BACKGROUND The management of immature permanent teeth with open apices in pediatric patients presents unique challenges,particularly in cases of nonvital pulp.Modern advancements in materials and techniques have signi...BACKGROUND The management of immature permanent teeth with open apices in pediatric patients presents unique challenges,particularly in cases of nonvital pulp.Modern advancements in materials and techniques have significantly improved the predictability and success of apexification procedures.In this case,a 16-yearold patient presented with an immature necrotic tooth requiring apexification.Contemporary approaches incorporate calcium silicate-based materials such as mineral trioxide aggregate(MTA),Biodentine,and bioceramic putty,along with bioceramic sealers and enhanced canal cleaning including internal heating and ultrasonic activation with sodium hypochlorite(NaOCl)for disinfection,and sealing.Additionally,magnification tools such as dental operating microscopes ensure precise visualization for accurate material placement,while a micro-apical placement(MAP)system guarantees void-free MTA delivery.These advancements improve procedural outcomes and minimize the risk of iatrogenic errors,making apexification a more predictable and reliable treatment option in pediatric patients with immature teeth.CASE SUMMARY A 16-year-old patient presented with a nonvital maxillary central incisor with an open apex,secondary to trauma.Due to the lack of apical closure,traditional root canal obturation was not feasible.Apexification was chosen as the treatment modality to induce the formation of a calcified apical barrier,allowing for proper root canal sealing.Historically,calcium hydroxide was the material of choice for apexification,requiring multiple visits and prolonged treatment duration.However,the introduction of bioceramic materials such as MTA has revolutionized the procedure,offering superior outcomes with reduced treatment time.In this case,the apexification procedure involved thorough canal disinfection using NaOCl,enhanced by internal heating,ultrasonic activation,and double-sided vented needle irrigation.Under the dental operating microscope,MTA was precisely placed at the apex using a MAP system,ensuring a dense,void-free apical barrier.The remaining canal space was subsequently sealed with a bioceramic sealer to promote long-term stability and healing.CONCLUSION This case highlights the effectiveness of a modern approach for apexification in a pediatric patient.The use of advanced materials and techniques facilitated the formation of a stable apical barrier,ensuring long-term tooth retention and function.By incorporating precise irrigation protocols,internal heating,ultrasonic activation,and magnification tools,the treatment achieved thorough disinfection and optimal material placement.These advancements make apexification a predictable and reliable treatment option for young patients with immature necrotic teeth,preserving their natural dentition and preventing future complications.展开更多
In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and electrospinning.The new concept of regenerati...In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and electrospinning.The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic properties.All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds.Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers.The results were promising and opened new frontiers for utilizing these materials on a larger scale.The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration.Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties.All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.展开更多
Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral microbiome.Herein,for the first time...Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral microbiome.Herein,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)scaffolds.The morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in vitro.The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance.During the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release.The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects.Finally,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model.Overall,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.展开更多
Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone for...Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation properties.In this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate bioceramics.These findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate bioceramics.This correlation was subsequently validated through degradation experiments.Furthermore,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of bioceramics.This discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.展开更多
This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic sinc...This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic since then, and the present situation of research on and development of the biological requirement put forward to bioce-ramic performance by the biont and comes to that the bioce-ramics is the most promising biological material in the modern medical clinic application.展开更多
The article describes the performance, properties and application of bioceramics in the medical clinic and reviews and discusses the advance in the research into several typical bioceramics, such as aluminium oxide bi...The article describes the performance, properties and application of bioceramics in the medical clinic and reviews and discusses the advance in the research into several typical bioceramics, such as aluminium oxide bioceramics, carbons, bioactive glassceramics, calcium phosphate bioceramics, bioceramic composite materials etc, and comes to that bioceramics is the most promising bioactive material in the modern medical clinic application.展开更多
To eliminate thermal stress and cracks in the process of laser cladding, a kind of bioceramic coating with gradient compositional design was prepared on the surface of Ti alloy by using wide-band laser cladding. And e...To eliminate thermal stress and cracks in the process of laser cladding, a kind of bioceramic coating with gradient compositional design was prepared on the surface of Ti alloy by using wide-band laser cladding. And effect of Y2O3 content on gradient bioceramic composite coating was studied. The experimental results indicate that adding rare earth can refine grain. Different rare earth contents affect formation of HA and β-TCP in bioceramic coating. When the content of rare earth ranges from 0.4% to 0.6%, the active extent of rare earth in synthesizing HA and β-TCP is the best, which indicates that “monosodium glutamate” effect of rare earth plays a dominant role. However, when rare earth content is up to 0.8%, the amount of synthesizing HA and β-TCP in coating conversely goes down, which demonstrates that rare earth gradually losts its catalysis in manufacturing HA and β-TCP.展开更多
Background:Venous ulcer represents the most advanced stage of chronic venous insufficiency.It is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inabili...Background:Venous ulcer represents the most advanced stage of chronic venous insufficiency.It is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inability to work,need for hospitalization and frequent outpatient follow-up.Objective:We investigated the treatment benefits of far-infrared ceramic(cFIR),in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores,quality of life,serum bio-markers of oxidative stress and antioxidant defense enzymes.Design,setting,participants and interventions:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul,Brazil.We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.Main outcome measures:The following evaluations were conducted at baseline and after 15,30,60 and90 days:ulcer healing score,quality of life,and serum markers of oxidative stress and antioxidant enzyme activity.Results:Patients(n=24)with lower limb venous ulcers were randomized into two treatment groups.cFIR decreased the ulcer size on day 30(P=0.042)and 90(P=0.034)and the total ulcer healing scale scores on day 30(P=0.049)and 90(P=0.02)of the treatment,when compared to baseline.Additionally,cFIR improved tissue type(epithelial tissue)on day 60(P=0.022)when compared to baseline evaluation.Conclusion:cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.Trial registration:RBR-8c7xzn on ReBEC.展开更多
Plasma electrolytic oxidation(PEO)has held great potential for the advancement of biodegradable implants,as it helps in developing porous bioceramic coatings on the surface of magnesium alloys.In this research work,Mg...Plasma electrolytic oxidation(PEO)has held great potential for the advancement of biodegradable implants,as it helps in developing porous bioceramic coatings on the surface of magnesium alloys.In this research work,MgO-based bioceramic coatings containing the Si,P,Ca,Na,and F elements have been successfully fabricated on an AZ31 magnesium alloy plate utilizing the PEO method.The characteristic current-voltage behavior of the samples during the process was surveyed in an electrolyte containing Ca(H_(2)PO_(4))_(2),Na_(2)SiO_(3)·9H_(2)O,Na_(3)PO_(4)·12H_(2)O,NaF,and KOH with a pH of 12.5 and electrical conductivity of 20 mS/cm^(-1).The results revealed that applying a voltage of 350-400 V(that is 50-100 V higher than the breakdown limit)could greatly facilitate the synthesis of a PEO ceramic coating with fewer defects and more uniform morphology.The resulting coating was a compositionally graded bioceramic layer with a thickness in the range of 3.5±0.4 to 6.0±0.7µm,comprising the above-mentioned elements as promising bioactive agents.The synthesized ceramic features were investigated in terms of the elemental distribution of components through the thickness,which indicated a gradual rise in the Si and P contents and,conversely,a decline in the F content towards the outer surface.The growth mechanism of the PEO coating has been discussed accordingly.展开更多
Microwave joining is a rapid developmental new technique in recent years. This paper introduces a new microwave joining equipment which was made by our lab, succeeds in alumina ceramic - hydroxylapatite bioceramic jo...Microwave joining is a rapid developmental new technique in recent years. This paper introduces a new microwave joining equipment which was made by our lab, succeeds in alumina ceramic - hydroxylapatite bioceramic join in the equipment, and analyzes the join situation of join boundary by using scanning electron microscope (SEM), this paper analyzes the mechanism of microwave joining also. (Author abstract) 4 Refs.展开更多
To investigate the efficiency of clodronate modifying HA bioceramics,and to evaluate the effect of clodronate modifying HA bioceramics on the cells in vitro,clodronate modified the porous HA bioceramics for bone scaff...To investigate the efficiency of clodronate modifying HA bioceramics,and to evaluate the effect of clodronate modifying HA bioceramics on the cells in vitro,clodronate modified the porous HA bioceramics for bone scaffold by chelation .The outermost layer of the specimens was analyzd by XPS and FI-IR ,The depth profile was investigated by the argon-ion sputtering method.The cell culture test was conducted using MC3T3-E1 osteoblastic cells,The cells were inoculated and cultured on the scaffolds.Morphological observation of the cells,MTT test and ALP activity test evaluated the cell attachment ,proliferation and activity on the scaffolds.The cell culture test in cell quantity and morphology indicated active proliferation of the cells on the scaffolds.The ALP activity of the cells cultured for 3d and 7d on clodronate-HA bioceramics was slightly higher than that on HA bioceramics ,but the difference was not signifcant,This result indicated that clodronate-HA bioeramics had favorable cytocompatibility to be used as bone scaffold with potential ability to improve asteogensis.展开更多
Calcium hydroxyapatite （Ca10（PO4）6（OH）2） has been synthesized in short duration by rapid solution combustion by employing different fuels. Calcium nitrate was taken as source of calcium and diammonium hydrogen p...Calcium hydroxyapatite （Ca10（PO4）6（OH）2） has been synthesized in short duration by rapid solution combustion by employing different fuels. Calcium nitrate was taken as source of calcium and diammonium hydrogen phosphate served as the source of phosphate ions. Citric acid, tartaric acid, sucrose, glycine and urea were used as the fuels and nitrate ions and nitric acid were used as oxidizers. The influence of fuels on the morphology of the phase formed was studied. Results of the studies by powder X-ray diffraction and Fourier-transform infrared spectroscopy showed the formation of hydroxyapatite as a major phase for all the fuels. The thermal analysis of the decomposed precursor showed variation in heat content for different fuels. Scanning electron microscopy showed different morphologies of the products obtained by different fuels. Chemical analyses to determine the Ca：P atomic ratio in synthesized ceramics showed that the ratio was 1：1.66.展开更多
Background: One of the ideal properties of a root canal sealer is to have a good sealing ability, especially at the apical third of the root. Objective: To evaluate the comparison of the apical leakage between obturat...Background: One of the ideal properties of a root canal sealer is to have a good sealing ability, especially at the apical third of the root. Objective: To evaluate the comparison of the apical leakage between obturation using bioceramic sealer (BS) and polydimethylsiloxane sealer (PS). Materials and Methods: Thirty-six mandibular premolars were equally divided into two groups and were obturated with single cone technique. The sealers used for Group I and Group II were BS and PS respectively. After obturation, the samples were incubated (37°C, 24 h), sealed with two coats of nail polish except for 2 mm from the apex, submerged in the Indian ink for 7 days, decalcified, dehydrated, and made transparent according to Robertson technique. Dye penetration was evaluated under stereomicroscope. Samples without dye penetration were given score 0, dye penetration ≤ 0.5 mm were given score 1, 0.51 - 1 mm were given score 2, and >1 mm were given score 3. Result: The largest proportion distribution in BS group was at the score 1 (55.6%), whereas in PS group was at the score 2 (44.4%). Conclusion: Bioceramic sealer showed similar apical leakage to polydimethylsiloxane sealer. Clinical Relevance: Based on this study, bioceramic sealer can be recommended to be used as sealer with low level of apical leakage as well as polydimethylsiloxane sealer.展开更多
Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical pro...Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical properties in the materials. The products were characterized by TGA-DTA, XRD, FT-IR, SEM-EDS, TEM and XPS techniques. The results indicate the presence of two polymorphic phases of wollastonite, the β-wollastonite and α-wollastonite with a transition temperature of the β phase to α phase at approximately 1250℃. These materials were soaked in a simulated body fluid (SBF) during 1, 2 and 3 weeks, to study their solubility and bioactivity. The effect of different wollastonite phases on the solubility of Ca and Si, as well as the capacity of producing layers of “newly formed apatite” on the surfaces of these materials in SBF solution were analyzed.展开更多
A layer of premixed CaHPO 4·2H 2O CaCO 3 Y 2O 3 powders stuck on pretreated surface of Ti 6Al 4V alloy substrate was successfully transformed into a composite of rare earth bioceramic coating by laser synthesizin...A layer of premixed CaHPO 4·2H 2O CaCO 3 Y 2O 3 powders stuck on pretreated surface of Ti 6Al 4V alloy substrate was successfully transformed into a composite of rare earth bioceramic coating by laser synthesizing and cladding only once. The microstructure and properties of the coating material were introduced. The titanium alloy with bioceramic coating on one side were implanted into the femur bone and thigh muscles of adult Mongrel dogs for testing its biocompatibility. The results of implantation experiments show that the microstructure of the coating material is static, the bonding properties between coating and substrate are better. The bioceramic coating had not toxicity side effectiveness on the body and there is a better compatibility of osteoconducton. No effect of the coating material on the bio activity of osteoblast and osteoclast was found.展开更多
Experiments for investigating the problem to improve the mechanical properties of FHA [Ca(10) (PO4)6F(OH)] biomaterial have been presented in this paper. ZrO2 micro-particle, as strengthening phase, is added into FHA ...Experiments for investigating the problem to improve the mechanical properties of FHA [Ca(10) (PO4)6F(OH)] biomaterial have been presented in this paper. ZrO2 micro-particle, as strengthening phase, is added into FHA matrix material to make a composite biomaterial. Various mechanical properties were tested. Distribution be haviour of ZrO2 particle in sintered material and phase structure ' changes of material at elevated temperature were investigated by means of X-ray and SEM. Some biologic experiments were also carried out on animals to estimate the biological function of the corn posite material.展开更多
The gradient bioceramic coating was prepared on the surface of titanium alloy using wide-band laser cladding.The dynamics of gradient bioceramic composite coating containing hydroxyapatite(HA)prepared with mixture of ...The gradient bioceramic coating was prepared on the surface of titanium alloy using wide-band laser cladding.The dynamics of gradient bioceramic composite coating containing hydroxyapatite(HA)prepared with mixture of CaHPO4·2H2O and CaCO3 under the condition of wide-band laser was studied theoretically.The corresponding mathematical model and its numerical solution were presented.The examination experiment showed that HA bioceramic composite coatings can be obtained by appropriately choosing wide-band laser cladding parameters.The microstructure and surface morphology of HA bioceramic coating were observed by SEM and X-ray diffraction.The experimental results showed that the bioceramic coating is composed of HA,β-TCP,CaO,CaTiO3 and TiO2.The surface of bioceramic coating takes coral-shaped structure or short-rod piled structure,which helps osteoblast grow into bioceramic and improves the biocompatibility.展开更多
A tricalcium phosphate(TCP)material was produced from sardine and mackerel waste using a heat treatment method after a Soxhlet extraction to obtain the non-soluble portion of fish waste.The bones were annealed at temp...A tricalcium phosphate(TCP)material was produced from sardine and mackerel waste using a heat treatment method after a Soxhlet extraction to obtain the non-soluble portion of fish waste.The bones were annealed at temperatures between 400℃ and 1200℃.The thermal analysis(TG-DTA)was carried out to investigate the thermal stability of TCP and to confirm the removal of organic matter from the raw fish.The calcined bones were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),and field emission scanning electron microscopy(FESEM).The calcium to phosphorous weight ratio was determined by ICP-AES.FT-IR and XRD confirmed the similarities to syntheticβ-TCP(JCPDS-09-169),FE-SEM results revealed the formation of nanostructured TCP.These results suggest that varying the isolation temperature between 600-1200℃ has tremendous impact on the production of TCP from fish bone waste with the required properties.展开更多
The contraceptive efficacy and local effects of bioceramw IUD in rat were studied. The experiment was divided into four groups ： bioceramic IUD group ; stainless steel IUD group ; operation control group ; normal con...The contraceptive efficacy and local effects of bioceramw IUD in rat were studied. The experiment was divided into four groups ： bioceramic IUD group ; stainless steel IUD group ; operation control group ; normal control group. All IUD samples were put into uterus of rats, The experimental results show that the alumina bioceramic has a strong contraceptive effect for those rats. In bioceramic IUD group the endometrial inflammation reaction was as mild as that in stainless IUD group during the.early days （ 30 days ） and gradually abated with time during the late days （60 days ）. The experiments show that the alumina bioceramic has a good biocompatibility and contraceptive effects and hint at the alumina bioceramw IUD may become a more safety reproduction family planning IUD.展开更多
BACKGROUND The objective of this work is displaying a successful treatment for an internal resorption case under operating microscope using bioceramic material.CASE SUMMARY Periapical radiograph showed radiolucent les...BACKGROUND The objective of this work is displaying a successful treatment for an internal resorption case under operating microscope using bioceramic material.CASE SUMMARY Periapical radiograph showed radiolucent lesion representing large internal resorption of the root.The respective defect was obturated using endoscquence bioceramic material follow up at the month 18 after treatment revealed no abnormal finings clinically and radiographically.CONCLUSION New generations bioceramics have many advantages that internal root resorption cases can benefit from.The use of operating microscope helps to apply obturating materials with precision.However,long term study on a large sample is required in future studies.展开更多
文摘BACKGROUND The management of immature permanent teeth with open apices in pediatric patients presents unique challenges,particularly in cases of nonvital pulp.Modern advancements in materials and techniques have significantly improved the predictability and success of apexification procedures.In this case,a 16-yearold patient presented with an immature necrotic tooth requiring apexification.Contemporary approaches incorporate calcium silicate-based materials such as mineral trioxide aggregate(MTA),Biodentine,and bioceramic putty,along with bioceramic sealers and enhanced canal cleaning including internal heating and ultrasonic activation with sodium hypochlorite(NaOCl)for disinfection,and sealing.Additionally,magnification tools such as dental operating microscopes ensure precise visualization for accurate material placement,while a micro-apical placement(MAP)system guarantees void-free MTA delivery.These advancements improve procedural outcomes and minimize the risk of iatrogenic errors,making apexification a more predictable and reliable treatment option in pediatric patients with immature teeth.CASE SUMMARY A 16-year-old patient presented with a nonvital maxillary central incisor with an open apex,secondary to trauma.Due to the lack of apical closure,traditional root canal obturation was not feasible.Apexification was chosen as the treatment modality to induce the formation of a calcified apical barrier,allowing for proper root canal sealing.Historically,calcium hydroxide was the material of choice for apexification,requiring multiple visits and prolonged treatment duration.However,the introduction of bioceramic materials such as MTA has revolutionized the procedure,offering superior outcomes with reduced treatment time.In this case,the apexification procedure involved thorough canal disinfection using NaOCl,enhanced by internal heating,ultrasonic activation,and double-sided vented needle irrigation.Under the dental operating microscope,MTA was precisely placed at the apex using a MAP system,ensuring a dense,void-free apical barrier.The remaining canal space was subsequently sealed with a bioceramic sealer to promote long-term stability and healing.CONCLUSION This case highlights the effectiveness of a modern approach for apexification in a pediatric patient.The use of advanced materials and techniques facilitated the formation of a stable apical barrier,ensuring long-term tooth retention and function.By incorporating precise irrigation protocols,internal heating,ultrasonic activation,and magnification tools,the treatment achieved thorough disinfection and optimal material placement.These advancements make apexification a predictable and reliable treatment option for young patients with immature necrotic teeth,preserving their natural dentition and preventing future complications.
文摘In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and electrospinning.The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic properties.All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds.Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers.The results were promising and opened new frontiers for utilizing these materials on a larger scale.The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration.Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties.All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.
基金supported by the Key Research and Development Program of Zhejiang Province Foundation(No.2019C03027)the Zhejiang Provincial Natural Science Foundation of China(No.LZ22E020002)+1 种基金the Scientific Research Fund of Zhejiang Provincial Education Department(No.Y202148333)the Zhejiang Provincial Basic Research for Public Welfare Funds(Nos.LGF22E030002,LGF21H140001,and LTGY23H140005),China.
文摘Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral microbiome.Herein,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)scaffolds.The morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in vitro.The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance.During the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release.The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects.Finally,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model.Overall,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.
基金National Key Research and Development Program of China (2023YFB3813000)National Natural Science Foundation of China (52272256)State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology)(2022-KF-77)。
文摘Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation properties.In this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate bioceramics.These findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate bioceramics.This correlation was subsequently validated through degradation experiments.Furthermore,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of bioceramics.This discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.
文摘This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic since then, and the present situation of research on and development of the biological requirement put forward to bioce-ramic performance by the biont and comes to that the bioce-ramics is the most promising biological material in the modern medical clinic application.
文摘The article describes the performance, properties and application of bioceramics in the medical clinic and reviews and discusses the advance in the research into several typical bioceramics, such as aluminium oxide bioceramics, carbons, bioactive glassceramics, calcium phosphate bioceramics, bioceramic composite materials etc, and comes to that bioceramics is the most promising bioactive material in the modern medical clinic application.
基金Project supported by Governor's Foundation of Guizhou Province (2004-07)
文摘To eliminate thermal stress and cracks in the process of laser cladding, a kind of bioceramic coating with gradient compositional design was prepared on the surface of Ti alloy by using wide-band laser cladding. And effect of Y2O3 content on gradient bioceramic composite coating was studied. The experimental results indicate that adding rare earth can refine grain. Different rare earth contents affect formation of HA and β-TCP in bioceramic coating. When the content of rare earth ranges from 0.4% to 0.6%, the active extent of rare earth in synthesizing HA and β-TCP is the best, which indicates that “monosodium glutamate” effect of rare earth plays a dominant role. However, when rare earth content is up to 0.8%, the amount of synthesizing HA and β-TCP in coating conversely goes down, which demonstrates that rare earth gradually losts its catalysis in manufacturing HA and β-TCP.
基金supported by the National Council for Scientific and Technological Development(CNPq,grant number476454/2013-1)the Research Support and Innovation Foundation of the State of Santa Catarina(FAPESC,grant numbers 3414/2012and FAPESC-2019TR73)+2 种基金the Coordination for the Improvement of Higher Education Personnel(CAPES)the UNISUL and UNIJUI Scientific Initiation Program(PUIC)supported by research fellowships from CNPq(309407/2017-6).
文摘Background:Venous ulcer represents the most advanced stage of chronic venous insufficiency.It is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inability to work,need for hospitalization and frequent outpatient follow-up.Objective:We investigated the treatment benefits of far-infrared ceramic(cFIR),in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores,quality of life,serum bio-markers of oxidative stress and antioxidant defense enzymes.Design,setting,participants and interventions:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul,Brazil.We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.Main outcome measures:The following evaluations were conducted at baseline and after 15,30,60 and90 days:ulcer healing score,quality of life,and serum markers of oxidative stress and antioxidant enzyme activity.Results:Patients(n=24)with lower limb venous ulcers were randomized into two treatment groups.cFIR decreased the ulcer size on day 30(P=0.042)and 90(P=0.034)and the total ulcer healing scale scores on day 30(P=0.049)and 90(P=0.02)of the treatment,when compared to baseline.Additionally,cFIR improved tissue type(epithelial tissue)on day 60(P=0.022)when compared to baseline evaluation.Conclusion:cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.Trial registration:RBR-8c7xzn on ReBEC.
文摘Plasma electrolytic oxidation(PEO)has held great potential for the advancement of biodegradable implants,as it helps in developing porous bioceramic coatings on the surface of magnesium alloys.In this research work,MgO-based bioceramic coatings containing the Si,P,Ca,Na,and F elements have been successfully fabricated on an AZ31 magnesium alloy plate utilizing the PEO method.The characteristic current-voltage behavior of the samples during the process was surveyed in an electrolyte containing Ca(H_(2)PO_(4))_(2),Na_(2)SiO_(3)·9H_(2)O,Na_(3)PO_(4)·12H_(2)O,NaF,and KOH with a pH of 12.5 and electrical conductivity of 20 mS/cm^(-1).The results revealed that applying a voltage of 350-400 V(that is 50-100 V higher than the breakdown limit)could greatly facilitate the synthesis of a PEO ceramic coating with fewer defects and more uniform morphology.The resulting coating was a compositionally graded bioceramic layer with a thickness in the range of 3.5±0.4 to 6.0±0.7µm,comprising the above-mentioned elements as promising bioactive agents.The synthesized ceramic features were investigated in terms of the elemental distribution of components through the thickness,which indicated a gradual rise in the Si and P contents and,conversely,a decline in the F content towards the outer surface.The growth mechanism of the PEO coating has been discussed accordingly.
基金The research was supported by the Natural Science Foundation of Hubei Province(95J57)
文摘Microwave joining is a rapid developmental new technique in recent years. This paper introduces a new microwave joining equipment which was made by our lab, succeeds in alumina ceramic - hydroxylapatite bioceramic join in the equipment, and analyzes the join situation of join boundary by using scanning electron microscope (SEM), this paper analyzes the mechanism of microwave joining also. (Author abstract) 4 Refs.
文摘To investigate the efficiency of clodronate modifying HA bioceramics,and to evaluate the effect of clodronate modifying HA bioceramics on the cells in vitro,clodronate modified the porous HA bioceramics for bone scaffold by chelation .The outermost layer of the specimens was analyzd by XPS and FI-IR ,The depth profile was investigated by the argon-ion sputtering method.The cell culture test was conducted using MC3T3-E1 osteoblastic cells,The cells were inoculated and cultured on the scaffolds.Morphological observation of the cells,MTT test and ALP activity test evaluated the cell attachment ,proliferation and activity on the scaffolds.The cell culture test in cell quantity and morphology indicated active proliferation of the cells on the scaffolds.The ALP activity of the cells cultured for 3d and 7d on clodronate-HA bioceramics was slightly higher than that on HA bioceramics ,but the difference was not signifcant,This result indicated that clodronate-HA bioeramics had favorable cytocompatibility to be used as bone scaffold with potential ability to improve asteogensis.
文摘Calcium hydroxyapatite （Ca10（PO4）6（OH）2） has been synthesized in short duration by rapid solution combustion by employing different fuels. Calcium nitrate was taken as source of calcium and diammonium hydrogen phosphate served as the source of phosphate ions. Citric acid, tartaric acid, sucrose, glycine and urea were used as the fuels and nitrate ions and nitric acid were used as oxidizers. The influence of fuels on the morphology of the phase formed was studied. Results of the studies by powder X-ray diffraction and Fourier-transform infrared spectroscopy showed the formation of hydroxyapatite as a major phase for all the fuels. The thermal analysis of the decomposed precursor showed variation in heat content for different fuels. Scanning electron microscopy showed different morphologies of the products obtained by different fuels. Chemical analyses to determine the Ca：P atomic ratio in synthesized ceramics showed that the ratio was 1：1.66.
文摘Background: One of the ideal properties of a root canal sealer is to have a good sealing ability, especially at the apical third of the root. Objective: To evaluate the comparison of the apical leakage between obturation using bioceramic sealer (BS) and polydimethylsiloxane sealer (PS). Materials and Methods: Thirty-six mandibular premolars were equally divided into two groups and were obturated with single cone technique. The sealers used for Group I and Group II were BS and PS respectively. After obturation, the samples were incubated (37°C, 24 h), sealed with two coats of nail polish except for 2 mm from the apex, submerged in the Indian ink for 7 days, decalcified, dehydrated, and made transparent according to Robertson technique. Dye penetration was evaluated under stereomicroscope. Samples without dye penetration were given score 0, dye penetration ≤ 0.5 mm were given score 1, 0.51 - 1 mm were given score 2, and >1 mm were given score 3. Result: The largest proportion distribution in BS group was at the score 1 (55.6%), whereas in PS group was at the score 2 (44.4%). Conclusion: Bioceramic sealer showed similar apical leakage to polydimethylsiloxane sealer. Clinical Relevance: Based on this study, bioceramic sealer can be recommended to be used as sealer with low level of apical leakage as well as polydimethylsiloxane sealer.
文摘Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical properties in the materials. The products were characterized by TGA-DTA, XRD, FT-IR, SEM-EDS, TEM and XPS techniques. The results indicate the presence of two polymorphic phases of wollastonite, the β-wollastonite and α-wollastonite with a transition temperature of the β phase to α phase at approximately 1250℃. These materials were soaked in a simulated body fluid (SBF) during 1, 2 and 3 weeks, to study their solubility and bioactivity. The effect of different wollastonite phases on the solubility of Ca and Si, as well as the capacity of producing layers of “newly formed apatite” on the surfaces of these materials in SBF solution were analyzed.
文摘A layer of premixed CaHPO 4·2H 2O CaCO 3 Y 2O 3 powders stuck on pretreated surface of Ti 6Al 4V alloy substrate was successfully transformed into a composite of rare earth bioceramic coating by laser synthesizing and cladding only once. The microstructure and properties of the coating material were introduced. The titanium alloy with bioceramic coating on one side were implanted into the femur bone and thigh muscles of adult Mongrel dogs for testing its biocompatibility. The results of implantation experiments show that the microstructure of the coating material is static, the bonding properties between coating and substrate are better. The bioceramic coating had not toxicity side effectiveness on the body and there is a better compatibility of osteoconducton. No effect of the coating material on the bio activity of osteoblast and osteoclast was found.
文摘Experiments for investigating the problem to improve the mechanical properties of FHA [Ca(10) (PO4)6F(OH)] biomaterial have been presented in this paper. ZrO2 micro-particle, as strengthening phase, is added into FHA matrix material to make a composite biomaterial. Various mechanical properties were tested. Distribution be haviour of ZrO2 particle in sintered material and phase structure ' changes of material at elevated temperature were investigated by means of X-ray and SEM. Some biologic experiments were also carried out on animals to estimate the biological function of the corn posite material.
基金Sponsored by Governor′s Foundation of Guizhou Province(2004-10)
文摘The gradient bioceramic coating was prepared on the surface of titanium alloy using wide-band laser cladding.The dynamics of gradient bioceramic composite coating containing hydroxyapatite(HA)prepared with mixture of CaHPO4·2H2O and CaCO3 under the condition of wide-band laser was studied theoretically.The corresponding mathematical model and its numerical solution were presented.The examination experiment showed that HA bioceramic composite coatings can be obtained by appropriately choosing wide-band laser cladding parameters.The microstructure and surface morphology of HA bioceramic coating were observed by SEM and X-ray diffraction.The experimental results showed that the bioceramic coating is composed of HA,β-TCP,CaO,CaTiO3 and TiO2.The surface of bioceramic coating takes coral-shaped structure or short-rod piled structure,which helps osteoblast grow into bioceramic and improves the biocompatibility.
文摘A tricalcium phosphate(TCP)material was produced from sardine and mackerel waste using a heat treatment method after a Soxhlet extraction to obtain the non-soluble portion of fish waste.The bones were annealed at temperatures between 400℃ and 1200℃.The thermal analysis(TG-DTA)was carried out to investigate the thermal stability of TCP and to confirm the removal of organic matter from the raw fish.The calcined bones were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),and field emission scanning electron microscopy(FESEM).The calcium to phosphorous weight ratio was determined by ICP-AES.FT-IR and XRD confirmed the similarities to syntheticβ-TCP(JCPDS-09-169),FE-SEM results revealed the formation of nanostructured TCP.These results suggest that varying the isolation temperature between 600-1200℃ has tremendous impact on the production of TCP from fish bone waste with the required properties.
基金Funded by the Education Office of Hubei Province of China(No.98D006)
文摘The contraceptive efficacy and local effects of bioceramw IUD in rat were studied. The experiment was divided into four groups ： bioceramic IUD group ; stainless steel IUD group ; operation control group ; normal control group. All IUD samples were put into uterus of rats, The experimental results show that the alumina bioceramic has a strong contraceptive effect for those rats. In bioceramic IUD group the endometrial inflammation reaction was as mild as that in stainless IUD group during the.early days （ 30 days ） and gradually abated with time during the late days （60 days ）. The experiments show that the alumina bioceramic has a good biocompatibility and contraceptive effects and hint at the alumina bioceramw IUD may become a more safety reproduction family planning IUD.
文摘BACKGROUND The objective of this work is displaying a successful treatment for an internal resorption case under operating microscope using bioceramic material.CASE SUMMARY Periapical radiograph showed radiolucent lesion representing large internal resorption of the root.The respective defect was obturated using endoscquence bioceramic material follow up at the month 18 after treatment revealed no abnormal finings clinically and radiographically.CONCLUSION New generations bioceramics have many advantages that internal root resorption cases can benefit from.The use of operating microscope helps to apply obturating materials with precision.However,long term study on a large sample is required in future studies.
