Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights...Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.展开更多
This study introduces a nanostructured MgO coating fabricated via anodization in a non-aqueous electrolyte,offering a novel approach to addressing the challenges of corrosion resistance and biofunctionality.The surfac...This study introduces a nanostructured MgO coating fabricated via anodization in a non-aqueous electrolyte,offering a novel approach to addressing the challenges of corrosion resistance and biofunctionality.The surface was characterized before and after immersion testing using field emission scanning electron microscopy(FESEM),energy-dispersive X-ray spectroscopy(EDX),and X-ray diffraction(XRD).Electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization tests demonstrated a 2-fold reduction in the corrosion resistance compared to untreated magnesium.Biomineralization studies demonstrated the uniform formation of apatite with a Ca/P ratio of 1.35 on the nanostructured surface after 14 days in simulated body fluid(SBF),surpassing that of microstructured MgO.Hydrogen evolution decreased from 912±38μL cm^(-2)for untreated Mg to 615±32μL cm^(-2)for the Mg/MgO nanostructure and 545±29μL cm^(-2)for the Mg/Mg O/HA sample.These findings highlight the potential of nanostructured MgO coatings to advance Mg-based implants by providing enhanced corrosion protection,improved biomineralization,reduced hemolysis and increased cell viability,and reduced H_(2)generation.展开更多
Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was...Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was prepared by laser treatment and multiple acid etching. The surface morphologies of different titanium alloy substrates were characterized by scanning electron microscopy (SEM). The effects of micro-nanostructured surfaces on the cellular responses were investigated in vitro by observing hydroxyapatite formation, cell morphology and cell adhesion. The results indicate that the micro-sized structure promoted the adhesion and proliferation of cultured osteoblasts. Furthermore, the micro-nanostructured surface was more conducive to cell adhension stretching compared with the micro-structured surface. All results suggest that the micro-nanostructured surface improved the biocompatibility and integration of tissue onto titanium alloy implants.展开更多
In order to develop a new plant-source insecticide,some active components from Cichorium intybus L.were extracted with mineral ether,ethyl ether,ethyl acetate,respectively.It were testified the effects of the componen...In order to develop a new plant-source insecticide,some active components from Cichorium intybus L.were extracted with mineral ether,ethyl ether,ethyl acetate,respectively.It were testified the effects of the components on the development of Mythimna separate Walker and anti-feeding by feeding and weighting method.The results showed that the body weight of the larvae fed by the extracts with organic solvents was significantly lower than the control;the body weight of the larvae fed by the extracts with organic solvents was significantly different in different solvents in 3-5 days.The corrected mortality of the ethyl acetate treatment was the highest（52.05%）,and the development period of the larvae treated by ethyl acetate was about 4-10 days longer than the control and the corresponding pupating rate was the lowest（43.30%）.Therefore,the effect of ethyl acetate extract was most significant.Moreover,the pupa weight of the treatments was little more than the control.The extracts from Cichorium intybus L.leaves had highest bioactivity mainly in anti-feeding activity on Mythimna separate Walker.展开更多
基金Financial support from National University of Singapore (NUS)(AcRF A-8000-126-00-00)。
文摘Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.
基金The authors thank the DFG(KI 2169/2-1)the European Union(EU-RIA NOMAD,101091669)for funding this work+1 种基金The Micro and Nanoanalytics Facility(MNaF),funded by the DFG(DFG INST 221/131-1)at the University of Siegen,and the Materials Science Faculty of the Isfahan University of Technology(IUT)were utilized for some of the work and analysis,respectively.
文摘This study introduces a nanostructured MgO coating fabricated via anodization in a non-aqueous electrolyte,offering a novel approach to addressing the challenges of corrosion resistance and biofunctionality.The surface was characterized before and after immersion testing using field emission scanning electron microscopy(FESEM),energy-dispersive X-ray spectroscopy(EDX),and X-ray diffraction(XRD).Electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization tests demonstrated a 2-fold reduction in the corrosion resistance compared to untreated magnesium.Biomineralization studies demonstrated the uniform formation of apatite with a Ca/P ratio of 1.35 on the nanostructured surface after 14 days in simulated body fluid(SBF),surpassing that of microstructured MgO.Hydrogen evolution decreased from 912±38μL cm^(-2)for untreated Mg to 615±32μL cm^(-2)for the Mg/MgO nanostructure and 545±29μL cm^(-2)for the Mg/Mg O/HA sample.These findings highlight the potential of nanostructured MgO coatings to advance Mg-based implants by providing enhanced corrosion protection,improved biomineralization,reduced hemolysis and increased cell viability,and reduced H_(2)generation.
基金Projects(5117530651575320)supported by the National Natural Science Foundation of China+1 种基金Project(TS20130922)supported by the Taishan Scholar Foundation,ChinaProject(2014JC020)supported by the Fundamental Research Funds for the Central Universities of China
文摘Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was prepared by laser treatment and multiple acid etching. The surface morphologies of different titanium alloy substrates were characterized by scanning electron microscopy (SEM). The effects of micro-nanostructured surfaces on the cellular responses were investigated in vitro by observing hydroxyapatite formation, cell morphology and cell adhesion. The results indicate that the micro-sized structure promoted the adhesion and proliferation of cultured osteoblasts. Furthermore, the micro-nanostructured surface was more conducive to cell adhension stretching compared with the micro-structured surface. All results suggest that the micro-nanostructured surface improved the biocompatibility and integration of tissue onto titanium alloy implants.
基金Supported by International Cooperation Project from Ministry of Science and Technology"Cooperation Research of Chicory Natural Production Extraction and Identification"(2008DFA31650)Shaanxi International Cooperation Project"Cooperation Research of Chicory Natural Production Extraction and Identification"(2008KW-29)~~
文摘In order to develop a new plant-source insecticide,some active components from Cichorium intybus L.were extracted with mineral ether,ethyl ether,ethyl acetate,respectively.It were testified the effects of the components on the development of Mythimna separate Walker and anti-feeding by feeding and weighting method.The results showed that the body weight of the larvae fed by the extracts with organic solvents was significantly lower than the control;the body weight of the larvae fed by the extracts with organic solvents was significantly different in different solvents in 3-5 days.The corrected mortality of the ethyl acetate treatment was the highest（52.05%）,and the development period of the larvae treated by ethyl acetate was about 4-10 days longer than the control and the corresponding pupating rate was the lowest（43.30%）.Therefore,the effect of ethyl acetate extract was most significant.Moreover,the pupa weight of the treatments was little more than the control.The extracts from Cichorium intybus L.leaves had highest bioactivity mainly in anti-feeding activity on Mythimna separate Walker.
