In this study,the biological effects of functionalized carbon nanotubes(CNTs)were investigated on cell morphology,proliferation,apoptosis,tissue pathology and blood test in vivo&in vitro.The functionalized CNTs ha...In this study,the biological effects of functionalized carbon nanotubes(CNTs)were investigated on cell morphology,proliferation,apoptosis,tissue pathology and blood test in vivo&in vitro.The functionalized CNTs had good biocompatibility at lower concentrations,and the functionalized single-walled carbon nanotubes(SWCNTs)perform in the early period in the animal body and multi-walled carbon nanotubes(MWCNTs)mainly in the late.The results show successful functional groups and no change in toxicity in functional samples compared with the primary sample,and there is a safety dosage on the normal cells and tissue.In subsequent studies,antitumoral investigations of modified samples will be evaluated.展开更多
With large-scale production and application at large scale,carbon nanotubes(CNTs)may cause ad-verse response to the environment and human health.Thus,study on bio-effects and safety of CNTs has attracted great attenti...With large-scale production and application at large scale,carbon nanotubes(CNTs)may cause ad-verse response to the environment and human health.Thus,study on bio-effects and safety of CNTs has attracted great attention from scientists and governments worldwide.This report briefly summa-rizes the main results from the in vitro toxicity study of CNTs.The emphasis is placed on the descrip-tion of a variety of factors affecting CNTs cytotoxicity,including species of CNTs,impurities contained,lengths of CNTs,aspect ratios,chemical modification,and assaying methods of cytotoxicity.However,experimental information obtained thus far on CNTs'cytotoxicity is lacking in comparability,and some-times there is controversy about it.In order to assess more accurately the potential risks of CNTs to human health,we suggest that care should be taken for issues such as chemical modification and quantitative characterization of CNTs in cytotoxicity assessment.More importantly,studies on physical and chemical mechanisms of CNTs'cytotoxicity should be strengthened;assaying methods and evaluating criteria characterized by nanotoxicology should be gradually established.展开更多
基金supported by the grant from the National Natural Science Fundation(Project No.81102016).
文摘In this study,the biological effects of functionalized carbon nanotubes(CNTs)were investigated on cell morphology,proliferation,apoptosis,tissue pathology and blood test in vivo&in vitro.The functionalized CNTs had good biocompatibility at lower concentrations,and the functionalized single-walled carbon nanotubes(SWCNTs)perform in the early period in the animal body and multi-walled carbon nanotubes(MWCNTs)mainly in the late.The results show successful functional groups and no change in toxicity in functional samples compared with the primary sample,and there is a safety dosage on the normal cells and tissue.In subsequent studies,antitumoral investigations of modified samples will be evaluated.
基金the National Natural Science Foundation of China(Grant Nos.10475109 and 10775168)Shanghai Municipal Commission for Science and Technology(Grant Nos.0552nm033,0652nm016 and 0752nm021)the 973 Program(Grant No.2006CB705605)
文摘With large-scale production and application at large scale,carbon nanotubes(CNTs)may cause ad-verse response to the environment and human health.Thus,study on bio-effects and safety of CNTs has attracted great attention from scientists and governments worldwide.This report briefly summa-rizes the main results from the in vitro toxicity study of CNTs.The emphasis is placed on the descrip-tion of a variety of factors affecting CNTs cytotoxicity,including species of CNTs,impurities contained,lengths of CNTs,aspect ratios,chemical modification,and assaying methods of cytotoxicity.However,experimental information obtained thus far on CNTs'cytotoxicity is lacking in comparability,and some-times there is controversy about it.In order to assess more accurately the potential risks of CNTs to human health,we suggest that care should be taken for issues such as chemical modification and quantitative characterization of CNTs in cytotoxicity assessment.More importantly,studies on physical and chemical mechanisms of CNTs'cytotoxicity should be strengthened;assaying methods and evaluating criteria characterized by nanotoxicology should be gradually established.
