A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D...A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.展开更多
This paper presents the development and validation of China’s first benchmark measurement system for neutron leakage time-of-flight(TOF)spectra using a ^(252)Cf spontaneous fission source and spherical polyethylene s...This paper presents the development and validation of China’s first benchmark measurement system for neutron leakage time-of-flight(TOF)spectra using a ^(252)Cf spontaneous fission source and spherical polyethylene sample.EJ-309 and CLYC scintillation detectors were used for neutron detection,and a shadow cone was employed for background suppression.Notably,the SiC detector was,for the first time on this platform,applied as the start-time signal generator in TOF spectrum measurement.The TOF spectrum covering the energy range of 0.15−8.00 MeV was measured,and the results were systematically compared with evaluated data from four major nuclear libraries:ENDF/B-Ⅷ.1,JEFF-3.3,JENDL-5,and CENDL-3.2.The comparison revealed strong agreement across the full spectrum,with calculated to experimental(C/E)deviations remaining within 5%in the high-energy region and within 13%at low energies.These results verify the system’s stability and suitability for integral experiments.The established benchmark platform provides a strong technical foundation for future neutron nuclear data validation,particularly in shielding applications and the improvement of fission-spectrum nuclear databases.展开更多
基金financially supported by Special Funds of the State Environmental Protection Public Welfare Industry(201009049201309049)+1 种基金National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI12B03)the Fundamental Research Funds for the Central Universities(2015JBM108)
文摘A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.
基金Supported by the Continuous-Support Basic Scientific Research Project (BJ010261223282)。
文摘This paper presents the development and validation of China’s first benchmark measurement system for neutron leakage time-of-flight(TOF)spectra using a ^(252)Cf spontaneous fission source and spherical polyethylene sample.EJ-309 and CLYC scintillation detectors were used for neutron detection,and a shadow cone was employed for background suppression.Notably,the SiC detector was,for the first time on this platform,applied as the start-time signal generator in TOF spectrum measurement.The TOF spectrum covering the energy range of 0.15−8.00 MeV was measured,and the results were systematically compared with evaluated data from four major nuclear libraries:ENDF/B-Ⅷ.1,JEFF-3.3,JENDL-5,and CENDL-3.2.The comparison revealed strong agreement across the full spectrum,with calculated to experimental(C/E)deviations remaining within 5%in the high-energy region and within 13%at low energies.These results verify the system’s stability and suitability for integral experiments.The established benchmark platform provides a strong technical foundation for future neutron nuclear data validation,particularly in shielding applications and the improvement of fission-spectrum nuclear databases.
