In this study,a new algorithm of fractional beta chaotic maps is proposed to generate chaotic sequences for image encryption.The proposed technique generates multi random sequences by shuffling the image pixel positio...In this study,a new algorithm of fractional beta chaotic maps is proposed to generate chaotic sequences for image encryption.The proposed technique generates multi random sequences by shuffling the image pixel position.This technique is used to blur the pixels connecting the input and encrypted images and to increase the attack resistance.The proposed algorithm makes the encryption process sophisticated by using fractional chaotic maps,which hold the properties of pseudo-randomness.The fractional beta sequences are utilized to alter the image pixels to decryption attacks.The experimental results proved that the proposed image encryption algorithm successfully encrypted and decrypted the images with the same keys.The output findings indicate that our proposed algorithm has good entropy and low correlation coefficients.This translates to enhanced security against different attacks.A MATLAB programming tool was used to implement and assess the image quality measures.A comparison with other image encryption techniques regarding the visual inspection and signal-to-noise ratio is provided.展开更多
Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization an...Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization and economic planning. Forecasting gold reserves and estimating their production lifespan are complex tasks that require robust statistical models capable of capturing the underlying dynamics of gold deposit accumulation and extraction. To this end, the four-parameter Beta distribution function emerges as a promising candidate due to its flexibility and ability to handle non-negative data. This research aims to investigate the fitness and applicability of the four-parameter Beta distribution function for forecasting Ghana’s gold reserves and estimating the production lifespan of this precious resource. The empirical paper relied mainly on quarterly secondary datasets on gold reserve between the years 2009 and 2022 secured from the Minerals Commission of Ghana, Accra. Several known statistical distributions including Beta, Weibull, Normal, Logistic and Gamma were explored with Maximum Likelihood Estimation (MLE) and evaluated using model selection criteria as AIC and BIC. Goodness of Fits were evaluated using Kolmogorov-Smirnov Test (K-S), Cramer-Von Mises Statistic and Anderson-Darling Statistic. Based on the analysis conducted, the four-parameter Beta distribution provided the best fit for gold reserve in Ghana. At a 99.9% confidence level and considering the current annual average gold production estimate of 3,700,031.248 to 4,302,647.888 ounces, the projected lifespan of gold production in Ghana extends to the year 1,953,765. This astounding estimate suggests that the country’s gold reserves are expected to sustain production for an extended period, providing a critical resource for economic development and supporting the mining industry well into the distant future.展开更多
Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization an...Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization and economic planning. Forecasting gold reserves and estimating their production lifespan are complex tasks that require robust statistical models capable of capturing the underlying dynamics of gold deposit accumulation and extraction. To this end, the four-parameter Beta distribution function emerges as a promising candidate due to its flexibility and ability to handle non-negative data. This research aims to investigate the fitness and applicability of the four-parameter Beta distribution function for forecasting Ghana’s gold reserves and estimating the production lifespan of this precious resource. The empirical paper relied mainly on quarterly secondary datasets on gold reserve between the years 2009 and 2022 secured from the Minerals Commission of Ghana, Accra. Several known statistical distributions including Beta, Weibull, Normal, Logistic and Gamma were explored with Maximum Likelihood Estimation (MLE) and evaluated using model selection criteria as AIC and BIC. Goodness of Fits were evaluated using Kolmogorov-Smirnov Test (K-S), Cramer-Von Mises Statistic and Anderson-Darling Statistic. Based on the analysis conducted, the four-parameter Beta distribution provided the best fit for gold reserve in Ghana. At a 99.9% confidence level and considering the current annual average gold production estimate of 3,700,031.248 to 4,302,647.888 ounces, the projected lifespan of gold production in Ghana extends to the year 1,953,765. This astounding estimate suggests that the country’s gold reserves are expected to sustain production for an extended period, providing a critical resource for economic development and supporting the mining industry well into the distant future.展开更多
Several densities or probability laws of continuous random variables derive from the Euler Gamma function. These laws form the basis of sampling theory, namely hypothesis testing and estimation. Namely the gamma, beta...Several densities or probability laws of continuous random variables derive from the Euler Gamma function. These laws form the basis of sampling theory, namely hypothesis testing and estimation. Namely the gamma, beta, and Student law, through the chi-square law and the normal law are all distributions resulting from applications of Euleur functions.展开更多
Water is a vital resource, and can also sometimes be a destructive force. As such, it is important to manage this resource. The prediction of stream flows is an important component of this management. Hydrological mod...Water is a vital resource, and can also sometimes be a destructive force. As such, it is important to manage this resource. The prediction of stream flows is an important component of this management. Hydrological models are very useful in accomplishing this task. The objective of this study is to develop and apply an optimization method useful for calibrating a deterministic model of the daily flows of the Miramichi River watershed (New Brunswick). The model used is the CEQUEAU model. The model is calibrated by applying a genetic algorithm. The Nash-Sutcliffe efficiency criterion, modified to penalize physically unrealistic results, was used as the objective function. The model was calibrated using flow data (1975-2000) from a gauging station on the Southwest Miramichi River (catchment area of 5050 km2), obtaining a Nash-Sutcliffe criterion of 0.83. Model validation was performed using flow data (2001-2009) from the same station (Nash-Sutcliffe criterion value of 0.80). This suggests that the model calibration is sufficiently robust to be used for future predictions. A second model validation was performed using data from three other measuring stations on the same watershed. The model performed well in all three additional locations (Nash-Sutcliffe criterion values of 0.77, 0.76 and 0.74), but was performing less well when applied to smaller sub-basins. Nonetheless, the relatively strong performance of the model suggests that it could be used to predict flows anywhere in the watershed, but caution is suggested for applications in small sub-basins. The performance of the CEQUEAU model was also compared to a simple benchmark model (average of each calendar day). A sensitivity analysis was also performed.展开更多
In this paper, it is shown that Hardy-Hilbert＇s integral inequality with parameter is improved by means of a sharpening of Hoeder＇s inequality. A new inequality is established as follows：∫^∞α∫^∞α f（x）g（y）...In this paper, it is shown that Hardy-Hilbert＇s integral inequality with parameter is improved by means of a sharpening of Hoeder＇s inequality. A new inequality is established as follows：∫^∞α∫^∞α f（x）g（y）/（x＋y＋2β）dxdy〈π/sin（π/p）{∫^∞α f^p（x）dx}1/p·{∫^∞αgq（x）dx}1/q·（1-R）^m,where R=（Sp （F, h） - Sq （G, h））^2, m= min （1/p, 1/q）. As application; an extension of Hardy-Littlewood＇s inequality is given.展开更多
The paper introduce the measurement of some beam parameters for Hefei Light Source (HLS) by frequency domain technique, which include the betatron tune, average beta function, natural chromaticity, corrected chroinati...The paper introduce the measurement of some beam parameters for Hefei Light Source (HLS) by frequency domain technique, which include the betatron tune, average beta function, natural chromaticity, corrected chroinaticity, and center frequency. Additionally, the measurement of the influence of DC clearing electrodes on the betatron tune shift is also described. Some measurement results are given. The measurement results are compared with the theoretical values and shown to be in good agreement.展开更多
Type 2 diabetes(T2D)is a multifactorial metabolic disorder affecting more than 450 million people across the globe.With the increasing prevalence of T2D and obesity,the role of fat accumulation at sites other than sub...Type 2 diabetes(T2D)is a multifactorial metabolic disorder affecting more than 450 million people across the globe.With the increasing prevalence of T2D and obesity,the role of fat accumulation at sites other than subcutaneous adipose tissue has received significant attention in the pathophysiology of T2D.Over the past decade and a half,a pressing concern has emerged on investigating the association of pancreatic fat accumulation or pancreatic steatosis with the development of disease.While a few reports have suggested a possible association between pancreatic fat and T2D and/or impaired glucose metabolism,a few reports suggest a lack of such association.Pancreatic fat has also been linked with genetic risk of developing T2D,prediabetes,reduced insulin secretion,and beta cell dysfunction albeit some confounding factors such as age and ethnicity may affect the outcome.With the technological advancements in clinical imaging and progress in assessment of pancreatic beta cell function,our understanding of the role of pancreatic fat in causing insulin resistance and development of various etiologies of T2D has significantly improved.This review summarizes various findings on the possible association of pancreatic fat accumulation with the pathophysiology of T2D.展开更多
The beta function measurement is used to detect the shift in the betatron tune as the strength of an individual quadrupole magnet is varied. A GUI （graphic user interface） tool for the beta function measurement is d...The beta function measurement is used to detect the shift in the betatron tune as the strength of an individual quadrupole magnet is varied. A GUI （graphic user interface） tool for the beta function measurement is developed using the MATLAB program language in the Linux environment, which facilitates the commissioning of the Shanghai Synchrotron Radiation Facility （SSRF） storage ring. In this paper, we describe the design of the application and give some measuring results and discussions about the definition of the measurement. The program has been optimized to solve some restrictions of the AT tracking code. After the correction with LOCO （linear optics from closed orbits）, the horizontal and the vertical root mean square values （rms values） can be reduced to 0.12 and 0.10.展开更多
By means of a sharpening of Hoelder＇s inequality, Hardy-Hilbert＇s integral inequality with parameters is improved. Some new inequalities are established,
In this paper, the expression of the norm of a self-adjoint integral operator T ： L^2（0, ∞） → L^2 （0, ∞） is obtained. As applications, a new bilinear integral inequality with a best constant factor is establis...In this paper, the expression of the norm of a self-adjoint integral operator T ： L^2（0, ∞） → L^2 （0, ∞） is obtained. As applications, a new bilinear integral inequality with a best constant factor is established and some particular cases are considered.展开更多
Aims The evolutionary history and functional traits of species can illumi-nate ecological processes supporting coexistence in diverse forest communities.However,little has been done in decoupling the rela-tive importa...Aims The evolutionary history and functional traits of species can illumi-nate ecological processes supporting coexistence in diverse forest communities.However,little has been done in decoupling the rela-tive importance of these mechanisms on the turnover of phylogenetic and functional characteristics across life stages and spatial scales.Therefore,this study aims to estimate the contribution of environment and dispersal on the turnover of phylogenetic and functional diversity across life stages and spatial scales,in order to build a coherent pic-ture of the processes responsible for species coexistence.Methods We conducted the study in Xishuangbanna Forest Dynamics Plot in Yunnan Province,southwest China.We used four different spatial point process models to estimate the relative importance of disper-sal limitation and environmental filtering.The functional traits and phylogenetic relationships of all individual trees were incorporated in the analyses to generate measures of dissimilarity in terms of pair-wise and nearest-neighbor phylogenetic and functional characteris-tics across life stages and spatial scales.Important Findings We found non-random patterns of phylogenetic and functional turnover across life stages and spatial scales.Environmental filtering structured pairwise phylogenetic and functional beta diversity across spatial scales,while dispersal limitation alone,and in combination with environment filtering,shaped nearest neighbor phylogenetic and functional beta diversity.The relative importance of dispersal limitation and environmental filtering appeared to change with life stage but not with spatial scale.Our findings suggest that phylogenetic and functional beta diversity help to reveal the ecological processes responsible for evolu-tionary and functional assembly and highlight the importance of using a range of different metrics to gain full insights into these processes.展开更多
Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose sti...Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.Methods The FABP2 Ala54Thr variation was detected by PCR/HhaI digestion in 231 Chinese subjects (116 with normal glucose tolerance (NGT), 54 with impaired glucose tolerance (IGT) and 61 with NIDDM). Plasma glucose, insulin and C peptide levels before and after 75 g glucose load as well as fasting lipid profile were determined.Results (1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2 Ala54Thr variation was neither associated with fasting and post challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2 hour and total C peptide levels and smaller AUC representing lesser C peptide secretion after glucose challenge than those with genotype Thr54( ) (Ala54 homozygotes) (P= 0.04 , 0.03, 0.01 and 0.01 respectively). The serum insulin levels changed in the same tendency.Conclusions The glucose stimulated insulin secretion (GSIS) reserve of islet beta cells is more limited in subjects with FABP2 Thr54(+) genotype than in those with FABP2 Thr54(-) genotype. It suggests that FABP2 codon 54 variation might contribute to the insufficient insulin secretion in the development of NIDDM in Chinese.展开更多
The Shanghai Synchrotron Radiation Facility (SSRF) is a low emittance third-generation synchrotron radiation light source. Some optics parameters of the storage ring were measured when commissioning. This report prese...The Shanghai Synchrotron Radiation Facility (SSRF) is a low emittance third-generation synchrotron radiation light source. Some optics parameters of the storage ring were measured when commissioning. This report presents the common methods for measuring some optics parameters of the storage ring, including the betatron tune, beta function, chromaticity, natural chromaticity and dispersion. The results and analysis of measurement for the optics parameters are given here, which are indispensable for the orbit correction of the accelerator and the nonlinear optimization.展开更多
Ab initio calculations of the orbital and the ground state energies of some open- and closed-shell atoms over Slater type orbitals with quantum numbers integer and Slater type orbitals with quantum numbers noninteger ...Ab initio calculations of the orbital and the ground state energies of some open- and closed-shell atoms over Slater type orbitals with quantum numbers integer and Slater type orbitals with quantum numbers noninteger have been performed. In order to increase the efficiency of these calculations the atomic two-electron integrals were expressed in terms of incomplete beta function. Results were observed to be in good agreement with the literature.展开更多
文摘In this study,a new algorithm of fractional beta chaotic maps is proposed to generate chaotic sequences for image encryption.The proposed technique generates multi random sequences by shuffling the image pixel position.This technique is used to blur the pixels connecting the input and encrypted images and to increase the attack resistance.The proposed algorithm makes the encryption process sophisticated by using fractional chaotic maps,which hold the properties of pseudo-randomness.The fractional beta sequences are utilized to alter the image pixels to decryption attacks.The experimental results proved that the proposed image encryption algorithm successfully encrypted and decrypted the images with the same keys.The output findings indicate that our proposed algorithm has good entropy and low correlation coefficients.This translates to enhanced security against different attacks.A MATLAB programming tool was used to implement and assess the image quality measures.A comparison with other image encryption techniques regarding the visual inspection and signal-to-noise ratio is provided.
文摘Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization and economic planning. Forecasting gold reserves and estimating their production lifespan are complex tasks that require robust statistical models capable of capturing the underlying dynamics of gold deposit accumulation and extraction. To this end, the four-parameter Beta distribution function emerges as a promising candidate due to its flexibility and ability to handle non-negative data. This research aims to investigate the fitness and applicability of the four-parameter Beta distribution function for forecasting Ghana’s gold reserves and estimating the production lifespan of this precious resource. The empirical paper relied mainly on quarterly secondary datasets on gold reserve between the years 2009 and 2022 secured from the Minerals Commission of Ghana, Accra. Several known statistical distributions including Beta, Weibull, Normal, Logistic and Gamma were explored with Maximum Likelihood Estimation (MLE) and evaluated using model selection criteria as AIC and BIC. Goodness of Fits were evaluated using Kolmogorov-Smirnov Test (K-S), Cramer-Von Mises Statistic and Anderson-Darling Statistic. Based on the analysis conducted, the four-parameter Beta distribution provided the best fit for gold reserve in Ghana. At a 99.9% confidence level and considering the current annual average gold production estimate of 3,700,031.248 to 4,302,647.888 ounces, the projected lifespan of gold production in Ghana extends to the year 1,953,765. This astounding estimate suggests that the country’s gold reserves are expected to sustain production for an extended period, providing a critical resource for economic development and supporting the mining industry well into the distant future.
文摘Ghana, renowned for its abundant gold reserves, plays a significant role in the global mining industry. Effective management and accurate forecasting of these reserves are vital for sustainable resource utilization and economic planning. Forecasting gold reserves and estimating their production lifespan are complex tasks that require robust statistical models capable of capturing the underlying dynamics of gold deposit accumulation and extraction. To this end, the four-parameter Beta distribution function emerges as a promising candidate due to its flexibility and ability to handle non-negative data. This research aims to investigate the fitness and applicability of the four-parameter Beta distribution function for forecasting Ghana’s gold reserves and estimating the production lifespan of this precious resource. The empirical paper relied mainly on quarterly secondary datasets on gold reserve between the years 2009 and 2022 secured from the Minerals Commission of Ghana, Accra. Several known statistical distributions including Beta, Weibull, Normal, Logistic and Gamma were explored with Maximum Likelihood Estimation (MLE) and evaluated using model selection criteria as AIC and BIC. Goodness of Fits were evaluated using Kolmogorov-Smirnov Test (K-S), Cramer-Von Mises Statistic and Anderson-Darling Statistic. Based on the analysis conducted, the four-parameter Beta distribution provided the best fit for gold reserve in Ghana. At a 99.9% confidence level and considering the current annual average gold production estimate of 3,700,031.248 to 4,302,647.888 ounces, the projected lifespan of gold production in Ghana extends to the year 1,953,765. This astounding estimate suggests that the country’s gold reserves are expected to sustain production for an extended period, providing a critical resource for economic development and supporting the mining industry well into the distant future.
文摘Several densities or probability laws of continuous random variables derive from the Euler Gamma function. These laws form the basis of sampling theory, namely hypothesis testing and estimation. Namely the gamma, beta, and Student law, through the chi-square law and the normal law are all distributions resulting from applications of Euleur functions.
文摘Water is a vital resource, and can also sometimes be a destructive force. As such, it is important to manage this resource. The prediction of stream flows is an important component of this management. Hydrological models are very useful in accomplishing this task. The objective of this study is to develop and apply an optimization method useful for calibrating a deterministic model of the daily flows of the Miramichi River watershed (New Brunswick). The model used is the CEQUEAU model. The model is calibrated by applying a genetic algorithm. The Nash-Sutcliffe efficiency criterion, modified to penalize physically unrealistic results, was used as the objective function. The model was calibrated using flow data (1975-2000) from a gauging station on the Southwest Miramichi River (catchment area of 5050 km2), obtaining a Nash-Sutcliffe criterion of 0.83. Model validation was performed using flow data (2001-2009) from the same station (Nash-Sutcliffe criterion value of 0.80). This suggests that the model calibration is sufficiently robust to be used for future predictions. A second model validation was performed using data from three other measuring stations on the same watershed. The model performed well in all three additional locations (Nash-Sutcliffe criterion values of 0.77, 0.76 and 0.74), but was performing less well when applied to smaller sub-basins. Nonetheless, the relatively strong performance of the model suggests that it could be used to predict flows anywhere in the watershed, but caution is suggested for applications in small sub-basins. The performance of the CEQUEAU model was also compared to a simple benchmark model (average of each calendar day). A sensitivity analysis was also performed.
文摘In this paper, it is shown that Hardy-Hilbert＇s integral inequality with parameter is improved by means of a sharpening of Hoeder＇s inequality. A new inequality is established as follows：∫^∞α∫^∞α f（x）g（y）/（x＋y＋2β）dxdy〈π/sin（π/p）{∫^∞α f^p（x）dx}1/p·{∫^∞αgq（x）dx}1/q·（1-R）^m,where R=（Sp （F, h） - Sq （G, h））^2, m= min （1/p, 1/q）. As application; an extension of Hardy-Littlewood＇s inequality is given.
基金Supported by National Important Project on Science-Phase Ⅱ of National Synchrotron Radiation Laboratory
文摘The paper introduce the measurement of some beam parameters for Hefei Light Source (HLS) by frequency domain technique, which include the betatron tune, average beta function, natural chromaticity, corrected chroinaticity, and center frequency. Additionally, the measurement of the influence of DC clearing electrodes on the betatron tune shift is also described. Some measurement results are given. The measurement results are compared with the theoretical values and shown to be in good agreement.
文摘Type 2 diabetes(T2D)is a multifactorial metabolic disorder affecting more than 450 million people across the globe.With the increasing prevalence of T2D and obesity,the role of fat accumulation at sites other than subcutaneous adipose tissue has received significant attention in the pathophysiology of T2D.Over the past decade and a half,a pressing concern has emerged on investigating the association of pancreatic fat accumulation or pancreatic steatosis with the development of disease.While a few reports have suggested a possible association between pancreatic fat and T2D and/or impaired glucose metabolism,a few reports suggest a lack of such association.Pancreatic fat has also been linked with genetic risk of developing T2D,prediabetes,reduced insulin secretion,and beta cell dysfunction albeit some confounding factors such as age and ethnicity may affect the outcome.With the technological advancements in clinical imaging and progress in assessment of pancreatic beta cell function,our understanding of the role of pancreatic fat in causing insulin resistance and development of various etiologies of T2D has significantly improved.This review summarizes various findings on the possible association of pancreatic fat accumulation with the pathophysiology of T2D.
文摘The beta function measurement is used to detect the shift in the betatron tune as the strength of an individual quadrupole magnet is varied. A GUI （graphic user interface） tool for the beta function measurement is developed using the MATLAB program language in the Linux environment, which facilitates the commissioning of the Shanghai Synchrotron Radiation Facility （SSRF） storage ring. In this paper, we describe the design of the application and give some measuring results and discussions about the definition of the measurement. The program has been optimized to solve some restrictions of the AT tracking code. After the correction with LOCO （linear optics from closed orbits）, the horizontal and the vertical root mean square values （rms values） can be reduced to 0.12 and 0.10.
文摘By means of a sharpening of Hoelder＇s inequality, Hardy-Hilbert＇s integral inequality with parameters is improved. Some new inequalities are established,
基金Supported by the Emphases Natural Science Foundation of Guangdong Institutions of Higher Learning,College and University(No.05Z026)
文摘In this paper, the expression of the norm of a self-adjoint integral operator T ： L^2（0, ∞） → L^2 （0, ∞） is obtained. As applications, a new bilinear integral inequality with a best constant factor is established and some particular cases are considered.
基金National Natural Science Foundation of China(31400362 and 31670442)the National Key Basic Research Program of China(2014CB954100)+1 种基金the West Light Foundation of the Chinese Academy of Sciences and the Chinese Academy of Sciences Youth Innovation Promotion Association(2016352)the Applied Fundamental Research Foundation of Yunnan Province(2014GA003).
文摘Aims The evolutionary history and functional traits of species can illumi-nate ecological processes supporting coexistence in diverse forest communities.However,little has been done in decoupling the rela-tive importance of these mechanisms on the turnover of phylogenetic and functional characteristics across life stages and spatial scales.Therefore,this study aims to estimate the contribution of environment and dispersal on the turnover of phylogenetic and functional diversity across life stages and spatial scales,in order to build a coherent pic-ture of the processes responsible for species coexistence.Methods We conducted the study in Xishuangbanna Forest Dynamics Plot in Yunnan Province,southwest China.We used four different spatial point process models to estimate the relative importance of disper-sal limitation and environmental filtering.The functional traits and phylogenetic relationships of all individual trees were incorporated in the analyses to generate measures of dissimilarity in terms of pair-wise and nearest-neighbor phylogenetic and functional characteris-tics across life stages and spatial scales.Important Findings We found non-random patterns of phylogenetic and functional turnover across life stages and spatial scales.Environmental filtering structured pairwise phylogenetic and functional beta diversity across spatial scales,while dispersal limitation alone,and in combination with environment filtering,shaped nearest neighbor phylogenetic and functional beta diversity.The relative importance of dispersal limitation and environmental filtering appeared to change with life stage but not with spatial scale.Our findings suggest that phylogenetic and functional beta diversity help to reveal the ecological processes responsible for evolu-tionary and functional assembly and highlight the importance of using a range of different metrics to gain full insights into these processes.
文摘Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.Methods The FABP2 Ala54Thr variation was detected by PCR/HhaI digestion in 231 Chinese subjects (116 with normal glucose tolerance (NGT), 54 with impaired glucose tolerance (IGT) and 61 with NIDDM). Plasma glucose, insulin and C peptide levels before and after 75 g glucose load as well as fasting lipid profile were determined.Results (1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2 Ala54Thr variation was neither associated with fasting and post challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2 hour and total C peptide levels and smaller AUC representing lesser C peptide secretion after glucose challenge than those with genotype Thr54( ) (Ala54 homozygotes) (P= 0.04 , 0.03, 0.01 and 0.01 respectively). The serum insulin levels changed in the same tendency.Conclusions The glucose stimulated insulin secretion (GSIS) reserve of islet beta cells is more limited in subjects with FABP2 Thr54(+) genotype than in those with FABP2 Thr54(-) genotype. It suggests that FABP2 codon 54 variation might contribute to the insufficient insulin secretion in the development of NIDDM in Chinese.
基金Supported by Major State Basic Research Development Program of China (2002CB713600)
文摘The Shanghai Synchrotron Radiation Facility (SSRF) is a low emittance third-generation synchrotron radiation light source. Some optics parameters of the storage ring were measured when commissioning. This report presents the common methods for measuring some optics parameters of the storage ring, including the betatron tune, beta function, chromaticity, natural chromaticity and dispersion. The results and analysis of measurement for the optics parameters are given here, which are indispensable for the orbit correction of the accelerator and the nonlinear optimization.
文摘Ab initio calculations of the orbital and the ground state energies of some open- and closed-shell atoms over Slater type orbitals with quantum numbers integer and Slater type orbitals with quantum numbers noninteger have been performed. In order to increase the efficiency of these calculations the atomic two-electron integrals were expressed in terms of incomplete beta function. Results were observed to be in good agreement with the literature.
