物理机制,设计一种集成结型场效应晶体管(JFET)的双沟槽SiC MOSFET(IJ-MOS)。与传统SiC MOSFET(CON-MOS)相比,IJ-MOS在性能上取得了显著提升:其反向导通电压从CON-MOS的2.92 V降至1.83 V,反向恢复电荷减少43.7%,反向恢复峰值电流下降31.7%,总开关损耗削减24.2%。此外,IJ-MOS通过有效抑制反向续流时体二极管的激活,显著降低了双极退化的发生概率,从而增强了器件的长期可靠性。这一新型设计使IJMOS成为高频开关电路和反向续流应用中更为优越的解决方案。 展开更多
关键词 SiC MOSFET 双极退化 反向导通 开关损耗
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喹硫平治疗双相情感障碍的临床价值研究
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作者 李春梅 《中国现代药物应用》 2025年第6期118-121,共4页
目的分析双相情感障碍实施喹硫平治疗的临床价值。方法68例双相情感障碍患者,采用单双号法分为参考组、试验组,各34例。参考组行碳酸锂治疗,试验组在参考组基础上加用喹硫平治疗。比较两组神经营养指标[神经元特异性烯醇化酶(NSE)、胶... 目的分析双相情感障碍实施喹硫平治疗的临床价值。方法68例双相情感障碍患者,采用单双号法分为参考组、试验组,各34例。参考组行碳酸锂治疗,试验组在参考组基础上加用喹硫平治疗。比较两组神经营养指标[神经元特异性烯醇化酶(NSE)、胶质细胞源性神经营养因子(GDNF)、脑源性神经营养因子(BDNF)]、炎症指标[白细胞介素-10(IL-10)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]、恢复情况[倍克-拉范森躁狂量表(BRMS)、简易智能精神状态检查量表(MMSE)、汉密尔顿抑郁量表(HAMD)评分]、治疗效果。结果治疗后,试验组NSE(5.66±0.78)ng/ml低于参考组的(9.04±1.27)ng/ml,GDNF(562.13±20.37)pg/ml、BDNF(13.24±1.06)μg/L高于参考组的(471.11±45.23)pg/ml、(11.80±1.55)μg/L(P<0.05)。治疗后,试验组IL-10(131.58±8.09)pg/ml、IL-1β(54.03±6.12)pg/ml、TNF-α(49.61±8.92)pg/ml均低于参考组的(146.04±10.78)、(62.99±7.85)、(64.88±10.35)pg/ml(P<0.05)。治疗后,两组BRMS、HAMD评分均低于本组治疗前,MMSE评分均高于本组治疗前,且试验组BRMS评分(5.03±0.79)分、HAMD评分(6.12±1.04)分低于参考组的(9.74±1.28)、(12.83±1.47)分,MMSE评分(23.19±2.05)分高于参考组的(18.44±2.71)分(P<0.05)。试验组治疗总有效率97.06%高于参考组的79.41%(P<0.05)。结论喹硫平对双相情感障碍患者情感症状的调节效果好,能纠正神经营养状态,减轻炎症反应,提升认知功能,治疗效果显著。 展开更多
关键词 双相情感障碍 喹硫平 治疗效果 恢复情况
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基于双极工艺的典型模拟电路电离总剂量效应及加固策略
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作者 赵晓凡 王忠芳 +4 位作者 马毛旦 张涛 丁宏宇 李彦广 阳永衡 《上海航天(中英文)》 2025年第4期97-102,共6页
聚焦标准双极工艺模拟集成电路在空间辐射环境下的电离总剂量效应及其加固策略。探讨了模拟电路在航天器中不可替代的核心作用,分析了电离总剂量效应的物理机制及其对双极电路的退化机理,强调了加固设计的必要性。详细阐述了电路加固方... 聚焦标准双极工艺模拟集成电路在空间辐射环境下的电离总剂量效应及其加固策略。探讨了模拟电路在航天器中不可替代的核心作用,分析了电离总剂量效应的物理机制及其对双极电路的退化机理,强调了加固设计的必要性。详细阐述了电路加固方法,并以运算放大器和电压基准源为例,具体分析了其电离总剂量效应退化规律与加固设计要点。研究表明:基于标准双极工艺的运算放大器,未经设计加固,在30 krad(Si)(1 rad=0.01 J/kg)总剂量辐照下,电参数会出现严重超差。针对敏感参数采取电路加固设计,可提升双极模拟电路的空间辐射耐受能力,对保障航天器长寿命可靠运行具有重要意义。 展开更多
关键词 双极工艺 电离总剂量效应 运算放大器 辐射加固
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无抽搐电休克治疗联合药物对双相情感障碍躁狂相治疗的有效性
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作者 孙猛猛 张来臣 张成兰 《系统医学》 2025年第8期63-66,共4页
目的 探讨对双相情感障碍躁狂相患者采用无抽搐电休克+药物治疗的有效性。方法 方便选取枣庄市精神卫生中心于2021年3月—2023年12月收治的100例双相情感障碍躁狂相患者展开研究,按治疗方法分为两组,参照组(50例)采用碳酸锂药物进行口... 目的 探讨对双相情感障碍躁狂相患者采用无抽搐电休克+药物治疗的有效性。方法 方便选取枣庄市精神卫生中心于2021年3月—2023年12月收治的100例双相情感障碍躁狂相患者展开研究,按治疗方法分为两组,参照组(50例)采用碳酸锂药物进行口服治疗;研究组(50例)在参照组基础上,采用无抽搐电休克方法展开疾病治疗。比较两组杨氏躁狂评定量表(Young Manic Rating Scale, YMRS)评分、炎性因子水平以及治疗效果。结果 与参照组YMRS评分展开对比,研究组更低,差异均有统计学意义(P均<0.05);治疗后,与参照组炎性因子水平对比,研究组更优,差异均有统计学意义(P均<0.05);研究组治疗总有效率为98.00%(49/50),高于参照组的82.00%(41/50),差异有统计学意义(χ^(2)=7.111,P<0.05)。结论 双相情感障碍躁狂相患者在接受治疗期间,临床将无抽搐电休克疗法以及药物治疗方法充分联合,可提高药物治疗有效性,并改善炎性因子水平以及疾病严重程度。 展开更多
关键词 无抽搐电休克治疗 药物 双相情感障碍躁狂相 治疗有效性 炎性因子水平 YMRS评分
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