This paper presents numerical investigations into a ridged surface whose design is inspired by the geometry of a Farrer’sscallop.The objective of the performed research is to assess if the proposed Bioinspired Ridged...This paper presents numerical investigations into a ridged surface whose design is inspired by the geometry of a Farrer’sscallop.The objective of the performed research is to assess if the proposed Bioinspired Ridged Surface (BRS) can potentiallyimprove wear resistance of soil-engaging components used in agricultural machinery and to validate numerical simulationsperformed using software based on the Discrete Element Method (DEM).The wear performance of the BRS is experimentallydetermined and also compared with a conventional flat surface.Different size of soil particles and relative velocities between theabrasive sand and the testing surfaces are used.Comparative results show that the numerical simulations are in agreement withthe experimental results and support the hypothesis that abrasive wear is greatly reduced by substituting a conventional flatsurface with the BRS.展开更多
Medical devices are a major component of precision medicine and play a key role in medical treatment,particularly with the rapid development of minimally invasive surgery and wearable devices.Their tissue contact prop...Medical devices are a major component of precision medicine and play a key role in medical treatment,particularly with the rapid development of minimally invasive surgery and wearable devices.Their tissue contact properties strongly affect device performance and patient health(e.g.,heat coagulation and slipperiness on surgical graspers).However,the design and optimization of these device surfaces are still indistinct and have no supporting principles.Under such conditions,natural surfaces with various unique functions can provide solutions.This review summarizes the current progress in natural functional surfaces for medical devices,including ultra-slipperiness and strong wet attachment.The underlying mechanisms of these surfaces are attributed to their coupling effects and featured micronano structures.Depending on various medical requirements,adaptable designs and fabrication methods have been developed.Additionally,various medical device surfaces have been validated to achieve enhanced contact properties.Based on these studies,a more promising future for medical devices can be achieved for enhanced precision medicine and human health.展开更多
Wetting properties are significant for a hydrophobic surface and normally characterized by the equilibrium contact angle.In this manuscript,a mesoscopic method based on multiphase multiple-relaxation-time Lattice Bolt...Wetting properties are significant for a hydrophobic surface and normally characterized by the equilibrium contact angle.In this manuscript,a mesoscopic method based on multiphase multiple-relaxation-time Lattice Boltzmann method has been presented and applied to simulate the contact angle at three-phase interfaces of a solid surface with micro-pillar structure.The influence of different parameters including pillar height,pillar width,inter-pillar spacing,intrinsic contact angle and the volume of the liquid drop on the equilibrium contact angle has been comprehensively investigated.The effect of geometry parameters of the micro-pillar structure on the wetting transition from Cassie–Baxter state to Wenzel state has also been studied.The results indicate that when the inter-pillar spacing is less than a certain value or the pillar height is greater than a certain value,the contact form between the droplet and the surface satisfies the Cassie–Baxter state.When the contact form satisfies the Cassie–Baxter state,the contact angle gradually increases with the increase of the inter-pillar spacing;the contact angle does not change significantly with the pillar height;the contact angle gradually decreases and approaches the intrinsic contact angle with the pillar width increases.Moreover,the contact angle increases with the increase of the intrinsic contact angle,and the contact angle is not sensitive to the change of droplet volume when the droplet volume is between 0.5 and10μl.展开更多
The advent of antibiotics revolutionized the management of bacterial infections,yet their clinical efficacy is catastrophically undermined by the global emergence of antimicrobial resistance(AMR).Furthermore,the situa...The advent of antibiotics revolutionized the management of bacterial infections,yet their clinical efficacy is catastrophically undermined by the global emergence of antimicrobial resistance(AMR).Furthermore,the situation is aggravated by the fact that the formation of bacterial biofilm on material surfaces significantly enhances their tolerance to antibiotics.Therefore,there is an urgent need for new approaches that employ antibacterial mechanisms distinct from those of conventional antibiotics to mitigate the risk of AMR.Recently,naturally occurring surfaces found on typical plants and insects that take advantage of physical topography can either inhibit bacterial adhesion or directly inactivate bacterial cells,showing innovative“outside-the-box”prospects for antibacterial applications and garnering considerable interest due to their drug-free nature.Bioinspired micro-/nanostructures that mimic natural surface patterns have been replicated on various biomaterials to enhance their antibacterial properties.This review summarizes and explains the current advances in bioinspired antibacterial surfaces,as well as the underlying mechanisms of various strategies.Subsequently,synergistic antimicrobial surfaces,comprising a combination of various physical antibacterial strategies,are reviewed to highlight their potential for highly efficient disinfection and long-lasting antibacterial performance.Finally,the biomedical applications,coupled with the future challenges of bio-inspired antibacterial strategies,were further discussed.We hope this review could provide valuable insights for developing innovative,antibiotic-free antibacterial strategies that deliver powerful performance in combating AMR.展开更多
Transparent superhydrophobic coatings hold significant potential for applications in architectural glass and optoelectronic devices.However,obtaining good compatibility between highly transparent,low haze and excellen...Transparent superhydrophobic coatings hold significant potential for applications in architectural glass and optoelectronic devices.However,obtaining good compatibility between highly transparent,low haze and excellent mechanical stability in a superhydrophobicity coating remains a significant challenge.Inspired by the natural protection mechanism of the hierarchical structure of leaf veins,we have designed and fabricated transparent superhydrophobic coatings with highly detailed hierarchical vein-like ridges via a template-assisted multi-mask photolithography and inverted mold process combined with a spraying technique.The coated glass exhibited not only outstanding superhydrophobicity,with contact angle≥160°and sliding angle≤1.5°but also a high optical transmittance of 88.4%and a low haze of 8.1%,as well as remarkable mechanical durability and weather resistance.展开更多
The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural per...The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.展开更多
基金supported by the National High Technology Research and Development Program of China(863 Program)(Grant No.2009AA043603-4,2009AA043604-2)by National Foundations of Agricultural Technological Transformation of China(Grant No.2009GB23600507)+1 种基金by National Natural Science Foundation of China(Grant No.50675087,50635030)by "985 Project" of Jilin University
文摘This paper presents numerical investigations into a ridged surface whose design is inspired by the geometry of a Farrer’sscallop.The objective of the performed research is to assess if the proposed Bioinspired Ridged Surface (BRS) can potentiallyimprove wear resistance of soil-engaging components used in agricultural machinery and to validate numerical simulationsperformed using software based on the Discrete Element Method (DEM).The wear performance of the BRS is experimentallydetermined and also compared with a conventional flat surface.Different size of soil particles and relative velocities between theabrasive sand and the testing surfaces are used.Comparative results show that the numerical simulations are in agreement withthe experimental results and support the hypothesis that abrasive wear is greatly reduced by substituting a conventional flatsurface with the BRS.
基金National Natural Science Foundation of China(Grant Nos.T2121003,51935001,51725501,and 51905022)National Key R&D Program of China(Grant No.2019YFB1309702).
文摘Medical devices are a major component of precision medicine and play a key role in medical treatment,particularly with the rapid development of minimally invasive surgery and wearable devices.Their tissue contact properties strongly affect device performance and patient health(e.g.,heat coagulation and slipperiness on surgical graspers).However,the design and optimization of these device surfaces are still indistinct and have no supporting principles.Under such conditions,natural surfaces with various unique functions can provide solutions.This review summarizes the current progress in natural functional surfaces for medical devices,including ultra-slipperiness and strong wet attachment.The underlying mechanisms of these surfaces are attributed to their coupling effects and featured micronano structures.Depending on various medical requirements,adaptable designs and fabrication methods have been developed.Additionally,various medical device surfaces have been validated to achieve enhanced contact properties.Based on these studies,a more promising future for medical devices can be achieved for enhanced precision medicine and human health.
基金The authors are grateful for the financial support from the National Natural Science Foundation of China(Grant no.12172377and Grant no,11772351)theOpen Research Fund of Key Laboratory of Construction and Safety of Water Engineering of the Ministry of Water Resources,China Institute of Water Resources and Hydropower Research(Grant no.202007).
文摘Wetting properties are significant for a hydrophobic surface and normally characterized by the equilibrium contact angle.In this manuscript,a mesoscopic method based on multiphase multiple-relaxation-time Lattice Boltzmann method has been presented and applied to simulate the contact angle at three-phase interfaces of a solid surface with micro-pillar structure.The influence of different parameters including pillar height,pillar width,inter-pillar spacing,intrinsic contact angle and the volume of the liquid drop on the equilibrium contact angle has been comprehensively investigated.The effect of geometry parameters of the micro-pillar structure on the wetting transition from Cassie–Baxter state to Wenzel state has also been studied.The results indicate that when the inter-pillar spacing is less than a certain value or the pillar height is greater than a certain value,the contact form between the droplet and the surface satisfies the Cassie–Baxter state.When the contact form satisfies the Cassie–Baxter state,the contact angle gradually increases with the increase of the inter-pillar spacing;the contact angle does not change significantly with the pillar height;the contact angle gradually decreases and approaches the intrinsic contact angle with the pillar width increases.Moreover,the contact angle increases with the increase of the intrinsic contact angle,and the contact angle is not sensitive to the change of droplet volume when the droplet volume is between 0.5 and10μl.
基金financial support through the National Science Foundation of China(No.52305317)the research collaboration project between the National Natural Science Foundation of China and the National Research Foundation of Korea(No.W2412095)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2022QB040,ZR2022QH006,ZR20230B113)the Youth Innovation Team of Shandong Province(2024KJH045).
文摘The advent of antibiotics revolutionized the management of bacterial infections,yet their clinical efficacy is catastrophically undermined by the global emergence of antimicrobial resistance(AMR).Furthermore,the situation is aggravated by the fact that the formation of bacterial biofilm on material surfaces significantly enhances their tolerance to antibiotics.Therefore,there is an urgent need for new approaches that employ antibacterial mechanisms distinct from those of conventional antibiotics to mitigate the risk of AMR.Recently,naturally occurring surfaces found on typical plants and insects that take advantage of physical topography can either inhibit bacterial adhesion or directly inactivate bacterial cells,showing innovative“outside-the-box”prospects for antibacterial applications and garnering considerable interest due to their drug-free nature.Bioinspired micro-/nanostructures that mimic natural surface patterns have been replicated on various biomaterials to enhance their antibacterial properties.This review summarizes and explains the current advances in bioinspired antibacterial surfaces,as well as the underlying mechanisms of various strategies.Subsequently,synergistic antimicrobial surfaces,comprising a combination of various physical antibacterial strategies,are reviewed to highlight their potential for highly efficient disinfection and long-lasting antibacterial performance.Finally,the biomedical applications,coupled with the future challenges of bio-inspired antibacterial strategies,were further discussed.We hope this review could provide valuable insights for developing innovative,antibiotic-free antibacterial strategies that deliver powerful performance in combating AMR.
基金supported by the National Key Research and Development Program of China(2022YFA1205200)the National Natural Science Foundation of China(52033003)the Natural Science Foundation of Hubei Province(2024AFB702)。
文摘Transparent superhydrophobic coatings hold significant potential for applications in architectural glass and optoelectronic devices.However,obtaining good compatibility between highly transparent,low haze and excellent mechanical stability in a superhydrophobicity coating remains a significant challenge.Inspired by the natural protection mechanism of the hierarchical structure of leaf veins,we have designed and fabricated transparent superhydrophobic coatings with highly detailed hierarchical vein-like ridges via a template-assisted multi-mask photolithography and inverted mold process combined with a spraying technique.The coated glass exhibited not only outstanding superhydrophobicity,with contact angle≥160°and sliding angle≤1.5°but also a high optical transmittance of 88.4%and a low haze of 8.1%,as well as remarkable mechanical durability and weather resistance.
基金the NIH/NIDCR under awards R01DE026117(CA)F30DE029105(NGF)+2 种基金and T90DE0227232(NGF)The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.This work was supported by the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Orthopaedic Research Program(PRORP)under Applied Research Award No W81XWH-20-1-0563(CA)The U.S.Army Medical Research Acquisition Activity,839 Chandler Street,Fort Detrick MD 21702-5014 is the awarding and administering acquisition office.Opinions,interpretations,conclusions,and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense.The work was also supported by a 3M Science and Technology Fellowship(NGF).The funding bodies had no role in study design,the collection,analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication. CA acknowledges support from the Fundaci´o Bosch Aymerich through a FBA-BIST-UIC fellowship. IBEC is a member of the CERCA Programme/Generalitat de Catalunya.
文摘The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.
