The queen bee embryo, the chrysalis of the queen bee, is very nutritious and valuable and is also a natural product in the process of manufacturing royal jelly. In modern industrial production, the embryo is produced ...The queen bee embryo, the chrysalis of the queen bee, is very nutritious and valuable and is also a natural product in the process of manufacturing royal jelly. In modern industrial production, the embryo is produced by transplanting one-day-old worker bee chrysalises into queen bee shaped incubators to allow worker bees to feed them believing they are queen bees. As a result, the weight of these chrysalises increases by some 1,000 times in 70 hours. When the royal jelly is collected, the chrysalises must be展开更多
Bioadhesives have potential advantages over sutures and staples for wound closure,hemostasis,and in vivo dressing applications.However,the tissue adhesives reported so far typically fail to integrate an in vivo adhesi...Bioadhesives have potential advantages over sutures and staples for wound closure,hemostasis,and in vivo dressing applications.However,the tissue adhesives reported so far typically fail to integrate an in vivo adhesion fault-tolerant mechanism with autonomous therapeutic activity.Here,we present the unprecedented develop-ment of a bioadhesive based on the coenzyme factor lipoic acid(LA),featuring an upper critical solution tem-perature and adhesion fault-tolerance.The in-situ ring-opening polymerization of LA triggered by aggregation in the naturally occurring sodium queen bee acid(SQBA)nanomicelles,leads to nanomicelle self-crosslinking via strong ionic hydrogen bonds,resulting in the formation of a thermoresponsive bioadhesive(PolyLA-SQBA).PolyLA-SQBA exhibits thermally switchable and reusable adhesion,forming rapid and robust adhesion on oral mucosa at physiological temperature,and detaching from the adhered tissue without residue upon cooling.Leveraging the natural bioactivity of LA and SQBA,PolyLA-SQBA demonstrates excellent biocompatibility,potent antioxidant activity,and exhibits significant inhibitory effects against common oral pathogens.With its intelligent responsiveness,efficient adhesion,and sustained release of bioactive molecules,PolyLA-SQBA effectively delivers both LA and SQBA to oral ulcer sites,reducing inflammatory cytokine levels and signifi-cantly accelerating the healing of oral ulcers.展开更多
文摘The queen bee embryo, the chrysalis of the queen bee, is very nutritious and valuable and is also a natural product in the process of manufacturing royal jelly. In modern industrial production, the embryo is produced by transplanting one-day-old worker bee chrysalises into queen bee shaped incubators to allow worker bees to feed them believing they are queen bees. As a result, the weight of these chrysalises increases by some 1,000 times in 70 hours. When the royal jelly is collected, the chrysalises must be
基金support for this work from the National Natural Science Foundation of China(Grant No.52233008,52303201,52473143).
文摘Bioadhesives have potential advantages over sutures and staples for wound closure,hemostasis,and in vivo dressing applications.However,the tissue adhesives reported so far typically fail to integrate an in vivo adhesion fault-tolerant mechanism with autonomous therapeutic activity.Here,we present the unprecedented develop-ment of a bioadhesive based on the coenzyme factor lipoic acid(LA),featuring an upper critical solution tem-perature and adhesion fault-tolerance.The in-situ ring-opening polymerization of LA triggered by aggregation in the naturally occurring sodium queen bee acid(SQBA)nanomicelles,leads to nanomicelle self-crosslinking via strong ionic hydrogen bonds,resulting in the formation of a thermoresponsive bioadhesive(PolyLA-SQBA).PolyLA-SQBA exhibits thermally switchable and reusable adhesion,forming rapid and robust adhesion on oral mucosa at physiological temperature,and detaching from the adhered tissue without residue upon cooling.Leveraging the natural bioactivity of LA and SQBA,PolyLA-SQBA demonstrates excellent biocompatibility,potent antioxidant activity,and exhibits significant inhibitory effects against common oral pathogens.With its intelligent responsiveness,efficient adhesion,and sustained release of bioactive molecules,PolyLA-SQBA effectively delivers both LA and SQBA to oral ulcer sites,reducing inflammatory cytokine levels and signifi-cantly accelerating the healing of oral ulcers.
