Hemoglobin hydrolysate is derived from the enzymatic degradation of hemoglobin.This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mic...Hemoglobin hydrolysate is derived from the enzymatic degradation of hemoglobin.This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver homeostasis.We found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 weeks.Duodenal iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative stress.With the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis recovered.In addition,hemoglobin hydrolysate enhanced the hepatic antioxidant capacity.Taken together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.展开更多
Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible oil.Presently,improving rapeseed plant architecture is an effect...Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible oil.Presently,improving rapeseed plant architecture is an effective way to increase rapeseed yield with higher planting density.However,the regulatory mechanism of rapeseed plant architecture is poorly understood.In this study,a dwarf rapeseed mutant dwarf08(df08)is obtained by ethyl methane sulfonate(EMS)-mutagenesis.The decrease in plant height of df08 is mainly caused by the reduction in main inflorescence length and first effective branch height and controlled by a single semi-dominant gene.The hybrid plants(F1)show a semi-dwarf phenotype.Through map-based cloning and transgenic assay,we confirm that the nonsynonymous single nucleotide variant(SNV)(C to T)in BnaC03.BIN2,which is homologous with Arabidopsis(Arabidopsis thaliana)BIN2,is responsible for the dwarfism of df08.BnaC03.BIN2 interacts with BnaBZR1/BES1 and involves in brassinosteroids(BRs)signal transduction.Proline to Leucine substitution in 284(P284L)enhances the protein stability of BnaC03.bin2-D,disrupts BRs signal transduction and affects the expression of genes regulating cell division,leading to dwarfism of df08.This study provides a new insight for the mechanism of rapeseed plant height regulation and creates an elite germplasm that can be used for genetic improvement of rapeseed architecture.展开更多
There are more uncertainties with ice hydrometeor representations and related processes than liquid hydrometeors within microphysics parameterization(MP)schemes because of their complicated geometries and physical pro...There are more uncertainties with ice hydrometeor representations and related processes than liquid hydrometeors within microphysics parameterization(MP)schemes because of their complicated geometries and physical properties.Idealized supercell simulations are produced using the WRF model coupled with“full”Hebrew University spectral bin MP(HU-SBM),and NSSL and Thompson bulk MP(BMP)schemes.HU-SBM downdrafts are typically weaker than those of the NSSL and Thompson simulations,accompanied by less rain evaporation.HU-SBM produces more cloud ice(plates),graupel,and hail than the BMPs,yet precipitates less at the surface.The limiting mass bins(and subsequently,particle size)of rimed ice in HU-SBM and slower rimed ice fall speeds lead to smaller melting-level net rimed ice fluxes than those of the BMPs.Aggregation from plates in HU-SBM,together with snow–graupel collisions,leads to a greater snow contribution to rain than those of the BMPs.Replacing HU-SBM’s fall speeds using the formulations of the BMPs after aggregating the discrete bin values to mass mixing ratios and total number concentrations increases net rain and rimed ice fluxes.Still,they are smaller in magnitude than bulk rain,NSSL hail,and Thompson graupel net fluxes near the surface.Conversely,the melting-layer net rimed ice fluxes are reduced when the fall speeds for the NSSL and Thompson simulations are calculated using HU-SBM fall speed formulations after discretizing the bulk particle size distributions(PSDs)into spectral bins.The results highlight precipitation sensitivity to storm dynamics,fall speed,hydrometeor evolution governed by process rates,and MP PSD design.展开更多
针对海量风电数据下风电机组异常数据处理、功率曲线模型构建精度低等问题,提出一种基于IR-BIN算法的风功率曲线模型构建算法。首先,为了降低风电机组异常数据对风功率曲线模型准确性,提高风功率曲线对数据分布表征水平,提出了一种基于...针对海量风电数据下风电机组异常数据处理、功率曲线模型构建精度低等问题,提出一种基于IR-BIN算法的风功率曲线模型构建算法。首先,为了降低风电机组异常数据对风功率曲线模型准确性,提高风功率曲线对数据分布表征水平,提出了一种基于四分位法、准则的异常数据处理方法。其次,提出一种IR-BIN算法的风功率曲线构建方法,以提高风功率曲线构建准确性、减小利用风功率曲线构建误差,综合分析风功率曲线模型评价指标、曲线偏差、契合率等指标,评估所提方法构建曲线模型准确性。最后,以2019年5月份内蒙古塞罕坝风电机组数据进行分析,实验结果表明:与建模效果较好的IR方法相比所提方法R2提高了0.005,其余3种评价指标均处于最好值;所提IR-BIN方法构建曲线与理论曲线契合率约为0.9214,高于其余4种方法构建曲线契合率,应用于风电机组健康性能评估,评估结果与实际情况基本一致。In response to the challenges of abnormal data processing and the low accuracy in constructing power curve models for wind power units amidst extensive wind power big data, we propose an algorithm for wind power curve model construction based on the IR-BIN algorithm. Firstly, to enhance the accuracy of the wind power curve model and improve its representation of data distribution, we introduce an anomaly detection method utilizing quartile analysis and a three-sigma criterion. Secondly, we present a construction methodology for wind power curves grounded in the IR-BIN algorithm aimed at increasing modelling precision while minimizing errors in curve construction. The evaluation index, curve deviation and fit rate of the wind power curve model are analyzed comprehensively, and the accuracy of the curve model constructed by the proposed method is evaluated. Finally, based on the data of Saihanba Wind turbine in Inner Mongolia in May 2019, and the experimental results show that compared to the superior performing IR method, our proposed approach achieves an R2 increase of 0.005 along with optimal values across three additional evaluation metrics. The fit rate between our constructed curve and its theoretical counterpart under the IR-BIN method is approximately 0.9214, surpassing that achieved by four other methods. This methodology has been applied effectively to evaluate health performance in wind turbines, yielding results consistent with actual operational conditions.展开更多
建筑能耗分析中透过玻璃窗日射负荷占有较大比重,B IN能耗计算方法(也叫温、湿频数法)认为该项负荷与温度成简单的线性关系,这样处理过于粗略。一方面日射负荷与温度不是直线关系;另一方面确定两点时,负荷所对应的代表温度的选取主观因...建筑能耗分析中透过玻璃窗日射负荷占有较大比重,B IN能耗计算方法(也叫温、湿频数法)认为该项负荷与温度成简单的线性关系,这样处理过于粗略。一方面日射负荷与温度不是直线关系;另一方面确定两点时,负荷所对应的代表温度的选取主观因素很大,缺乏客观标准。针对这个问题,先得到逐日最大日射得热因数DJ m ax,乘以逐时冷负荷系数得到透过玻璃窗日射负荷与温度的全年逐时详细关系。再按朝向统计不同温度下日射负荷的平均值,得出温度与冷负荷的实用关系,经过统计处理计算方法仍可以比较简单。并将这种方法求得的冷负荷与原方法作了比较。由于它反映了温度与该部分冷负荷的真实关系,使负荷和能耗计算精度提高。并以成都南向玻璃窗为例介绍了新统计关系的使用方法。展开更多
基金supported by the National Natural Science Foundation of China(32072211)Jiangsu Province Department of Education(Innovation Group of Meat Nutrition and Biotechnology)。
文摘Hemoglobin hydrolysate is derived from the enzymatic degradation of hemoglobin.This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver homeostasis.We found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 weeks.Duodenal iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative stress.With the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis recovered.In addition,hemoglobin hydrolysate enhanced the hepatic antioxidant capacity.Taken together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.
基金supported by the National Key Research and Development Program of China(2022YFD1200401)the National Natural Science Foundation of China(U22A20477,32172095)the Central Public-interest Scientific Institution Basal Research Fund(Y2022QC21).
文摘Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible oil.Presently,improving rapeseed plant architecture is an effective way to increase rapeseed yield with higher planting density.However,the regulatory mechanism of rapeseed plant architecture is poorly understood.In this study,a dwarf rapeseed mutant dwarf08(df08)is obtained by ethyl methane sulfonate(EMS)-mutagenesis.The decrease in plant height of df08 is mainly caused by the reduction in main inflorescence length and first effective branch height and controlled by a single semi-dominant gene.The hybrid plants(F1)show a semi-dwarf phenotype.Through map-based cloning and transgenic assay,we confirm that the nonsynonymous single nucleotide variant(SNV)(C to T)in BnaC03.BIN2,which is homologous with Arabidopsis(Arabidopsis thaliana)BIN2,is responsible for the dwarfism of df08.BnaC03.BIN2 interacts with BnaBZR1/BES1 and involves in brassinosteroids(BRs)signal transduction.Proline to Leucine substitution in 284(P284L)enhances the protein stability of BnaC03.bin2-D,disrupts BRs signal transduction and affects the expression of genes regulating cell division,leading to dwarfism of df08.This study provides a new insight for the mechanism of rapeseed plant height regulation and creates an elite germplasm that can be used for genetic improvement of rapeseed architecture.
基金This research was primarily supported by a NOAA Warn-on-Forecast(WoF)grant(Grant No.NA16OAR4320115).
文摘There are more uncertainties with ice hydrometeor representations and related processes than liquid hydrometeors within microphysics parameterization(MP)schemes because of their complicated geometries and physical properties.Idealized supercell simulations are produced using the WRF model coupled with“full”Hebrew University spectral bin MP(HU-SBM),and NSSL and Thompson bulk MP(BMP)schemes.HU-SBM downdrafts are typically weaker than those of the NSSL and Thompson simulations,accompanied by less rain evaporation.HU-SBM produces more cloud ice(plates),graupel,and hail than the BMPs,yet precipitates less at the surface.The limiting mass bins(and subsequently,particle size)of rimed ice in HU-SBM and slower rimed ice fall speeds lead to smaller melting-level net rimed ice fluxes than those of the BMPs.Aggregation from plates in HU-SBM,together with snow–graupel collisions,leads to a greater snow contribution to rain than those of the BMPs.Replacing HU-SBM’s fall speeds using the formulations of the BMPs after aggregating the discrete bin values to mass mixing ratios and total number concentrations increases net rain and rimed ice fluxes.Still,they are smaller in magnitude than bulk rain,NSSL hail,and Thompson graupel net fluxes near the surface.Conversely,the melting-layer net rimed ice fluxes are reduced when the fall speeds for the NSSL and Thompson simulations are calculated using HU-SBM fall speed formulations after discretizing the bulk particle size distributions(PSDs)into spectral bins.The results highlight precipitation sensitivity to storm dynamics,fall speed,hydrometeor evolution governed by process rates,and MP PSD design.
文摘针对海量风电数据下风电机组异常数据处理、功率曲线模型构建精度低等问题,提出一种基于IR-BIN算法的风功率曲线模型构建算法。首先,为了降低风电机组异常数据对风功率曲线模型准确性,提高风功率曲线对数据分布表征水平,提出了一种基于四分位法、准则的异常数据处理方法。其次,提出一种IR-BIN算法的风功率曲线构建方法,以提高风功率曲线构建准确性、减小利用风功率曲线构建误差,综合分析风功率曲线模型评价指标、曲线偏差、契合率等指标,评估所提方法构建曲线模型准确性。最后,以2019年5月份内蒙古塞罕坝风电机组数据进行分析,实验结果表明:与建模效果较好的IR方法相比所提方法R2提高了0.005,其余3种评价指标均处于最好值;所提IR-BIN方法构建曲线与理论曲线契合率约为0.9214,高于其余4种方法构建曲线契合率,应用于风电机组健康性能评估,评估结果与实际情况基本一致。In response to the challenges of abnormal data processing and the low accuracy in constructing power curve models for wind power units amidst extensive wind power big data, we propose an algorithm for wind power curve model construction based on the IR-BIN algorithm. Firstly, to enhance the accuracy of the wind power curve model and improve its representation of data distribution, we introduce an anomaly detection method utilizing quartile analysis and a three-sigma criterion. Secondly, we present a construction methodology for wind power curves grounded in the IR-BIN algorithm aimed at increasing modelling precision while minimizing errors in curve construction. The evaluation index, curve deviation and fit rate of the wind power curve model are analyzed comprehensively, and the accuracy of the curve model constructed by the proposed method is evaluated. Finally, based on the data of Saihanba Wind turbine in Inner Mongolia in May 2019, and the experimental results show that compared to the superior performing IR method, our proposed approach achieves an R2 increase of 0.005 along with optimal values across three additional evaluation metrics. The fit rate between our constructed curve and its theoretical counterpart under the IR-BIN method is approximately 0.9214, surpassing that achieved by four other methods. This methodology has been applied effectively to evaluate health performance in wind turbines, yielding results consistent with actual operational conditions.
文摘建筑能耗分析中透过玻璃窗日射负荷占有较大比重,B IN能耗计算方法(也叫温、湿频数法)认为该项负荷与温度成简单的线性关系,这样处理过于粗略。一方面日射负荷与温度不是直线关系;另一方面确定两点时,负荷所对应的代表温度的选取主观因素很大,缺乏客观标准。针对这个问题,先得到逐日最大日射得热因数DJ m ax,乘以逐时冷负荷系数得到透过玻璃窗日射负荷与温度的全年逐时详细关系。再按朝向统计不同温度下日射负荷的平均值,得出温度与冷负荷的实用关系,经过统计处理计算方法仍可以比较简单。并将这种方法求得的冷负荷与原方法作了比较。由于它反映了温度与该部分冷负荷的真实关系,使负荷和能耗计算精度提高。并以成都南向玻璃窗为例介绍了新统计关系的使用方法。
