This report presents a forensic evaluation of a case involving blindness(visual acuity grade 5)following a bee/wasp sting to the left eye.Through systematic analysis of the patient’s multiple hospital admissions,post...This report presents a forensic evaluation of a case involving blindness(visual acuity grade 5)following a bee/wasp sting to the left eye.Through systematic analysis of the patient’s multiple hospital admissions,postoperative follow-up data,and a review of the pathological mechanisms of ocular injury caused by bee venom,this study comprehensively assesses the injury characteristics,treatment course,and visual outcomes.Bee venom induces severe complications such as corneal damage,uveitis,cataract,and secondary glaucoma through multiple mechanisms including direct cytotoxicity,immune-inflammatory responses,and enzymatic hydrolysis.Despite interventions including anterior chamber irrigation,phacoemulsification with intraocular lens implantation,and antiglaucoma surgery,the affected eye ultimately lost light perception.Forensic examination confirmed the absence of light perception in the left eye and abnormal visual pathway function,consistent with clinical observations.According to the relevant Chinese disability assessment standard(JR/T 0083-2013,Article 4.2.2),the injury was classified as grade 7 disability.This study provides an in-depth discussion of the mechanisms and key forensic identification points in bee-sting-induced blindness,offering a scientific reference for similar forensic clinical cases.展开更多
Bees are essential to human life and ecosystems,significantly contributing to medicine,economics,and environmental equilibrium.Bees serve an essential function as pollinators,facilitating the cultivation of various fr...Bees are essential to human life and ecosystems,significantly contributing to medicine,economics,and environmental equilibrium.Bees serve an essential function as pollinators,facilitating the cultivation of various fruits and vegetables.Bees contribute approximately 117 billion US dollars annually to the economy through their role in crop pollination.They have a direct impact on 35%of agricultural crops and 84%of cultivated plants.Bee products,including honey,propolis,and royal jelly,have been utilized in various traditional medicine practices across numerous countries.These substances have been utilized for their anti-inflammatory,antioxidant,and antibacterial properties.In addition to their economic,ecological,and medical significance,they serve as bioindicators for assessing the health of ecological systems by monitoring distribution and population dynamics.This offers important insights into the current situation,especially regarding the substantial impacts of climate change on the environment.This article seeks to synthesize data from various studies to examine the impact of climate change on bee populations and their habitats.This study illustrates the significant effects of future climate models for 2050 and 2070 on bee distribution,resulting in the decline of specific species populations.展开更多
Anastasis is a phenomenon described as a cellular escape from ethanol-induced cell death.Although the relevant mechanism has not yet been fully elucidated,anastasis is thought to play a role in drug resistance in canc...Anastasis is a phenomenon described as a cellular escape from ethanol-induced cell death.Although the relevant mechanism has not yet been fully elucidated,anastasis is thought to play a role in drug resistance in cancer cells.To date,the regulation of anastasis in normal and cancerous cells has not been clarified.展开更多
This paper uses an innovative improved artificial bee colony(IABC)algorithm to aid in the fabrication of a highly responsive phasemodulation surface plasmon resonance(SPR)biosensor.In this biosensor’s sensing structu...This paper uses an innovative improved artificial bee colony(IABC)algorithm to aid in the fabrication of a highly responsive phasemodulation surface plasmon resonance(SPR)biosensor.In this biosensor’s sensing structure,a double-layer Ag-Au metal film is combined with a blue phosphorene/transition metal dichalcogenide(BlueP/TMDC)hybrid structure and graphene.In the optimization function of the IABC method,the reflectivity at resonance angle is incorporated as a constraint to achieve high phase sensitivity.The performance of the Ag-Au-BlueP/TMDC-graphene heterostructure as optimized by the IABC method is compared with that of a similar structure optimized using the traditional ABC algorithm.The results indicate that optimization using the IABC method gives significantly more phase sensitivity,together with lower reflectivity,than can be achieved with the traditional ABC method.The highest phase sensitivity of 3.662×10^(6) °/RIU is achieved with a bilayer of BlueP/WS2 and three layers of graphene.Moreover,analysis of the electric field distribution demonstrates that the optimal arrangement can be utilized for enhanced detection of small biomolecules.Thus,given the exceptional sensitivity achieved,the proposed method based on the IABC algorithm has great promise for use in the design of high-performance SPR biosensors with a variety of multilayer structures.展开更多
The optimization of turbine blades is crucial in improving the efficiency of wind energy systems and developing clean energy production models.This paper presented a novel approach to the structural design of smallsca...The optimization of turbine blades is crucial in improving the efficiency of wind energy systems and developing clean energy production models.This paper presented a novel approach to the structural design of smallscale turbine blades using the Artificial Bee Colony(ABC)Algorithm based on the stochastic method to optimize both mass and cost(objective functions).The study used computational fluid dynamics(CFD)and structural analysis to consider the fluid-structure interaction.The optimization algorithm defined several variables:structural constraints,the type of composite material,and the number of composite layers to form a mathematical model.The numerical modeling was performed using the Ansys Fluent software and its Fluid-Structure Interaction(FSI)module.The ANSYS Composite PrePost(ACP)advanced composite modeling method was utilized in the structural design of composite materials.This study showed that the structurally optimized small-scale turbine blades provided a sustainable solution with improved efficiency compared to traditional designs.Furthermore,using CFD,structural analysis,and material characterization techniques first considered in this study highlights the importance of considering structural behavior when optimizing turbine blade designs.展开更多
The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differ...The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differences between SHS and cobalt-60 isotope(^(60)Co)radiation treatment.The number of total plate count(TPC)and mold colonies(MC)remained within the limits of the standards after SHS treatment at 140℃for 2 min.Neither TPC nor MC were detected after^(60)Co irradiation.Peroxidase(POD)and polyphenol oxidase(PPO)activities significantly decreased with increasing temperature and duration of SHS,while^(60)Co radiation completely inactivated PPO.Compared to^(60)Co radiation,SHS treatment inhibited the deterioration of rape bee pollen by avoiding hydroperoxide production and lipid oxidation due to lack of oxygen.These results suggested SHS under 140℃for 2 min was the most suitable to inactivate the microorganisms and enzymes in rape bee pollen with minimal lipid oxidation.展开更多
Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenol...Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.展开更多
In order to establish the lake eutrophic evaluation model for multiple indices,based on the gauge transformation,an index formula in the form of a logarithmic power function was proposed to design an eutrophic evaluat...In order to establish the lake eutrophic evaluation model for multiple indices,based on the gauge transformation,an index formula in the form of a logarithmic power function was proposed to design an eutrophic evaluation model for the ＂ normalized values＂ of multi-indexes.The parameters in the formula were also optimized by bee immune evolutionary algorithm（BEIEA）.The universal index formula was suitable to multiindices items for eutrophic evaluation.At the same time,the formula was applied to practical eutrophic evaluations in 10 regions of Dong Lake.The evaluation results were coincident with those obtained from the power function of weighted sums and also with actual conditions.It was shown that the bee immune evolutionary algorithm was suitable to the parameter optimization in the eutrophic evaluation model.展开更多
文摘This report presents a forensic evaluation of a case involving blindness(visual acuity grade 5)following a bee/wasp sting to the left eye.Through systematic analysis of the patient’s multiple hospital admissions,postoperative follow-up data,and a review of the pathological mechanisms of ocular injury caused by bee venom,this study comprehensively assesses the injury characteristics,treatment course,and visual outcomes.Bee venom induces severe complications such as corneal damage,uveitis,cataract,and secondary glaucoma through multiple mechanisms including direct cytotoxicity,immune-inflammatory responses,and enzymatic hydrolysis.Despite interventions including anterior chamber irrigation,phacoemulsification with intraocular lens implantation,and antiglaucoma surgery,the affected eye ultimately lost light perception.Forensic examination confirmed the absence of light perception in the left eye and abnormal visual pathway function,consistent with clinical observations.According to the relevant Chinese disability assessment standard(JR/T 0083-2013,Article 4.2.2),the injury was classified as grade 7 disability.This study provides an in-depth discussion of the mechanisms and key forensic identification points in bee-sting-induced blindness,offering a scientific reference for similar forensic clinical cases.
文摘Bees are essential to human life and ecosystems,significantly contributing to medicine,economics,and environmental equilibrium.Bees serve an essential function as pollinators,facilitating the cultivation of various fruits and vegetables.Bees contribute approximately 117 billion US dollars annually to the economy through their role in crop pollination.They have a direct impact on 35%of agricultural crops and 84%of cultivated plants.Bee products,including honey,propolis,and royal jelly,have been utilized in various traditional medicine practices across numerous countries.These substances have been utilized for their anti-inflammatory,antioxidant,and antibacterial properties.In addition to their economic,ecological,and medical significance,they serve as bioindicators for assessing the health of ecological systems by monitoring distribution and population dynamics.This offers important insights into the current situation,especially regarding the substantial impacts of climate change on the environment.This article seeks to synthesize data from various studies to examine the impact of climate change on bee populations and their habitats.This study illustrates the significant effects of future climate models for 2050 and 2070 on bee distribution,resulting in the decline of specific species populations.
基金supported by the Karadeniz Technical University(Nos.FBA-2018-7951 and FYL-2019-8116)the Scientific and Technological Research Council of Türkiye(TUBITAK)(No.123Z002).
文摘Anastasis is a phenomenon described as a cellular escape from ethanol-induced cell death.Although the relevant mechanism has not yet been fully elucidated,anastasis is thought to play a role in drug resistance in cancer cells.To date,the regulation of anastasis in normal and cancerous cells has not been clarified.
基金funded by the National Natural Science Foundation of China(Grant No.52375547)the Natural Science Foundation of Chongqing,China(Grant Nos.CSTB2022NSCQ-BHX0736 and CSTB2022NSCQ-MSX1523)the Chongqing Scientific Institution Incentive Performance Guiding Special Projects(Grant No.CSTB2024JXJL-YFX0034).
文摘This paper uses an innovative improved artificial bee colony(IABC)algorithm to aid in the fabrication of a highly responsive phasemodulation surface plasmon resonance(SPR)biosensor.In this biosensor’s sensing structure,a double-layer Ag-Au metal film is combined with a blue phosphorene/transition metal dichalcogenide(BlueP/TMDC)hybrid structure and graphene.In the optimization function of the IABC method,the reflectivity at resonance angle is incorporated as a constraint to achieve high phase sensitivity.The performance of the Ag-Au-BlueP/TMDC-graphene heterostructure as optimized by the IABC method is compared with that of a similar structure optimized using the traditional ABC algorithm.The results indicate that optimization using the IABC method gives significantly more phase sensitivity,together with lower reflectivity,than can be achieved with the traditional ABC method.The highest phase sensitivity of 3.662×10^(6) °/RIU is achieved with a bilayer of BlueP/WS2 and three layers of graphene.Moreover,analysis of the electric field distribution demonstrates that the optimal arrangement can be utilized for enhanced detection of small biomolecules.Thus,given the exceptional sensitivity achieved,the proposed method based on the IABC algorithm has great promise for use in the design of high-performance SPR biosensors with a variety of multilayer structures.
基金Scientific Research Projects Unit of Erciyes University under the contract numbers:FDK-2019-8616 and FDK-2025-14774(https://bap.erciyes.edu.tr/,accessed on 12 October 2025)The Scientific and Technological Research Council of Turkey(TUB˙ITAK)for the Doctoral Scholarship for Priority Areas 2211/C for Ramazan OZKAN(https://tubitak.gov.tr,accessed on 12 October 2025).
文摘The optimization of turbine blades is crucial in improving the efficiency of wind energy systems and developing clean energy production models.This paper presented a novel approach to the structural design of smallscale turbine blades using the Artificial Bee Colony(ABC)Algorithm based on the stochastic method to optimize both mass and cost(objective functions).The study used computational fluid dynamics(CFD)and structural analysis to consider the fluid-structure interaction.The optimization algorithm defined several variables:structural constraints,the type of composite material,and the number of composite layers to form a mathematical model.The numerical modeling was performed using the Ansys Fluent software and its Fluid-Structure Interaction(FSI)module.The ANSYS Composite PrePost(ACP)advanced composite modeling method was utilized in the structural design of composite materials.This study showed that the structurally optimized small-scale turbine blades provided a sustainable solution with improved efficiency compared to traditional designs.Furthermore,using CFD,structural analysis,and material characterization techniques first considered in this study highlights the importance of considering structural behavior when optimizing turbine blade designs.
基金supported by National Natural Science Foundations of China(32472396,31871861 and 31501548)The Apicultural Industry Technology System(NCYTI-43-KXJ17)The Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2015-IAR)。
文摘The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differences between SHS and cobalt-60 isotope(^(60)Co)radiation treatment.The number of total plate count(TPC)and mold colonies(MC)remained within the limits of the standards after SHS treatment at 140℃for 2 min.Neither TPC nor MC were detected after^(60)Co irradiation.Peroxidase(POD)and polyphenol oxidase(PPO)activities significantly decreased with increasing temperature and duration of SHS,while^(60)Co radiation completely inactivated PPO.Compared to^(60)Co radiation,SHS treatment inhibited the deterioration of rape bee pollen by avoiding hydroperoxide production and lipid oxidation due to lack of oxygen.These results suggested SHS under 140℃for 2 min was the most suitable to inactivate the microorganisms and enzymes in rape bee pollen with minimal lipid oxidation.
基金supported by Key Research and Development Program of Hubei Province(2022BBA0072)Applied Fundamental Frontier Project of Wuhan Science and Technology Bureau(2020020601012271)。
文摘Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.
基金Supported by Science and Technology Basic Special Project(2009IM020100)National Natural Science Foundation of China(5077904250739002)~~
文摘In order to establish the lake eutrophic evaluation model for multiple indices,based on the gauge transformation,an index formula in the form of a logarithmic power function was proposed to design an eutrophic evaluation model for the ＂ normalized values＂ of multi-indexes.The parameters in the formula were also optimized by bee immune evolutionary algorithm（BEIEA）.The universal index formula was suitable to multiindices items for eutrophic evaluation.At the same time,the formula was applied to practical eutrophic evaluations in 10 regions of Dong Lake.The evaluation results were coincident with those obtained from the power function of weighted sums and also with actual conditions.It was shown that the bee immune evolutionary algorithm was suitable to the parameter optimization in the eutrophic evaluation model.
