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ZBED2通过糖酵解代谢诱导肝细胞癌中PD-L1表达促进免疫逃逸的机制研究 被引量:2
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作者 黄金石 丁亚亭 曹建中 《中国免疫学杂志》 北大核心 2025年第2期367-373,共7页
目的:探讨锌指BED结构域含蛋白2(ZBED2)通过糖酵解通路对肝细胞癌(HCC)免疫逃逸的影响及潜在机制。方法:生物信息学数据库分析ZBED2在HCC组织中的表达情况及二者的结合位点,分析ZBED2调控的通路,以及ZBED2与糖酵解基因的相关性。qPCR和W... 目的:探讨锌指BED结构域含蛋白2(ZBED2)通过糖酵解通路对肝细胞癌(HCC)免疫逃逸的影响及潜在机制。方法:生物信息学数据库分析ZBED2在HCC组织中的表达情况及二者的结合位点,分析ZBED2调控的通路,以及ZBED2与糖酵解基因的相关性。qPCR和Western blot检测ZBED2及程序性细胞死亡配体1(PD-L1)在HCC细胞中的表达,MTT检测细胞活力,细胞毒性实验检测CD8+T细胞毒性,ELISA检测细胞因子表达;细胞外流量分析仪检测胞外酸化率(ECAR)和耗氧率(OCR),qPCR检测糖酵解相关基因表达,试剂盒检测糖酵解指标,免疫组织化学染色检测肿瘤组织中CD8^(+)T细胞表达。结果:ZBED2在HCC中表达上调,过表达ZBED2可促进PD-L1表达,抑制CD8^(+)T细胞对HCC细胞的毒性。过表达ZBED2通过激活糖酵解通路抑制HCC中CD8^(+)T细胞活性,进一步添加糖酵解抑制剂2-脱氧-D-葡萄糖(2-DG)减弱了以上结果。体内实验发现,敲低ZBED2可抑制小鼠肿瘤生长及PD-L1表达,促进体内CD8+T细胞浸润。结论:ZBED2通过糖酵解代谢诱导HCC中PDL1表达,促进免疫逃逸。 展开更多
关键词 锌指bed结构域含蛋白2 糖酵解 肝细胞癌 免疫逃逸
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EXPERIMENTAL STUDY OF GAS—SOLID SUSPENSION FLOWS IN VORTEXING FLUIDIZED BED CHAMBER FREEBOARD
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作者 赵长遂 朱皑强 +1 位作者 G.Yang S.Nieh 《Journal of Southeast University(English Edition)》 EI CAS 1991年第1期24-31,共8页
Gas flows and particle mass flux were measured and clutriation experimentswere conducted in two cold test models of vortexing fluidized bed(VFB).The experimen-tal results show that the secondary air injected tangentia... Gas flows and particle mass flux were measured and clutriation experimentswere conducted in two cold test models of vortexing fluidized bed(VFB).The experimen-tal results show that the secondary air injected tangentially creates strong vortexes,estab-lishes particle suspension layers and internal circulation,and suppresses the elutriation offine particles greatly.The vortexing fluidized bed combustion has bright prospect bccauseof its much higher combustion efficiency and desulphidation efficiency than bubblingfluidized bed combustion due to long particle residence time and high slip velocity betweengas and solid,and its simpler configuration and lower cost than circulating fluidized bedcombustion. 展开更多
关键词 combustion fluidized bed/vortexing fluidized bed frecboard suspension layer mass flux ELUTRIATION SWIRL number
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Incineration of kitchen waste with high nitrogen in vortexing fluidized-bed incinerator and its NO emission characteristics 被引量:2
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作者 Feng Duan Chiensong Chyang +1 位作者 Jiaruei Wen Jim Tso 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2013年第9期1841-1846,共6页
Some municipal solid waste (MSW) can be used as the fuel. Combustion of MSW with high nitrogen content is successfully conducted in a lab-scale vortexing fluidized-bed incinerator (VFBI). Pigskin with 16.5 wt.% ni... Some municipal solid waste (MSW) can be used as the fuel. Combustion of MSW with high nitrogen content is successfully conducted in a lab-scale vortexing fluidized-bed incinerator (VFBI). Pigskin with 16.5 wt.% nitrogen content was used to simulate the high nitrogen content kitchen waste, and silica sand was used as the bed material. The effects of operating conditions, such as the bed temperature, freeboard temperature, excess oxygen ratio, and static bed height on the CO and NO concentrations at the exit of combustor and cyclone were investigated. The experimental results show that the freeboard temperature is the most important factor for CO emission. The order of operating conditions impact on the NO emission is: (1) excess oxygen ratio; (2) bed temperature; (3) freeboard temperature; and (4) static bed height. Utilizing cyclone can significantly reduce the CO emission concentration when the CO concentration released from the freeboard is higher than 50 ppm. On the other hand, the cyclone has no significant effect on the NO emission. Despite having high nitrogen content, a low conversion from fuel-N to NO was attained. Compared with other types of combustors, VFBI reduces the CO and NO emission concentrations much better when burning MSW with high nitrogen content. 展开更多
关键词 INCINERATION high nitrogen content vortexing fluidized bed pollutant emission
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Pollutant emission characteristics of rice husk combustion in a vortexing fluidized bed incinerator 被引量:4
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作者 Feng Duan Chiensong Chyang +1 位作者 Yucheng Chin Jim Tso 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2013年第2期335-339,共5页
Rice husk with high volatile content was burned in a pilot scale vortexing fluidized bed incinerator. The fluidized bed incinerator was constructed of 6 mm stainless steel with 0.45 m in diameter and 5 m in height. Th... Rice husk with high volatile content was burned in a pilot scale vortexing fluidized bed incinerator. The fluidized bed incinerator was constructed of 6 mm stainless steel with 0.45 m in diameter and 5 m in height. The emission characteristics of CO, NO, and SO2 were studied. The effects of operating parameters, such as primary air flow rate, secondary air flow rate, and excess air ratio on the pollutant emissions were also investigated. The results show that a large proportion of combustion occurs at the bed surface and the freeboard zone. The SO2 concentration in the flue gas decreases with increasing excess air ratio, while the NOx concentration shows reverse trend. The flow rate of secondary air has a significant impact on the CO emission. For a fixed primary air flowrate, CO emission decreases with the secondary air flowrate. For a fixed excess air ratio, CO emission decreases with the ratio of secondary to primary air flow. The minimum CO emission of 72 ppm is attained at the operating condition of 40% excess air ratio and 0.6 partition air ratio. The NOx and SO2 concentrations in the flue gas at this condition are 159 and 36 ppm, which conform to the EPA regulation of Taiwan. 展开更多
关键词 incineration rice husk vortexing fluidized bed pollutant emission
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Adding vortexing to the Maki technique provides no benefit for the diagnosis of catheter colonization or catheter-related bacteremia
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作者 Leonardo Lorente Maria Lecuona Fernandez +7 位作者 Adriana González-Mesa Judith Oliveras-Roura Cristina Rosado Pablo Cabrera Emma Casal Alejandro Jiménez María Luisa Mora Ana Madueño 《World Journal of Critical Care Medicine》 2024年第1期58-64,共7页
BACKGROUND A previous study compared vortexing and Maki techniques for the diagnosis of catheter-related bloodstream infection(CRBSI),and concluded that vortexing was not superior to Maki method.AIM To determine wheth... BACKGROUND A previous study compared vortexing and Maki techniques for the diagnosis of catheter-related bloodstream infection(CRBSI),and concluded that vortexing was not superior to Maki method.AIM To determine whether the combined use of vortexing and Maki techniques provides profitability versus the Maki technique for the diagnosis of catheter tip colonization(CTC)and CRBSI.METHODS Observational and prospective study carried out in an Intensive Care Unit.Patients with suspected catheter-related infection(CRI)and with one central venous catheter for at least 7 days were included.The area under the curve(AUC)of the Maki technique,the vortexing technique and the combination of both techniques for the diagnosis of CTC and CRBSI were compared.RESULTS We included 136 episodes of suspected CRI.We found 21 cases of CTC of which 10 were also CRBSI cases.Of the 21 CTC episodes,18(85.7%)were diagnosed by Maki technique and vortexing technique,3(14.3%)only by the technique of Maki,and none only by technique of vortexing.Of the 10 CRBSI episodes,9(90.0%)were diagnosed by the techniques of Maki and vortexing,1(10.0%)was diagnosed only by the technique of Maki,and none only by the technique of vortexing.We no found differences in the comparison of AUC between the technique of Maki and the combination of Maki and vortexing techniques for the diagnosis of CTC(P=0.99)and CRBSI(P=0.99).CONCLUSION The novel finding of our study was that the combined use of vortexing and Maki techniques did not provide profitability to the technique of Maki alone to CRBSI diagnosis of. 展开更多
关键词 vortexing Maki Bloodstream infection COLONIZATION
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Super-high bed sintering for iron ores:variation and optimization of bed resistance 被引量:1
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作者 Liang-ping Xu Lin Xiong +4 位作者 Hui-bo Liu Xi-duan Yang Ai-xiang Mao Pei-dun Chen Guang-hui Li 《Journal of Iron and Steel Research International》 2025年第1期40-51,共12页
As the bed depth increases,sintering yield increases,but the productivity decreases.To reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and com... As the bed depth increases,sintering yield increases,but the productivity decreases.To reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the laboratory.The results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 mm.After improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 kPa.By using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 kPa.The bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 mm.After optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly. 展开更多
关键词 Super-high bed sintering bed resistance Permeability PRODUCTIVITY Wet zone Combustion zone
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Multifactorial impacts of B-doping on Fe_(81)Ga_(19) alloys prepared by laser-beam powder bed fusion:Microstructure,magnetostriction,and osteogenesis 被引量:1
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作者 Chengde Gao Liyuan Wang +2 位作者 Youwen Deng Shuping Peng Cijun Shuai 《Journal of Materials Science & Technology》 2025年第2期14-26,共13页
Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit fr... Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit frustrating magnetostriction coefficients when presented in bulk dimensions.It is well-established that the magnetostrictive performance of Fe-Ga alloys is intimately linked to their phase and crystal structures.In this study,various concentrations of boron(B)were doped into Fe_(81)Ga_(19) alloys via the laser-beam powder bed fusion(LPBF)technique to tailor the crystal and phase structures,thereby improving the magnetostrictive performance.The results revealed the capacity for quick solidification of the LPBF process in expediting the solid solution of B element,which increased both lattice distortion and dislocations within the Fe-Ga matrix.These factors contributed to an elevation in the density of the modified-D0_(3) phase structure.Moreover,the prepared Fe-Ga-B alloys also exhibited a(001)preferred grain orientation caused by the high thermal gradients during the LPBF process.As a result,a maximum magnetostriction coefficient of 105 ppm was achieved in the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy.In alternating magnetic fields,all the LPBF-prepared alloys showed good dynamic magnetostriction response without visible hysteresis,while the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy presented a notable enhancement of~30%in magnetostriction coefficient when compared with the Fe_(81)Ga_(19) alloy.Moreover.the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy exhibited favorable biocompatibility and osteogenesis,as confirmed by increased alkaline phosphatase(ALP)activity and the formation of mineralized nodules.These findings suggest that the B-doped Fe-Ga alloys combined with the LPBF technique hold promise for the development of bulk magnetostrictive alloys that are applicable for bone repair applications. 展开更多
关键词 Fe-Ga alloys Laser-beam powder bed fusion Boron doping MAGNETOSTRICTION CYTOCOMPATIBILITY
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Anisotropy Evolution of Tensile Properties in Laser Powder Bed Fusion-Fabricated Inconel 625 Alloy at High Temperature 被引量:1
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作者 Jiaqing Liu Libo Zhou +5 位作者 Zeai Peng Boyi Chen Yijie Tan Jian Chen Weiying Huang Cong Li 《Acta Metallurgica Sinica(English Letters)》 2025年第4期555-569,共15页
This work investigated the anisotropy tensile properties of Inconel 625 alloy fabricated by laser powder bed fusion (LPBF) under various tests temperature, focusing the anisotropy evolution during the high temperature... This work investigated the anisotropy tensile properties of Inconel 625 alloy fabricated by laser powder bed fusion (LPBF) under various tests temperature, focusing the anisotropy evolution during the high temperature. The microstructure contained columnar grains with (111) texture in the vertical plane (90° sample), while a large equiaxed grain with (100) texture was produced in the horizontal plane (0° sample). As for 45° sample, a large number of equiaxed grains and a few columnar grains with (111) texture can be observed. The sample produced at a 0° orientation demonstrates the highest tensile strength, whereas the 90° sample exhibits the greatest elongation. Conversely, the 45° sample displays the least favorable overall performance. As the tests temperature increased from room temperature to 600℃, the anisotropy rate of ultimate tensile strength, yield strength and ductility between 0° and 45° samples, decreased from 8.98 to 6.96%, 2.36 to 1.28%, 19.93 to 12.23%, as well as between 0° and 90° samples decreased from 4.87 to 4.03%, 11.88 to 7.21% and 14.11 to 6.89%, respectively, because of the recovery of oriented columnar grains. 展开更多
关键词 Laser powder bed fusion Inconel 625 alloy Anisotropy evolution High temperature
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A novel solution treatment and aging for powder bed fusion-laser beam Ti-6Al-2Sn-4Zr-6Mo alloy:Microstructural and mechanical characterization
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作者 Gianluca Pirro Alessandra Martucci +2 位作者 Alessandro Morri Mariangela Lombardi Lorella Ceschini 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期414-424,共11页
Ti-6Al-4Zr-2Sn-6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion-laser beam(PBF-LB)technology.This alloy has the potential to replace Ti-6Al-4V in automotive and aerospace applicati... Ti-6Al-4Zr-2Sn-6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion-laser beam(PBF-LB)technology.This alloy has the potential to replace Ti-6Al-4V in automotive and aerospace applications,given its superior mechanical properties,which are approximately 10%higher in terms of ultimate tensile strength(UTS)and yield strength after appropriate heat treatment.In as-built conditions,the alloy is characterized by the presence of soft orthorhombicα″martensite,necessitating a postprocessing heat treatment to decompose this phase and enhance the mechanical properties of the alloy.Usually,PBFed Ti6246 components undergo an annealing process that transforms theα″martensite into anα-βlamellar microstructure.The primary objective of this research was to develop a solution treatment and aging(STA)heat treatment tailored to the unique microstructure produced by the additive manufacturing process to achieve an ultrafine bilamellar microstructure reinforced by precipitation hardening.This study investigated the effects of various solution temperatures in theα-βfield(ranging from 800 to 875℃),cooling media(air and water),and aging time to determine the optimal heat treatment parameters for achieving the desired bilamellar microstructure.For each heat treatment condition,differentα-βmicrostructures were found,varying in terms of theα/βratio and the size of the primaryα-phase lamellae.Particular attention was given to how these factors were influenced by increases in solution temperature and how microhardness correlated with the percentage of the metastableβphase present after quenching.Tensile tests were performed on samples subjected to the most promising heat treatment parameters.A comparison with literature data revealed that the optimized STA treatment enhanced hardness and UTS by13%and 23%,respectively,compared with those of the annealed alloy.Fracture surface analyses were conducted to investigate fracture mechanisms. 展开更多
关键词 powder bed fusion-laser beam titanium alloys heat treatments mechanical properties fractographic analysis
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Spatial correlation singularities and orbital angular momentum spectra of partially coherent beams with noncanonical vortex pairs
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作者 MEI Chao CHENG Ke +2 位作者 YI Xiao-wen FU Cai-ying ZENG Ti-xian 《中国光学(中英文)》 北大核心 2025年第5期1243-1254,共12页
By introducing noncanonical vortex pairs to partially coherent beams, spatial correlation singularity (SCS) and orbital angular momenta (OAM) of the resulting beams are studied using the Fraunhofer diffraction integra... By introducing noncanonical vortex pairs to partially coherent beams, spatial correlation singularity (SCS) and orbital angular momenta (OAM) of the resulting beams are studied using the Fraunhofer diffraction integral. The effect of noncanonical strength, off-axis distance and vortex sign on spatial correlation singularities in far field is stressed. Furthermore, far-field OAM spectra and densities are also investigated, and the OAM detection and crosstalk probabilities are discussed. The results show that the number of dislocations of SCS always equals the sum of absolute values of topological charges for canonical or noncanonical vortex pairs. Although the sum of the product of each OAM mode and its power weight equals the algebraic sum of topological charges for canonical vortex pairs, the relationship no longer holds in the noncanonical case except for opposite-charge vortex pairs. The changes of off-axis distance, noncanonical strength or coherence length can lead to a more dominant power in adjacent mode than that in center detection mode, which also indicates that crosstalk probabilities of adjacent modes exceed the center detection probability. This work may provide potential applications in OAM-based optical communication, imaging, sensing and computing. 展开更多
关键词 spatial correlation singularity orbital angular momentum noncanonical vortex partially coherent beam
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Hot Isostatic Pressing for Enhancing Mechanical Properties of Mo Alloys Prepared by Laser Powder Bed Fusion
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作者 Liang Xunwen Fu Zhongxue +3 位作者 Zhang Shiming Che Yusi Cheng Pengming Wang Pei 《稀有金属材料与工程》 北大核心 2025年第3期587-592,共6页
To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.... To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.27%to 0.22%,enabling the elements Mo and Ti to diffuse fully and to distribute more uniformly,and to forming a substantial number of low-angle grain boundaries.The tensile strength soars from 286±32 MPa to 598±22 MPa,while the elongation increases from 0.08%±0.02%to 0.18%±0.02%,without notable alterations in grain morphology during the tensile deformation.HIP treatment eliminates the molten pool boundaries,which are the primary source for premature failure in LPBFed Mo alloys.Consequently,HIP treatment emerges as a novel and effective approach for strengthening the mechanical properties of LPBFed Mo alloys,offering a fresh perspective on producing high-performance Mo-based alloys. 展开更多
关键词 Mo alloys hot isostatic pressing laser powder bed fusion mechanical properties
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Inherent Strain Modeling of Residual Stress and Deformation for Laser Powder Bed Fused Artificial Knee Implants Under Different Building Schemes
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作者 Li Chenchen Ren Xuepeng +2 位作者 Pan Laitao Shen Falei Fang Xiaoying 《稀有金属材料与工程》 北大核心 2025年第6期1417-1425,共9页
Through a modified inherent strain model based on the minimum residual stress and deformation,three building schemes with different building postures and support structures were evaluated by finite element analysis.Re... Through a modified inherent strain model based on the minimum residual stress and deformation,three building schemes with different building postures and support structures were evaluated by finite element analysis.Results demonstrate that according to the principle of reducing the overall height of the building and reducing the support structure with a large tilt angle from the building direction,the residual stress and deformation can be effectively reduced by proper design of building posture and support before laser powder bed melting.Moreover,without the data of thermophysical property variation of Ti-6Al-4V artificial knee implants with temperature,predicting the residual stress and deformation with acceptable accuracy and reduced time cost can be achieved by the inherent strain model. 展开更多
关键词 residual stress inherent strain method titanium alloy laser powder bed fusion additive manufacturing
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Comprehensive analysis of free-surface vortex formation mechanisms:advancements and perspectives
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作者 Zi-ming Wang Ben-chen Sun +3 位作者 Yue Li Sha Ji Xiao-bin Zhou Qiang Yue 《Journal of Iron and Steel Research International》 2025年第8期2183-2212,共30页
The free-surface vortex is a rotational flow phenomenon characterized by two-phase coupling,formed by the rupture of surface fluid in the final stage of discharge.It is a significant concept with broad applications in... The free-surface vortex is a rotational flow phenomenon characterized by two-phase coupling,formed by the rupture of surface fluid in the final stage of discharge.It is a significant concept with broad applications in engineering fields like metallurgy and hydraulics.The basic concepts and characteristics of free-surface vortices were introduced,and their hazards in various fields were discussed.The development of theoretical and numerical models over recent decades was reviewed,and the factors affecting vortex formation and existing suppression methods were outlined.Finally,the key challenges and focus areas on the study of free-surface vortex were summarized.With the ongoing advancements in computational fluid dynamics and experimental technology,research on free-surface vortices will become more in depth and precise.Additionally,interdisciplinary cooperation and technological innovation are expected to achieve precise control and optimal design of free-surface vortices,offering more efficient and sustainable solutions for metallurgy and related engineering fields. 展开更多
关键词 Free-surface vortex Numerical simulation Flow characteristics vortex suppression
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Novel control method of vortex breakdown over delta wing using dual synthetic jets
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作者 Hao WANG Zhenbing LUO +3 位作者 Xiong DENG Yan ZHOU Zhijie ZHAO Jianyuan ZHANG 《Chinese Journal of Aeronautics》 2025年第5期52-64,共13页
To delay the vortex breakdown position of the slender delta wing,this study innovativelyproposes the application of control near the Leading-Edge Vortex(LEV)core sweeping path,whichis called Coupled Core Rotation Dual... To delay the vortex breakdown position of the slender delta wing,this study innovativelyproposes the application of control near the Leading-Edge Vortex(LEV)core sweeping path,whichis called Coupled Core Rotation Dual Synthetic Jets(CCR-DSJ)control.The results show that thevortex breakdown points at each angle of attack are moved backward after control,and the max-imum delayed displacement is 32.4%of the root chord at 30°.Besides,there is a linear relationshipbetween the breakdown position and the angle of attack after control,indicating that CCR-DSJcontrol has a significant effect on the pressure gradient of the vortex axis.Furthermore,the lift coef-ficient C_(L)is enhanced after control,with a maximum CLincrement of 0.078 at 27°,and an effectiveincrement interval of[25°,32°].This interval is different from most previous studies,which isdirectly related to the position of the actuators.According to the lift change mechanism,the anglesof attack are divided into three stages:Stage 1(a=15°–25°),Stage 2(a=25°–32°),and Stage 3(a=32°–40°).In conclusion,CCR-DSJ control can significantly change the pressure distribution,thereby offering promising prospects for the flight stage of the slender delta wing. 展开更多
关键词 vortex breakdown Delta wing vortex core Core rotation Dual synthetic jets
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Impacts of bed roughness and orientation on hydraulic jump:A review
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作者 Nishank Agrawal Ellora Padhi 《Water Science and Engineering》 2025年第1期90-101,共12页
Hydraulic jumps are a prevalent phenomenon in flows through spillways,chutes,and sluice gates.As hydraulic jumps exhibit substantial kinetic energy,the downstream of a hydraulic structure is prone to scour.To mitigate... Hydraulic jumps are a prevalent phenomenon in flows through spillways,chutes,and sluice gates.As hydraulic jumps exhibit substantial kinetic energy,the downstream of a hydraulic structure is prone to scour.To mitigate downstream scour and enhance energy dissipation,hydraulic jumps are often directed into stilling basins with various bed configurations,including horizontal,sloping,rough,and their combinations.This review compiles numerous analytical and experimental studies on hydraulic jumps under various bed conditions.The effect of bed roughness on sequent depth ratio,roller and jump lengths,shear stress,and energy dissipation is critically reviewed.The impacts of roughness height,flow Froude number,and bed angle on jump characteristics are discussed,substantiated by comparative analyses for distinct roughness heights.The results indicate that bed roughness intensifies shear stress,resulting in augmented energy dissipation and reductions in jump length and sequent depth.Additionally,the analytical and empirical equations proposed by researchers for different jump scenarios are discussed,and their applicability under various conditions is summarized.Finally,it suggests considering the scale effect in future research to refine the comprehension of jump stability over adverse slopes. 展开更多
关键词 Rough sloping bed Sequent depth Roller length bed shear stress Energy dissipation
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Wake vortex safety assessment during cruise using a regional medium-short-range turbofan aircraft as an example
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作者 Weijun PAN Leilei DENG +1 位作者 Yuanfei LENG Fan LI 《Chinese Journal of Aeronautics》 2025年第4期193-203,共11页
Regional turbofan aircraft,which are used for medium-short distances,have a heightened risk of high-altitude Wake Vortices(VV)because of their tail-mounted engines and high horizontal tail configurations.For some regi... Regional turbofan aircraft,which are used for medium-short distances,have a heightened risk of high-altitude Wake Vortices(VV)because of their tail-mounted engines and high horizontal tail configurations.For some regional medium-short-range turbofan aircraft,this threat is higher than that for conventionally designed aircraft.To analyze the flight safety of turbofan aircraft during cruise,this study developed a model to assess wake vortex encounters based on evolutionary high-altitude wake flow patterns.First,the high-altitude wake vortex aircraft dissipation patterns were analyzed by combining Quick Access Recorder(QAR)flight data with the wake vortex evolution model.Then,to consider the uniqueness of the medium-short-range turbofan aircraft,the severity of the wake vortex encounters was simulated using an induced roll moment coefficient.The proposed high-altitude wake vortex encounter model was able to identify and assess the highaltitude wake vortex changes,the bearing moments at different altitudes,and the atmospheric pressure conditions.Using the latest wake separation standards from the International Civil Aviation Organization(ICAO),acceptable safety wake intervals for follower aircraft in different scenarios were determined for the safety assessment.The results indicate that compared to mid and low altitudes,the high-altitude aircraft wake vortex dissipation rate is faster,the ultimate bearing moment is weaker,and the roll moment coefficient is higher,which confirm that there is elevated wake vortex encounter severity for regional turbofan aircraft.As safety is found to deteriorate when encountering wake vortices at altitudes higher than 8 km,new medium-short-range turbofan regional aircraft require higher safety margins than the latest wake separation standards. 展开更多
关键词 vortex flow Air traffic control Aircraft wake separation Regional turbofan aircraft High-altitude wake vortex
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Perfect Confinement of Acoustic Vortex by Phase-Gradient Metacage
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作者 Xicheng Fang Songsong Li +5 位作者 Baoyin Sun Dongyang Yan Junyi Yang Jie Luo Dongliang Gao Yadong Xu 《Chinese Physics Letters》 2025年第3期80-84,共5页
Acoustic wave isolation and noise reduction are significant challenges in the fields of physics and various applications.Traditional noise-control devices are often hampered by substantial size limitations,and their o... Acoustic wave isolation and noise reduction are significant challenges in the fields of physics and various applications.Traditional noise-control devices are often hampered by substantial size limitations,and their operational efficacy is generally restricted to planar waveforms.In this study,we demonstrate perfect confinement of acoustic vortex waves using an acoustic metacage consisting of phase-gradient metasurfaces.By leveraging the parity-reversed diffraction rule of phase-gradient metasurfaces,the designed metacage exhibited remarkable capabilities for the perfect confinement of acoustic vortex waves,showing robust performance even in the presence of source offsets.These findings present a promising strategy for developing precise and adaptable acoustic confinement technologies. 展开更多
关键词 ACOUSTIC PERFECT vortex
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Vortex Dynamics in Binary Ultracold Rydberg Atomic System
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作者 Yu Zhong Dan-Feng Yang +3 位作者 Ya-Xian Liu Jia Li Houria Triki Qin Zhou 《Chinese Physics Letters》 2025年第8期15-25,共11页
The vortex dynamics after the initial ring dark solitons in two-component ultracold Rydberg atomic systems have been investigated.The two parameters characterizing the Rydberg long-range interaction—namely,the Rydber... The vortex dynamics after the initial ring dark solitons in two-component ultracold Rydberg atomic systems have been investigated.The two parameters characterizing the Rydberg long-range interaction—namely,the Rydberg strength and the blockade radius—along with the initial depth,are identified as the main factors that affect the vortex dynamics.In the absence of Rydberg soft-core potential and spin-orbit coupling,the late vortex dipoles move along x-or y-axis first.However,this work demonstrates that,with certain Rydberg strength and blockade radius,the late vortex dipoles move towards the edge at an oblique angle to the coordinate axes,and it reveals that the Rydberg nonlocal nonlinear interaction shortens the lifetime of late vortices.When the intra-component and inter-component Rydberg strengths are different,the backgrounds of the two components gradually complement each other,and the lifetime of late vortices is significantly shortened.The presented results show that the Rydberg dressing breaks the rule that the initial average depth determines the number and paths of vortices.The motion features of vortex dipoles in the ultracold Rydberg atomic system have been ascertained,and their directions of movement can be predicted to some degree based on the rotation directions and initial positions of the vortices. 展开更多
关键词 ultracold Rydberg atomic system vortex dynamics vortex dipole ring dark solitons blockade radius rydberg strength Rydberg strength Rydberg long range interaction
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Vortex Mössbauer Effect as Nanoscale Probe of Chiral Structures
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作者 Yixin Li Youjing Wang +6 位作者 Kai Zhao Zhiguo Ma Yumiao Wang Yi Yang Xiangjin Kong Changbo Fu Yu-Gang Ma 《Chinese Physics Letters》 2025年第6期27-37,共11页
Chirality,a common phenomenon in nature,appears in structures ranging from galaxies and condensed matter to atomic nuclei.There is a persistent demand for new,high-precision methods to detect chiral structures,particu... Chirality,a common phenomenon in nature,appears in structures ranging from galaxies and condensed matter to atomic nuclei.There is a persistent demand for new,high-precision methods to detect chiral structures,particularly at the microscale.Here,we propose a novel method,vortex Mössbauer spectroscopy,for probing chiral structures.By leveraging the orbital angular momentum carried by vortex beams,this approach achieves high precision in detecting chiral structures at scales ranging from nanometers to hundreds of nanometers.Our simulation shows the ratio of characteristic lines in the Mössbauer spectra of ^(57)Fe under vortex beams exhibits differences of up to four orders of magnitude for atomic structures with different arrangements.Additionally,simulations reveal the response of ^(229m)Th chiral structures to vortex beams with opposite angular momenta differs by approximately 49-fold.These significant spectral variations indicate that this new vortex Mössbauer probe holds great potential for investigating the microscopic chiral structures and interactions of matter. 展开更多
关键词 condensed matter chiral structures m ssbauer spectroscopyfor atomic nucleithere vortex beamsthis orbital angular momentum detecting chiral structures vortex M ssbauer spectroscopy
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ZBED3、CYFRA21-1和VEGF与肝癌晚期患者短期死亡风险的相关性
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作者 陈威龙 王永兵 陈泽刚 《检验医学》 2025年第4期338-343,共6页
目的 探讨含BED型锌指蛋白3(ZBED3)、细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)在肝癌晚期患者死亡风险评估中的价值。方法 选取2020年1月—2022年12月重庆市梁平区人民医院肝癌晚期患者99例。收集所有研究对象的临床资料,... 目的 探讨含BED型锌指蛋白3(ZBED3)、细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)在肝癌晚期患者死亡风险评估中的价值。方法 选取2020年1月—2022年12月重庆市梁平区人民医院肝癌晚期患者99例。收集所有研究对象的临床资料,并检测ZBED3、CYFRA21-1、VEGF、甲胎蛋白(AFP)、异常凝血酶原(PIVKAⅡ)、白细胞(WBC)计数,计算中性粒细胞/淋巴细胞比值(NLR)。对所有患者随访180 d,根据是否死亡分为死亡组(35例)和存活组(64例)。采用Spearman相关分析评估各项指标之间的相关性。采用受试者工作特征(ROC)曲线评价各项指标判断肝癌晚期患者短期死亡的效能。采用Kaplan-Meier生存曲线分析肝癌晚期患者的生存情况。采用Cox回归分析评估肝癌晚期患者短期死亡的影响因素。结果 死亡组CYFRA21-1、VEGF、ZBED3、AFP、PIVKAⅡ、WBC计数、NLR和Child-Pugh评分均高于存活组(P<0.001),其他指标2个组之间差异均无统计学意义(P>0.05)。肝癌晚期患者死亡与否与CYFRA21-1、VEGF、ZBED3、Child-Pugh评分、AFP、PIVKAⅡ、WBC计数、NLR均呈正相关(r值分别为0.609、0.364、0.760、0.759、0.651、0.639、0.527、0.728,P<0.05)。CYFRA21-1、ZBED3、ChildPugh评分、VEGF、AFP、PIVKAⅡ、WBC计数、NLR判断肝癌晚期患者短期死亡的曲线下面积(AUC)分别为0.868、0.720、0.959、0.955、0.893、0.886、0.818、0.939。CYFRA21-1、VEGF、ZBED3高水平组存活率(26.5%、15.0%、3.3%)均分别低于低水平组(84.5%、77.2%、91.3%)(Log-rankχ2值分别为37.424、32.449、99.247,P<0.001)。AFP、WBC计数、ZBED3、Child-Pugh评分是HCC晚期患者短期死亡的危险因素[风险比(HR)值分别为1.008、1.946、1.013、1.237,95%可信区间(CI)分别为1.002~1.014、1.418~2.672、1.028~1.042、1.049~1.460,P<0.05]。结论 ZBED3、CYFRA21-1、VEGF与肝癌晚期患者短期死亡有关。ZBED3与传统指标AFP、WBC计数、Child-Pugh评分联合对肝癌晚期患者短期死亡风险有较高的预测价值。 展开更多
关键词 bed型锌指蛋白3 细胞角蛋白19片段 血管内皮生长因子 肝癌 死亡风险
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