Brassica rapa L.is an edible and medical plant in China used for treating various diseases,especially in the Tibet region.In this study,the chemical constituents of Brassica rapa L.extract(BE)was clarified by UHPLC-MS...Brassica rapa L.is an edible and medical plant in China used for treating various diseases,especially in the Tibet region.In this study,the chemical constituents of Brassica rapa L.extract(BE)was clarified by UHPLC-MS and anti-fatigue ability of BE was assessed through the behavior test and weight-loaded forced swimming test in mice.Then we determined several biochemical parameters related to fatigue to explore possible reasons.Results indicate that BE could significantly enhance exercise performance in mice,and there was a significant improvement in both grip-strength and the time on rota-rods.Meanwhile,BE showed significant anti-fatigue effects by decreasing the blood lactic acid(BLA),blood urea nitrogen(BUN),and creatine kinase(CK)levels and increasing the lactate dehydrogenase(LDH)and malondialdehyde(MDA)levels.Increases in superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were observed and reactive oxygen species(ROS)levels was regulated.Liver and muscle glycogen levels and adenosine triphosphate(ATP)levels were also significantly increased.Pearson correlation analysis indicates that fatigue-related indexes including metabolites and energy-related indexes were significantly correlated with antioxidant levels.In conclusion,BE possesses remarkable anti-fatigue activity,thereby shows great potential for improving exercise performance and alleviating physical fatigue and can be considered as a functional food supplement for further development.展开更多
As one of the most common social relationships among college students,the dormitory interpersonal relationship has important effects on students'psychology and behavior.For quantitative analysis of the dormitory i...As one of the most common social relationships among college students,the dormitory interpersonal relationship has important effects on students'psychology and behavior.For quantitative analysis of the dormitory interpersonal influence on college students'emergency evacuation behavior,an evacuation simulation experiment of college students carried out and coupling questionnaire survey,measurement and social force model of society to visualize the normal dormitory interpersonal relationship and emergency evacuation following relationship of college students,then simulation experiment is used to explore the impact of different types of dormitory relationship structure on emergency evacuation.The results show that dormitory interpersonal relationship is an important component of college students'interpersonal network and has an important impact on emergency evacuation behavior.The close and united dormitory relationship has a good promotion effect on the emergency evacuation efficiency.When the emergency occurs,the dormitory interpersonal relationship of college students will partly transform into the leader-following behavior relationship,and the evacuation efficiency will decrease.The influence of dormitory interpersonal relationship on evacuation behavior is related to gender and grade which is higher for female students than male students,and is higher for junior students than senior students.展开更多
Many herbs and plant extracts have traditionally been used to enhance physical endurance and increase vitality.These natural products may contain active compounds such as antioxidants,adaptogens,and neuroprotective ag...Many herbs and plant extracts have traditionally been used to enhance physical endurance and increase vitality.These natural products may contain active compounds such as antioxidants,adaptogens,and neuroprotective agents,which help alleviate fatigue and restore energy,but have not been developed enough as new anti-fatigue nutritional supplements.Schisandra chinensis,also known as Wu Wei Zi,is a medicinal and edible plant native to China.It is rich in various bioactive components and possesses significant pharmacological activities.The current study was designed to investigate the effect of Schisandra chinensis extract(SCE)on fatigue in mice,and further to elucidate its possible underlying mechanism.The results showed that SCE significantly prolonged the swimming time,increased the levels of hepatic glycogen and muscular glycogen,while reducing the levels of lactic acid(LA),blood urea nitrogen(BUN),and malondialdehyde(MDA).Furthermore,it enhanced the activities of glutathione peroxidase(GSH-PX),superoxide dismutase(SOD),and catalase(CAT).Pearson correlation analysis also revealed a strong correlation between the anti-fatigue effects and antioxidant activities of SCE in mice vivo.Western blotting results showed that SCE alleviated fatigue by activating the AMPK/PGC-1αsignaling pathway and simultaneously increasing the expression levels of Nrf2,HO-1,and NQO1 proteins in mouse skeletal muscle.Therefore,SCE could be considered as a potential anti-fatigue nutritional supplement in functional foods,beneficial for alleviating exercise-induced fatigue.展开更多
基金financially supported by Military Medical Science and Technology Youth Cultivation Program(21QNPY095).
文摘Brassica rapa L.is an edible and medical plant in China used for treating various diseases,especially in the Tibet region.In this study,the chemical constituents of Brassica rapa L.extract(BE)was clarified by UHPLC-MS and anti-fatigue ability of BE was assessed through the behavior test and weight-loaded forced swimming test in mice.Then we determined several biochemical parameters related to fatigue to explore possible reasons.Results indicate that BE could significantly enhance exercise performance in mice,and there was a significant improvement in both grip-strength and the time on rota-rods.Meanwhile,BE showed significant anti-fatigue effects by decreasing the blood lactic acid(BLA),blood urea nitrogen(BUN),and creatine kinase(CK)levels and increasing the lactate dehydrogenase(LDH)and malondialdehyde(MDA)levels.Increases in superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were observed and reactive oxygen species(ROS)levels was regulated.Liver and muscle glycogen levels and adenosine triphosphate(ATP)levels were also significantly increased.Pearson correlation analysis indicates that fatigue-related indexes including metabolites and energy-related indexes were significantly correlated with antioxidant levels.In conclusion,BE possesses remarkable anti-fatigue activity,thereby shows great potential for improving exercise performance and alleviating physical fatigue and can be considered as a functional food supplement for further development.
基金Supported by Tianjin Social Science Project (TJGL21-019)。
文摘As one of the most common social relationships among college students,the dormitory interpersonal relationship has important effects on students'psychology and behavior.For quantitative analysis of the dormitory interpersonal influence on college students'emergency evacuation behavior,an evacuation simulation experiment of college students carried out and coupling questionnaire survey,measurement and social force model of society to visualize the normal dormitory interpersonal relationship and emergency evacuation following relationship of college students,then simulation experiment is used to explore the impact of different types of dormitory relationship structure on emergency evacuation.The results show that dormitory interpersonal relationship is an important component of college students'interpersonal network and has an important impact on emergency evacuation behavior.The close and united dormitory relationship has a good promotion effect on the emergency evacuation efficiency.When the emergency occurs,the dormitory interpersonal relationship of college students will partly transform into the leader-following behavior relationship,and the evacuation efficiency will decrease.The influence of dormitory interpersonal relationship on evacuation behavior is related to gender and grade which is higher for female students than male students,and is higher for junior students than senior students.
基金supported by the National Natural Science Foundation of China(31170510)the National College Students’innovation and entrepreneurship training program(202210225104)+1 种基金the National Science Foundation of Heilongjiang Province,China(LH 2020C035),the Fundamental Research Funds for the Central Universities(2572019BA09)the China Postdoctoral Science Foundation Project(2016M600239)for their support.The authors thank these institutions for their contributions to this study.
文摘Many herbs and plant extracts have traditionally been used to enhance physical endurance and increase vitality.These natural products may contain active compounds such as antioxidants,adaptogens,and neuroprotective agents,which help alleviate fatigue and restore energy,but have not been developed enough as new anti-fatigue nutritional supplements.Schisandra chinensis,also known as Wu Wei Zi,is a medicinal and edible plant native to China.It is rich in various bioactive components and possesses significant pharmacological activities.The current study was designed to investigate the effect of Schisandra chinensis extract(SCE)on fatigue in mice,and further to elucidate its possible underlying mechanism.The results showed that SCE significantly prolonged the swimming time,increased the levels of hepatic glycogen and muscular glycogen,while reducing the levels of lactic acid(LA),blood urea nitrogen(BUN),and malondialdehyde(MDA).Furthermore,it enhanced the activities of glutathione peroxidase(GSH-PX),superoxide dismutase(SOD),and catalase(CAT).Pearson correlation analysis also revealed a strong correlation between the anti-fatigue effects and antioxidant activities of SCE in mice vivo.Western blotting results showed that SCE alleviated fatigue by activating the AMPK/PGC-1αsignaling pathway and simultaneously increasing the expression levels of Nrf2,HO-1,and NQO1 proteins in mouse skeletal muscle.Therefore,SCE could be considered as a potential anti-fatigue nutritional supplement in functional foods,beneficial for alleviating exercise-induced fatigue.
