As a follow-up to the successful International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC)held at the National University of Singapore in 2023[1]and at the University of Tokyo in 2024[2],BDMC2025 too...As a follow-up to the successful International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC)held at the National University of Singapore in 2023[1]and at the University of Tokyo in 2024[2],BDMC2025 took place at the University of Oxford in the UK from August 8th to August 10th this year.After the meeting,a participant from the University of Cambridge described his experience of attending BDMC2025 on the social media platform LinkedIn in the following terms:“Many thanks to the organizers for a fantastic event bringing together nearly everyone at the interface of Biofabrication,Materials Science,and Biomedical Engineering”[3].The conference was held on the campus of the University of Oxford and 190 researchers from 55 academic institutions across 10 countries and regions attended(Fig.1).展开更多
目的:探讨3D打印个性化钛网的引导骨再生(guided bone regeneration,GBR)术及富血小板纤维蛋白(platelet-rich fibrin,PRF)/Bio-Oss复合物修复牙槽骨缺损的应用。方法:纳入2021年3月至2024年2月于甘肃省中医院口腔颌面外科行GBR骨增量...目的:探讨3D打印个性化钛网的引导骨再生(guided bone regeneration,GBR)术及富血小板纤维蛋白(platelet-rich fibrin,PRF)/Bio-Oss复合物修复牙槽骨缺损的应用。方法:纳入2021年3月至2024年2月于甘肃省中医院口腔颌面外科行GBR骨增量手术的牙槽骨缺损患者68例,随机分为3D组(n=34)与传统组(n=34),3D组使用3D打印个性化钛网及PRF/BioOss复合物,传统组使用传统钛网及PRF/Bio-Oss复合物。对比2组术后2、4、6个月的牙槽骨增加高度、宽度、体积及并发症发生率。结果:3D组术后2、4、6个月的牙槽骨增加高度、宽度与传统组相比,但差异均无统计学意义(P>0.05)。3D组术后2个月、4个月的牙槽骨增加体积均高于传统组,但差异均无统计学意义(P>0.05),术后6个月时牙槽骨增加体积显著高于传统组(P<0.05)。3D组发生早期暴露、晚期暴露、总暴露、创口感染的比例均低于传统组,但差异均无统计学意义(P>0.05)。结论:3D打印个性化钛网及PRF/Bio-Oss复合物的GBR术修复牙槽骨缺损效果良好,术后6个月骨增加体积显著高于应用传统钛网的GBR术,且不影响其安全性,值得临床推广应用。展开更多
The objective of this document is to describe the design and implementation of an intelligent biomedical system. The system consists of an array of multiple sensors. The sensors are connected to the Arduino Uno device...The objective of this document is to describe the design and implementation of an intelligent biomedical system. The system consists of an array of multiple sensors. The sensors are connected to the Arduino Uno device to allow data capture and processing. The captured signals from the sensors are then digitized by the microcontroller. The data from the microcontroller are accessible via two different portals: the LCD display and the LabVIEW graphical user interface. The microcontroller is also equipped with a GSM module to send the alert message to the user upon occurrence of events that simulate abnormal activity in the biological parameters of the user.展开更多
A trilogy review, based on more than 300 references, is used to underline three challenges facing 1) the supply of sustainable, durable and protected biosourced ingredients such as lipids, 2) the accounting for valuab...A trilogy review, based on more than 300 references, is used to underline three challenges facing 1) the supply of sustainable, durable and protected biosourced ingredients such as lipids, 2) the accounting for valuable bio-by-products, such as whey proteins that have added-value potential removing their environmental weight and 3) the practical reliable synthetic biology and evolutionary engineering that already serve as a technology and science basis to expand from, such as for biopolymer growth. Bioresources, which are the major topic of this review, must provide answers to several major challenges related to health, food, energy or chemistry of tomorrow. They offer a wide range of ingredients which are available in trees, plants, grasses, vegetables, algae, milk, food wastes, animal manures and other organic wastes. Researches in this domain must be oriented towards a bio-sustainable-economy based on new valuations of the potential of those renewable biological resources. This will aim at the substitution of fossil raw materials with renewable raw materials to ensure the sustainability of industrial processes by providing bioproducts through innovative processes using for instance micro-organisms and enzymes (the so-called white biotechnology). The final stage objective is to manufacture high value-added products gifted with the right set of physical, chemical and biological properties leading to particularly innovative applications. In this review, three examples are considered in a green context open innovation and bigger data environment. Two of them (lipids antioxidants and milk proteins) concern food industry while the third (biomonomers and corresponding bioplastics and derivatives) relates to biomaterials industry. Lipids play a crucial role in the food industry, but they are chemically unstable and very sensitive to atmospheric oxidation which leads to the formation of numerous by-compounds which have adverse effects on lipids quality attributes and on the nutritive value of meat. To overcome this problem, natural antioxidants, with a positive impact on the safety and acceptability of the food system, have been discovered and evaluated. In the same context, milk proteins and their derivatives are of great interest. They can be modified by enzymatic means leading to the formation of by-products that are able to increase their functionality and possible applications. They can also produce bioactive peptides, a field with almost unlimited research potential. On the other hand, biosourced chemicals and materials, mainly biomonomers and biopolymers, are already produced today. Metabolic engineering tools and strategies to engineer synthetic enzyme pathways are developed to manufacture, from renewable feedstocks, with high yields, a number of monomer building-block chemicals that can be used to produce replacements to many conventional plastic materials. Through those three examples this review aims to highlight recent and important advancements in production, modification and applications of the studied bioproducts. Bigger data analysis and artificial intelligence may help reweight practical and theoretical observations and concepts in these fields;helping to cross the boarders of expert traditional exploration fields and sometime fortresses.展开更多
BIO ORGANS(BIO)是百脉根中调控器官形态及大小的基因。首先改良了矮牵牛愈伤诱导和再生体系,并进一步利用根癌农杆菌介导法定向将BIO及其突变基因bio导入矮牵牛中进行功能研究。结果证实含0.1mg/L6-BA的MS培养基有利于矮牵牛组培苗的增...BIO ORGANS(BIO)是百脉根中调控器官形态及大小的基因。首先改良了矮牵牛愈伤诱导和再生体系,并进一步利用根癌农杆菌介导法定向将BIO及其突变基因bio导入矮牵牛中进行功能研究。结果证实含0.1mg/L6-BA的MS培养基有利于矮牵牛组培苗的增殖,添加了1.0mg/L 6-BA和0.1mg/L NAA的MS培养基有利于愈伤以及不定芽的诱导。对转基因植株目的基因的PCR检测结果显示,BIO及其突变基因bio被成功转入了矮牵牛中。表型观察结果显示:转BIO及其突变基因bio的植株叶片边缘均呈现不规则形态,部分叶片缺刻,出现由一个叶片向两个叶片分裂的趋势。其中转BIO基因植株部分叶片面积减小,叶片变窄或几乎只剩主叶脉。该研究证实BIO基因对保持叶片器官形态起到关键的作用,从而为进一步探索BIO基因的调控机制提供了实验依据。展开更多
文摘As a follow-up to the successful International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC)held at the National University of Singapore in 2023[1]and at the University of Tokyo in 2024[2],BDMC2025 took place at the University of Oxford in the UK from August 8th to August 10th this year.After the meeting,a participant from the University of Cambridge described his experience of attending BDMC2025 on the social media platform LinkedIn in the following terms:“Many thanks to the organizers for a fantastic event bringing together nearly everyone at the interface of Biofabrication,Materials Science,and Biomedical Engineering”[3].The conference was held on the campus of the University of Oxford and 190 researchers from 55 academic institutions across 10 countries and regions attended(Fig.1).
文摘目的:探讨3D打印个性化钛网的引导骨再生(guided bone regeneration,GBR)术及富血小板纤维蛋白(platelet-rich fibrin,PRF)/Bio-Oss复合物修复牙槽骨缺损的应用。方法:纳入2021年3月至2024年2月于甘肃省中医院口腔颌面外科行GBR骨增量手术的牙槽骨缺损患者68例,随机分为3D组(n=34)与传统组(n=34),3D组使用3D打印个性化钛网及PRF/BioOss复合物,传统组使用传统钛网及PRF/Bio-Oss复合物。对比2组术后2、4、6个月的牙槽骨增加高度、宽度、体积及并发症发生率。结果:3D组术后2、4、6个月的牙槽骨增加高度、宽度与传统组相比,但差异均无统计学意义(P>0.05)。3D组术后2个月、4个月的牙槽骨增加体积均高于传统组,但差异均无统计学意义(P>0.05),术后6个月时牙槽骨增加体积显著高于传统组(P<0.05)。3D组发生早期暴露、晚期暴露、总暴露、创口感染的比例均低于传统组,但差异均无统计学意义(P>0.05)。结论:3D打印个性化钛网及PRF/Bio-Oss复合物的GBR术修复牙槽骨缺损效果良好,术后6个月骨增加体积显著高于应用传统钛网的GBR术,且不影响其安全性,值得临床推广应用。
文摘The objective of this document is to describe the design and implementation of an intelligent biomedical system. The system consists of an array of multiple sensors. The sensors are connected to the Arduino Uno device to allow data capture and processing. The captured signals from the sensors are then digitized by the microcontroller. The data from the microcontroller are accessible via two different portals: the LCD display and the LabVIEW graphical user interface. The microcontroller is also equipped with a GSM module to send the alert message to the user upon occurrence of events that simulate abnormal activity in the biological parameters of the user.
文摘A trilogy review, based on more than 300 references, is used to underline three challenges facing 1) the supply of sustainable, durable and protected biosourced ingredients such as lipids, 2) the accounting for valuable bio-by-products, such as whey proteins that have added-value potential removing their environmental weight and 3) the practical reliable synthetic biology and evolutionary engineering that already serve as a technology and science basis to expand from, such as for biopolymer growth. Bioresources, which are the major topic of this review, must provide answers to several major challenges related to health, food, energy or chemistry of tomorrow. They offer a wide range of ingredients which are available in trees, plants, grasses, vegetables, algae, milk, food wastes, animal manures and other organic wastes. Researches in this domain must be oriented towards a bio-sustainable-economy based on new valuations of the potential of those renewable biological resources. This will aim at the substitution of fossil raw materials with renewable raw materials to ensure the sustainability of industrial processes by providing bioproducts through innovative processes using for instance micro-organisms and enzymes (the so-called white biotechnology). The final stage objective is to manufacture high value-added products gifted with the right set of physical, chemical and biological properties leading to particularly innovative applications. In this review, three examples are considered in a green context open innovation and bigger data environment. Two of them (lipids antioxidants and milk proteins) concern food industry while the third (biomonomers and corresponding bioplastics and derivatives) relates to biomaterials industry. Lipids play a crucial role in the food industry, but they are chemically unstable and very sensitive to atmospheric oxidation which leads to the formation of numerous by-compounds which have adverse effects on lipids quality attributes and on the nutritive value of meat. To overcome this problem, natural antioxidants, with a positive impact on the safety and acceptability of the food system, have been discovered and evaluated. In the same context, milk proteins and their derivatives are of great interest. They can be modified by enzymatic means leading to the formation of by-products that are able to increase their functionality and possible applications. They can also produce bioactive peptides, a field with almost unlimited research potential. On the other hand, biosourced chemicals and materials, mainly biomonomers and biopolymers, are already produced today. Metabolic engineering tools and strategies to engineer synthetic enzyme pathways are developed to manufacture, from renewable feedstocks, with high yields, a number of monomer building-block chemicals that can be used to produce replacements to many conventional plastic materials. Through those three examples this review aims to highlight recent and important advancements in production, modification and applications of the studied bioproducts. Bigger data analysis and artificial intelligence may help reweight practical and theoretical observations and concepts in these fields;helping to cross the boarders of expert traditional exploration fields and sometime fortresses.
