Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer's disease(AD),its preparation technology,characteristics and in vivo ef...Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer's disease(AD),its preparation technology,characteristics and in vivo effects were evaluated.Methods:The morphological and rheological properties were evaluated.The preventive effects of T-BII ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1(M1)expression and pathological changes.Results:Results revealed that T-BII ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1(CA1)area.Conclusion:T-BII ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by scopolamine.This,thereby,lays forth a new treatment option for preventing AD.展开更多
Multilayered photovoltaic absorbers have triggered widespread attention for their unique structure and properties.However,multilayered materials in the randomly oriented polycrystalline thin-film lead to ineffective c...Multilayered photovoltaic absorbers have triggered widespread attention for their unique structure and properties.However,multilayered materials in the randomly oriented polycrystalline thin-film lead to ineffective carrier transport and collection,which hinders the process of achieving high-performance solar cells.Herein,this issue is tackled by producing the three-dimensional(3D)heterojunction BiI3 nanosheets(NSs)solar cells,which embed vertically aligned monocrystalline BiI3 NSs into spiro-OMeTAD.The preferred orientation of BiI3 NSs and large p-n junction areas of 3D heterojunction structure enable a strong light absorption and effective carrier transport and collection,and thus a power conversion efficiency(PCE)of 1.45%was achieved.Moreover,this PCE is the highest ever reported for BiI3 based solar cells to our best knowledge.Moreover,the nonencapsulated device remained 96%of the initial PCE after 24 h continuous one sun illumination at^70%humidity condition,and 82%of the initial PCE after 1-month storage at^30%humidity condition.展开更多
基金This study was funded by the Beijing Natural Science Foundation(7202147).
文摘Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer's disease(AD),its preparation technology,characteristics and in vivo effects were evaluated.Methods:The morphological and rheological properties were evaluated.The preventive effects of T-BII ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1(M1)expression and pathological changes.Results:Results revealed that T-BII ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1(CA1)area.Conclusion:T-BII ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by scopolamine.This,thereby,lays forth a new treatment option for preventing AD.
基金General Research Fund,Grant/Award Number:16237816National Key Basic Research Program of China,Grant/Award Number:2015CB921600+5 种基金National Natural Science Foundation of China,Grant/Award Numbers:51672231,61574076Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20180330the Science and Technology Plan of Shenzhen,Grant/Award Number:JCYJ20170818114107730supported by the Science and Technology Plan of Shenzhen(JCYJ20170818114107730),National Natural Science Foundation of China(Project No.51672231),The General Research Fund(Project No.16237816)from the Hong Kong Research Grant Council,Natural Science Foundation of Jiangsu Province(Project No.BK20180330)National Natural Science Foundation of China(Project No.61574076)National Key Basic Research Program of China(Project No.2015CB921600).
文摘Multilayered photovoltaic absorbers have triggered widespread attention for their unique structure and properties.However,multilayered materials in the randomly oriented polycrystalline thin-film lead to ineffective carrier transport and collection,which hinders the process of achieving high-performance solar cells.Herein,this issue is tackled by producing the three-dimensional(3D)heterojunction BiI3 nanosheets(NSs)solar cells,which embed vertically aligned monocrystalline BiI3 NSs into spiro-OMeTAD.The preferred orientation of BiI3 NSs and large p-n junction areas of 3D heterojunction structure enable a strong light absorption and effective carrier transport and collection,and thus a power conversion efficiency(PCE)of 1.45%was achieved.Moreover,this PCE is the highest ever reported for BiI3 based solar cells to our best knowledge.Moreover,the nonencapsulated device remained 96%of the initial PCE after 24 h continuous one sun illumination at^70%humidity condition,and 82%of the initial PCE after 1-month storage at^30%humidity condition.
