Purpose:To investigate the influence of electroencephalograph bionic electrical stimulation on neuronal activity in patients with Alzheimer's disease(AD)using resting-state blood oxygen level dependent functional ...Purpose:To investigate the influence of electroencephalograph bionic electrical stimulation on neuronal activity in patients with Alzheimer's disease(AD)using resting-state blood oxygen level dependent functional MRI(BOLD-fMRI)and amplitude of low-frequency fluctuation(ALFF)and fraction ALFF(fALFF)analysis.Methods:42 AD patients were divided into two groups in accordance with the randomized double blind principle,every group was 21.Treatment group received electroencephalograph bionic electrical stimulation.Both groups received resting-state BOLD-fMRI scanning before and after treatment and comparing differences in ALFF and fALFF in each group by statistical methods.Correlation analysis was performed between ALFF or fALFF images and neuropsychological tests scale after treatment.Results:Post-therapy brain regions with higher ALFF included left cerebellum posterior lobe,right cerebellum posterior lobe,left hippocampus/parahippocampus,left posterior cingulated cortex,left dorsolateral prefrontal cortex,right inferior parietal lobule in treatment group.Higher fALFF was observed in the right inferior parietal lobule.In the placebo group lower ALFF was observed in bilateral cerebellum posterior lobe and left posterior cingulated cortex.Alzheimer's Disease Assessment Scale-Cognitive section was closely correlated with ALFF in left cerebellum posterior lobe and right cerebellum posterior lobe.Conclusion:These results indicated improved neuronal activity in some brain areas could be achieved in AD after treatment of electroencephalograph bionic electrical stimulation.The change of BOLD-fMRI signal might provide a potential imaging strategy for studying neural mechanisms of electroencephalograph bionic electrical stimulation for AD.展开更多
Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counseling. There is no prosthesis that...Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counseling. There is no prosthesis that allows the amputees near normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities, and international conflicts, there is a growing requirement for novel strategies and new discov- eries. Advances have been made in technological, material, and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and tech- nologies to allow for the regeneration of injured tissues,recording on tissue signals and feedback to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits, and thumb in the upper extremity. Regenerative engineering focused on the regen- eration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past 30 years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdis- ciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feedback will be the important goals in regenerative engineering over the next two decades.展开更多
Pain is a common sensory experience in our daily lives.Persistent or recurrent pain affects over 30%of the global population,imposing a significant burden on individuals and society.Nevertheless,normal pain perception...Pain is a common sensory experience in our daily lives.Persistent or recurrent pain affects over 30%of the global population,imposing a significant burden on individuals and society.Nevertheless,normal pain perception functions as a warning mechanism for the body and is essential for survival.The propagation of electrical signals is central to pain perception,and the capacity to modulate these signals is crucial for human pain regulation.Currently,the applications for electrical stimulation in pain management are gradually expanding,offering patients innovative treatment options.Additionally,advancements in bionics have led to increased attention on reconstructing pain perception through artificial synapses,electronic skin,and prosthetics.Here,we focus on the dual role of electrical stimulation in both pain management and pain reconstruction,highlighting their shared developmental trends.展开更多
基金sponsored by Chongqing Haikun medical instrument LTD.
文摘Purpose:To investigate the influence of electroencephalograph bionic electrical stimulation on neuronal activity in patients with Alzheimer's disease(AD)using resting-state blood oxygen level dependent functional MRI(BOLD-fMRI)and amplitude of low-frequency fluctuation(ALFF)and fraction ALFF(fALFF)analysis.Methods:42 AD patients were divided into two groups in accordance with the randomized double blind principle,every group was 21.Treatment group received electroencephalograph bionic electrical stimulation.Both groups received resting-state BOLD-fMRI scanning before and after treatment and comparing differences in ALFF and fALFF in each group by statistical methods.Correlation analysis was performed between ALFF or fALFF images and neuropsychological tests scale after treatment.Results:Post-therapy brain regions with higher ALFF included left cerebellum posterior lobe,right cerebellum posterior lobe,left hippocampus/parahippocampus,left posterior cingulated cortex,left dorsolateral prefrontal cortex,right inferior parietal lobule in treatment group.Higher fALFF was observed in the right inferior parietal lobule.In the placebo group lower ALFF was observed in bilateral cerebellum posterior lobe and left posterior cingulated cortex.Alzheimer's Disease Assessment Scale-Cognitive section was closely correlated with ALFF in left cerebellum posterior lobe and right cerebellum posterior lobe.Conclusion:These results indicated improved neuronal activity in some brain areas could be achieved in AD after treatment of electroencephalograph bionic electrical stimulation.The change of BOLD-fMRI signal might provide a potential imaging strategy for studying neural mechanisms of electroencephalograph bionic electrical stimulation for AD.
基金funding from the Raymond and Beverly Sackler Center for Biomedical,Biological,Physical and Engineering Sciencesthe funding from National Science Foundation Award(Nos.IIP-1311907,IIP-1355327 and EFRI-1332329)+2 种基金the Presidential Faculty Fellowship Award from President William Clintonthe Presidential Award for Excellence in Science,Mathematics,and Engineering Mentorship from President Barack Obamathe NIH Director’s Pioneer Award(No.1DP1AR068147-01)
文摘Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counseling. There is no prosthesis that allows the amputees near normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities, and international conflicts, there is a growing requirement for novel strategies and new discov- eries. Advances have been made in technological, material, and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and tech- nologies to allow for the regeneration of injured tissues,recording on tissue signals and feedback to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits, and thumb in the upper extremity. Regenerative engineering focused on the regen- eration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past 30 years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdis- ciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feedback will be the important goals in regenerative engineering over the next two decades.
基金supported by the National Nature Science Foundation of China(82471000 and 82325012)National Key Research and Development Program(2023YFC2509100 to Kai Jiao)。
文摘Pain is a common sensory experience in our daily lives.Persistent or recurrent pain affects over 30%of the global population,imposing a significant burden on individuals and society.Nevertheless,normal pain perception functions as a warning mechanism for the body and is essential for survival.The propagation of electrical signals is central to pain perception,and the capacity to modulate these signals is crucial for human pain regulation.Currently,the applications for electrical stimulation in pain management are gradually expanding,offering patients innovative treatment options.Additionally,advancements in bionics have led to increased attention on reconstructing pain perception through artificial synapses,electronic skin,and prosthetics.Here,we focus on the dual role of electrical stimulation in both pain management and pain reconstruction,highlighting their shared developmental trends.
