Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-lin...Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.展开更多
Growth retardation affects the health and production of livestock,while overexertion can cause sudden cardiac arrest.Both cases are considered to be metabolic disorders and are detrimental to livestock production.Effe...Growth retardation affects the health and production of livestock,while overexertion can cause sudden cardiac arrest.Both cases are considered to be metabolic disorders and are detrimental to livestock production.Effective measures for relieving or treating these disorders are scarce.However,Pimpinella thellungiana H.Wolff(P.thellungiana),a medicinal herb,has been reported to relieve growth retardation and overexertion in ethnopharmacological clinical trials.This paper summarizes and classifies a total of 106 bioactive compounds that were isolated and identified from P.thellungiana,including flavonoids,simple phenylpropanoids,coumarins,volatile compounds,and simple polyphenols,and discusses its pharmaceutical benefits,including its growth-promoting,antioxidant,anti-inflammatory,anti-atherosclerotic,and hepatoprotective properties.The nutrition,metabolism,biological activities,and pharmacological effects of the principal compounds of P.thellungiana in livestock are reviewed,as well as their potential molecular targets and metabolic signaling pathways in which these compounds are involved.However,the pharmacological and toxicological effects of some compounds have not been well documented,and further investigations of the bioactive compounds are needed.Such studies are crucial for the development of natural drugs or feed additives from P.thellungiana to alleviate growth retardation and mitigate injuries from overexertion in livestock.展开更多
基金supported by the National Natural Science Foundation of China(No. 51773209)the National Basic Research Program(No. 2017YFC1103300)the Strategic Priority Research Program of Chinese Academy of Sciences(No. XDB12020300)
文摘Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.
基金supported by the National Natural Science Foundation of China[32260844]Tianshan Talent Project of Xinjiang[2024]+1 种基金Bingtuan Science and Technology Program[2023AB078]International Partnership Program of the Chinese Academy of Sciences[092GJHZ2023062GC].
文摘Growth retardation affects the health and production of livestock,while overexertion can cause sudden cardiac arrest.Both cases are considered to be metabolic disorders and are detrimental to livestock production.Effective measures for relieving or treating these disorders are scarce.However,Pimpinella thellungiana H.Wolff(P.thellungiana),a medicinal herb,has been reported to relieve growth retardation and overexertion in ethnopharmacological clinical trials.This paper summarizes and classifies a total of 106 bioactive compounds that were isolated and identified from P.thellungiana,including flavonoids,simple phenylpropanoids,coumarins,volatile compounds,and simple polyphenols,and discusses its pharmaceutical benefits,including its growth-promoting,antioxidant,anti-inflammatory,anti-atherosclerotic,and hepatoprotective properties.The nutrition,metabolism,biological activities,and pharmacological effects of the principal compounds of P.thellungiana in livestock are reviewed,as well as their potential molecular targets and metabolic signaling pathways in which these compounds are involved.However,the pharmacological and toxicological effects of some compounds have not been well documented,and further investigations of the bioactive compounds are needed.Such studies are crucial for the development of natural drugs or feed additives from P.thellungiana to alleviate growth retardation and mitigate injuries from overexertion in livestock.
